CN104662021B - 新的双环吡啶酮类 - Google Patents
新的双环吡啶酮类 Download PDFInfo
- Publication number
- CN104662021B CN104662021B CN201380048982.5A CN201380048982A CN104662021B CN 104662021 B CN104662021 B CN 104662021B CN 201380048982 A CN201380048982 A CN 201380048982A CN 104662021 B CN104662021 B CN 104662021B
- Authority
- CN
- China
- Prior art keywords
- methyl
- compound
- trifluoromethyl
- mmol
- tetrahydrofuran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)(**)C(*)(*)C(C)(C)N(C(*)(*)*(C1*=C)C11[C@@](*)*1N1C2=C(*)C(*)=C(**)C1=O)C2=O Chemical compound CC(C)(**)C(*)(*)C(C)(C)N(C(*)(*)*(C1*=C)C11[C@@](*)*1N1C2=C(*)C(*)=C(**)C1=O)C2=O 0.000 description 10
- NAOAPKHNTBCWEH-PWHKKFIBSA-N C/C(/C1CC(CNCCO)CCC1)=C\C=C(/C)\Cl Chemical compound C/C(/C1CC(CNCCO)CCC1)=C\C=C(/C)\Cl NAOAPKHNTBCWEH-PWHKKFIBSA-N 0.000 description 1
- JQMBWFFRDCKMPK-WDEREUQCSA-N C=C([C@H](CC1)O[C@H]1c1cc(F)c(C(F)(F)F)c(F)c1)N Chemical compound C=C([C@H](CC1)O[C@H]1c1cc(F)c(C(F)(F)F)c(F)c1)N JQMBWFFRDCKMPK-WDEREUQCSA-N 0.000 description 1
- LWFLVOBZYLXRMP-UHFFFAOYSA-N C=CCC(C(F)(F)F)O Chemical compound C=CCC(C(F)(F)F)O LWFLVOBZYLXRMP-UHFFFAOYSA-N 0.000 description 1
- ZGLZHSHKLYMINH-UHFFFAOYSA-N CC(C)(C)[Si-](c1ccccc1)c1ccccc1 Chemical compound CC(C)(C)[Si-](c1ccccc1)c1ccccc1 ZGLZHSHKLYMINH-UHFFFAOYSA-N 0.000 description 1
- LZDTYPTYCSPHBT-UHFFFAOYSA-N CC(C)(C)[Si](c1ccccc1)(c1ccccc1)OCC(CC1)OC1=O Chemical compound CC(C)(C)[Si](c1ccccc1)(c1ccccc1)OCC(CC1)OC1=O LZDTYPTYCSPHBT-UHFFFAOYSA-N 0.000 description 1
- MODMVGIBPNYLMU-UHFFFAOYSA-N CC(C)(NCCO)OC(CC=C)C(F)(F)F Chemical compound CC(C)(NCCO)OC(CC=C)C(F)(F)F MODMVGIBPNYLMU-UHFFFAOYSA-N 0.000 description 1
- KOVMWGNUCLQTEH-XFDRKBDESA-N C[C@@H](C(CC=C1C(C=C(C2C(F)(F)F)F)=CC2F)[O]1=N)N(Cc1ccccc1)Cc1ccccc1 Chemical compound C[C@@H](C(CC=C1C(C=C(C2C(F)(F)F)F)=CC2F)[O]1=N)N(Cc1ccccc1)Cc1ccccc1 KOVMWGNUCLQTEH-XFDRKBDESA-N 0.000 description 1
- XBHGPYCZPIKCFG-ROUUACIJSA-N C[C@@H](C[C@@H](CO[Si](C(C)(C)C)(c1ccccc1)c1ccccc1)O1)C1=O Chemical compound C[C@@H](C[C@@H](CO[Si](C(C)(C)C)(c1ccccc1)c1ccccc1)O1)C1=O XBHGPYCZPIKCFG-ROUUACIJSA-N 0.000 description 1
- XFJDCAZYCNVWSQ-LPHOPBHVSA-N C[C@@H]([C@H]1OC(N)=CC1)N(Cc1ccccc1)Cc1ccccc1 Chemical compound C[C@@H]([C@H]1OC(N)=CC1)N(Cc1ccccc1)Cc1ccccc1 XFJDCAZYCNVWSQ-LPHOPBHVSA-N 0.000 description 1
- IHSMSMJMHIISEX-KPXOXKRLSA-O C[C@@H]1[C@H](c2ccc(C(F)(F)F)cc2)O[C@H](C[OH2+])C1 Chemical compound C[C@@H]1[C@H](c2ccc(C(F)(F)F)cc2)O[C@H](C[OH2+])C1 IHSMSMJMHIISEX-KPXOXKRLSA-O 0.000 description 1
- PIFKJTNWEUADSH-SECBINFHSA-N C[C@H](c1ccc(C(F)(F)F)cc1)OC(C)(C)OS(C)(=O)=O Chemical compound C[C@H](c1ccc(C(F)(F)F)cc1)OC(C)(C)OS(C)(=O)=O PIFKJTNWEUADSH-SECBINFHSA-N 0.000 description 1
- OYYMPYLZKJAZAT-UHFFFAOYSA-N Cc(nc1)c[n]1C1=CC=C(C(O)=O)NC1=O Chemical compound Cc(nc1)c[n]1C1=CC=C(C(O)=O)NC1=O OYYMPYLZKJAZAT-UHFFFAOYSA-N 0.000 description 1
- DWEWXGZAFBYSSR-UHFFFAOYSA-N OCCNC1CCCC1 Chemical compound OCCNC1CCCC1 DWEWXGZAFBYSSR-UHFFFAOYSA-N 0.000 description 1
