CN105102455B - 亲水性自消耗连接子及其缀合物 - Google Patents

亲水性自消耗连接子及其缀合物 Download PDF

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Publication number
CN105102455B
CN105102455B CN201380073519.6A CN201380073519A CN105102455B CN 105102455 B CN105102455 B CN 105102455B CN 201380073519 A CN201380073519 A CN 201380073519A CN 105102455 B CN105102455 B CN 105102455B
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alkyl
compound
group
connexon
heterocycle
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Chinese (zh)
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CN105102455A (zh
Inventor
林荣华
林士瑶
谢昱祁
黄久珍
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Taiwan Medical Holding Co ltd
Wholeheart Medical Biotechnology Co ltd
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Taiwan Medical International Co ltd
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201380073519.6A 2012-12-21 2013-12-20 亲水性自消耗连接子及其缀合物 Expired - Fee Related CN105102455B (zh)

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CN201810460861.6A CN108546283A (zh) 2012-12-21 2013-12-20 亲水性自消耗连接子及其缀合物

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US201261745448P 2012-12-21 2012-12-21
US61/745,448 2012-12-21
US201361785027P 2013-03-14 2013-03-14
US61/785,027 2013-03-14
PCT/US2013/077306 WO2014100762A1 (en) 2012-12-21 2013-12-20 Hydrophilic self-immolative linkers and conjugates thereof

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CN105102455B true CN105102455B (zh) 2018-05-25

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