CN1049893C - 缬无环鸟苷盐酸盐及其制法和其制药应用 - Google Patents

缬无环鸟苷盐酸盐及其制法和其制药应用 Download PDF

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Publication number
CN1049893C
CN1049893C CN96192662A CN96192662A CN1049893C CN 1049893 C CN1049893 C CN 1049893C CN 96192662 A CN96192662 A CN 96192662A CN 96192662 A CN96192662 A CN 96192662A CN 1049893 C CN1049893 C CN 1049893C
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China
Prior art keywords
hydrochloride
valacv
anhydrous crystalline
crystalline forms
alcohol
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN96192662A
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English (en)
Chinese (zh)
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CN1179159A (zh
Inventor
B·H·卡尔特尔
J·M·帕尔丁
P·G·瓦尔拉希金
R·A·文尼克
W·B·格鲁布三世
G·A·科维
P·G·拉克
D·M·斯金内尔
D·J·瓦特鲁普
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Wellcome Foundation Ltd
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Wellcome Foundation Ltd
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Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of CN1179159A publication Critical patent/CN1179159A/zh
Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN96192662A 1995-01-20 1996-01-19 缬无环鸟苷盐酸盐及其制法和其制药应用 Expired - Fee Related CN1049893C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9501178.9A GB9501178D0 (en) 1995-01-20 1995-01-20 Guanine derivative
GB9501178.9 1995-01-20

Publications (2)

Publication Number Publication Date
CN1179159A CN1179159A (zh) 1998-04-15
CN1049893C true CN1049893C (zh) 2000-03-01

Family

ID=10768347

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96192662A Expired - Fee Related CN1049893C (zh) 1995-01-20 1996-01-19 缬无环鸟苷盐酸盐及其制法和其制药应用

Country Status (40)

Country Link
US (1) US6107302A (enExample)
EP (1) EP0804436B1 (enExample)
JP (1) JP3176633B2 (enExample)
KR (1) KR100376074B1 (enExample)
CN (1) CN1049893C (enExample)
AP (1) AP662A (enExample)
AR (1) AR002270A1 (enExample)
AT (1) ATE302777T1 (enExample)
AU (1) AU702794B2 (enExample)
BG (1) BG63393B1 (enExample)
BR (1) BR9606768A (enExample)
CA (1) CA2210799C (enExample)
CY (1) CY2531B1 (enExample)
CZ (1) CZ297065B6 (enExample)
DE (1) DE69635106T2 (enExample)
DK (1) DK0804436T3 (enExample)
EA (1) EA000364B1 (enExample)
EE (1) EE03528B1 (enExample)
ES (1) ES2248806T3 (enExample)
FI (1) FI973063L (enExample)
GB (1) GB9501178D0 (enExample)
GE (1) GEP20001940B (enExample)
HR (1) HRP960024B1 (enExample)
HU (1) HU222993B1 (enExample)
IL (1) IL116831A (enExample)
IN (1) IN182468B (enExample)
IS (1) IS2268B (enExample)
NO (1) NO315558B1 (enExample)
NZ (1) NZ298851A (enExample)
OA (1) OA10499A (enExample)
PL (1) PL182175B1 (enExample)
RO (1) RO118693B1 (enExample)
RS (1) RS49518B (enExample)
SI (1) SI0804436T1 (enExample)
SK (1) SK285329B6 (enExample)
TR (1) TR199700656T1 (enExample)
UA (1) UA46001C2 (enExample)
UY (1) UY25779A1 (enExample)
WO (1) WO1996022291A1 (enExample)
ZA (1) ZA96449B (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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CN1250449A (zh) * 1997-01-17 2000-04-12 味之素株式会社 新型z－伐昔洛韦结晶
GB0010446D0 (en) * 2000-04-28 2000-06-14 Glaxo Wellcome Kk Pharmaceutical formulation
EA007485B1 (ru) * 2001-02-24 2006-10-27 Берингер Ингельхайм Фарма Гмбх Унд Ко. Кг Производные ксантина, способ их получения, фармацевтическая композиция на их основе и способ ее получения
EP1436295A4 (en) * 2001-09-07 2007-07-11 Teva Pharma CRISTALLINE FORMS OF VALACYCLOVIR HYDROCHLORIDE
JP2005511612A (ja) * 2001-11-05 2005-04-28 グラクソ　グループ　リミテッド 塩酸バラシクロビルの無水結晶形
JP2005508993A (ja) * 2001-11-14 2005-04-07 テバ ファーマシューティカル インダストリーズ リミティド バラシクロビルの合成及び精製
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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050070711A1 (en) * 2002-10-16 2005-03-31 Igor Lifshitz Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
CA2548608A1 (en) * 2002-12-09 2004-06-24 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
US7786302B2 (en) * 2003-05-30 2010-08-31 Eczacibasi-Zentiva Kimyasal Urunler Sanayi Ve Ticaret A.S. Crystalline forms of valacyclovir hydrochloride
KR100871621B1 (ko) 2003-06-02 2008-12-02 테바 파마슈티컬 인더스트리즈 리미티드 발라시클로비르 히드로클로라이드의 신규한 결정질 형태
MXPA06008197A (es) * 2004-01-21 2007-04-02 Teva Pharma Proceso para la preparacion de clorhidrato de valaciclovir.
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
JP2008504255A (ja) * 2004-06-30 2008-02-14 テバ ファーマシューティカル インダストリーズ リミティド 結晶塩酸バラシクロビル中の残留アルコールを低減する方法
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
US7846937B2 (en) * 2005-05-25 2010-12-07 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
EP1746098A1 (en) * 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20070112193A1 (en) * 2005-11-14 2007-05-17 Khunt Mayur D Valacyclovir process
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
MX2008014024A (es) 2006-05-04 2008-11-14 Boehringer Ingelheim Int Formas poliformas.
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN1903854B (zh) * 2006-08-09 2012-05-23 丽珠医药集团股份有限公司 一种合成盐酸伐昔洛韦的方法
US20080167325A1 (en) * 2006-12-27 2008-07-10 Bs Praveen Kumar Valacyclovir compositions
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof
GB0710277D0 (en) * 2007-05-30 2007-07-11 Univ Birmingham Use of antivirals in the treatment of medical disorders
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US20090076039A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched valacyclovir
PE20140960A1 (es) * 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
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UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
CN103816158A (zh) * 2008-08-15 2014-05-28 勃林格殷格翰国际有限公司 用于治疗fab-相关疾病的嘌呤衍生物
CN102149407A (zh) 2008-09-10 2011-08-10 贝林格尔.英格海姆国际有限公司 治疗糖尿病和相关病症的组合疗法
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN107011345A (zh) 2008-12-23 2017-08-04 勃林格殷格翰国际有限公司 有机化合物的盐形式
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EP2504002B1 (en) 2009-11-27 2019-10-09 Boehringer Ingelheim International GmbH Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
KR101927068B1 (ko) 2010-05-05 2018-12-10 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
KR20200028498A (ko) 2010-06-24 2020-03-16 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CN102584825B (zh) * 2011-01-17 2014-04-02 四川科伦药物研究有限公司 一种合成盐酸伐昔洛韦的方法
HUE061596T2 (hu) 2011-07-15 2023-07-28 Boehringer Ingelheim Int Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
US20140296520A1 (en) * 2011-11-25 2014-10-02 Piramal Enterprises Limited Process for the preparation of valacyclovir hydrochloride
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596542A1 (en) * 1987-08-15 1994-05-11 The Wellcome Foundation Limited Therapeutic nucleosides

