CN105960405B - 谷氨酰胺酶抑制剂 - Google Patents
谷氨酰胺酶抑制剂 Download PDFInfo
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- CN105960405B CN105960405B CN201580006698.0A CN201580006698A CN105960405B CN 105960405 B CN105960405 B CN 105960405B CN 201580006698 A CN201580006698 A CN 201580006698A CN 105960405 B CN105960405 B CN 105960405B
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- substituted
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- compound
- pyridin
- disease
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- C07—ORGANIC CHEMISTRY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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| BR112016021620A2 (pt) * | 2014-03-21 | 2018-07-10 | Agios Pharmaceuticals Inc | compostos e seus métodos de uso |
| EA033919B1 (ru) | 2014-04-30 | 2019-12-10 | Пфайзер Инк. | Соединённые циклоалкилом дигетероциклические производные |
| HUE049600T2 (hu) | 2014-07-03 | 2020-10-28 | Univ Texas | GLS1 inhibitorok betegségek kezelésére |
| US10660861B2 (en) | 2014-07-09 | 2020-05-26 | The Johns Hopkins University | Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy |
| CA2990457C (en) * | 2015-06-30 | 2024-07-02 | Board Of Regents, University Of Texas System | PYRROLIDINYL AND PIPERIDINYL DERIVATIVES AND RELATED PHARMACEUTICAL COMPOSITIONS USEFUL AS GLS1 INHIBITORS |
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| WO2018102715A1 (en) * | 2016-12-02 | 2018-06-07 | Indiana University Research And Technology Corporation | Compositions and methods for treating and/or reducing corneal dystrophy |
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| US20190269705A1 (en) * | 2017-11-27 | 2019-09-05 | Regents Of The University Of Minnesota | Methods and materials for treating graft versus host disease |
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