GB9425211D0 - Substituted 1H-imidazoles - Google Patents
Substituted 1H-imidazolesInfo
- Publication number
- GB9425211D0 GB9425211D0 GBGB9425211.1A GB9425211A GB9425211D0 GB 9425211 D0 GB9425211 D0 GB 9425211D0 GB 9425211 A GB9425211 A GB 9425211A GB 9425211 D0 GB9425211 D0 GB 9425211D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- imidazoles
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
| MX9505063A MX9505063A (es) | 1994-12-14 | 1995-12-05 | Tetralina- e indano-1h-imidazoles. |
| TW084113098A TW303362B (enExample) | 1994-12-14 | 1995-12-08 | |
| US08/569,947 US5658938A (en) | 1994-12-14 | 1995-12-08 | Substituted 1H-imidazoles |
| RO95-02138A RO113346B1 (ro) | 1994-12-14 | 1995-12-08 | Derivati de 1h-imidazol si procedee pentru prepararea acestora |
| PL95311736A PL311736A1 (en) | 1994-12-14 | 1995-12-08 | Derivatives of 1h-imidazoles |
| SG1995002072A SG33624A1 (en) | 1994-12-14 | 1995-12-08 | Substituted 1H-imidazoles |
| BG100208A BG63043B1 (bg) | 1994-12-14 | 1995-12-08 | Заместени 1н-имидазоли, метод за тяхното получаване и приложението им като лекарствени средства |
| IS4311A IS4311A (is) | 1994-12-14 | 1995-12-08 | Setin 1H-imíðazól, aðferð til framleiðslu þeirra og notkun þeirra |
| IL11632595A IL116325A (en) | 1994-12-14 | 1995-12-11 | Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them |
| SK1550-95A SK155095A3 (en) | 1994-12-14 | 1995-12-11 | Substituted 1h-imidazoles |
| NZ280646A NZ280646A (en) | 1994-12-14 | 1995-12-11 | 4-naphthalenyl (and indenyl)-1h-imidazole derivatives; pharmaceutical compositions |
| FI955927A FI955927L (fi) | 1994-12-14 | 1995-12-11 | Substituoidut 1H-imidatsolit |
| HU9503549A HUT73980A (en) | 1994-12-14 | 1995-12-12 | Substituted 1h-imidazoles and pharmaceutical compositions containing them |
| AU40368/95A AU693614B2 (en) | 1994-12-14 | 1995-12-12 | Substituted 1H-imidazoles |
| CN95120834A CN1054376C (zh) | 1994-12-14 | 1995-12-12 | 取代的1h-咪唑 |
| EE9500064A EE9500064A (et) | 1994-12-14 | 1995-12-12 | Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid |
| CZ953271A CZ327195A3 (en) | 1994-12-14 | 1995-12-12 | Substituted 1h-imidazoles |
| ARP950100512A AR002257A1 (es) | 1994-12-14 | 1995-12-12 | Compuesto 1h-imidazol util como agente anti-isquemico cardiaco o agente anti-hipertensivo. procedimiento para su preparacion y composicion farmaceuticaque lo contiene. |
| ZA9510554A ZA9510554B (en) | 1994-12-14 | 1995-12-12 | Substituted 1H-imidazoles |
| NO955034A NO305316B1 (no) | 1994-12-14 | 1995-12-12 | Nye substituerte 1H-imidazoler og farmas°ytiske preparater inneholdende disse |
| BR9505815A BR9505815A (pt) | 1994-12-14 | 1995-12-13 | Composto processos para a preparação do mesmo e para obter um efeito anti-isquêmico e anti-hipertensivo e para produzir atividade agonista 2 pré-sináptica e antagonista 1 pós-sináptica em um paciente e composição farmacêutica |
| RU95120582/04A RU2156239C2 (ru) | 1994-12-14 | 1995-12-13 | Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе |
| EP95870132A EP0717037A1 (fr) | 1994-12-14 | 1995-12-13 | 1H-imidazoles substitués ayant une activité alpha 2-agoniste et alpha 1-antagoniste |
| CA002165133A CA2165133A1 (en) | 1994-12-14 | 1995-12-13 | Substituted 1h-imidazoles |
