GB9425211D0 - Substituted 1H-imidazoles - Google Patents

Substituted 1H-imidazoles

Info

Publication number
GB9425211D0
GB9425211D0 GBGB9425211.1A GB9425211A GB9425211D0 GB 9425211 D0 GB9425211 D0 GB 9425211D0 GB 9425211 A GB9425211 A GB 9425211A GB 9425211 D0 GB9425211 D0 GB 9425211D0
Authority
GB
United Kingdom
Prior art keywords
imidazoles
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9425211.1A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB9425211.1A priority Critical patent/GB9425211D0/en
Application filed by UCB SA filed Critical UCB SA
Publication of GB9425211D0 publication Critical patent/GB9425211D0/en
Priority to MX9505063A priority patent/MX9505063A/es
Priority to TW084113098A priority patent/TW303362B/zh
Priority to BG100208A priority patent/BG63043B1/bg
Priority to IS4311A priority patent/IS4311A/is
Priority to PL95311736A priority patent/PL311736A1/xx
Priority to SG1995002072A priority patent/SG33624A1/en
Priority to US08/569,947 priority patent/US5658938A/en
Priority to RO95-02138A priority patent/RO113346B1/ro
Priority to SK1550-95A priority patent/SK155095A3/sk
Priority to FI955927A priority patent/FI955927L/fi
Priority to NZ280646A priority patent/NZ280646A/en
Priority to IL11632595A priority patent/IL116325A/xx
Priority to ARP950100512A priority patent/AR002257A1/es
Priority to AU40368/95A priority patent/AU693614B2/en
Priority to EE9500064A priority patent/EE9500064A/xx
Priority to NO955034A priority patent/NO305316B1/no
Priority to CZ953271A priority patent/CZ327195A3/cs
Priority to CN95120834A priority patent/CN1054376C/zh
Priority to HU9503549A priority patent/HUT73980A/hu
Priority to ZA9510554A priority patent/ZA9510554B/xx
Priority to CA002165133A priority patent/CA2165133A1/en
Priority to RU95120582/04A priority patent/RU2156239C2/ru
Priority to EP95870132A priority patent/EP0717037A1/fr
Priority to JP7324502A priority patent/JPH08208622A/ja
Priority to BR9505815A priority patent/BR9505815A/pt
Priority to KR1019950049572A priority patent/KR960022474A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB9425211.1A 1994-12-14 1994-12-14 Substituted 1H-imidazoles Pending GB9425211D0 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles
MX9505063A MX9505063A (es) 1994-12-14 1995-12-05 Tetralina- e indano-1h-imidazoles.
RO95-02138A RO113346B1 (ro) 1994-12-14 1995-12-08 Derivati de 1h-imidazol si procedee pentru prepararea acestora
IS4311A IS4311A (is) 1994-12-14 1995-12-08 Setin 1H-imíðazól, aðferð til framleiðslu þeirra og notkun þeirra
BG100208A BG63043B1 (bg) 1994-12-14 1995-12-08 Заместени 1н-имидазоли, метод за тяхното получаване и приложението им като лекарствени средства
TW084113098A TW303362B (enExample) 1994-12-14 1995-12-08
PL95311736A PL311736A1 (en) 1994-12-14 1995-12-08 Derivatives of 1h-imidazoles
SG1995002072A SG33624A1 (en) 1994-12-14 1995-12-08 Substituted 1H-imidazoles
US08/569,947 US5658938A (en) 1994-12-14 1995-12-08 Substituted 1H-imidazoles
SK1550-95A SK155095A3 (en) 1994-12-14 1995-12-11 Substituted 1h-imidazoles
FI955927A FI955927L (fi) 1994-12-14 1995-12-11 Substituoidut 1H-imidatsolit
NZ280646A NZ280646A (en) 1994-12-14 1995-12-11 4-naphthalenyl (and indenyl)-1h-imidazole derivatives; pharmaceutical compositions
IL11632595A IL116325A (en) 1994-12-14 1995-12-11 Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them
ARP950100512A AR002257A1 (es) 1994-12-14 1995-12-12 Compuesto 1h-imidazol util como agente anti-isquemico cardiaco o agente anti-hipertensivo. procedimiento para su preparacion y composicion farmaceuticaque lo contiene.
AU40368/95A AU693614B2 (en) 1994-12-14 1995-12-12 Substituted 1H-imidazoles
ZA9510554A ZA9510554B (en) 1994-12-14 1995-12-12 Substituted 1H-imidazoles
EE9500064A EE9500064A (et) 1994-12-14 1995-12-12 Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
NO955034A NO305316B1 (no) 1994-12-14 1995-12-12 Nye substituerte 1H-imidazoler og farmas°ytiske preparater inneholdende disse
CZ953271A CZ327195A3 (en) 1994-12-14 1995-12-12 Substituted 1h-imidazoles
CN95120834A CN1054376C (zh) 1994-12-14 1995-12-12 取代的1h-咪唑
HU9503549A HUT73980A (en) 1994-12-14 1995-12-12 Substituted 1h-imidazoles and pharmaceutical compositions containing them
CA002165133A CA2165133A1 (en) 1994-12-14 1995-12-13 Substituted 1h-imidazoles
BR9505815A BR9505815A (pt) 1994-12-14 1995-12-13 Composto processos para a preparação do mesmo e para obter um efeito anti-isquêmico e anti-hipertensivo e para produzir atividade agonista 2 pré-sináptica e antagonista 1 pós-sináptica em um paciente e composição farmacêutica
RU95120582/04A RU2156239C2 (ru) 1994-12-14 1995-12-13 Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе
EP95870132A EP0717037A1 (fr) 1994-12-14 1995-12-13 1H-imidazoles substitués ayant une activité alpha 2-agoniste et alpha 1-antagoniste
JP7324502A JPH08208622A (ja) 1994-12-14 1995-12-13 置換された１ｈ−イミダゾール
KR1019950049572A KR960022474A (ko) 1994-12-14 1995-12-14 치환된 1h-이미다졸

