CN107441157A - A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin - Google Patents
A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin Download PDFInfo
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- CN107441157A CN107441157A CN201710738805.XA CN201710738805A CN107441157A CN 107441157 A CN107441157 A CN 107441157A CN 201710738805 A CN201710738805 A CN 201710738805A CN 107441157 A CN107441157 A CN 107441157A
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- Prior art keywords
- pogostemon cablin
- crude slice
- materical crude
- medicine materical
- concoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Microbiology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin.The technique is cleaned, eluted after the harvesting of Pogostemon cablin medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried.Pogostemon cablin powder decoction pieces prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine Pogostemon cablin medicine materical crude slice.
Background technology
Chinese medicine Pogostemon cablin is labiate Pogostemon cablinPogostemon cablin(Blanco) Benth. dry ground
Upper part.With eliminating dampness with aromatics, and middle preventing or arresting vomiting, the effect of delivering relieving summer-heat, it is mainly used in treating turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, heat
Wet exterior syndrome, damp-warm syndrome is from the beginning of burnout of generating heat is uncomfortable in chest not relax, and cold-dampness closes heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
The processing mode of conventional Pogostemon cablin medicine materical crude slice is：After harvesting, impurity is removed, is dried, directly packing storage and transport.
These dry Pogostemon cablin Hygienic Indexes can not be up to standard, easily occur medicinal material go mouldy, so as to cause the decline of medical material quanlity and
The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjusting
Agent prescription and ensure its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of Pogostemon cablin medicinal material.Due to granule pieces system
During standby, extraction not only time consumption and energy consumption, and also because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Out.Further, since the Pogostemon cablin medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Lose and very big.In order to ensure the clinic of Pogostemon cablin medicinal material is effective, steady quality, a kind of new Pogostemon cablin medicine materical crude slice is urgently opened
Hair.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin ".This technique can be most
The polarity and the nonpolar active ingredient that retain in Pogostemon cablin medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring the wide leaves of pulse plants
The steady quality and clinical safety of fragrant medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in Pogostemon cablin picking time, is cleaned, is cut into 1 ~ 2cm section, the water of 0.5 ~ 1 times of amount of medicinal material weight is added, stirs
Mix 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, institute
The surplus dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice
Filter, obtains Pogostemon cablin concoction.By the flower Chinese violet concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains relative density as 1.02 ~ 1.10
Concentrate.This concentrate is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90
~120℃.Collect dried object to be crushed, after crossing 60 ~ 100 mesh sieves, vacuum packaging, produce fresh squeeze of Pogostemon cablin and be dried in vacuo powder
Medicine materical crude slice.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of Pogostemon cablin is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, it is printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh Pogostemon cablin medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being spray-dried, resulting powder decoction pieces,
The active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume,
Quality is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By the Pogostemon cablin medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, fresh squeezing is taken advantage of, collect and just squeeze concoction, the dregs of a decoction add the water of 5 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 5
Times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain Pogostemon cablin concoction.By institute
The flower Chinese violet concoction obtained is concentrated under reduced pressure, and temperature is set as 60 DEG C.When gained concentrate relative density is 1.03, spraying is transferred to
Drying tower is spray-dried, and intake air temperature is set as 140 DEG C, and air outlet temperature is set as 110 DEG C, collects dried object, powder
It is broken, 60 mesh sieves are crossed, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the Pogostemon cablin medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 20 minutes,
Fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 3 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 4 times of amounts
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain Pogostemon cablin concoction.By gained
Flower Chinese violet concoction is concentrated under reduced pressure, and temperature is set as 65 DEG C.When gained concentrate relative density is 1.05, spray drying is transferred to
Tower is spray-dried, and intake air temperature is set as 120 DEG C, and air outlet temperature is set as 90 DEG C, collects dried object, crushes, mistake
80 mesh sieves, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin, it is characterised in that：Gathered in Pogostemon cablin picking time Its herb, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, receive Collection just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain Pogostemon cablin concoction.
- A kind of 2. fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin according to claim 1, it is characterised in that： By the Pogostemon cablin concoction of gained in claim 1, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the concentration that relative density is 1.02 ~ 1.10 Liquid, it is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90 ~ 120 DEG C, collects dry Dry thing is crushed, and after crossing 60 ~ 100 mesh sieves, aerosol container, produces the fresh squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738805.XA CN107441157A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738805.XA CN107441157A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin |
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| Publication Number | Publication Date |
|---|---|
| CN107441157A true CN107441157A (en) | 2017-12-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738805.XA Pending CN107441157A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Pogostemon cablin |
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| CN (1) | CN107441157A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN106109559A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738805.XA patent/CN107441157A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN106109559A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
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Application publication date: 20171208 |
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