| JP7324502A JPH08208622A (ja) | 1994-12-14 | 1995-12-13 | 置換された1h−イミダゾール |
| KR1019950049572A KR960022474A (ko) | 1994-12-14 | 1995-12-14 | 치환된 1h-이미다졸 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB9425211D0 true GB9425211D0 (en) | 1995-02-15 |
Family
ID=10765918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB9425211.1A Pending GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5658938A (enExample) |
| EP (1) | EP0717037A1 (enExample) |
| JP (1) | JPH08208622A (enExample) |
| KR (1) | KR960022474A (enExample) |
| CN (1) | CN1054376C (enExample) |
| AR (1) | AR002257A1 (enExample) |
| AU (1) | AU693614B2 (enExample) |
| BG (1) | BG63043B1 (enExample) |
| BR (1) | BR9505815A (enExample) |
| CA (1) | CA2165133A1 (enExample) |
| CZ (1) | CZ327195A3 (enExample) |
| EE (1) | EE9500064A (enExample) |
| FI (1) | FI955927L (enExample) |
| GB (1) | GB9425211D0 (enExample) |
| HU (1) | HUT73980A (enExample) |
| IL (1) | IL116325A (enExample) |
| IS (1) | IS4311A (enExample) |
| MX (1) | MX9505063A (enExample) |
| NO (1) | NO305316B1 (enExample) |
| NZ (1) | NZ280646A (enExample) |
| PL (1) | PL311736A1 (enExample) |
| RO (1) | RO113346B1 (enExample) |
| RU (1) | RU2156239C2 (enExample) |
| SK (1) | SK155095A3 (enExample) |
| TW (1) | TW303362B (enExample) |
| ZA (1) | ZA9510554B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
| GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
| ZA981080B (en) | 1997-02-11 | 1998-08-12 | Warner Lambert Co | Bicyclic inhibitors of protein farnesyl transferase |
| US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
| US20030073850A1 (en) * | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
| US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
| PE20011321A1 (es) | 2000-05-08 | 2002-01-03 | Orion Corp | Indanilimizadoles policiclicos nuevos con actividad adrenergica alfa 2 |
| TW200306783A (en) * | 2002-04-29 | 2003-12-01 | Fmc Corp | Pesticidal heterocycles |
| US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
| FI20022159A0 (fi) * | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
| JP2009524618A (ja) * | 2006-01-27 | 2009-07-02 | エフ.ホフマン−ラ ロシュ アーゲー | Cns障害の処置における2−イミダゾールの使用 |
| CA2666762C (en) * | 2006-10-19 | 2014-12-30 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| CN101528709B (zh) * | 2006-10-19 | 2012-02-01 | 弗·哈夫曼-拉罗切有限公司 | 对痕量胺相关受体有亲和性的氨基甲基-2-咪唑类 |
| JP5064511B2 (ja) * | 2006-11-02 | 2012-10-31 | エフ.ホフマン−ラ ロシュ アーゲー | 痕跡アミン関連受容体調節剤としての置換2−イミダゾール |
| RU2456281C2 (ru) * | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
| ATE509628T1 (de) * | 2006-12-13 | 2011-06-15 | Hoffmann La Roche | Neue 2-imidazole als liganden für trace amine associated receptors (taar) |
| US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| JP5248528B2 (ja) | 2007-02-02 | 2013-07-31 | エフ.ホフマン−ラ ロシュ アーゲー | Cns疾患用のtaar1リガンドとしての新規2−アミノオキサゾリン |
| EP2142538B1 (en) * | 2007-02-13 | 2011-10-26 | Schering Corporation | Derivatives and analogs of chroman as functionally selective alpha2c adrenoreceptor agonists |
| AU2008216797A1 (en) * | 2007-02-13 | 2008-08-21 | Pharmacopeia, Llc | Functionally selective alpha2C adrenoreceptor agonists |
| WO2008100480A1 (en) * | 2007-02-13 | 2008-08-21 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
