CN107320566A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade Download PDFInfo
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- CN107320566A CN107320566A CN201710738617.7A CN201710738617A CN107320566A CN 107320566 A CN107320566 A CN 107320566A CN 201710738617 A CN201710738617 A CN 201710738617A CN 107320566 A CN107320566 A CN 107320566A
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- Prior art keywords
- black nightshade
- freeze
- squeezing
- crude slice
- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of black nightshade medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Black Nightshade Herb medicine materical crude slice prepared by this method, remains the polarity and nonpolar active ingredient in medicinal material while to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine black nightshade medicine materical crude slice.
Background technology
Chinese medicine black nightshade is plant of Solanaceae black nightshadeSolanum nigrumL. aerial part.With clearing heat and detoxicating, diuresis
Effect.Clinic is mainly used in sore and toxic, skin eczema, difficult urination, chronic senile tracheitis, leukorrhea, prostate
The treatment of inflammation, dysentery etc..
The processing mode of conventional black nightshade medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.This
Dry black nightshade Hygienic Index can not be up to standard a bit, easily occurs medicinal material and goes mouldy, so as to cause decline and the clinic of medical material quanlity
The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody
Side and ensure its clinical efficacy.
At present, in the market also has the granule pieces sale that black nightshade medicinal material is made after extraction.Because prepared by granule pieces
During, not only time consumption and energy consumption is extracted, and be difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Come.Further, since the black nightshade medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of black nightshade medicinal material is effective, steady quality, a kind of new black nightshade medicine materical crude slice is urgently developed.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade ".This technique can be maximum
The polarity and nonpolar active ingredient that retain in black nightshade medicinal material of limit, it is to avoid medicinal material is processed and storage and transport process in existing medicine materical crude slice
In caused by active ingredient loss and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring black nightshade medicine materical crude slice
Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in black nightshade picking time, is cleaned, the section of 1 ~ 2cm length is cut into, 0.5 ~ 1 times of amount of medicinal material weight is added
Water, stirs 15 ~ 30 minutes, takes advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, pressure
Extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~
200 mesh screens, obtain black nightshade concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, it is 1.05 ~ 1.25 to obtain relative density
Medicinal extract.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set as-
15 DEG C ~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, crosses 60 ~ 100 mesh
Sieve, packaging produces the fresh squeezing freeze-dried powder medicine materical crude slice of black nightshade.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of the included upper black nightshade of bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, be used as " identity card " of product.In addition, in the packaging bag of product, being printed on two
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as levy.
The present invention is advantageous in that：
Fresh black nightshade medicinal material, which is cleaned, directly to be squeezed after washing, filters, is concentrated under reduced pressure, being freeze-dried, and resulting powder decoction pieces can
To retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume is greatly reduced compared to traditional medicine materical crude slice volume, matter
Amount is more stablized, beneficial to accumulating and clinical adjustment, with very significant social effect and economic implications.
Embodiment
Embodiment 1
By the black nightshade medicinal material of fresh collection, clean, be cut into the section of 1cm length, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, takes advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction
Squeezed again with squeezer, leaching concoction.Above-mentioned 3 black nightshade concoctions are merged, 60 mesh screens, filtrate decompression concentration, temperature are used
It is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.By scars
It is freeze-dried after taking-up, temperature is set as -18 DEG C, and pressure is 0.09Mpa, and the time is 24 hours.Collect lyophilized products, powder
It is broken, 60 mesh sieves are crossed, pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Embodiment 2
By the black nightshade medicinal material of fresh collection, clean, be cut into the section of 2cm length, add the water of 1 times of amount of medicinal material weight, stir 30 minutes,
Take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction are again
Squeezed with squeezer, leaching concoction.Above-mentioned 3 black nightshade concoctions are merged, 100 mesh screens are used, filtrate decompression concentration, temperature is set
It is set to 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.Scars are taken out
It is freeze-dried afterwards, temperature is set as -40 DEG C, and pressure is 0.09Mpa, and the time is 48 hours.Lyophilized products are collected, are crushed, mistake
100 mesh sieves, pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade, it is characterised in that：Its ground is gathered in black nightshade picking time
Upper part, is cleaned, and is cut into the section of 1 ~ 2cm length, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, is stirred 15 ~ 30 minutes, is taken advantage of fresh squeezing,
Collect just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens obtain black nightshade concoction.
2. a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade according to claim 1, it is characterised in that：Will
The black nightshade concoction of gained, is concentrated under reduced pressure in 40 ~ 80 DEG C in claim 2, obtains the medicinal extract that relative density is 1.05 ~ 1.25, put-
Freeze in 20 DEG C ~ -80 DEG C refrigerators 6 ~ 24 hours, be freeze-dried after taking-up, temperature is set as -15 DEG C ~ 40 DEG C, and pressure is set as
0.06 ~ 0.09MPa, the time is 8 ~ 48 hours, collects lyophilized products, is crushed, and crosses 60 ~ 100 mesh sieves, and packaging produces the fresh squeezing of black nightshade cold
Freeze dry powder decoction pieces.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738617.7A CN107320566A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738617.7A CN107320566A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107320566A true CN107320566A (en) | 2017-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738617.7A Pending CN107320566A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738617.7A patent/CN107320566A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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| PB01 | Publication | ||
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Application publication date: 20171107 |