CN107334833A - A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf - Google Patents
A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf Download PDFInfo
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- CN107334833A CN107334833A CN201710739032.7A CN201710739032A CN107334833A CN 107334833 A CN107334833 A CN 107334833A CN 201710739032 A CN201710739032 A CN 201710739032A CN 107334833 A CN107334833 A CN 107334833A
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- loguat leaf
- squeezing
- concoction
- spray
- materical crude
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- 239000003814 drug Substances 0.000 title claims abstract description 22
- 239000008187 granular material Substances 0.000 title claims abstract description 12
- 238000005516 engineering process Methods 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 235000020985 whole grains Nutrition 0.000 claims abstract description 5
- 238000003306 harvesting Methods 0.000 claims abstract description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 5
- 230000014759 maintenance of location Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000011122 softwood Substances 0.000 claims description 4
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 claims description 2
- 238000009461 vacuum packaging Methods 0.000 claims description 2
- 235000013339 cereals Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 238000001694 spray drying Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract description 3
- 230000000192 social effect Effects 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 241001092070 Eriobotrya Species 0.000 description 1
- 235000009008 Eriobotrya japonica Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf.The technique is cleaned, eluted after the harvesting of loguat leaf medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, and collects spray drying product, through crushing with just squeezing concoction mixing granulation, is vacuum-packed after whole grain.Loguat leaf granule pieces prepared by this method, remain the polarity in medicinal material and nonpolar active ingredient to greatest extent.Granule pieces good fluidity, beneficial to accumulating, convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine loguat leaf medicine materical crude slice.
Background technology
Chinese medicine loguat leaf is rosaceous plant loquatEriobotrya japonicaThunb. leaf.This product has clearly
Lung cough-relieving, stopping nausea and vomiting by lowering the adverse flow of QI, and stomach diuresis, the effect of cough-relieving.Available for cough with lung heat is treated, circulation of vital energy in the wrong direction asthma is anxious, gastropyretic vomiting, the sound of vomiting
Inverse, dry is quenched one's thirst.
The processing mode of conventional loguat leaf medicine materical crude slice is：After harvesting, impurity is removed, is dried, accumulating of packing.To medicine materical crude slice factory again
Profit, chopping are washed, is dried.Such medicine materical crude slice, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, no
Adjusted beneficial to formula and ensure its clinical efficacy, or even the harm of recessiveness is brought to patient.
At present, in the market also has the manufactured granule pieces sale after extraction of loguat leaf medicinal material.The preparation of granule pieces
Process, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be carried
Take out.Further, since the loguat leaf medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient
Loss is also very big.In order to ensure the clinic of loguat leaf medicinal material is effective, steady quality, a kind of new loguat leaf medicine materical crude slice is urgently
Exploitation.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf ".This technique can be most
The polarity and the nonpolar active ingredient that retain in loguat leaf medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring loquat
The steady quality and clinical safety of leaf medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
After loguat leaf harvesting, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 points
Clock, fresh squeezing to be taken advantage of, collect and just squeeze concoction, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add the water of 1 ~ 5 times of amount,
Stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after twice
Concoction is squeezed, 100 ~ 200 mesh screens, obtains loguat leaf concoction.Obtained loguat leaf concoction is depressurized under the conditions of 40 ~ 75 DEG C dense
It is reduced to relative density and is 1.02 ~ 1.15 concentrate, and this concentrate is spray-dried, intake air temperature is set as 90 ~ 140
DEG C, air outlet temperature is 80 ~ 110 DEG C, collects desciccate, and 60 ~ 100 mesh sieves are crossed after crushing.Above-mentioned loguat leaf is spray-dried
Powder, mixed with the first squeezing concoction of retention, prepare softwood, pelletized, 50 ~ 80 DEG C of drying 4 ~ 8 hours, whole grain, is vacuum-packed.In product
On the label of packaging bag, the name of an article, medicinal part, planting site, medicine materical crude slice manufacturer, date of manufacture, Contents of Main Components, property in printing
The information such as taste channel tropism, major function, usage and dosage, toxic side effect and contraindication.The thin layer that loguat leaf is enclosed in bag differentiates collection of illustrative plates
And/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, Quick Response Code is printed on, is led to
Overscanning can link the letter such as former plant photo, medicinal material photo, medicine materical crude slice photo, character and microscopical characters feature for obtaining product
Breath.
