CN107260797A - A kind of wrinkled giant hyssop is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology - Google Patents
A kind of wrinkled giant hyssop is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology Download PDFInfo
- Publication number
- CN107260797A CN107260797A CN201710460834.4A CN201710460834A CN107260797A CN 107260797 A CN107260797 A CN 107260797A CN 201710460834 A CN201710460834 A CN 201710460834A CN 107260797 A CN107260797 A CN 107260797A
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- Prior art keywords
- giant hyssop
- wrinkled giant
- fresh
- vacuum drying
- preparation technology
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
Powder decoction pieces and its preparation technology are dried in vacuo the invention discloses a kind of fresh squeeze of wrinkled giant hyssop.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of wrinkled giant hyssop medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is dried in vacuo；Condensate liquid separation volatile oil is concentrated, and is mixed with vacuum drying thing, sieving pack.Wrinkled Gianthyssop Herb medicine materical crude slice prepared by this method, remains the active ingredient in medicinal material to greatest extent.Medicine materical crude slice is easy to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine wrinkled giant hyssop medicine materical crude slice.
Background technology
Chinese medicine wrinkled giant hyssop is Labiatae wrinkled giant hyssop platymiscium wrinkled giant hyssopAgastache rugosa (Fisch. et Mey.) O.
Ktze. dry aerial parts.This moral character is pungent, tepor.Returns spleen, stomach, lung channel.This product, which has, eliminates dampness with aromatics, and middle preventing or arresting vomiting, delivers
The function of relieving summer-heat.Available for turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome is from the beginning of, burnout of generating heat, and uncomfortable in chest not relax, cold-dampness is closed
Heat, stomachache is vomited and diarrhoea, the treatment of nasosinusitis headache etc..
The processing mode of conventional wrinkled giant hyssop medicine materical crude slice is：Its aerial part is extracted in picking time, shred, dry in the shade or dry into
Medicine；Or it is collated, dry after, packing storage and transport.These dry wrinkled giant hyssop medicinal materials be transported to after prepared slices of Chinese crude drugs factory, it is necessary to
Elution, section, and redry.Existing process time and effort consuming, process is repeated, and adds the production cost of medicine materical crude slice.In this process
In not only result in water miscible a large amount of losses therein, and the also substantial amounts of loss of its abundant volatile effective component, from
And cause the decline of medical material quanlity and the reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily pollute and go mouldy, matter
Amount it is difficult to ensure that, be unfavorable for formula and adjust and ensure its clinical efficacy.
At present, in the market also has the granule pieces sale that wrinkled giant hyssop medicinal material is made after extraction.Because prepared by granule pieces
During, not only time consumption and energy consumption is extracted, and be difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Come.Further, since the wrinkled giant hyssop medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of wrinkled giant hyssop medicinal material is effective, steady quality, a kind of new wrinkled giant hyssop medicine materical crude slice and its preparation technology are urgently
It is to be developed.
The content of the invention
The invention discloses " a kind of wrinkled giant hyssop is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology ".This technique can be most
The polarity and nonpolar active ingredient that retain in wrinkled giant hyssop medicinal material of limits, it is to avoid medicinal material is in the processing of existing medicine materical crude slice and accumulating
The loss of active ingredient and the decline of medical material quanlity caused by journey, reduce pollution of the medicinal material by mould etc., to ensuring that wrinkled giant hyssop drinks
The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in wrinkled giant hyssop picking time, is cleaned, after washing, the section of 1 ~ 10cm length is cut into, fresh pressure extracting juice, the dregs of a decoction is taken advantage of
Add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration, the gained dregs of a decoction press extracting juice again, merge concoction and with 80 ~
200 mesh sieve net filtrations.By the decoction filtered, be concentrated under reduced pressure in 40 ~ 65 DEG C, obtain relative density be 1.05 ~ 1.30 medicinal extract in
40 ~ 60 DEG C vacuum drying 4 ~ 8 hours after crush.Meanwhile, the wrinkled giant hyssop condensed water for the gained that is concentrated under reduced pressure is collected, 1% ~ 5% weight is added
NaCl, be stirred to dissolve.This solution is positioned in oil water separator, in standing 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment.Point
From and collect top oil reservoir, be charged with the anhydrous Na of 1% ~ 5% weight2SO4, shake after 5 ~ 10min clocks, less than 25 DEG C room temperatures
Place 1 ~ 6 hour, filtering obtains Herba Agastaches Rugosae volatile oil.This Herba Agastaches Rugosae volatile oil for eliminating moisture is dried in vacuo with above-mentioned wrinkled giant hyssop
Powder is well mixed, and crosses 40 ~ 100 mesh sieves, and vacuum packaging produces fresh squeeze of wrinkled giant hyssop and is dried in vacuo powder decoction pieces.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of wrinkled giant hyssop is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, be used as " identity card " of product.In addition, in the packaging bag of product, being printed on two
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as levy.
The present invention is advantageous in that：
Fresh wrinkled giant hyssop medicinal material cleans direct segment after washing and squeezes, filters, being concentrated under reduced pressure, being dried in vacuo, separating oil, mixing, institute
Obtained powder decoction pieces, can completely retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume is compared to tradition
Medicine materical crude slice volume is greatly reduced, and quality is more stablized, beneficial to accumulating and clinical adjustment, with very significant social effect and warp
Ji meaning.
