CN105998131A - Chinese lobelia freshly-squeezed spray drying powder decoction tablets and preparation process thereof - Google Patents
Chinese lobelia freshly-squeezed spray drying powder decoction tablets and preparation process thereof Download PDFInfo
- Publication number
- CN105998131A CN105998131A CN201610582758.XA CN201610582758A CN105998131A CN 105998131 A CN105998131 A CN 105998131A CN 201610582758 A CN201610582758 A CN 201610582758A CN 105998131 A CN105998131 A CN 105998131A
- Authority
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- China
- Prior art keywords
- herba lobeliae
- lobeliae chinensis
- spray drying
- preparation process
- freshly
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000843 powder Substances 0.000 title claims abstract description 8
- 238000001694 spray drying Methods 0.000 title abstract description 7
- 240000003146 Lobelia chinensis Species 0.000 title abstract 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 15
- 230000008901 benefit Effects 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 4
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000003825 pressing Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 238000003860 storage Methods 0.000 abstract description 3
- 230000000717 retained effect Effects 0.000 abstract description 2
- 238000009461 vacuum packaging Methods 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000012567 medical material Substances 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 241000208671 Campanulaceae Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses Chinese lobelia freshly-squeezed spray drying powder decoction tablets and a preparation process thereof. The preparation process includes: after picking Chinese lobelia, selecting, drip-washing, freshly squeezing, and filtering to obtain medicine juice; adding water into medicine residue, stirring, filtering, and squeezing; mixing the medicine juice; depressurizing for concentrating, spray drying, collecting a spray drying product, smashing, and vacuum packaging. Polar and nonpolar active ingredients in the Chinese lobelia powder decoction tablets prepared by the process are retained to the greatest extent. The decoction tablets are conducive to storage and transport, convenient to compound, controllable in quality and reliable in treatment effect and are of important significance in guaranteeing clinical treatment effect of traditional Chinese medicine. The preparation process has remarkable social benefit and economic benefit in popularization and implementation.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Herba Lobeliae Chinensis decoction pieces.
Background technology
Chinese medicine Herba Lobeliae Chinensis is Campanulaceae Herba Lobeliae ChinensisLobelia chinensis Lour. dry herb.This product has
There are the effects such as inducing diuresis to remove edema, heat-clearing and toxic substances removing, can be used for treating extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting etc..
The processing mode of common Herba Lobeliae Chinensis decoction pieces is: summer gathers, and removes silt, cleans, dries, then accumulating of packing.
This type of prepared herbal medicine in small pieces ready for decoction, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for that formula is adjusted
With guarantee its clinical efficacy, even to patient bring recessiveness harm.
At present, granule pieces market also having Herba Lobeliae Chinensis medical material to make after extracting is sold.The preparation of granule pieces
Process, extracts not only time consumption and energy consumption, and because conventional substantial amounts of water does solvent, the nonpolar effective ingredient in medical material is difficult to be carried
Take out.Additionally, due to the Herba Lobeliae Chinensis medical material extracted also is to be dried and through long-time storage, therefore, effective ingredient
Loss is also the biggest.In order to ensure Herba Lobeliae Chinensis medical material clinical effectively, steady quality, a kind of novel Herba Lobeliae Chinensis decoction pieces and
Preparation technology urgently develops.
Summary of the invention
The invention discloses " a kind of Herba Lobeliae Chinensis fresh squeezing spray-dried powders decoction pieces and preparation technology thereof ".This technique is permissible
The polarity in Herba Lobeliae Chinensis medical material and nonpolar effective ingredient is retained, it is to avoid medical material is processed at existing decoction pieces while to greatest extent
With loss and the decline of medical material quanlity of the effective ingredient caused in storage and transport process, reduce the medical material pollution by mycete etc., to really
Steady quality and the clinical safety of protecting Herba Lobeliae Chinensis decoction pieces effectively have great importance.
To achieve these goals, the technical scheme is that
Gather its herb collection period Herba Lobeliae Chinensis, clean, after washing, take advantage of fresh squeezing.Gained medicinal residues add the water of 1 ~ 5 times amount,
Stirring 5 ~ 30min, filter press filter pressing extracting juice.Remaining medicinal residues are squeezed extracting juice again.Merge three medicine juice, with 40 ~ 120 mesh sieves
Filter, obtain Herba Lobeliae Chinensis medicine juice.The Herba Lobeliae Chinensis medicine juice obtained is evaporated under the conditions of 40 ~ 75 DEG C relative density be 1.02 ~
The concentrated solution of 1.15, and this concentrated solution is spray-dried, intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110
DEG C, collect desciccate, cross 60 ~ 100 mesh sieves after pulverizing, be vacuum-packed.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, decoction pieces manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and contraindication.The included upper lotus of bag
Thin layer differentiate collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " identity card " of product.Additionally, in the packaging bag of product,
It is printed on Quick Response Code, the acquisition former plant photo of product, medical material photo, decoction pieces photo, character and micro-can be linked by scanning
The information such as diagnostic characteristics.
