CN107334789A - A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush - Google Patents
A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush Download PDFInfo
- Publication number
- CN107334789A CN107334789A CN201710738524.4A CN201710738524A CN107334789A CN 107334789 A CN107334789 A CN 107334789A CN 201710738524 A CN201710738524 A CN 201710738524A CN 107334789 A CN107334789 A CN 107334789A
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- CN
- China
- Prior art keywords
- scouring rush
- crude slice
- materical crude
- medicine materical
- concoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush.The technique is cleaned, eluted after the harvesting of scouring rush's medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried.Common Scouring Rush Herb medicine materical crude slice prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine scouring rush's medicine materical crude slice.
Background technology
Chinese medicine scouring rush is the herb of Equisetaceae plant scouring rush.With clear liver and improve vision, stop blooding, inducing diuresis for treating strangurtia and other effects.It is clinical
It is mainly used in treating under anemopyretic cold, cough, red eye, swell pain, cloudiness, nosebleed epistaxis, hematuria, discharging fresh blood stool, stranguria, jaundice, band, bone
Folding etc..
The processing mode of conventional scouring rush's medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.This
Dry scouring rush's Hygienic Index can not be up to standard a bit, and medicinal material easily occurs and goes mouldy, so as to cause the decline of medical material quanlity and clinic
The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody
Just and ensure its clinical efficacy.
At present, in the market has Chinese medicine manufactured granule pieces sale after extraction.Due to granule pieces preparation process
In, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted.
Further, since scouring rush's medicinal material of extraction is also to dry and stored by long-time, therefore, the loss of active ingredient is also very
Big.In order to ensure the clinic of scouring rush's medicinal material is effective, steady quality, a kind of new scouring rush's medicine materical crude slice is urgently developed.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush ".This technique can be maximum
The polarity and the nonpolar active ingredient that retain in scouring rush's medicinal material of limit, avoid medicinal material from being processed and storage and transport process in existing medicine materical crude slice
In the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring scouring rush's medicine materical crude slice
Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered picking time in scouring rush, is cleaned, is cut into the section of 1 ~ 2cm length, is added the water of 0.5 ~ 1 times of amount of medicinal material weight, is stirred
Mix 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, institute
The surplus dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice
Filter, obtains scouring rush's concoction.By the flower Chinese violet concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, it is 1.02 ~ 1.10 to obtain relative density
Concentrate.This concentrate is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, air outlet temperature is set as 90 ~
120℃.Collect dried object to be crushed, after crossing 60 ~ 100 mesh sieves, vacuum packaging, produce fresh squeeze of scouring rush and be dried in vacuo powder drink
Piece.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of the included upper scouring rush of bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Fresh scouring rush's medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being spray-dried, and resulting powder decoction pieces can
To retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume, matter
Amount is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By scouring rush's medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 minutes,
Fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 5 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 5 times of amounts
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain scouring rush's concoction.By the flower of gained
Chinese violet concoction is concentrated under reduced pressure, and temperature is set as 60 DEG C.When gained concentrate relative density is 1.03, spray drying tower is transferred to
It is spray-dried, intake air temperature is set as 140 DEG C, and air outlet temperature is set as 110 DEG C, collects dried object, crushes, and crosses 60
Mesh sieve, pack, 1kg/ bags, adds packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By scouring rush's medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 20 minutes, take advantage of
Fresh squeezing, collect just squeeze concoction, the dregs of a decoction add 3 times amount water, stir 5min, press extracting juice, the remaining dregs of a decoction add 4 times amount
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain scouring rush's concoction.By the flower ground of gained
Fourth concoction is concentrated under reduced pressure, and temperature is set as 65 DEG C.When gained concentrate relative density is 1.05, it is transferred to spray drying tower and enters
Row spray drying, intake air temperature are set as 120 DEG C, and air outlet temperature is set as 90 DEG C, collects dried object, crushes, and crosses 80 mesh
Sieve, pack, 1kg/ bags, adds packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush, it is characterised in that：It is complete that picking time its is gathered in scouring rush Grass, clean, be cut into the section of 1 ~ 2cm length, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect Concoction is just squeezed, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, Press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain scouring rush's concoction.
- A kind of 2. fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush according to claim 1, it is characterised in that：Will Scouring rush's concoction of gained, is concentrated under reduced pressure in 40 ~ 80 DEG C in claim 1, obtains the concentrate that relative density is 1.02 ~ 1.10, It is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90 ~ 120 DEG C, collects drying Thing is crushed, and after crossing 60 ~ 100 mesh sieves, aerosol container, produces the fresh squeezing spray-dried powders medicine materical crude slice of scouring rush.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738524.4A CN107334789A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738524.4A CN107334789A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107334789A true CN107334789A (en) | 2017-11-10 |
Family
ID=60214344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738524.4A Pending CN107334789A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of scouring rush |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN106109559A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738524.4A patent/CN107334789A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN106109559A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171110 |