CN1054376C - 取代的1h-咪唑 - Google Patents

取代的1h-咪唑 Download PDF

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Publication number
CN1054376C
CN1054376C CN95120834A CN95120834A CN1054376C CN 1054376 C CN1054376 C CN 1054376C CN 95120834 A CN95120834 A CN 95120834A CN 95120834 A CN95120834 A CN 95120834A CN 1054376 C CN1054376 C CN 1054376C
Authority
CN
China
Prior art keywords
imidazoles
compound
tetrahydrochysene
naphthyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95120834A
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English (en)
Chinese (zh)
Other versions
CN1133837A (zh
Inventor
J·P·吉尔斯
G·莫特
E·迪佛尔丁格
J·P·海尼查特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of CN1133837A publication Critical patent/CN1133837A/zh
Application granted granted Critical
Publication of CN1054376C publication Critical patent/CN1054376C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN95120834A 1994-12-14 1995-12-12 取代的1h-咪唑 Expired - Fee Related CN1054376C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9425211.1 1994-12-14
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (2)

Publication Number Publication Date
CN1133837A CN1133837A (zh) 1996-10-23
CN1054376C true CN1054376C (zh) 2000-07-12

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95120834A Expired - Fee Related CN1054376C (zh) 1994-12-14 1995-12-12 取代的1h-咪唑

Country Status (26)

Country Link
US (1) US5658938A (enExample)
EP (1) EP0717037A1 (enExample)
JP (1) JPH08208622A (enExample)
KR (1) KR960022474A (enExample)
CN (1) CN1054376C (enExample)
AR (1) AR002257A1 (enExample)
AU (1) AU693614B2 (enExample)
BG (1) BG63043B1 (enExample)
BR (1) BR9505815A (enExample)
CA (1) CA2165133A1 (enExample)
CZ (1) CZ327195A3 (enExample)
EE (1) EE9500064A (enExample)
FI (1) FI955927L (enExample)
GB (1) GB9425211D0 (enExample)
HU (1) HUT73980A (enExample)
IL (1) IL116325A (enExample)
IS (1) IS4311A (enExample)
MX (1) MX9505063A (enExample)
NO (1) NO305316B1 (enExample)
NZ (1) NZ280646A (enExample)
PL (1) PL311736A1 (enExample)
RO (1) RO113346B1 (enExample)
RU (1) RU2156239C2 (enExample)
SK (1) SK155095A3 (enExample)
TW (1) TW303362B (enExample)
ZA (1) ZA9510554B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104603129A (zh) * 2012-09-17 2015-05-06 霍夫曼-拉罗奇有限公司 三唑甲酰胺衍生物

