CN105339436B - 4,4-二取代环己基桥连七甲川花菁染料及其应用 - Google Patents

4,4-二取代环己基桥连七甲川花菁染料及其应用 Download PDF

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CN105339436B
CN105339436B CN201480016214.6A CN201480016214A CN105339436B CN 105339436 B CN105339436 B CN 105339436B CN 201480016214 A CN201480016214 A CN 201480016214A CN 105339436 B CN105339436 B CN 105339436B
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independently
alkyl
compound
halogen
hydrogen
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CN105339436A (zh
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纳拉锡姆哈查理·纳拉亚南
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Visen Medical Inc
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
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    • A61K49/0013—Luminescence
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    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
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    • A61K51/041—Heterocyclic compounds
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    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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CN201480016214.6A 2013-03-15 2014-03-14 4,4-二取代环己基桥连七甲川花菁染料及其应用 Active CN105339436B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798562P 2013-03-15 2013-03-15
US61/798,562 2013-03-15
PCT/US2014/029224 WO2014144702A2 (en) 2013-03-15 2014-03-14 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof

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CN105339436A CN105339436A (zh) 2016-02-17
CN105339436B true CN105339436B (zh) 2018-05-25

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US (5) US9897604B2 (https=)
EP (2) EP2970674B1 (https=)
JP (2) JP6580552B2 (https=)
CN (1) CN105339436B (https=)
AU (1) AU2014228808C1 (https=)
CA (1) CA2901000C (https=)
WO (1) WO2014144702A2 (https=)

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CN101296927A (zh) 2005-09-02 2008-10-29 Visen医药公司 生物相容的含n,n-二取代磺酰胺的荧光染料标记
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
ES2658852T3 (es) 2008-01-18 2018-03-12 Visen Medical, Inc. Agentes de imaginología fluorescentes
AU2012253502C1 (en) 2011-05-09 2017-12-14 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
JP6606487B2 (ja) 2013-03-15 2019-11-13 ビセン メディカル， インコーポレイテッド ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素
CN105339436B (zh) * 2013-03-15 2018-05-25 文森医学公司 4,4-二取代环己基桥连七甲川花菁染料及其应用
US10561729B2 (en) 2016-08-11 2020-02-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near-IR light-cleavable conjugates and conjugate precursors
CN107400080B (zh) * 2017-07-27 2020-03-31 中国科学院烟台海岸带研究所 一种基于花菁的有机化合物及其中间体的应用
JP2020050610A (ja) * 2018-09-27 2020-04-02 国立研究開発法人理化学研究所 バイオイメージング剤
CN109985252A (zh) * 2019-05-10 2019-07-09 南京鼓楼医院 一种新型双模态小分子造影剂及其制备方法与应用
CN110642839B (zh) * 2019-08-14 2022-04-01 深圳大学 一种纳米探针及其制备方法与应用
CN113045563A (zh) * 2019-12-27 2021-06-29 上海泓博智源医药股份有限公司 一种感蓝光谱增感剂的制备方法
CN112920171A (zh) * 2021-01-29 2021-06-08 南京邮电大学 一种含四嗪单元的花菁化合物及其制备方法和应用
CN113350336B (zh) * 2021-07-01 2022-06-10 中国人民解放军陆军军医大学 一种七甲川吲哚花菁或其衍生物的用途
CN115403503B (zh) * 2022-09-02 2023-05-26 中国药科大学 七甲川花菁素类染料偶联物、制法、药物组合物和应用
CN117169182B (zh) * 2023-08-30 2024-03-15 广州沙艾生物科技有限公司 一种干细胞治疗制剂体外效力检测方法及其应用

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