AU2014228808C1 - 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof - Google Patents
4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof Download PDFInfo
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- AU2014228808C1 AU2014228808C1 AU2014228808A AU2014228808A AU2014228808C1 AU 2014228808 C1 AU2014228808 C1 AU 2014228808C1 AU 2014228808 A AU2014228808 A AU 2014228808A AU 2014228808 A AU2014228808 A AU 2014228808A AU 2014228808 C1 AU2014228808 C1 AU 2014228808C1
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- independently
- halogen
- alkyl
- compound
- so3h
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- 0 CC(C)C1(C)C(*CCC[C@]2CC(C)CC2)C1 Chemical compound CC(C)C1(C)C(*CCC[C@]2CC(C)CC2)C1 0.000 description 5
- UFPPQMGEHMZJHE-UHFFFAOYSA-N CC(C)(C(NCCS(O)(=O)=O)=O)C(O)=O Chemical compound CC(C)(C(NCCS(O)(=O)=O)=O)C(O)=O UFPPQMGEHMZJHE-UHFFFAOYSA-N 0.000 description 1
- VKMPGMRMUOPUAW-UHFFFAOYSA-O CC1(C)c(cc(cc2)S(O)(=O)=O)c2[N+](CCC[S](C)(O)(=O)=O)=C1/C=C/C(CC(C1)(C(NCCCCCC(C)=O)=O)C(NCCS(O)(=O)=O)=O)=C/C1=C/C=C(\C1(C)C)/N(CCCS(O)(=O)=O)c(cc2)c1cc2S(O)(=O)=O Chemical compound CC1(C)c(cc(cc2)S(O)(=O)=O)c2[N+](CCC[S](C)(O)(=O)=O)=C1/C=C/C(CC(C1)(C(NCCCCCC(C)=O)=O)C(NCCS(O)(=O)=O)=O)=C/C1=C/C=C(\C1(C)C)/N(CCCS(O)(=O)=O)c(cc2)c1cc2S(O)(=O)=O VKMPGMRMUOPUAW-UHFFFAOYSA-O 0.000 description 1
- HGVSQTHQEHRAQO-UHFFFAOYSA-O CCCNC(C(CC(/C=C/C(C1(C)C)=[N+](CC)c2c1cccc2)=C1)(C/C1=C\C=C1\N(CC)c2ccccc2C1(C)C)C(NCCCCCC(OCC)=O)=O)=O Chemical compound CCCNC(C(CC(/C=C/C(C1(C)C)=[N+](CC)c2c1cccc2)=C1)(C/C1=C\C=C1\N(CC)c2ccccc2C1(C)C)C(NCCCCCC(OCC)=O)=O)=O HGVSQTHQEHRAQO-UHFFFAOYSA-O 0.000 description 1
- YCTHHIHZMDTWKR-UHFFFAOYSA-O CCN1c(cccc2)c2O/C1=C\C=C(/CC(C1)(C(NCCS(O)(=O)=O)=O)C(OCC)=O)\C=C1/C=C/c1[n+](CC)c2ccccc2[o]1 Chemical compound CCN1c(cccc2)c2O/C1=C\C=C(/CC(C1)(C(NCCS(O)(=O)=O)=O)C(OCC)=O)\C=C1/C=C/c1[n+](CC)c2ccccc2[o]1 YCTHHIHZMDTWKR-UHFFFAOYSA-O 0.000 description 1
- YUDWYVSMBDDFFK-UHFFFAOYSA-O CCN1c(cccc2)c2O/C1=C\C=C(/CC(C1)(C(O)=O)C(OCC)=O)\C=C1/C=C/c1[n+](CC)c2ccccc2[o]1 Chemical compound CCN1c(cccc2)c2O/C1=C\C=C(/CC(C1)(C(O)=O)C(OCC)=O)\C=C1/C=C/c1[n+](CC)c2ccccc2[o]1 YUDWYVSMBDDFFK-UHFFFAOYSA-O 0.000 description 1
- DGHRNJGSVBHRMI-UHFFFAOYSA-O CCN1c(cccc2)c2S/C1=C\C=C(/CC(C1)(C(NCCCCCC(N)=O)=O)C(NCCS(O)(=O)=O)=O)\C=C1/C=C/c1[n+](CC)c2ccccc2[s]1 Chemical compound CCN1c(cccc2)c2S/C1=C\C=C(/CC(C1)(C(NCCCCCC(N)=O)=O)C(NCCS(O)(=O)=O)=O)\C=C1/C=C/c1[n+](CC)c2ccccc2[s]1 DGHRNJGSVBHRMI-UHFFFAOYSA-O 0.000 description 1
- JBNNBXCOVWIEQI-UHFFFAOYSA-N CCN1c2ccccc2C(C)(C)/C1=C\C=C(/CC(C1)(C(C)=O)C(C)=O)\C=C1/C=C/C(C1(C)C)=[N+](CC)c2c1cccc2 Chemical compound CCN1c2ccccc2C(C)(C)/C1=C\C=C(/CC(C1)(C(C)=O)C(C)=O)\C=C1/C=C/C(C1(C)C)=[N+](CC)c2c1cccc2 JBNNBXCOVWIEQI-UHFFFAOYSA-N 0.000 description 1
