CN107375380A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago Download PDFInfo
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- CN107375380A CN107375380A CN201710739111.8A CN201710739111A CN107375380A CN 107375380 A CN107375380 A CN 107375380A CN 201710739111 A CN201710739111 A CN 201710739111A CN 107375380 A CN107375380 A CN 107375380A
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- China
- Prior art keywords
- tussilago
- materical crude
- crude slice
- medicine materical
- squeezing
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago.The technique is cleaned, eluted after the harvesting of tussilago medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried, and collects lyophilized products, is vacuum-packed after crushed.Common Coltsfoot Flower medicine materical crude slice prepared by this method, remain polarity and nonpolar active ingredient in medicinal material simultaneously to greatest extent.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine tussilago medicine materical crude slice.
Background technology
Chinese medicine tussilago is feverfew coltsfootTussilago farfaraL. dry flower.This product has under moistening lung
Gas, it is relieving cough and reducing sputum the effect of, be mainly used in new chronic cough and cough, dyspnea and cough with excessive sputum, the treatment of overstrain cough hemoptysis etc..
The processing mode of conventional tussilago medicine materical crude slice is：Excavated before December or frozen ground when flower is not yet unearthed, remove bennet
And silt, dry in the shade, then accumulating of packing.Such medicine materical crude slice, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, and quality is difficult
Ensure, be unfavorable for formula adjustment and ensure its clinical efficacy, or even the harm of recessiveness is brought to patient.
At present, in the market also has the manufactured granule pieces sale after extraction of tussilago medicinal material.The preparation of granule pieces
Process, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be carried
Take out.Further, since the tussilago medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient
Loss is also very big.In order to ensure tussilago medicinal material clinic effectively, steady quality, a kind of new tussilago medicine materical crude slice and its
Preparation technology urgently develops.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago ".This technique can be most
The polarity and the nonpolar active ingredient that retain in tussilago medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring coltsfoot
The steady quality and clinical safety of flower medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
After tussilago harvests, clean, be cut into 0.4 ~ 0.8cm fragment, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stirring 15 ~
30 minutes, fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, remaining medicine
Slag add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain
Tussilago concoction.Obtained tussilago concoction is concentrated under reduced pressure into the leaching that relative density is 1.05 ~ 1.25 under the conditions of 40 ~ 75 DEG C
Cream, and this medicinal extract is freezed 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then be freeze-dried, pressure are 0.06 ~ 0.09MPa, temperature
For -15 ~ -40 DEG C, cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, and sieving, packaging.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The included upper tussilago of bag
Thin layer differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product,
Quick Response Code is printed on, can be linked by scanning and obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo, character and micro-
The information such as diagnostic characteristics.
The present invention is advantageous in that：
The tussilago medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being freeze-dried, resulting powder
Last medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume significantly
Ground reduces, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, and there is very significant society to anticipate
Justice and economic implications.
Embodiment
Embodiment 1
By the tussilago medicinal material of fresh collection, clean, be cut into 0.4cm fragment, add the water of 0.5 times of amount of medicinal material weight, stirring
15 minutes, fresh squeezing is taken advantage of, takes juice.The gained dregs of a decoction add the running water of 3 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.It is surplus
Under the dregs of a decoction again with squeezer press extracting juice.Above-mentioned 3 concoctions are merged, with 100 mesh sieve net filtrations.Filtrate decompression concentrates, temperature
Degree is set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15, medicinal extract is freezed 6 hours in -80 DEG C of refrigerators.Take out
East knot thing, freeze-drying, pressure 0.09Mpa, temperature are -20 DEG C, are dried 24 hours.Lyophilized products are taken out, low-temperature grinding, cross 80
Mesh sieve, moisture are not higher than 12%, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the tussilago medicinal material of fresh collection, clean, be cut into 0.8cm fragment, add the water of 1 times of amount of medicinal material weight, stirring 30
Minute, fresh squeezing is taken advantage of, takes juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.It is remaining
The dregs of a decoction again with squeezer press extracting juice.Above-mentioned 3 concoctions are merged, with 80 mesh sieve net filtrations.Filtrate decompression is concentrated, and temperature is set
It is set to 70 DEG C.When medicinal extract relative density obtained by concentration is 1.10, medicinal extract is freezed 8 hours in -80 DEG C of refrigerators.Take out east knot
Thing, freeze-drying, pressure 0.08Mpa, temperature are -40 DEG C, are dried 48 hours.Lyophilized products are taken out, low-temperature grinding, cross 60 mesh
Sieve, moisture are not higher than 12%, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago, it is characterised in that：After tussilago harvests, wash Only, 0.4 ~ 0.8cm fragment is cut into, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, stirs 15 ~ 30 minutes, takes advantage of fresh squeezing, is collected Concoction is just squeezed, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, Press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain tussilago concoction.
- A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago according to claim 1, it is characterised in that： Obtained tussilago concoction is concentrated under reduced pressure into relative density under the conditions of 40 ~ 75 DEG C and is 1.05 ~ 1.25 medicinal extract, and this is soaked Cream freezes 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then is freeze-dried, and pressure is 0.06 ~ 0.09MPa, and temperature is -15 ~ -40 DEG C, cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, and sieving, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739111.8A CN107375380A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739111.8A CN107375380A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375380A true CN107375380A (en) | 2017-11-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739111.8A Pending CN107375380A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of tussilago |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871195A (en) * | 2012-09-17 | 2013-01-16 | 上海交通大学 | Angelica keiskei kidz effervescence medicine slice rich in flavone and preparation method thereof |
| CN105213453A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213459A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710739111.8A patent/CN107375380A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871195A (en) * | 2012-09-17 | 2013-01-16 | 上海交通大学 | Angelica keiskei kidz effervescence medicine slice rich in flavone and preparation method thereof |
| CN105213453A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213459A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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Application publication date: 20171124 |
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