CN107320582A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet Download PDFInfo
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- CN107320582A CN107320582A CN201710738985.1A CN201710738985A CN107320582A CN 107320582 A CN107320582 A CN 107320582A CN 201710738985 A CN201710738985 A CN 201710738985A CN 107320582 A CN107320582 A CN 107320582A
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- China
- Prior art keywords
- chinese violet
- freeze
- crude slice
- materical crude
- medicine materical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of Chinese violet medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Tokyo Violet Herb medicine materical crude slice prepared by this method, remains the polarity and nonpolar active ingredient in medicinal material while to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine Chinese violet medicine materical crude slice.
Background technology
Chinese medicine Chinese violet is Violaceae Chinese violetViola yedoensis Makino drying herb.This
Sample bitter, acrid, cold；The thoughts of returning home, lung channel；With clearing heat and detoxicating, cool blood detumescence, the effect of clearing heat and promoting diuresis cures mainly furunculosis, carbuncle swells, scrofula
Scrofula, jaundice, dysentery, diarrhoea, hot eyes, larynx numbness, venomous snake bite.
The processing mode of conventional Chinese violet medicine materical crude slice is：Spring, the harvesting of season in autumn two, remove impurity, dry, directly packing storage
Hide and transport.These Chinese violet Hygienic Indexes dried can not be up to standard, easily occurs medicinal material and goes mouldy, so as to cause medicinal material product
The decline of matter and the reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur to go bad and contaminated, quality is difficult to protect
Card, is unfavorable for conditioning agent formulation and ensures its clinical efficacy.
At present, in the market also has the granule pieces sale that Chinese violet medicinal material is made after extraction.Due to granule pieces
In preparation process, not only time consumption and energy consumption is extracted, and the nonpolar active ingredient done because commonly using water in solvent, medicinal material is difficult to be carried
Take out.Further, since the Chinese violet medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient
Loss be also very big.In order to ensure the clinic of Chinese violet medicinal material is effective, steady quality, a kind of new Chinese violet drink
Piece is urgently developed.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet ".This technique can be with
To greatest extent retain Chinese violet medicinal material in polarity and nonpolar active ingredient, it is to avoid medicinal material existing medicine materical crude slice processing and
The loss of active ingredient and the decline of medical material quanlity caused by storage and transport process, reduce pollution of the medicinal material by mould etc., to ensuring
The steady quality and clinical safety of Chinese violet medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in Chinese violet picking time, is cleaned, the wide pieces of 1 ~ 2cm are cut into, 0.5 ~ 1 times of amount of medicinal material weight is added
Water, stirs 15 ~ 30 minutes, takes advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, pressure
Extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~
200 mesh screens, obtain Chinese violet concoction.By the concoction of gained, be concentrated under reduced pressure in 40 ~ 80 DEG C, obtain relative density for 1.05 ~
1.25 medicinal extract.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set
It is set to -15 DEG C ~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, the time is 8 ~ 48 hours, collects lyophilized products, crushes, excessively 60 ~
100 mesh sieves, packaging produces the fresh squeezing freeze-dried powder medicine materical crude slice of Chinese violet.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Chinese violet is enclosed in bag
Thin layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in the packaging bag of product, print
There is Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the micro- mirror for obtaining product can be linked by scanning
The information such as other feature.
The present invention is advantageous in that：
Fresh Chinese violet medicinal material, which is cleaned, directly to be squeezed after washing, filters, is concentrated under reduced pressure, being freeze-dried, resulting powder drink
Piece, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume greatly subtracts compared to traditional medicine materical crude slice volume
Small, quality is more stablized, beneficial to accumulating and clinical adjustment, with very significant social effect and economic implications.
Embodiment
Embodiment 1
By the Chinese violet medicinal material of fresh collection, clean, be cut into the wide pieces of 1cm, add the water of 0.5 times of amount of medicinal material weight, stirring
15 minutes, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.Gained
The dregs of a decoction are squeezed with squeezer again, leaching concoction.Above-mentioned 3 Chinese violet concoctions are merged, 60 mesh screens are used, filtrate decompression is dense
Contracting, temperature is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.Will
Scars are freeze-dried after taking out, and temperature is set as -18 DEG C, and pressure is 0.09Mpa, and the time is 24 hours.Collect lyophilized
Thing, is crushed, and crosses 60 mesh sieves, and pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Embodiment 2
By the Chinese violet medicinal material of fresh collection, clean, be cut into the wide pieces of 2cm, add the water of 1 times of amount of medicinal material weight, stirring 30
Minute, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.Gained medicine
Slag is squeezed with squeezer again, leaching concoction.Above-mentioned 3 Chinese violet concoctions are merged, 100 mesh screens are used, filtrate decompression is dense
Contracting, temperature is set as 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.Will
Scars are freeze-dried after taking out, and temperature is set as -40 DEG C, and pressure is 0.09Mpa, and the time is 48 hours.Collect lyophilized
Thing, is crushed, and crosses 100 mesh sieves, and pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet, it is characterised in that：In Chinese violet picking time
Its herb is gathered, is cleaned, the wide pieces of 1 ~ 2cm are cut into, the water of 0.5 ~ 1 times of amount of medicinal material weight is added, stirs 15 ~ 30 minutes, takes advantage of fresh
Squeezing, collects and just squeezes concoction, and the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add 1 ~ 5
Times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens obtain Chinese violet medicine
Juice.
2. a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet according to claim 1, its feature exists
In：By the Chinese violet concoction of gained in claim 2, it is concentrated under reduced pressure in 40 ~ 80 DEG C, it is 1.05 ~ 1.25 to obtain relative density
Medicinal extract, put in -20 DEG C ~ -80 DEG C refrigerators and freeze 6 ~ 24 hours, be freeze-dried after taking-up, temperature is set as -15 DEG C ~ 40 DEG C, pressure
Power is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, and crosses 60 ~ 100 mesh sieves, and packaging produces purple
Flower Chinese violet is fresh to squeeze freeze-dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738985.1A CN107320582A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738985.1A CN107320582A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107320582A true CN107320582A (en) | 2017-11-07 |
Family
ID=60228220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738985.1A Pending CN107320582A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet |
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| Country | Link |
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| CN (1) | CN107320582A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213459A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213475A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213661A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738985.1A patent/CN107320582A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213459A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213475A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213661A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171107 |
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| WD01 | Invention patent application deemed withdrawn after publication |