- CFSKPUGCMLQVOO-UHFFFAOYSA-O CCOC(C(CC(/C=C/C(C1(C)C)=[N+](CCCS(O)(=O)=O)c(cc2)c1cc2S(O)(=O)=O)=C1)(C/C1=C\C=C1/Oc(cccc2)c2N1CCCS(O)(=O)=O)C(O)=O)=O Chemical compound CCOC(C(CC(/C=C/C(C1(C)C)=[N+](CCCS(O)(=O)=O)c(cc2)c1cc2S(O)(=O)=O)=C1)(C/C1=C\C=C1/Oc(cccc2)c2N1CCCS(O)(=O)=O)C(O)=O)=O CFSKPUGCMLQVOO-UHFFFAOYSA-O 0.000 description 1
- MJAWECCNALQRGL-UHFFFAOYSA-O CCOC(C(CC(/C=C/C(C1(C)C)=[N+](CCCS(O)(=O)=O)c2c1c(cccc1)c1cc2)=C1)(C/C1=C\C=C(/C1(C)C)\N(CCCS(O)(=O)=O)c2c1c1ccccc1cc2)C(O)=O)=O Chemical compound CCOC(C(CC(/C=C/C(C1(C)C)=[N+](CCCS(O)(=O)=O)c2c1c(cccc1)c1cc2)=C1)(C/C1=C\C=C(/C1(C)C)\N(CCCS(O)(=O)=O)c2c1c1ccccc1cc2)C(O)=O)=O MJAWECCNALQRGL-UHFFFAOYSA-O 0.000 description 1
- PHBLWIRBWTUCDA-UHFFFAOYSA-O CCOC(C(CC(/C=C/C(C1(C)C)=[N+](CCCS(O)(=O)=O)c2c1cc(C)cc2)=C1)(C/C1=C\C=C1/Oc(cccc2)c2N1CCCS(O)(=O)=O)C(NCCS(O)(=O)=O)=O)=O Chemical compound CCOC(C(CC(/C=C/C(C1(C)C)=[N+](CCCS(O)(=O)=O)c2c1cc(C)cc2)=C1)(C/C1=C\C=C1/Oc(cccc2)c2N1CCCS(O)(=O)=O)C(NCCS(O)(=O)=O)=O)=O PHBLWIRBWTUCDA-UHFFFAOYSA-O 0.000 description 1
- XWCYTJVOQXWXTL-UHFFFAOYSA-N CCOC(CCCN(C)S(c1ccc2N=C(C)C(C)(C)c2c1)(=O)=O)=O Chemical compound CCOC(CCCN(C)S(c1ccc2N=C(C)C(C)(C)c2c1)(=O)=O)=O XWCYTJVOQXWXTL-UHFFFAOYSA-N 0.000 description 1
- XAABBBQBNHRYFN-UHFFFAOYSA-N CCOC(CCCNC)=O Chemical compound CCOC(CCCNC)=O XAABBBQBNHRYFN-UHFFFAOYSA-N 0.000 description 1
- ZLBZKWPINAVJOK-UHFFFAOYSA-N CNCCCS(O)(=O)=O Chemical compound CNCCCS(O)(=O)=O ZLBZKWPINAVJOK-UHFFFAOYSA-N 0.000 description 1
- OQJIQCZNNPNDSU-UHFFFAOYSA-O C[S](CCC[NH3+])(O)(=O)=O Chemical compound C[S](CCC[NH3+])(O)(=O)=O OQJIQCZNNPNDSU-UHFFFAOYSA-O 0.000 description 1
- BYFTUYFBISUADC-UHFFFAOYSA-O C[S](CCC[n+]1c(/C=C/C(CC(C2)(C(NCCCCCC(O)=O)=O)C(NCCS(O)(=O)=O)=O)=C/C2=C/C=C2\Sc(cccc3)c3N2CCCS(O)(=O)=O)[s]c2ccccc12)(O)(=O)=O Chemical compound C[S](CCC[n+]1c(/C=C/C(CC(C2)(C(NCCCCCC(O)=O)=O)C(NCCS(O)(=O)=O)=O)=C/C2=C/C=C2\Sc(cccc3)c3N2CCCS(O)(=O)=O)[s]c2ccccc12)(O)(=O)=O BYFTUYFBISUADC-UHFFFAOYSA-O 0.000 description 1
- LHNLMUAUPCHQPK-UHFFFAOYSA-O C[S](CCC[n+]1c(/C=C/C(CC(C2)(C(NCCCCCC(ON(C(CC3)=O)C3=O)=O)=O)C(NCCS(O)(=O)=O)=O)=C/C2=C/C=C2\Sc(cccc3)c3N2CCCS(O)(=O)=O)[s]c2ccccc12)(O)(=O)=O Chemical compound C[S](CCC[n+]1c(/C=C/C(CC(C2)(C(NCCCCCC(ON(C(CC3)=O)C3=O)=O)=O)C(NCCS(O)(=O)=O)=O)=C/C2=C/C=C2\Sc(cccc3)c3N2CCCS(O)(=O)=O)[s]c2ccccc12)(O)(=O)=O LHNLMUAUPCHQPK-UHFFFAOYSA-O 0.000 description 1
Classifications
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- A—HUMAN NECESSITIES
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- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
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- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798562P | 2013-03-15 | 2013-03-15 | |