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
GB9425211D0 true GB9425211D0 (en) 1995-02-15

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9425211.1A Pending GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Country Status (26)

Country Link
US (1) US5658938A (enExample)
EP (1) EP0717037A1 (enExample)
JP (1) JPH08208622A (enExample)
KR (1) KR960022474A (enExample)
CN (1) CN1054376C (enExample)
AR (1) AR002257A1 (enExample)
AU (1) AU693614B2 (enExample)
BG (1) BG63043B1 (enExample)
BR (1) BR9505815A (enExample)
CA (1) CA2165133A1 (enExample)
CZ (1) CZ327195A3 (enExample)
EE (1) EE9500064A (enExample)
FI (1) FI955927L (enExample)
GB (1) GB9425211D0 (enExample)
HU (1) HUT73980A (enExample)
IL (1) IL116325A (enExample)
IS (1) IS4311A (enExample)
MX (1) MX9505063A (enExample)
NO (1) NO305316B1 (enExample)
NZ (1) NZ280646A (enExample)
PL (1) PL311736A1 (enExample)
RO (1) RO113346B1 (enExample)
RU (1) RU2156239C2 (enExample)
SK (1) SK155095A3 (enExample)
TW (1) TW303362B (enExample)
ZA (1) ZA9510554B (enExample)

Families Citing this family (51)

