CN107375352A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern Download PDFInfo
- Publication number
- CN107375352A CN107375352A CN201710738688.7A CN201710738688A CN107375352A CN 107375352 A CN107375352 A CN 107375352A CN 201710738688 A CN201710738688 A CN 201710738688A CN 107375352 A CN107375352 A CN 107375352A
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- Prior art keywords
- phoenix
- tail fern
- freeze
- squeezing
- crude slice
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern.The technique is cleaned, eluted after the harvesting of phoenix-tail fern medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Phoenix-tail fern powder decoction pieces prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese Trsditional Medicine of Pteris Multifida Poir medicine materical crude slice.
Background technology
Chinese Trsditional Medicine of Pteris Multifida Poir is the complete stool of Pteridaceae plant phoenix-tail fern.With clearing heat and promoting diuresis, cooling blood and hemostasis, subdhing swelling and detoxicating etc.
Effect, clinic are mainly used in treating dysentery, enteritis, icteric hepatitis, spit blood, have blood in stool, the illness such as hematuria.
The processing mode of conventional phoenix-tail fern medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.
These dry phoenix-tail fern Hygienic Indexes can not be up to standard, easily occur medicinal material go mouldy, so as to cause the decline of medical material quanlity and
The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjusting
Agent prescription and ensure its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of phoenix-tail fern medicinal material.Due to granule pieces system
During standby, extraction not only time consumption and energy consumption, and also because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Out.Further, since the phoenix-tail fern medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Lose and very big.In order to ensure the clinic of phoenix-tail fern medicinal material is effective, steady quality, a kind of new phoenix-tail fern medicine materical crude slice is urgently opened
Hair.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern ".This technique can be most
The polarity and the nonpolar active ingredient that retain in phoenix-tail fern medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring phoenix tail
The steady quality and clinical safety of careless medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in phoenix-tail fern picking time, is cleaned, is cut into the section of 1 ~ 2cm length, adds the water of 0.5 ~ 1 times of amount of medicinal material weight,
Stirring 15 ~ 30 minutes, takes advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, squeezing
Take juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200
Mesh screen, obtain phoenix-tail fern concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains relative density as 1.05 ~ 1.25
Medicinal extract.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set as-
15 DEG C ~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, crosses 60 ~ 100 mesh
Sieve, packaging, produce the fresh squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of phoenix-tail fern is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, it is printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh phoenix-tail fern medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being freeze-dried, resulting powder decoction pieces,
The active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume,
Quality is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By the phoenix-tail fern medicinal material of fresh collection, clean, be cut into the section of 1cm length, add the water of 0.5 times of amount of medicinal material weight, stirring 15
Minute, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.Gained medicine
Slag is squeezed with squeezer again, leaching concoction.Above-mentioned 3 phoenix-tail fern concoctions are merged, with 60 mesh screens, filtrate decompression concentrates,
Temperature is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.It will freeze
Knot thing is freeze-dried after taking out, and temperature is set as -18 DEG C, pressure 0.09Mpa, and the time is 24 hours.Collect lyophilized products,
Crush, cross 60 mesh sieves, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the phoenix-tail fern medicinal material of fresh collection, clean, be cut into the section of 2cm length, add the water of 1 times of amount of medicinal material weight, stir 30 points
Clock, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction
Squeezed again with squeezer, leaching concoction.Above-mentioned 3 phoenix-tail fern concoctions are merged, with 100 mesh screens, filtrate decompression concentration, temperature
Degree is set as 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.By scars
It is freeze-dried after taking-up, temperature is set as -40 DEG C, pressure 0.09Mpa, and the time is 48 hours.Collect lyophilized products, powder
It is broken, 100 mesh sieves are crossed, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern, it is characterised in that：Gathered in phoenix-tail fern picking time Its herb, clean, be cut into the section of 1 ~ 2cm length, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, Collect just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain phoenix-tail fern concoction.
- A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern according to claim 1, it is characterised in that： By the phoenix-tail fern concoction of gained in claim 2, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the leaching that relative density is 1.05 ~ 1.25 Cream, put in -20 DEG C ~ -80 DEG C refrigerators and freeze 6 ~ 24 hours, be freeze-dried after taking-up, temperature is set as -15 DEG C ~ 40 DEG C, and pressure is set It is set to 0.06 ~ 0.09MPa, the time is 8 ~ 48 hours, collects lyophilized products, crushes, and crosses 60 ~ 100 mesh sieves, packaging, produces phoenix-tail fern Fresh squeezing freeze-dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738688.7A CN107375352A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738688.7A CN107375352A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375352A true CN107375352A (en) | 2017-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738688.7A Pending CN107375352A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern |
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| CN (1) | CN107375352A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN107028998A (en) * | 2017-06-19 | 2017-08-11 | 徐漫 | A kind of field thistle is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
-
2017
- 2017-08-25 CN CN201710738688.7A patent/CN107375352A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN107028998A (en) * | 2017-06-19 | 2017-08-11 | 徐漫 | A kind of field thistle is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
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Application publication date: 20171124 |