| US61/798,562 | 2013-03-15 | ||
| PCT/US2014/029224 WO2014144702A2 (en) | 2013-03-15 | 2014-03-14 | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2014228808A1 AU2014228808A1 (en) | 2015-08-27 |
| AU2014228808B2 AU2014228808B2 (en) | 2018-09-06 |
| AU2014228808C1 true AU2014228808C1 (en) | 2018-12-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014228808A Active AU2014228808C1 (en) | 2013-03-15 | 2014-03-14 | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9897604B2 (https=) |
| EP (2) | EP2970674B1 (https=) |
| JP (2) | JP6580552B2 (https=) |
| CN (1) | CN105339436B (https=) |
| AU (1) | AU2014228808C1 (https=) |
| CA (1) | CA2901000C (https=) |
| WO (1) | WO2014144702A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2621137C (en) | 2005-09-02 | 2014-07-29 | Visen Medical, Inc. | Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels |
| WO2007136413A2 (en) | 2005-12-22 | 2007-11-29 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| US8815214B2 (en) | 2008-01-18 | 2014-08-26 | Visen Medical, Inc. | Fluorescent imaging agents |
| CN103687854A (zh) | 2011-05-09 | 2014-03-26 | 文森医学公司 | 碳酸酐酶靶向剂及其使用方法 |
| WO2014144702A2 (en) * | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| WO2018031448A1 (en) | 2016-08-11 | 2018-02-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near-ir light-cleavable conjugates and conjugate precursors |
| CN107400080B (zh) * | 2017-07-27 | 2020-03-31 | 中国科学院烟台海岸带研究所 | 一种基于花菁的有机化合物及其中间体的应用 |
| JP2020050610A (ja) * | 2018-09-27 | 2020-04-02 | 国立研究開発法人理化学研究所 | バイオイメージング剤 |
| CN109985252A (zh) * | 2019-05-10 | 2019-07-09 | 南京鼓楼医院 | 一种新型双模态小分子造影剂及其制备方法与应用 |
| CN110642839B (zh) * | 2019-08-14 | 2022-04-01 | 深圳大学 | 一种纳米探针及其制备方法与应用 |
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| CN112920171A (zh) * | 2021-01-29 | 2021-06-08 | 南京邮电大学 | 一种含四嗪单元的花菁化合物及其制备方法和应用 |
| CN113350336B (zh) * | 2021-07-01 | 2022-06-10 | 中国人民解放军陆军军医大学 | 一种七甲川吲哚花菁或其衍生物的用途 |
| CN115403503B (zh) * | 2022-09-02 | 2023-05-26 | 中国药科大学 | 七甲川花菁素类染料偶联物、制法、药物组合物和应用 |
| CN117169182B (zh) * | 2023-08-30 | 2024-03-15 | 广州沙艾生物科技有限公司 | 一种干细胞治疗制剂体外效力检测方法及其应用 |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219335A (en) | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
| US5571388A (en) * | 1984-03-29 | 1996-11-05 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| JP2521702B2 (ja) * | 1985-04-26 | 1996-08-07 | 株式会社リコー | 光情報記録媒体 |
| JPS6250187A (ja) * | 1985-08-29 | 1987-03-04 | Nippon Kayaku Co Ltd | 耐光堅牢度向上法 |
| JPS62103192A (ja) * | 1985-10-30 | 1987-05-13 | Olympus Optical Co Ltd | 光情報記録媒体 |
| JPS62103190A (ja) * | 1985-10-30 | 1987-05-13 | Olympus Optical Co Ltd | 光情報記録媒体 |