The present invention is advantageous in that：
The loguat leaf medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being spray-dried, pelletizing, gained
The granule pieces arrived, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume is compared to traditional medicine materical crude slice body
Product greatly reduces, good fluidity, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, has ten
Divide significant social effect and economic implications.
Embodiment
Embodiment 1
By the loguat leaf medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, fresh squeezing is taken advantage of, the first squeezing concoction for retaining 0.1% weight is separately used.The gained dregs of a decoction add the running water of 3 times of amounts, stir 20min, sheet frame
Filter press presses extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By the above-mentioned remaining concoction that just squeezes with subsequently pressing twice
Squeeze concoction to merge, with 100 mesh sieve net filtrations.Filtrate decompression concentrates, and temperature is set as 65 DEG C.In medicinal extract relative density obtained by concentration
For 1.05 when, spray drying, intake air temperature be 140 DEG C, air outlet temperature be 100 DEG C, collect spray drying thing, low-temperature grinding, mistake
80 mesh sieves.This spray dried powder is mixed into softwood processed with the first squeezing concoction of above-mentioned retention, pelletized, 75 DEG C of dryings 6 hours, whole grain,
Pack, 1kg/ bags, adds packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the loguat leaf medicinal material of fresh collection, clean, silt is washed with water, be cut into 2cm section, add 1 times of amount of medicinal material weight
Water, stir 30 minutes, take advantage of fresh squeezing, the first squeezing concoction for retaining 0.5% weight is separately used.The gained dregs of a decoction add the running water of 5 times of amounts, stir
Mix 30min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By above-mentioned remaining just squeezing concoction
Merge with subsequently squeezing concoction twice, with 100 mesh sieve net filtrations.Filtrate decompression concentrates, and temperature is set as 70 DEG C.Obtained by concentration
When medicinal extract relative density is 1.10, spray drying, intake air temperature is 120 DEG C, and air outlet temperature is 90 DEG C, collects spray drying thing,
Low-temperature grinding, cross 80 mesh sieves.This spray dried powder is mixed into softwood processed with the first squeezing concoction of above-mentioned retention, pelletized, 70 DEG C of dryings 8
Hour, whole grain, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (3)
- A kind of 1. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf, it is characterised in that：After loguat leaf harvesting, wash Only, 1 ~ 2cm section is cut into, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, is stirred 15 ~ 30 minutes, takes advantage of fresh squeezing, collects and just squeezes medicine Juice, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add the water of 1 ~ 5 times of amount, stirs 5 ~ 30min, presses extracting juice, The remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice Filter, obtains loguat leaf concoction.
- A kind of 2. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf according to claim 1, it is characterised in that： By the loguat leaf concoction obtained in claim 1 be concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C relative density be 1.02 ~ 1.15 it is dense Contracting liquid, and this concentrate is spray-dried, intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, is collected Desciccate, 60 ~ 100 mesh sieves are crossed after crushing.
- A kind of 3. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf according to claim 1, it is characterised in that： By the loguat leaf spray dried powder in claim 2, mixed with the first squeezing concoction retained in claim 1, prepare softwood, made Grain, 50 ~ 80 DEG C of dryings 4 ~ 8 hours, whole grain, vacuum packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739032.7A CN107334833A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739032.7A CN107334833A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107334833A true CN107334833A (en) | 2017-11-10 |
Family
ID=60215504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739032.7A Pending CN107334833A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf |
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| Country | Link |
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| CN (1) | CN107334833A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213660A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213474A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105708876A (en) * | 2016-02-11 | 2016-06-29 | 徐自升 | Sweet wormwood herb freshly-squeezed spraying drying particle decoction piece and preparation technology thereof |
| CN106038491A (en) * | 2016-07-23 | 2016-10-26 | 徐漫 | Freshly squeezed and spray-dried granular decoction pieces with verbena officinalis and process for preparing freshly squeezed and spray-dried granular decoction pieces |
| CN106074686A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710739032.7A patent/CN107334833A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213660A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213474A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105708876A (en) * | 2016-02-11 | 2016-06-29 | 徐自升 | Sweet wormwood herb freshly-squeezed spraying drying particle decoction piece and preparation technology thereof |
| CN106038491A (en) * | 2016-07-23 | 2016-10-26 | 徐漫 | Freshly squeezed and spray-dried granular decoction pieces with verbena officinalis and process for preparing freshly squeezed and spray-dried granular decoction pieces |
| CN106074686A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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Application publication date: 20171110 |
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