CN107320515A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala Download PDFInfo
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- CN107320515A CN107320515A CN201710738632.1A CN201710738632A CN107320515A CN 107320515 A CN107320515 A CN 107320515A CN 201710738632 A CN201710738632 A CN 201710738632A CN 107320515 A CN107320515 A CN 107320515A
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- Prior art keywords
- artemisia anomala
- crude slice
- materical crude
- medicine materical
- freeze
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of Artemisia anomala medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Driverse Wormword Herb medicine materical crude slice prepared by this method, remains the polarity and nonpolar active ingredient in medicinal material while to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine Artemisia anomala medicine materical crude slice.
Background technology
Chinese medicine Artemisia anomala is feverfew artemisia anomalasArtemisia anomalaS. Moore herb.It is logical with blood-breaking
Effect through, healing up sore and subduing swelling.Clinic is mainly used in treatment Amenorrhea abdominal mass, chest and abdomen swelling and pain, postpartum blood stasis, traumatic injury, metal-inflicted wound and gone out
The disease such as blood, Yong Du inflammation be swollen.
The processing mode of conventional Artemisia anomala medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.
These dry Artemisia anomala Hygienic Indexes can not be up to standard, easily occur medicinal material go mouldy so that cause medical material quanlity decline and
The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjusting
Agent prescription and ensure its clinical efficacy.
At present, in the market also has the granule pieces sale that Artemisia anomala medicinal material is made after extraction.Due to granule pieces system
During standby, not only time consumption and energy consumption is extracted, and is difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Out.Further, since the Artemisia anomala medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Mistake is also very big.In order to ensure the clinic of Artemisia anomala medicinal material is effective, steady quality, a kind of new Artemisia anomala medicine materical crude slice is urgently opened
Hair.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala ".This technique can be most
The polarity and nonpolar active ingredient that retain in Artemisia anomala medicinal material of limits, it is to avoid medicinal material is processed and accumulating in existing medicine materical crude slice
During caused by active ingredient loss and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring that Liu posts
The steady quality and clinical safety of slave's medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in Artemisia anomala picking time, is cleaned, the section of 1 ~ 2cm length is cut into, the water of 0.5 ~ 1 times of amount of medicinal material weight is added,
Stirring 15 ~ 30 minutes, takes advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, squeezing
Take juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 twice
Mesh screen, obtains Artemisia anomala concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, it is 1.05 ~ 1.25 to obtain relative density
Medicinal extract.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set as-
15 DEG C ~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, crosses 60 ~ 100 mesh
Sieve, packaging produces the fresh squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of Artemisia anomala is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in the packaging bag of product, being printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh Artemisia anomala medicinal material, which is cleaned, directly to be squeezed after washing, filters, is concentrated under reduced pressure, being freeze-dried, resulting powder decoction pieces,
The active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume is greatly reduced compared to traditional medicine materical crude slice volume,
Quality is more stablized, beneficial to accumulating and clinical adjustment, with very significant social effect and economic implications.
Embodiment
Embodiment 1
By the Artemisia anomala medicinal material of fresh collection, clean, be cut into the section of 1cm length, add the water of 0.5 times of amount of medicinal material weight, stirring 15
Minute, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.Gained medicine
Slag is squeezed with squeezer again, leaching concoction.Above-mentioned 3 Artemisia anomala concoctions are merged, 60 mesh screens are used, filtrate decompression is concentrated,
Temperature is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.It will freeze
Knot thing is freeze-dried after taking out, and temperature is set as -18 DEG C, and pressure is 0.09Mpa, and the time is 24 hours.Collect lyophilized products,
Crush, cross 60 mesh sieves, pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Embodiment 2
By the Artemisia anomala medicinal material of fresh collection, clean, be cut into the section of 2cm length, add the water of 1 times of amount of medicinal material weight, stir 30 points
Clock, takes advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction
Squeezed again with squeezer, leaching concoction.Above-mentioned 3 Artemisia anomala concoctions are merged, 100 mesh screens, filtrate decompression concentration, temperature are used
Degree is set as 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.By scars
It is freeze-dried after taking-up, temperature is set as -40 DEG C, and pressure is 0.09Mpa, and the time is 48 hours.Collect lyophilized products, powder
It is broken, 100 mesh sieves are crossed, pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala, it is characterised in that：In the collection of Artemisia anomala picking time
Its herb, is cleaned, and is cut into the section of 1 ~ 2cm length, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, is stirred 15 ~ 30 minutes, is taken advantage of fresh squeezing,
Collect just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens obtain Artemisia anomala concoction.
2. a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala according to claim 1, it is characterised in that：
By the Artemisia anomala concoction of gained in claim 2, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the leaching that relative density is 1.05 ~ 1.25
Cream, puts in -20 DEG C ~ -80 DEG C refrigerators and freezes 6 ~ 24 hours, is freeze-dried after taking-up, and temperature is set as -15 DEG C ~ 40 DEG C, and pressure is set
It is set to 0.06 ~ 0.09MPa, the time is 8 ~ 48 hours, collects lyophilized products, crushes, crosses 60 ~ 100 mesh sieves, packaging produces Artemisia anomala
Fresh squeezing freeze-dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738632.1A CN107320515A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738632.1A CN107320515A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala |
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| Publication Number | Publication Date |
|---|---|
| CN107320515A true CN107320515A (en) | 2017-11-07 |
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ID=60224937
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738632.1A Pending CN107320515A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala |
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| CN (1) | CN107320515A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738632.1A patent/CN107320515A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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Application publication date: 20171107 |
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