CN105687280A - Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof - Google Patents
Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof Download PDFInfo
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- CN105687280A CN105687280A CN201610083521.7A CN201610083521A CN105687280A CN 105687280 A CN105687280 A CN 105687280A CN 201610083521 A CN201610083521 A CN 201610083521A CN 105687280 A CN105687280 A CN 105687280A
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- 238000005516 engineering process Methods 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000843 powder Substances 0.000 title claims abstract description 12
- 235000001405 Artemisia annua Nutrition 0.000 title abstract description 17
- 240000000011 Artemisia annua Species 0.000 title abstract description 17
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 16
- 238000004108 freeze drying Methods 0.000 claims abstract description 15
- 230000008901 benefit Effects 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 4
- 239000000047 product Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 238000009288 screen filtration Methods 0.000 claims description 2
- 238000007711 solidification Methods 0.000 claims description 2
- 230000008023 solidification Effects 0.000 claims description 2
- 238000003860 storage Methods 0.000 abstract description 4
- 238000001914 filtration Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000000227 grinding Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003749 cleanliness Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000012567 medical material Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 4
- 230000007423 decrease Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000009461 vacuum packaging Methods 0.000 description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 240000004460 Tanacetum coccineum Species 0.000 description 1
- 230000005200 bud stage Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
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- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and a preparation technology thereof.The preparation technology includes collecting Artemisia annua medicinal materials, selecting the Artemisia annua medicinal materials meeting the cleanliness standards prior to drip washing, squeezing when the Artemisia annua medicinal materials are fresh and filtering Artemisia annua juice; stirring Artemisia annua residues by adding water, filtering and squeezing; blending all the juice prior to vacuum concentration, subjecting extract to freeze drying and grinding at a low temperature so as to obtain the freshly-squeezed freeze-dried Artemisia annua powder decoction pieces.The freshly-squeezed freeze-dried Artemisia annua powder decoction pieces prepared according to the preparation technology keep polar and nonpolar active ingredients maximally and are beneficial to storage and transportation, convenient for making up a prescription, controllable in quality and reliable in efficacy, thereby being of great significance to traditional Chinese medicine clinical efficacy guarantee.The preparation technology is of remarkable social significance and has remarkable economic benefit when being popularized and implemented.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the modern processing technique of Chinese medicine Herba Artemisiae Annuae decoction pieces。
Background technology
Chinese medicine Herba Artemisiae Annuae, for feverfew HUANGSONGArtemisiaannuaL. dry aerial parts。This product is gathered in bud stage, has clearing away summer-heat, except steaming, and effect of preventing the attack (or recurrence) of malaria。Clinic is usually used in pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat etc.。
The processing mode of conventional Herba Artemisiae Annuae decoction pieces is: extract aerial parts, and chopping is dried and is used as medicine；Or collated, dry after, packing storage and transport。After these dry Artemisia annuas are transported to prepared slices of Chinese crude drugs factory, it is necessary to cleaning, moistening, cutting, and redry。Existing technique time and effort consuming, operation repeats, and adds the production cost of decoction pieces。Not only resulting in a large amount of losses of aqueous soluble active constituent therein in the process, and moistening operation as carried out under high temperature, wet environment, very easily occurring medical material to go mouldy, thus causing the decline of medical material quanlity and the reduction of clinical efficacy。This type of prepared herbal medicine in small pieces ready for decoction, bulky, it is easy to pollute and go mouldy, quality it is difficult to ensure that, be unfavorable for conditioning agent formulation and guarantee its clinical efficacy。
At present, market also there is the granule pieces that Artemisia annua is made after extracting to sell。Owing to, in granule pieces preparation process, extracting not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar effective ingredient in medical material be difficult to be extracted。Additionally, due to the Artemisia annua extracted also is dry and through long-time storage, therefore, the loss of effective ingredient is also very big。In order to ensure clinical effective, the steady quality of Artemisia annua, a kind of novel Herba Artemisiae Annuae decoction pieces and preparation technology thereof urgently develop。
