CN107468727A - A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica - Google Patents
A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica Download PDFInfo
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- CN107468727A CN107468727A CN201710738674.5A CN201710738674A CN107468727A CN 107468727 A CN107468727 A CN 107468727A CN 201710738674 A CN201710738674 A CN 201710738674A CN 107468727 A CN107468727 A CN 107468727A
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- China
- Prior art keywords
- ardisia japonica
- crude slice
- materical crude
- medicine materical
- concoction
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica.The technique is cleaned, eluted after the harvesting of ardisia japonica medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried.Japanese Ardisia Herb medicine materical crude slice prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine ardisia japonica medicine materical crude slice.
Background technology
Chinese medicine ardisia japonica is the drying complete stool in the Myrsinacea plant Japanese ardisia.With preventing phlegm from forming and stopping coughing, dampness removing, the work(of promoting blood circulation
Effect.Clinic is usually used in cough, blood-stained sputum, chronic bronchitis, jaundice with damp-heat pathogen, injury from falling down etc..
The processing mode of conventional ardisia japonica medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.
These dry ardisia japonica Hygienic Indexes can not be up to standard, easily occur medicinal material go mouldy, so as to cause the decline of medical material quanlity and
The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjusting
Agent prescription and ensure its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of ardisia japonica medicinal material.Due to granule pieces system
During standby, extraction not only time consumption and energy consumption, and also because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Out.Further, since the ardisia japonica medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Lose and very big.In order to ensure the clinic of ardisia japonica medicinal material is effective, steady quality, a kind of new ardisia japonica medicine materical crude slice is urgently opened
Hair.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica ".This technique can be most
The polarity and the nonpolar active ingredient that retain in ardisia japonica medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce pollution of the medicinal material by mould etc., it is short to ensuring
The steady quality and clinical safety of tea-drinking piece effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in ardisia japonica picking time, is cleaned, is cut into the section of 1 ~ 2cm length, adds the water of 0.5 ~ 1 times of amount of medicinal material weight,
Stirring 15 ~ 30 minutes, fresh squeezing to be taken advantage of, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice,
The remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice
Filter, obtains ardisia japonica concoction.By the flower Chinese violet concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains relative density as 1.02 ~ 1.10
Concentrate.This concentrate is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90
~120℃.Collect dried object to be crushed, after crossing 60 ~ 100 mesh sieves, vacuum packaging, produce fresh squeeze of ardisia japonica and be dried in vacuo powder
Medicine materical crude slice.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of ardisia japonica is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, it is printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh ardisia japonica medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being spray-dried, resulting powder decoction pieces,
The active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume,
Quality is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By the ardisia japonica medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, fresh squeezing is taken advantage of, collect and just squeeze concoction, the dregs of a decoction add the water of 5 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 5
Times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain ardisia japonica concoction.By institute
The flower Chinese violet concoction obtained is concentrated under reduced pressure, and temperature is set as 60 DEG C.When gained concentrate relative density is 1.03, spraying is transferred to
Drying tower is spray-dried, and intake air temperature is set as 140 DEG C, and air outlet temperature is set as 110 DEG C, collects dried object, powder
It is broken, 60 mesh sieves are crossed, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the ardisia japonica medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 20 minutes,
Fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 3 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 4 times of amounts
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain ardisia japonica concoction.By gained
Flower Chinese violet concoction is concentrated under reduced pressure, and temperature is set as 65 DEG C.When gained concentrate relative density is 1.05, spray drying is transferred to
Tower is spray-dried, and intake air temperature is set as 120 DEG C, and air outlet temperature is set as 90 DEG C, collects dried object, crushes, mistake
80 mesh sieves, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica, it is characterised in that：Gathered in ardisia japonica picking time Its herb, clean, be cut into the section of 1 ~ 2cm length, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, Collect just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain ardisia japonica concoction.
- A kind of 2. fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica according to claim 1, it is characterised in that： By the ardisia japonica concoction of gained in claim 1, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the concentration that relative density is 1.02 ~ 1.10 Liquid, it is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90 ~ 120 DEG C, collects dry Dry thing is crushed, and after crossing 60 ~ 100 mesh sieves, aerosol container, produces the fresh squeezing spray-dried powders medicine materical crude slice of ardisia japonica.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738674.5A CN107468727A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738674.5A CN107468727A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica |
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| Publication Number | Publication Date |
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| CN107468727A true CN107468727A (en) | 2017-12-15 |
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|---|---|---|---|
| CN201710738674.5A Pending CN107468727A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of ardisia japonica |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN106109559A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738674.5A patent/CN107468727A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN106109559A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171215 |
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| WD01 | Invention patent application deemed withdrawn after publication |