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GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
ZA981080B (en) 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
PE20011321A1 (es) 2000-05-08 2002-01-03 Orion Corp Indanilimizadoles policiclicos nuevos con actividad adrenergica alfa 2
TW200306783A (en) * 2002-04-29 2003-12-01 Fmc Corp Pesticidal heterocycles
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
CN101374517A (zh) * 2006-01-27 2009-02-25 弗·哈夫曼-拉罗切有限公司 2-咪唑类化合物用于治疗cns病症的用途
CN101528710B (zh) * 2006-10-19 2012-11-07 弗·哈夫曼-拉罗切有限公司 氨基甲基-4-咪唑类
JP5167265B2 (ja) * 2006-10-19 2013-03-21 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連受容体に親和性を有するアミノメチル−２−イミダゾール
CN101535292A (zh) * 2006-11-02 2009-09-16 弗·哈夫曼-拉罗切有限公司 作为痕量胺相关受体的调节剂的取代的2-咪唑类化合物
AU2007321376A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
CN101557810B (zh) * 2006-12-13 2012-11-21 弗·哈夫曼-拉罗切有限公司 作为痕量胺相关受体（taar）的配体的新的2-咪唑类
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
KR101275405B1 (ko) 2007-02-02 2013-06-17 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료용 ｔａａｒ1 리간드로서 2-아미노옥사졸린
CN101657429A (zh) * 2007-02-13 2010-02-24 先灵公司 功能选择性α2C肾上腺素能受体激动剂
EP2142538B1 (en) * 2007-02-13 2011-10-26 Schering Corporation Derivatives and analogs of chroman as functionally selective alpha2c adrenoreceptor agonists
KR20090113326A (ko) * 2007-02-13 2009-10-29 쉐링 코포레이션 작용 선택적 알파2ｃ 아드레날린성 수용체 효능제
RU2460725C2 (ru) * 2007-02-15 2012-09-10 Ф. Хоффманн-Ля Рош Аг Новые 2-аминооксазолины в качестве лигандов taar1
WO2009003868A2 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
WO2009003867A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
EP2183216A1 (en) * 2007-07-27 2010-05-12 F. Hoffmann-Roche AG 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
WO2009016088A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of cns disorders
CN101784515A (zh) * 2007-08-03 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
US8383818B2 (en) 2008-02-21 2013-02-26 Merck Sharp & Dohme Corp. Functionally selective alpha2C adrenoreceptor agonists
RU2513086C2 (ru) * 2008-07-24 2014-04-20 Ф.Хоффманн-Ля Рош Аг Производные 4,5-дигидро-оксазол-2-ила
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US20110190247A1 (en) * 2008-08-04 2011-08-04 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
US8324213B2 (en) 2008-10-07 2012-12-04 Merck Sharp & Dohme Corp. Biaryl-spiroaminooxazoline analogues as alpha 2C adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
WO2013104591A1 (en) 2012-01-12 2013-07-18 F. Hoffmann-La Roche Ag Heterocyclic derivatives as trace amine associated receptors (taars)
HK1206720A1 (en) 2012-09-14 2016-01-15 霍夫曼-拉罗奇有限公司 Pyrazole carboxamide derivatives as taar modulators for use in the treatment of several disorders, such as depression, diabetes and parkinson's disease
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
RU2017107521A (ru) 2014-08-27 2018-10-01 Ф. Хоффманн-Ля Рош Аг Замещенные производные азетидина в качестве лигандов рецепторов следовых аминов taar
RU2017106928A (ru) 2014-08-27 2018-10-01 Ф. Хоффманн-Ля Рош Аг Замещенные производные пиразино[2,1-а]изохинолина для лечения заболеваний цнс
PL3429352T3 (pl) * 2016-03-17 2022-08-22 Fmc Corporation Sposób konwersji enancjomeru-S do jego postaci racemicznej
RU2731095C2 (ru) 2016-03-17 2020-08-28 Ф. Хоффманн-Ля Рош Аг Производное 5-этил-4-метил-пиразол-3-карбоксамида, обладающее активностью агониста taar
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

Citations (1)

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EP0269599A2 (fr) * 1986-11-04 1988-06-01 U C B, S.A. 1H-Imidazoles substitués

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JPS6048972A (ja) * 1983-08-25 1985-03-16 Dai Ichi Seiyaku Co Ltd テトラヒドロナフタレン誘導体
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
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JPH04210680A (ja) * 1990-12-01 1992-07-31 Nissan Chem Ind Ltd イミダゾール誘導体および植物生長調節剤
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Patent Citations (1)

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EP0269599A2 (fr) * 1986-11-04 1988-06-01 U C B, S.A. 1H-Imidazoles substitués

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104603129A (zh) * 2012-09-17 2015-05-06 霍夫曼-拉罗奇有限公司 三唑甲酰胺衍生物

Also Published As

Publication number Publication date
US5658938A (en) 1997-08-19
PL311736A1 (en) 1996-06-24
MX9505063A (es) 1997-01-31
AU693614B2 (en) 1998-07-02
IL116325A0 (en) 1996-03-31
IL116325A (en) 1999-10-28
BG63043B1 (bg) 2001-02-28
RU2156239C2 (ru) 2000-09-20
ZA9510554B (en) 1996-06-13
AU4036895A (en) 1996-06-20
HU9503549D0 (en) 1996-02-28
AR002257A1 (es) 1998-03-11
NZ280646A (en) 1996-08-27
FI955927A0 (fi) 1995-12-11
FI955927A7 (fi) 1996-06-15
IS4311A (is) 1996-06-15
RO113346B1 (ro) 1998-06-30
NO955034D0 (no) 1995-12-12
JPH08208622A (ja) 1996-08-13
TW303362B (enExample) 1997-04-21
FI955927L (fi) 1996-06-15
CZ327195A3 (en) 1996-07-17
CA2165133A1 (en) 1996-06-15
CN1133837A (zh) 1996-10-23
EP0717037A1 (fr) 1996-06-19
NO305316B1 (no) 1999-05-10
BR9505815A (pt) 1998-01-06
EE9500064A (et) 1996-06-17
NO955034L (no) 1996-06-17
HUT73980A (en) 1996-10-28
KR960022474A (ko) 1996-07-18
BG100208A (bg) 1996-07-31
GB9425211D0 (en) 1995-02-15
SK155095A3 (en) 1997-02-05

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