| JPS62124986A (ja) * | 1985-11-27 | 1987-06-06 | Mitsubishi Chem Ind Ltd | 光学的記録媒体 |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| JP2732275B2 (ja) * | 1989-01-20 | 1998-03-25 | キヤノン株式会社 | 光学記録媒体 |
| US5164297A (en) | 1990-05-03 | 1992-11-17 | Advanced Magnetics Inc. | Solvent mediated relaxation assay system |
| US5445970A (en) | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| DE69332952T2 (de) | 1992-09-04 | 2004-02-19 | The General Hospital Corp., Boston | Diagnostische und therapeutische Einheiten enthaltende biokompatible Polymere |
| US6593148B1 (en) * | 1994-03-01 | 2003-07-15 | Li-Cor, Inc. | Cyanine dye compounds and labeling methods |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| JPH08234463A (ja) | 1994-12-27 | 1996-09-13 | Fuji Photo Film Co Ltd | スキャニング露光を用いる画像形成方法 |
| IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| US5958667A (en) * | 1996-07-24 | 1999-09-28 | Agfa-Gevaert | Photothermographic recording material comprising IR-sensitizing dyes |
| EP0821271B1 (en) | 1996-07-24 | 2006-04-19 | Agfa-Gevaert | Process for preparing an Infra-red photothermographic material comprising a spectral sensitizer and a stilbene derivative supersensitizer and image recording method |
| JP3794793B2 (ja) * | 1996-07-24 | 2006-07-12 | アグフア−ゲヴエルト,ナームローゼ・フエンノートシヤツプ | 増感色素を含むフオトサーモグラフイ記録材料及びそのための記録法 |
| US5876915A (en) | 1996-07-24 | 1999-03-02 | Agfa-Gevaert | Photothermographic recording material comprising sensitizing dyes and a recording process therefor |
| EP0821266A1 (en) | 1996-07-24 | 1998-01-28 | Agfa-Gevaert N.V. | Photothermographic recording material comprising sensitizing dyes and a recording process therefor |
| DE69735697T2 (de) * | 1996-07-24 | 2007-01-18 | Agfa-Gevaert | Verfahren zur Herstellung eines photothermographischen Infrarotmaterials, das einen Spektralsensibilisator und einen Stilbenderivat-Supersensibilisator enthält und ein Aufzeichnungsverfahren |
| US6027709A (en) * | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6046585A (en) | 1997-11-21 | 2000-04-04 | Quantum Design, Inc. | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| JPH11185836A (ja) | 1997-12-16 | 1999-07-09 | Fuji Photo Film Co Ltd | 光電変換素子および光再生型光電気化学電池 |
| US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| ATE284433T1 (de) | 1999-07-02 | 2004-12-15 | Visen Medical Inc | Fluorescierende cyaninlabels mit einem sulphamidobrückenglied |
| DE60116510T2 (de) * | 2000-09-19 | 2006-07-13 | Li-Cor, Inc., Lincoln | Cyaninfarbstoffe |
| US7597878B2 (en) * | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
| CA2423806C (en) | 2000-09-29 | 2009-12-22 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