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GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
ZA981080B (en) 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
IL152401A0 (en) 2000-05-08 2003-05-29 Orion Corp New polycyclic indanylimidazoles with alpha2 adrenergic activity
TW200930291A (en) * 2002-04-29 2009-07-16 Bayer Cropscience Ag Pesticidal heterocycles
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
EP1981499A1 (en) * 2006-01-27 2008-10-22 F.Hoffmann-La Roche Ag Use of 2-imidazoles for the treatment of cns disorders
WO2008046756A1 (en) * 2006-10-19 2008-04-24 F. Hoffmann-La Roche Ag Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
CA2666762C (en) * 2006-10-19 2014-12-30 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
EP2086959B1 (en) * 2006-11-02 2011-11-16 F. Hoffmann-La Roche AG Substituted 2-imidazoles as modulators of the trace amine associated receptors
MX2009005047A (es) * 2006-11-16 2009-05-25 Hoffmann La Roche 4-imidazoles sustituidos.
MX2009005920A (es) * 2006-12-13 2009-06-16 Hoffmann La Roche Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina.
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
MX2009008255A (es) * 2007-02-02 2009-08-12 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos taar1.
CN101702905A (zh) * 2007-02-13 2010-05-05 先灵公司 功能选择性α2C肾上腺素能受体激动剂
JP2010518161A (ja) * 2007-02-13 2010-05-27 シェーリング コーポレイション 機能選択性α２Ｃアドレナリン受容体アゴニストとしてのクロマン誘導体および類似体
CA2678072A1 (en) * 2007-02-13 2008-08-21 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
KR101222412B1 (ko) * 2007-02-15 2013-01-15 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
CN101687812A (zh) 2007-07-02 2010-03-31 弗·哈夫曼-拉罗切有限公司 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物
WO2009003867A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
WO2009016048A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
CN101765425A (zh) * 2007-08-02 2010-06-30 弗·哈夫曼-拉罗切有限公司 苯甲酰胺衍生物用于治疗cns障碍的用途
BRPI0814758A2 (pt) * 2007-08-03 2015-03-03 Hoffmann La Roche Piridinacarboxamida e derivados de benzamida como ligantes taar1
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP2257546B1 (en) 2008-02-21 2012-08-15 Merck Sharp & Dohme Corp. Functionally selective alpha2c adrenoreceptor agonists
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
CN102083805A (zh) * 2008-07-24 2011-06-01 弗·哈夫曼-拉罗切有限公司 4,5-二氢-唑-2-基衍生物
WO2010017120A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
WO2010042473A1 (en) 2008-10-07 2010-04-15 Schering Corporation Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
RU2621050C2 (ru) 2012-01-12 2017-05-31 Ф. Хоффманн-Ля Рош Аг Гетероциклические производные в качестве рецепторов, ассоциированных со следовыми аминами (taars)
NO2895477T3 (enExample) 2012-09-14 2018-03-31
CA2879176C (en) * 2012-09-17 2020-10-27 F.Hoffmann-La Roche Ag Triazole carboxamide derivatives
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
CA2954098A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted azetidine derivatives as taar ligands
MX2016016190A (es) 2014-08-27 2017-03-08 Hoffmann La Roche Derivados de pirazino[2,1-a]isoquinolina sustituida para el tratamiento de trastornos del sistema nervioso central.
JP6814814B2 (ja) 2016-03-17 2021-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｔａａｒのアゴニストとしての活性を有する５−エチル−４−メチル−ピラゾール−３−カルボキサミド誘導体
CN108777958B (zh) * 2016-03-17 2021-03-12 Fmc有限公司 将s-对映体转换成其消旋形式的方法
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

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GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
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JPH04210680A (ja) * 1990-12-01 1992-07-31 Nissan Chem Ind Ltd イミダゾール誘導体および植物生長調節剤
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles

Also Published As

Publication number Publication date
AU4036895A (en) 1996-06-20
NO955034D0 (no) 1995-12-12
FI955927A0 (fi) 1995-12-11
FI955927A7 (fi) 1996-06-15
HUT73980A (en) 1996-10-28
RU2156239C2 (ru) 2000-09-20
SK155095A3 (en) 1997-02-05
KR960022474A (ko) 1996-07-18
CN1133837A (zh) 1996-10-23
NZ280646A (en) 1996-08-27
IL116325A (en) 1999-10-28
BR9505815A (pt) 1998-01-06
AU693614B2 (en) 1998-07-02
EE9500064A (et) 1996-06-17
MX9505063A (es) 1997-01-31
NO955034L (no) 1996-06-17
JPH08208622A (ja) 1996-08-13
US5658938A (en) 1997-08-19
ZA9510554B (en) 1996-06-13
PL311736A1 (en) 1996-06-24
TW303362B (enExample) 1997-04-21
CA2165133A1 (en) 1996-06-15
CN1054376C (zh) 2000-07-12
EP0717037A1 (fr) 1996-06-19
BG100208A (bg) 1996-07-31
AR002257A1 (es) 1998-03-11
RO113346B1 (ro) 1998-06-30
IS4311A (is) 1996-06-15
HU9503549D0 (en) 1996-02-28
FI955927L (fi) 1996-06-15
NO305316B1 (no) 1999-05-10
BG63043B1 (bg) 2001-02-28
CZ327195A3 (en) 1996-07-17
IL116325A0 (en) 1996-03-31

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