AU2002236683A1 - Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates - Google Patents

Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates

Info

Publication number
AU2002236683A1
AU2002236683A1 AU2002236683A AU3668302A AU2002236683A1 AU 2002236683 A1 AU2002236683 A1 AU 2002236683A1 AU 2002236683 A AU2002236683 A AU 2002236683A AU 3668302 A AU3668302 A AU 3668302A AU 2002236683 A1 AU2002236683 A1 AU 2002236683A1
Authority
AU
Australia
Prior art keywords
bisphosphonates
vivo
modified
osteoblastic activity
isotopic detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002236683A
Inventor
John V. Frangioni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Original Assignee
Beth Israel Deaconess Medical Center Inc
Beth Israel Hospital Association
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Center Inc, Beth Israel Hospital Association filed Critical Beth Israel Deaconess Medical Center Inc
Publication of AU2002236683A1 publication Critical patent/AU2002236683A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
AU2002236683A 2000-10-27 2001-10-29 Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates Abandoned AU2002236683A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24402000P 2000-10-27 2000-10-27
US60/244,020 2000-10-27
PCT/US2001/051312 WO2002038190A2 (en) 2000-10-27 2001-10-29 Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates

Publications (1)

Publication Number Publication Date
AU2002236683A1 true AU2002236683A1 (en) 2002-05-21

Family

ID=22921068

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002236683A Abandoned AU2002236683A1 (en) 2000-10-27 2001-10-29 Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates

Country Status (4)

Country Link
US (5) US6869593B2 (en)
EP (1) EP1341557A2 (en)
AU (1) AU2002236683A1 (en)
WO (1) WO2002038190A2 (en)

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US9913917B2 (en) 2005-12-22 2018-03-13 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
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US20120059310A1 (en) * 2010-09-07 2012-03-08 Rao Papineni Vibration induced in vivo substance targeting
IT1403567B1 (en) 2011-01-21 2013-10-31 Univ Palermo POLYMERIC VECTORS OF POLYASPARTAMID CONJUGATED TO BISPHOSPHONATES FOR THE DIRECTION OF DRUGS TO BONES.
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JP7023604B2 (en) * 2013-10-31 2022-02-22 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド Near-infrared fluorescence contrast bioimaging agent and its usage
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
WO2017053486A1 (en) * 2015-09-21 2017-03-30 University Of Southern California Bone active nitrogen-containing bisphosphonates with a near infrared fluorescent label
GB2569058B (en) * 2016-01-12 2021-04-14 Cedars Sinai Medical Center A method of osteogenic differentiation in microfluidic tissue culture systems
EP3411472A4 (en) 2016-02-01 2020-01-22 Cedars-Sinai Medical Center Systems and methods for growth of intestinal cells in microfluidic devices
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US8431714B2 (en) * 2007-04-16 2013-04-30 University Of Southern California Synthesis of drug conjugates via reaction with epoxide-containing linkers

Also Published As

Publication number Publication date
US20060002857A1 (en) 2006-01-05
US20110256065A1 (en) 2011-10-20
WO2002038190A3 (en) 2002-08-29
US7374746B2 (en) 2008-05-20
US6869593B2 (en) 2005-03-22
WO2002038190A2 (en) 2002-05-16
EP1341557A2 (en) 2003-09-10
US20090123383A1 (en) 2009-05-14
US20040028611A1 (en) 2004-02-12
US20070036724A1 (en) 2007-02-15

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