| MX2009008465A (es) * | 2007-02-15 | 2009-08-20 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos de taar1. |
| JP2010531837A (ja) | 2007-07-02 | 2010-09-30 | エフ.ホフマン−ラ ロシュ アーゲー | 微量アミン関連レセプター(taar)に対して良好な親和性を有する2−イミダゾリン |
| CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
| KR101133862B1 (ko) * | 2007-07-27 | 2012-04-06 | 에프. 호프만-라 로슈 아게 | Taar 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민 |
| EP2182935A1 (en) * | 2007-08-02 | 2010-05-12 | F. Hoffmann-Roche AG | The use of benzamide derivatives for the treatment of cns disorders |
| AU2008285795A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as TAAR1 ligands |
| CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
| WO2009105504A2 (en) | 2008-02-21 | 2009-08-27 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
| US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| AU2009273324A1 (en) * | 2008-07-24 | 2010-01-28 | F. Hoffmann-La Roche Ag | 4,5-dihydro-oxazol-2-yl derivatives |
| WO2010017120A1 (en) * | 2008-08-04 | 2010-02-11 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
| AR073628A1 (es) | 2008-10-07 | 2010-11-17 | Schering Corp | Analogos de biaril espiroaminooxazolina y espiroaminodiazolina moduladores de receptores adrenergicos alfa2c, composiciones farmaceuticas que los comprenden y uso de los mismos en rinitis alergica,trastornos cardiacos y otras enfermedades |
| US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
| US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| US8673950B2 (en) | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
| US8802673B2 (en) | 2011-03-24 | 2014-08-12 | Hoffmann-La Roche Inc | Heterocyclic amine derivatives |
| US9073911B2 (en) | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
| US9029370B2 (en) | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
| EP2802578B1 (en) | 2012-01-12 | 2015-10-07 | F.Hoffmann-La Roche Ag | Heterocyclic derivatives as trace amine associated receptors (taars) |
| ES2654653T3 (es) | 2012-09-14 | 2018-02-14 | F. Hoffmann-La Roche Ag | Derivados de pirazol-carboxamida como moduladores de TAAR para su uso en el tratamiento de varios trastornos, tales como depresión, diabetes y enfermedad de Parkinson |
| EP2895478B1 (en) * | 2012-09-17 | 2016-10-19 | F. Hoffmann-La Roche AG | Triazole carboxamide derivatives |
| WO2015165085A1 (en) | 2014-04-30 | 2015-11-05 | F.Hoffmann-La Roche Ag | Morpholin-pyridine derivatives |
| WO2016030306A1 (en) | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders |
| BR112017000160A2 (pt) | 2014-08-27 | 2017-10-31 | Hoffmann La Roche | derivados de azetidina substituidos como ligantes de taar |
| KR102362549B1 (ko) * | 2016-03-17 | 2022-02-11 | 에프엠씨 코포레이션 | S-거울상 이성질체를 이의 라세미체 형태로 전환하는 방법 |
| PE20181446A1 (es) | 2016-03-17 | 2018-09-12 | Hoffmann La Roche | Derivados de 5-etil-4-metil-pirazol-3-carboxamida con actividad como de taar |
| CN116496261B (zh) * | 2023-03-09 | 2025-06-27 | 中国人民解放军军事科学院军事医学研究院 | 4-(1h)-咪唑类衍生物及其医药用途 |
| CN118684628B (zh) * | 2024-05-20 | 2025-06-17 | 中国人民解放军军事科学院军事医学研究院 | 取代二氢茚基咪唑类化合物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6048972A (ja) * | 1983-08-25 | 1985-03-16 | Dai Ichi Seiyaku Co Ltd | テトラヒドロナフタレン誘導体 |
| GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
| GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| US5151526A (en) * | 1990-10-11 | 1992-09-29 | The United States Of America As Represented By The Secretary Of The Army | 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic |
| JPH04210680A (ja) * | 1990-12-01 | 1992-07-31 | Nissan Chem Ind Ltd | イミダゾール誘導体および植物生長調節剤 |
| GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
-
1994
- 1994-12-14 GB GBGB9425211.1A patent/GB9425211D0/en active Pending
-
1995
- 1995-12-05 MX MX9505063A patent/MX9505063A/es not_active IP Right Cessation
- 1995-12-08 US US08/569,947 patent/US5658938A/en not_active Expired - Fee Related
- 1995-12-08 IS IS4311A patent/IS4311A/is unknown
- 1995-12-08 RO RO95-02138A patent/RO113346B1/ro unknown
- 1995-12-08 PL PL95311736A patent/PL311736A1/xx unknown
- 1995-12-08 BG BG100208A patent/BG63043B1/bg unknown
- 1995-12-08 TW TW084113098A patent/TW303362B/zh active
- 1995-12-11 IL IL11632595A patent/IL116325A/xx not_active IP Right Cessation
- 1995-12-11 NZ NZ280646A patent/NZ280646A/en unknown
- 1995-12-11 SK SK1550-95A patent/SK155095A3/sk unknown
- 1995-12-11 FI FI955927A patent/FI955927L/fi unknown
- 1995-12-12 HU HU9503549A patent/HUT73980A/hu unknown
- 1995-12-12 AR ARP950100512A patent/AR002257A1/es unknown
- 1995-12-12 AU AU40368/95A patent/AU693614B2/en not_active Ceased
- 1995-12-12 CZ CZ953271A patent/CZ327195A3/cs unknown
- 1995-12-12 EE EE9500064A patent/EE9500064A/xx unknown
- 1995-12-12 NO NO955034A patent/NO305316B1/no not_active IP Right Cessation
- 1995-12-12 ZA ZA9510554A patent/ZA9510554B/xx unknown
- 1995-12-12 CN CN95120834A patent/CN1054376C/zh not_active Expired - Fee Related
- 1995-12-13 JP JP7324502A patent/JPH08208622A/ja active Pending
- 1995-12-13 RU RU95120582/04A patent/RU2156239C2/ru active
- 1995-12-13 EP EP95870132A patent/EP0717037A1/fr not_active Withdrawn
- 1995-12-13 BR BR9505815A patent/BR9505815A/pt not_active Application Discontinuation
- 1995-12-13 CA CA002165133A patent/CA2165133A1/en not_active Abandoned
- 1995-12-14 KR KR1019950049572A patent/KR960022474A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PL311736A1 (en) | 1996-06-24 |
| IL116325A0 (en) | 1996-03-31 |
| RU2156239C2 (ru) | 2000-09-20 |
| BG63043B1 (bg) | 2001-02-28 |
| CN1133837A (zh) | 1996-10-23 |
| IS4311A (is) | 1996-06-15 |
| EE9500064A (et) | 1996-06-17 |
| NO305316B1 (no) | 1999-05-10 |
| SK155095A3 (en) | 1997-02-05 |
| EP0717037A1 (fr) | 1996-06-19 |
| MX9505063A (es) | 1997-01-31 |
| HUT73980A (en) | 1996-10-28 |
| AU4036895A (en) | 1996-06-20 |
| NO955034D0 (no) | 1995-12-12 |
| NZ280646A (en) | 1996-08-27 |
| BG100208A (bg) | 1996-07-31 |
| CA2165133A1 (en) | 1996-06-15 |
| FI955927A0 (fi) | 1995-12-11 |
| FI955927A7 (fi) | 1996-06-15 |
| RO113346B1 (ro) | 1998-06-30 |
| US5658938A (en) | 1997-08-19 |
| NO955034L (no) | 1996-06-17 |
| CZ327195A3 (en) | 1996-07-17 |
| HU9503549D0 (en) | 1996-02-28 |
| CN1054376C (zh) | 2000-07-12 |
| FI955927L (fi) | 1996-06-15 |
| AU693614B2 (en) | 1998-07-02 |
| ZA9510554B (en) | 1996-06-13 |
| AR002257A1 (es) | 1998-03-11 |
| TW303362B (enExample) | 1997-04-21 |
| KR960022474A (ko) | 1996-07-18 |
| IL116325A (en) | 1999-10-28 |
| JPH08208622A (ja) | 1996-08-13 |
| BR9505815A (pt) | 1998-01-06 |
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