| AU2002236683A1 (en) | 2000-10-27 | 2002-05-21 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| US7383076B2 (en) | 2000-11-27 | 2008-06-03 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| US6615063B1 (en) | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| EP1209205A1 (en) | 2000-11-28 | 2002-05-29 | Innosense S.r.l. | Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds |
| EP1213583A1 (en) | 2000-12-06 | 2002-06-12 | Innosense S.r.l. | General method for the covalent immobilisation of indicators in, or onto a support useful for the fabrication of optical sensors |
| EP1221465A1 (en) | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetric, monofunctionalised polymethine dyes labelling reagents |
| US20030044353A1 (en) | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
| WO2003061711A2 (en) | 2002-01-16 | 2003-07-31 | Visen Medical, Inc. | Chromophore probes for optical imaging |
| WO2003079015A1 (en) | 2002-03-11 | 2003-09-25 | Visen Medical, Inc. | Optical imaging probes |
| EP1514093B1 (en) | 2002-06-04 | 2021-04-28 | Visen Medical, Inc. | Imaging volumes with arbitrary geometries in non-contact tomography |
| JP2004067816A (ja) * | 2002-08-05 | 2004-03-04 | Fuji Photo Film Co Ltd | セルロースアシレートフィルム及びその製造方法、並びに該フィルムを用いた光学フィルム、液晶表示装置及びハロゲン化銀写真感光材料 |
| JP2004083799A (ja) * | 2002-08-28 | 2004-03-18 | Fuji Photo Film Co Ltd | セルロースアシレートフィルム及びその製造方法、並びに該フィルムを用いた光学フィルム、液晶表示装置及びハロゲン化銀写真感光材料 |
| US7647091B2 (en) | 2003-02-05 | 2010-01-12 | The General Hospital Corporation | Method and system for free space optical tomography of diffuse media |
| WO2004108902A2 (en) | 2003-06-04 | 2004-12-16 | Visen Medical, Inc. | Biocompatible fluorescent silicon nanoparticles |
| WO2006063246A1 (en) | 2004-12-08 | 2006-06-15 | The General Hospital Corporation | System and method for normalized fluorescence or bioluminescence imaging |
| US20060239916A1 (en) | 2005-01-07 | 2006-10-26 | Kai Licha | Use of cyanine dyes for the diagnosis of proliferative diseases |
| CA2621137C (en) | 2005-09-02 | 2014-07-29 | Visen Medical, Inc. | Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels |
| US7947256B2 (en) | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
| EP1934202B1 (en) | 2005-09-02 | 2019-01-09 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| WO2007111669A2 (en) | 2005-12-22 | 2007-10-04 | Visen Medical, Inc. | Combined x-ray and optical tomographic imaging system |
| WO2007136413A2 (en) | 2005-12-22 | 2007-11-29 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| ITSV20060002A1 (it) * | 2006-01-19 | 2007-07-20 | Ferrania Technologies Spa | Colorante fluorescente di tipo cianinico |
| US20100189657A1 (en) | 2006-03-20 | 2010-07-29 | The General Hospital Corporation | Intramolecularly quenched fluorochrome conjugates and methods of use |