Family Cites Families (2)

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US5831075A (en) * 1993-06-10 1998-11-03 Rolabo Sl Amino acid ester of nucleoside analogues
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0596542A1 (en) * 1987-08-15 1994-05-11 The Wellcome Foundation Limited Therapeutic nucleosides

Also Published As

Publication number Publication date
ES2248806T3 (es) 2006-03-16
NZ298851A (en) 1999-01-28
HU222993B1 (hu) 2004-01-28
CN1179159A (zh) 1998-04-15
AR002270A1 (es) 1998-03-11
AP662A (en) 1998-08-19
SI0804436T1 (sl) 2006-02-28
PL321326A1 (en) 1997-12-08
CY2531B1 (en) 2006-04-12
DK0804436T3 (da) 2005-12-27
BG63393B1 (bg) 2001-12-29
DE69635106D1 (de) 2005-09-29
IS4527A (is) 1997-07-15
EE9700175A (et) 1998-02-16
JP3176633B2 (ja) 2001-06-18
NO315558B1 (no) 2003-09-22
IN182468B (enExample) 1999-04-17
IL116831A (en) 1998-10-30
NO973326D0 (no) 1997-07-18
GEP20001940B (en) 2000-02-05
HRP960024B1 (en) 2005-08-31
KR19980701525A (ko) 1998-05-15
HUP9801836A3 (en) 1999-06-28
GB9501178D0 (en) 1995-03-08
IL116831A0 (en) 1996-05-14
KR100376074B1 (ko) 2003-06-02
EA000364B1 (ru) 1999-06-24
SK285329B6 (sk) 2006-11-03
UY25779A1 (es) 2000-08-21
BR9606768A (pt) 1997-12-30
AU4453996A (en) 1996-08-07
FI973063A7 (fi) 1997-09-18
CA2210799C (en) 2008-06-10
EE03528B1 (et) 2001-10-15
CZ229497A3 (en) 1997-12-17
YU3396A (sh) 1998-12-23
US6107302A (en) 2000-08-22
FI973063L (fi) 1997-09-18
HRP960024A2 (en) 1997-10-31
NO973326L (no) 1997-09-16
EP0804436A1 (en) 1997-11-05
ATE302777T1 (de) 2005-09-15
WO1996022291A1 (en) 1996-07-25
CZ297065B6 (cs) 2006-08-16
CA2210799A1 (en) 1996-07-25
MX9705462A (es) 1997-10-31
TR199700656T1 (xx) 1998-03-21
RS49518B (sr) 2006-10-27
ZA96449B (en) 1996-08-07
IS2268B (is) 2007-07-15
OA10499A (en) 2002-04-10
EA199700124A1 (ru) 1997-12-30
BG101833A (bg) 1998-04-30
RO118693B1 (ro) 2003-09-30
AP9701058A0 (en) 1997-10-31
AU702794B2 (en) 1999-03-04
FI973063A0 (fi) 1997-07-18
SK96597A3 (en) 1998-02-04
PL182175B1 (pl) 2001-11-30
EP0804436B1 (en) 2005-08-24
DE69635106T2 (de) 2006-06-08
HUP9801836A2 (hu) 1999-05-28
UA46001C2 (uk) 2002-05-15
JPH11503718A (ja) 1999-03-30

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