Summary of the invention
The invention discloses " a kind of Herba Artemisiae Annuae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof "。This technique can retain the polarity in Artemisia annua and nonpolar effective ingredient to greatest extent, avoid the decline of the loss of effective ingredient that medical material causes in the processing of existing decoction pieces and storage and transport process and medical material quanlity, reduce the medical material pollution by mycete etc., the steady quality and clinical safety guaranteeing Herba Artemisiae Annuae decoction pieces is effectively had great importance。
To achieve these goals, the technical scheme is that
Gather its aerial parts collection period at Herba Artemisiae Annuae, clean, after washing, be cut into the section of 5 ~ 20cm length, take advantage of fresh squeezing, extracting juice。In the medicinal residues of gained, add the water stirring of 1 ~ 5 times amount, filter press filter pressing extracting juice。Now gained medicinal residues are two grades of medicinal residues, then it is carried out squeezing extracting juice。Merge the medicine juice of gained, with 100 ~ 200 screen filtrations。Filtrate, under 40 ~ 65 DEG C of conditions, is evaporated to the extractum that relative density is 1.05 ~ 1.30。Extractum is carried out lyophilization, and solidification point is-20 DEG C ~-80 DEG C, and freeze-off time is 6 ~ 12 hours, and vacuum is 0.06 ~ 0.09Mpa, and freeze-drying time is 8 ~ 24 hours。Lyophilized products is carried out cryogrinding pulverizing, and temperature of charge is less than 50 DEG C, and the final vacuum that sieves is packed。Above-mentioned all operations all should be carried out below room temperature 25 DEG C。Medicinal liquid, extractum and lyophilizing intermediate resting period, more than 2 hours, all should be deposited in the intermediate storage area that temperature controls below 10 DEG C。
On the label of product packaging bags, the information such as the name of an article of powder decoction pieces on note, medicinal part, time of gathering, planting site, manufacturer, date of manufacture, Contents of Main Components, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and contraindication。In the packaging bag of product, it is printed on Quick Response Code, by scanning information such as can linking the acquisition former plant photo of product, medical material photo, decoction pieces photo, character and microscopical identification feature, and the thin layer that can find Herba Artemisiae Annuae differentiates collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " identity card " of product。
The invention have benefit that:
The powder decoction pieces that fresh Artemisia annua is obtained after direct cutting squeezing, filtration, concentrating under reduced pressure, lyophilization, low-temperature grinding after cleaning washing, by fresh extracting juice technique and freeze drying process, shorten the time that medical material is heated, decrease the destruction of effective ingredient in medical material, retain the effective ingredient in medical material to greatest extent。This decoction pieces volume compares to tradition decoction pieces volume and is greatly reduced, and quality is more stable, is beneficial to accumulating, clinical adjustment and clothes for patients use, and therefore, this type decoction pieces has very significant social meaning and economic implications。
Detailed description of the invention
Embodiment 1
By the Artemisia annua of fresh collection, clean, with water wash, be cut into the section of 10cm length, take advantage of the squeezing of using fresh herb squeezer, collect medicine juice。Gained medicinal residues add the drinking water of 2 times amount, stir 20min, and after standing 30min, Aspirate supernatant filters to obtain medicine juice。Gained is precipitated as two grades of medicinal residues, then squeezes with squeezer, collects medicine juice。Being merged by the Herba Artemisiae Annuae medicine juice that above-mentioned 3 times are collected, filter with 100 eye mesh screens, concentrating under reduced pressure, temperature is set as 65 DEG C。When concentrating gained extractum relative density and being about 1.10, freezing 12 hours in-20 DEG C, take out postlyophilization, vacuum is 0.09Mpa, freeze-drying time is 12 hours, and cryogrinding is pulverized, and crosses 80 mesh sieves, pack, 1kg/ bag, adds packed antioxidant and desiccant, vacuum packaging, sealing and label sticking。
Embodiment 2