- RNOVGJWJVRESAA-UHFFFAOYSA-N Oc(cc1)c(C(F)(F)F)cc1F Chemical compound Oc(cc1)c(C(F)(F)F)cc1F RNOVGJWJVRESAA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703969P | 2012-09-21 | 2012-09-21 | |
| US61/703,969 | 2012-09-21 | ||
| PCT/IB2013/058347 WO2014045156A1 (en) | 2012-09-21 | 2013-09-06 | Novel bicyclic pyridinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104662021A CN104662021A (zh) | 2015-05-27 |
| CN104662021B true CN104662021B (zh) | 2016-08-24 |
Family
ID=49585452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380048982.5A Expired - Fee Related CN104662021B (zh) | 2012-09-21 | 2013-09-06 | 新的双环吡啶酮类 |
Country Status (46)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| AU2013366668B2 (en) | 2012-12-20 | 2017-07-20 | Janssen Pharmaceutica Nv | Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators |
| ES2612215T3 (es) | 2013-01-17 | 2017-05-12 | Janssen Pharmaceutica, N.V. | Novedosos derivados de pirido-piperazinona sustituidos como moduladores de gamma secretasa |
| JP6425717B2 (ja) * | 2013-10-04 | 2018-11-21 | ファイザー・インク | ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| AP2016009465A0 (en) * | 2014-04-01 | 2016-09-30 | Pfizer | Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators |
| MX368391B (es) * | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
| WO2016201168A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmceuticals Inc. | Oxadiazine compounds and methods of use thereof |
| EP3472162B1 (en) | 2016-06-16 | 2021-11-17 | F. Hoffmann-La Roche AG | Heteroaryl estrogen receptor modulators and uses thereof |
| WO2018111926A2 (en) | 2016-12-16 | 2018-06-21 | Inception 3, Inc. | Methods of treating cochlear synaptopathy |
| CA3114113A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions and methods related to otic therapeutic agents |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| US20220175776A1 (en) | 2019-04-08 | 2022-06-09 | Frequency Therapeutics, Inc. | Combination of chir99021 and valproic acid for treating hearing loss |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| CN113402490B (zh) * | 2021-03-29 | 2023-01-03 | 白银京宇新药业有限公司 | 一种1，2，6，7-四氢-8H-茚并[5，4-b]呋喃-8-酮的制备方法 |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| CN114034792B (zh) * | 2021-11-09 | 2024-06-25 | 山东新华制药股份有限公司 | 检测氯酮含量的液相色谱分析方法 |
Citations (6)
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| WO2007084595A2 (en) * | 2006-01-20 | 2007-07-26 | Schering Corporation | Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors |
| WO2009073779A1 (en) * | 2007-12-06 | 2009-06-11 | Schering Corporation | Gamma secretase modulators |
| WO2010094647A1 (en) * | 2009-02-19 | 2010-08-26 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators |
| WO2011048525A1 (en) * | 2009-10-20 | 2011-04-28 | Pfizer Inc. | Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators |
| CN102149713A (zh) * | 2008-07-08 | 2011-08-10 | 赛诺菲-安万特 | 吡啶并吡啶酮衍生物及其制备方法和治疗用途 |
| CN102762548A (zh) * | 2009-12-22 | 2012-10-31 | 沃泰克斯药物股份有限公司 | 磷脂酰肌醇3-激酶的异吲哚啉酮抑制剂 |
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