| US8221721B2 (en) | 2007-02-09 | 2012-07-17 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US8314406B2 (en) | 2007-04-06 | 2012-11-20 | The General Hospital Corporation | Systems and methods for optical imaging using early arriving photons |
| CA2740602C (en) | 2007-10-19 | 2017-05-02 | Visen Medical, Inc. | Imaging systems featuring waveguiding compensation |
| WO2009078970A1 (en) | 2007-12-14 | 2009-06-25 | Biotium, Inc. | Fluorescent compounds |
| US8815214B2 (en) | 2008-01-18 | 2014-08-26 | Visen Medical, Inc. | Fluorescent imaging agents |
| CN102026671B (zh) | 2008-03-14 | 2014-09-03 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
| CA2719839C (en) | 2008-03-25 | 2017-08-22 | Visen Medical, Inc. | Animal holder for in vivo tomographic imaging with multiple modalities |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| EP2428230A1 (en) * | 2008-12-25 | 2012-03-14 | Canon Kabushiki Kaisha | Probe for auditory hair cells. |
| AU2010286592B2 (en) | 2009-08-28 | 2015-08-13 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
| CA2810822C (en) | 2009-09-22 | 2018-03-06 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| CN103687854A (zh) | 2011-05-09 | 2014-03-26 | 文森医学公司 | 碳酸酐酶靶向剂及其使用方法 |
| US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| CN104955484B (zh) | 2012-08-15 | 2019-01-15 | 文森医学公司 | 用于前列腺癌成像的前列腺特异性抗原药剂及其使用方法 |
| US20150182518A1 (en) * | 2012-10-26 | 2015-07-02 | Canon Kabushiki Kaisha | Cancer cell inhibitory drug and cancer stem-cell detection probe |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| WO2014144702A2 (en) | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| WO2019067180A1 (en) * | 2017-09-29 | 2019-04-04 | Perkinelmer Health Sciences, Inc. | NIR-SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION |
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| US20200049709A1 (en) | 2020-02-13 |
| US10473658B2 (en) | 2019-11-12 |
| EP2970674A2 (en) | 2016-01-20 |
| JP2019151665A (ja) | 2019-09-12 |
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| EP3489309A1 (en) | 2019-05-29 |
| CA2901000C (en) | 2023-03-14 |
| US20180164312A1 (en) | 2018-06-14 |
| CN105339436B (zh) | 2018-05-25 |
| CN105339436A (zh) | 2016-02-17 |
| JP7018913B2 (ja) | 2022-02-14 |
| EP2970674B1 (en) | 2018-12-12 |
| JP2016519080A (ja) | 2016-06-30 |
| JP6580552B2 (ja) | 2019-09-25 |
| WO2014144702A2 (en) | 2014-09-18 |
| AU2014228808B2 (en) | 2018-09-06 |
| US20220178921A1 (en) | 2022-06-09 |
| WO2014144702A3 (en) | 2014-12-18 |
| US20140348746A1 (en) | 2014-11-27 |
| CA2901000A1 (en) | 2014-09-18 |
| US9897604B2 (en) | 2018-02-20 |
| AU2014228808A1 (en) | 2015-08-27 |
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