CN107320567A - A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet - Google Patents
A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet Download PDFInfo
- Publication number
- CN107320567A CN107320567A CN201710738772.9A CN201710738772A CN107320567A CN 107320567 A CN107320567 A CN 107320567A CN 201710738772 A CN201710738772 A CN 201710738772A CN 107320567 A CN107320567 A CN 107320567A
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- CN
- China
- Prior art keywords
- bittersweet
- concoction
- crude slice
- materical crude
- medicine materical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of bittersweet medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried.Bittersweet powder decoction pieces prepared by this method, remain the polarity and nonpolar active ingredient in medicinal material while to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to studies of Solanum lyratum Thunb medicine materical crude slice.
Background technology
Studies of Solanum lyratum Thunb is the herb of plant of Solanaceae bittersweet.There is clearing heat and promoting diuresis, removing toxicity for detumescence, anticancer.Clinic is main
It is used to treatment cure cold heating, icterepatitis, cholecystitis, cholelithiasis, cancer, uterus erosion, leukorrhea, nephritic dropsy, outer
With controlling carbuncle furuncle poison etc..
The processing mode of conventional bittersweet medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.This
Dry bittersweet Hygienic Index can not be up to standard a bit, easily occurs medicinal material and goes mouldy, so as to cause decline and the clinic of medical material quanlity
The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody
Side and ensure its clinical efficacy.
At present, in the market also has the granule pieces sale that bittersweet medicinal material is made after extraction.Because prepared by granule pieces
During, not only time consumption and energy consumption is extracted, and be difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Come.Further, since the bittersweet medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of bittersweet medicinal material is effective, steady quality, a kind of new bittersweet medicine materical crude slice is urgently developed.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet ".This technique can be maximum
The polarity and nonpolar active ingredient that retain in bittersweet medicinal material of limit, it is to avoid medicinal material is processed and storage and transport process in existing medicine materical crude slice
In caused by active ingredient loss and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring bittersweet medicine materical crude slice
Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in bittersweet picking time, is cleaned, the section of 1 ~ 2cm length is cut into, the water of 0.5 ~ 1 times of amount of medicinal material weight is added, stirs
Mix 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, institute
The surplus dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice
Filter, obtains bittersweet concoction.By the flower Chinese violet concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, it is 1.02 ~ 1.10 to obtain relative density
Concentrate.This concentrate being spray-dried, intake air temperature is set as 100 ~ 140 DEG C, air outlet temperature is set as 90 ~
120℃.Collect dried object to be crushed, cross after 60 ~ 100 mesh sieves, vacuum packaging produces fresh squeeze of bittersweet and is dried in vacuo powder drink
Piece.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of bittersweet is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, be used as " identity card " of product.In addition, in the packaging bag of product, being printed on two
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as levy.
The present invention is advantageous in that：
Fresh bittersweet medicinal material, which is cleaned, directly to be squeezed after washing, filters, is concentrated under reduced pressure, being spray-dried, and resulting powder decoction pieces can
To retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume is greatly reduced compared to traditional medicine materical crude slice volume, matter
Amount is more stablized, beneficial to accumulating and clinical adjustment, with very significant social effect and economic implications.
Embodiment
Embodiment 1
By the bittersweet medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 minutes,
Fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 5 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 5 times of amounts
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens obtain bittersweet concoction.By the flower of gained
Chinese violet concoction is concentrated under reduced pressure, and temperature is set as 60 DEG C.When gained concentrate relative density is 1.03, spray drying tower is transferred to
It is spray-dried, intake air temperature is set as 140 DEG C, and air outlet temperature is set as 110 DEG C, collects dried object, crushes, and crosses 60
Mesh sieve, pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Embodiment 2
By the bittersweet medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 20 minutes, take advantage of
Fresh squeezing, collect just squeeze concoction, the dregs of a decoction add 3 times amount water, stir 5min, press extracting juice, the remaining dregs of a decoction add 4 times amount
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens obtain bittersweet concoction.By the flower ground of gained
Fourth concoction is concentrated under reduced pressure, and temperature is set as 65 DEG C.When gained concentrate relative density is 1.05, it is transferred to spray drying tower and enters
Row spray drying, intake air temperature is set as 120 DEG C, and air outlet temperature is set as 90 DEG C, collects dried object, crushes, and crosses 80 mesh
Sieve, pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet, it is characterised in that：It is complete that its is gathered in bittersweet picking time
Grass, is cleaned, and is cut into the section of 1 ~ 2cm length, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, is stirred 15 ~ 30 minutes, is taken advantage of fresh squeezing, is collected
Concoction is just squeezed, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, presses extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount,
Press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens obtain bittersweet concoction.
2. a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet according to claim 1, it is characterised in that：Will
The bittersweet concoction of gained, is concentrated under reduced pressure in 40 ~ 80 DEG C in claim 1, obtains the concentrate that relative density is 1.02 ~ 1.10,
It is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90 ~ 120 DEG C, collects drying
Thing is crushed, and is crossed after 60 ~ 100 mesh sieves, aerosol container, produces the fresh squeezing spray-dried powders medicine materical crude slice of bittersweet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738772.9A CN107320567A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738772.9A CN107320567A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107320567A true CN107320567A (en) | 2017-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738772.9A Pending CN107320567A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105362528A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Folium Aloes fresh-squeezed spray-dried powder decoction pieces and preparation method thereof |
| CN105520986A (en) * | 2016-02-11 | 2016-04-27 | 徐自升 | Folium artemisiae argyi fresh juice spray-dried decoction powder and preparation process thereof |
| CN105998108A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed spray-dried powdery decoction pieces and preparation process thereof |
-
2017
- 2017-08-25 CN CN201710738772.9A patent/CN107320567A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105362528A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Folium Aloes fresh-squeezed spray-dried powder decoction pieces and preparation method thereof |
| CN105520986A (en) * | 2016-02-11 | 2016-04-27 | 徐自升 | Folium artemisiae argyi fresh juice spray-dried decoction powder and preparation process thereof |
| CN105998108A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed spray-dried powdery decoction pieces and preparation process thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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Application publication date: 20171107 |