By the Artemisia annua of fresh collection, clean, with water wash, be cut into the section of 50cm length, take advantage of the squeezing of using fresh herb squeezer, collect medicine juice。Gained medicinal residues add the drinking water of 2 times amount, stir 30min, and after standing 60min, Aspirate supernatant filters to obtain medicine juice。Gained is precipitated as two grades of medicinal residues, then squeezes with squeezer, collects medicine juice。Being merged by the Herba Artemisiae Annuae medicine juice that above-mentioned 3 times are collected, filter with 80 eye mesh screens, concentrating under reduced pressure, temperature is set as 60 DEG C。When concentrating gained extractum relative density and being about 1.05, freezing 8 hours in-80 DEG C, take out postlyophilization, vacuum is 0.08Mpa, freeze-drying time is 24 hours, and cryogrinding is pulverized, and crosses 100 mesh sieves, pack, 1kg/ bag, adds packed antioxidant and desiccant, vacuum packaging, sealing and label sticking。
Above example, is only the technological thought that this invention is described, it is impossible to limits the every technological thought proposed according to the present invention of protection scope of the present invention, any change done on technical scheme basis whereby, each falls within the scope of protection of the invention。
Claims (4)
1. a Herba Artemisiae Annuae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof, it is characterized in that: gather its aerial parts collection period at Herba Artemisiae Annuae, clean, after washing, it is cut into the section of 5 ~ 20cm length, takes advantage of fresh squeezing, extracting juice, medicinal residues add the water stirring of 1 ~ 5 times amount, and filter press filter pressing extracting juice, two grades of medicinal residues of gained squeeze extracting juice again。
2. a kind of Herba Artemisiae Annuae fresh squeezing lyophilization powder decoction pieces according to claim 1 and preparation technology thereof, it is characterized in that: merge the medicine juice of gained, with 100 ~ 200 screen filtrations, filtrate, under 40 ~ 65 DEG C of conditions, is evaporated to the extractum that relative density is 1.05 ~ 1.30。
3. a kind of Herba Artemisiae Annuae fresh squeezing lyophilization powder decoction pieces according to claim 1 and preparation technology thereof, it is characterized in that: the extractum in claim 2 is carried out lyophilization, solidification point is-20 DEG C ~-80 DEG C, freeze-off time is 6 ~ 12 hours, vacuum is 0.06 ~ 0.09Mpa, and freeze-drying time is 8 ~ 24 hours。
4. a kind of Herba Artemisiae Annuae fresh squeezing lyophilization powder decoction pieces according to claim 1 and preparation technology thereof, it is characterised in that: the lyophilized products in claim 3 is carried out cryogrinding pulverizing, and temperature of charge is less than 50 DEG C, and the final vacuum that sieves is packed。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610083521.7A CN105687280A (en) | 2016-02-11 | 2016-02-11 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610083521.7A CN105687280A (en) | 2016-02-11 | 2016-02-11 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
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| CN105687280A true CN105687280A (en) | 2016-06-22 |
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| CN201610083521.7A Pending CN105687280A (en) | 2016-02-11 | 2016-02-11 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213195A (en) * | 2017-06-18 | 2017-09-29 | 徐漫 | A kind of wrinkled giant hyssop is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107281237A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107375425A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of schizonepeta is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107412291A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii |
| CN107412302A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of eclipta |
| CN107485660A (en) * | 2017-08-25 | 2017-12-19 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
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|---|---|---|---|---|
| KR20020094790A (en) * | 2001-06-13 | 2002-12-18 | (주)양지 | Functional jelly and method of preparation thereof |
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-
2016
- 2016-02-11 CN CN201610083521.7A patent/CN105687280A/en active Pending
Patent Citations (3)
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| KR20020094790A (en) * | 2001-06-13 | 2002-12-18 | (주)양지 | Functional jelly and method of preparation thereof |
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| CN105213453A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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| 徐元贞等: "《中华方药宝典》", 31 March 2012, 河南科学技术出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213195A (en) * | 2017-06-18 | 2017-09-29 | 徐漫 | A kind of wrinkled giant hyssop is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107281237A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107375425A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of schizonepeta is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107412291A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii |
| CN107412302A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of eclipta |
| CN107485660A (en) * | 2017-08-25 | 2017-12-19 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
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Application publication date: 20160622 |