CN107412291A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii Download PDFInfo
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- CN107412291A CN107412291A CN201710739615.XA CN201710739615A CN107412291A CN 107412291 A CN107412291 A CN 107412291A CN 201710739615 A CN201710739615 A CN 201710739615A CN 107412291 A CN107412291 A CN 107412291A
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- Prior art keywords
- geranium wilfordii
- materical crude
- crude slice
- medicine materical
- concoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii.The technique is cleaned, eluted, segment after the harvesting of geranium wilfordii medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried, and collects lyophilized products, is vacuum-packed after crushed.Geranium wilfordii powder decoction pieces prepared by this method, remain polarity and nonpolar active ingredient in medicinal material simultaneously to greatest extent.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese Drug Lao-guan-cao medicine materical crude slice.
Background technology
Chinese Drug Lao-guan-cao is the dry aerial parts of MangNiu Er seedlings section plant Mang ox seedling, geranium wilfordii etc..This product, which has, dispels
It is the effect of wind, activating blood and clearing heat removing toxic substances, clinical treating rheumatalgia pain, contraction, bruise, enteritis, dysentery etc..
The processing mode of conventional geranium wilfordii medicine materical crude slice is：Summer, the harvesting of season in autumn two, remove impurity, dry, then accumulating of packing.
Such prepared herbal medicine in small pieces ready for decoction, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for formula adjust
With ensure its clinical efficacy, or even the harm of recessiveness is brought to patient.
At present, in the market also has the manufactured granule pieces sale after extraction of geranium wilfordii medicinal material.The preparation of granule pieces
Process, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be carried
Take out.Further, since the geranium wilfordii medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient
Loss is also very big.In order to ensure geranium wilfordii medicinal material clinic effectively, steady quality, a kind of new geranium wilfordii medicine materical crude slice and its
Preparation technology urgently develops.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii ".This technique can be most
The polarity and the nonpolar active ingredient that retain in geranium wilfordii medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring old stork
The steady quality and clinical safety of careless medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in geranium wilfordii picking time, is cleaned, is cut into 1 ~ 2cm section, adds 0.5 ~ 1 times of amount of medicinal material weight
Water, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and squeezing takes
Juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh twice
Filter is sieved through, obtains geranium wilfordii concoction.Obtained geranium wilfordii concoction is concentrated under reduced pressure into relative density as 1.05 under the conditions of 40 ~ 75 DEG C
~ 1.25 medicinal extract, and this medicinal extract is freezed 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then be freeze-dried, pressure is 0.06 ~
0.09MPa, temperature are -15 ~ -40 DEG C, and cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, are sieved, packaging is
Can.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Geranium wilfordii is enclosed in bag
Thin layer differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product,
Quick Response Code is printed on, can be linked by scanning and obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo, character and micro-
The information such as diagnostic characteristics.
The present invention is advantageous in that：
The geranium wilfordii medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being freeze-dried, resulting powder
Last medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume significantly
Ground reduces, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, and there is very significant society to anticipate
Justice and economic implications.
Embodiment
Embodiment 1
By the geranium wilfordii medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, fresh squeezing is taken advantage of, collect and just squeeze concoction.The gained dregs of a decoction add the running water of 3 times of amounts, stir 20min, and plate and frame filter press squeezing takes
Juice.The remaining dregs of a decoction press extracting juice with squeezer again.Above-mentioned 3 concoctions are merged, with 100 mesh sieve net filtrations.Filtrate decompression is dense
Contracting, temperature are set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15, it is small that medicinal extract is freezed in -80 DEG C of refrigerators to 6
When.East knot thing is taken out, freeze-drying, pressure 0.09Mpa, temperature is -20 DEG C, is dried 24 hours.Take out lyophilized products, low temperature powder
It is broken, 80 mesh sieves are crossed, moisture is not higher than 12%, pack, 1kg/ bags, adds packed antioxidant and drier, Vacuum Package, patch
Label.
Embodiment 2
By the geranium wilfordii medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 30 minutes,
Fresh squeezing is taken advantage of, collects and just squeezes concoction.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.It is surplus
Under the dregs of a decoction again with squeezer press extracting juice.Above-mentioned 3 concoctions are merged, with 80 mesh sieve net filtrations.Filtrate decompression concentrates, temperature
It is set as 70 DEG C.When medicinal extract relative density obtained by concentration is 1.10, medicinal extract is freezed 8 hours in -80 DEG C of refrigerators.Take out east
Thing is tied, freeze-drying, pressure 0.08Mpa, temperature is -40 DEG C, is dried 48 hours.Lyophilized products are taken out, low-temperature grinding, cross 60 mesh
Sieve, moisture are not higher than 12%, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii, it is characterised in that：Gathered in geranium wilfordii picking time Its aerial part, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh pressure Squeeze, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add 1 ~ 5 times The water of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain geranium wilfordii concoction.
- A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii according to claim 1, it is characterised in that： Obtained geranium wilfordii concoction is concentrated under reduced pressure into relative density under the conditions of 40 ~ 75 DEG C and is 1.05 ~ 1.25 medicinal extract, and this is soaked Cream freezes 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then is freeze-dried, and pressure is 0.06 ~ 0.09MPa, and temperature is -15 ~ -40 DEG C, cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, and sieving, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739615.XA CN107412291A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739615.XA CN107412291A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107412291A true CN107412291A (en) | 2017-12-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739615.XA Pending CN107412291A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105687280A (en) * | 2016-02-11 | 2016-06-22 | 徐自升 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
| CN105998395A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Herba Verbenae freshly squeezed freeze drying powder decoction piece and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710739615.XA patent/CN107412291A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105687280A (en) * | 2016-02-11 | 2016-06-22 | 徐自升 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
| CN105998395A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Herba Verbenae freshly squeezed freeze drying powder decoction piece and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171201 |
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| WD01 | Invention patent application deemed withdrawn after publication |