Embodiment
Embodiment 1
By the wrinkled giant hyssop medicinal material of fresh collection, clean, with water wash, be cut into the section of 5cm length, take advantage of the squeezing of using fresh herb squeezer, take juice.Institute
The drinking water that the dregs of a decoction add 2 times of amounts are obtained, 20min, plate and frame filter press pressure extracting juice is stirred.The gained dregs of a decoction squeeze medicine with squeezer again
Juice.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15,
It is transferred in vacuum drying chamber, is dried 6 hours in 60 DEG C, obtain vacuum drying thing.In addition, the wrinkled giant hyssop collected when being concentrated under reduced pressure is cold
Solidifying water, adds the NaCl of weight 5%, is stirred to dissolve.This solution is positioned in oil water separator, and it is quiet in 10 DEG C of environment
Put 24 hours, separate and collect upper strata volatile oil.The anhydrous Na of 2% weight is added into this volatile oil2SO4, shake after 10min clocks,
Less than 25 DEG C room temperatures are placed 6 hours, and filtering obtains Herba Agastaches Rugosae volatile oil.This volatile oil is mixed with above-mentioned wrinkled giant hyssop vacuum drying thing
It is even, 60 mesh sieves are crossed, pack 1kg/ bags, adds packed antioxidant and drier, Vacuum Package, labeling is got product.
Embodiment 2
By the wrinkled giant hyssop medicinal material of fresh collection, clean, with water wash, be cut into the section of 10cm length, take advantage of the squeezing of using fresh herb squeezer, take juice.
The gained dregs of a decoction add the drinking water of 3 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction squeeze medicine with squeezer again
Juice.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10,
It is transferred in vacuum drying chamber, is dried 8 hours in 60 DEG C, obtain vacuum drying thing.In addition, the wrinkled giant hyssop collected when being concentrated under reduced pressure is cold
Solidifying water, adds the NaCl of weight 3%, is stirred to dissolve.This solution is positioned in oil water separator, and stood in 10 DEG C of environment
24 hours, separate and collect upper strata volatile oil.The anhydrous Na of 5% weight is added into this volatile oil2SO4, shake after 5min clocks, 25 DEG C
Following room temperature is placed 12 hours, filtering, obtains Herba Agastaches Rugosae volatile oil.This volatile oil is well mixed with above-mentioned wrinkled giant hyssop vacuum drying thing,
80 mesh sieves are crossed, are packed, 1kg/ bags, packed antioxidant and drier is added, Vacuum Package, labeling is got product.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (3)
1. a kind of wrinkled giant hyssop is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology, it is characterised in that：It is gathered in wrinkled giant hyssop picking time
Aerial part, is cleaned, after washing, is cut into the section of 1 ~ 10cm length, takes advantage of fresh pressure extracting juice, and the dregs of a decoction add the water of 1 ~ 3 times of amount, and stirring 5 ~
30min, plate and frame filter press press filtration, the gained dregs of a decoction press extracting juice again, merge concoction and with 80 ~ 200 mesh sieve net filtrations.
2. a kind of wrinkled giant hyssop according to claim 1 is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology, it is characterised in that：
By the decoction of gained in claim 1,40 ~ 65 DEG C are concentrated under reduced pressure, and the medicinal extract that gained relative density is 1.05 ~ 1.30 is in 40 ~ 60
DEG C vacuum drying 4 ~ 8 hours after crush.
3. a kind of wrinkled giant hyssop according to claim 1 is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology, it is characterised in that：
The wrinkled giant hyssop condensed water of the gained that is concentrated under reduced pressure in claim 2 is collected, the NaCl of 1% ~ 5% weight is added, is stirred to dissolve, solution
Put in oil water separator, in being placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and be charged with 1% ~ 5% weight
The anhydrous Na of amount2SO4, shake after 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering, obtain Herba Agastaches Rugosae volatile oil, and will
It wants the wrinkled giant hyssop vacuum drying powder in 2 to be well mixed with right, crosses 40 ~ 100 mesh sieves, and vacuum packaging produces the fresh squeezing vacuum of wrinkled giant hyssop
Dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710460834.4A CN107260797A (en) | 2017-06-18 | 2017-06-18 | A kind of wrinkled giant hyssop is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710460834.4A CN107260797A (en) | 2017-06-18 | 2017-06-18 | A kind of wrinkled giant hyssop is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107260797A true CN107260797A (en) | 2017-10-20 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710460834.4A Pending CN107260797A (en) | 2017-06-18 | 2017-06-18 | A kind of wrinkled giant hyssop is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
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| CN (1) | CN107260797A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193920A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed vacuum drying peppermint powdery decoction pieces and preparation process thereof |
| CN105596396A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed artemisia apiacea vacuum-dried powder decoction pieces and preparation technology thereof |
| CN106074687A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
| CN106109532A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Lonicerae is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
-
2017
- 2017-06-18 CN CN201710460834.4A patent/CN107260797A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193920A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed vacuum drying peppermint powdery decoction pieces and preparation process thereof |
| CN105596396A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed artemisia apiacea vacuum-dried powder decoction pieces and preparation technology thereof |
| CN106109532A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Lonicerae is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
| CN106074687A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171020 |
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| WD01 | Invention patent application deemed withdrawn after publication |