The invention have benefit that:
The Herba Lobeliae Chinensis medical material of fresh collection, directly squeezes after cleaning washing, filters, concentrating under reduced pressure, spray drying, obtained powder
End decoction pieces, can retain the effective ingredient in medical material to greatest extent.This decoction pieces volume compares to tradition decoction pieces volume significantly
Ground reduces, vacuum packaging so that prepared slice quality is more stable, and beneficially accumulating and clinic is adjusted, and has very significantly society's meaning
Justice and economic implications.
Detailed description of the invention
Embodiment 1
By the Herba Lobeliae Chinensis medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice.Gained medicinal residues add 3
The tap water of times amount, stirs 20min, filter press squeezing extracting juice.Remaining medicinal residues squeeze extracting juice with squeezer again.By above-mentioned
3 times medicine juice merges, and filters with 100 eye mesh screens.Filtrate reduced in volume, temperature is set as 65 DEG C.Concentrating, gained extractum is the closeest
When degree is 1.05, being spray-dried, intake air temperature is 140 DEG C, and air outlet temperature is 100 DEG C, collection spray drying thing, low-temperature grinding,
Crossing 80 mesh sieves, moisture is not higher than 12%, packs, 1kg/ bag, adds packed antioxidant and desiccant, Vacuum Package, and labeling is i.e.
Can.
Embodiment 2
By the Herba Lobeliae Chinensis medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice.Gained medicinal residues add 5
The tap water of times amount, stirs 30min, filter press squeezing extracting juice.Remaining medicinal residues squeeze extracting juice with squeezer again.By above-mentioned
3 times medicine juice merges, and filters with 80 eye mesh screens.Filtrate reduced in volume, temperature is set as 70 DEG C.Concentrating gained extractum relative density
When being 1.10, being spray-dried, intake air temperature is 120 DEG C, and air outlet temperature is 90 DEG C, collects spray drying thing, low-temperature grinding, crosses 60
Mesh sieve, moisture is not higher than 12%, packs, 1kg/ bag, adds packed antioxidant and desiccant, Vacuum Package, labeling.
Above example, is only the technological thought that this invention is described, it is impossible to limit protection scope of the present invention whereby all
It is the technological thought proposed according to the present invention, any change done on the basis of technical scheme, each fall within present invention protection
Within the scope of.
Claims (2)
1. a Herba Lobeliae Chinensis fresh squeezing spray-dried powders decoction pieces and preparation technology thereof, it is characterised in that: adopt collection period Herba Lobeliae Chinensis
Collecting its herb, clean, after washing, take advantage of fresh squeezing, medicinal residues add the water of 1 ~ 5 times amount, stir 5 ~ 30min, filter press filter pressing
Extracting juice, remaining medicinal residues squeeze extracting juice again, merge three medicine juice, 40 ~ 120 mesh screen, obtain Herba Lobeliae Chinensis medicine juice.
A kind of Herba Lobeliae Chinensis fresh squeezing spray-dried powders decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: the Herba Lobeliae Chinensis medicine juice obtained is evaporated under the conditions of 40 ~ 75 DEG C the concentrated solution that relative density is 1.02 ~ 1.15, and
Being spray-dried by this concentrated solution, intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects to be dried and produces
Thing, crosses 60 ~ 100 mesh sieves, is vacuum-packed after pulverizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582758.XA CN105998131A (en) | 2016-07-23 | 2016-07-23 | Chinese lobelia freshly-squeezed spray drying powder decoction tablets and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582758.XA CN105998131A (en) | 2016-07-23 | 2016-07-23 | Chinese lobelia freshly-squeezed spray drying powder decoction tablets and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105998131A true CN105998131A (en) | 2016-10-12 |
Family
ID=57116987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610582758.XA Pending CN105998131A (en) | 2016-07-23 | 2016-07-23 | Chinese lobelia freshly-squeezed spray drying powder decoction tablets and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105998131A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157934A (en) * | 2017-06-19 | 2017-09-15 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213460A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105287860A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried powdery decoction piece and preparation technology thereof |
| CN105362528A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Folium Aloes fresh-squeezed spray-dried powder decoction pieces and preparation method thereof |
-
2016
- 2016-07-23 CN CN201610582758.XA patent/CN105998131A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213460A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105362528A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Folium Aloes fresh-squeezed spray-dried powder decoction pieces and preparation method thereof |
| CN105287860A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried powdery decoction piece and preparation technology thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157934A (en) * | 2017-06-19 | 2017-09-15 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
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| C06 | Publication | ||
| PB01 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161012 |