CN1046505C - 1－苄基－3－羟甲基－吲唑与脂族2－羟基酸的醚的制法 - Google Patents

1－苄基－3－羟甲基－吲唑与脂族2－羟基酸的醚的制法 Download PDF

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Publication number
CN1046505C
CN1046505C CN90100599A CN90100599A CN1046505C CN 1046505 C CN1046505 C CN 1046505C CN 90100599 A CN90100599 A CN 90100599A CN 90100599 A CN90100599 A CN 90100599A CN 1046505 C CN1046505 C CN 1046505C
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CN
China
Prior art keywords
formula
compound
benzyl
reaction mixture
react
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN90100599A
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English (en)
Chinese (zh)
Other versions
CN1044810A (zh
Inventor
布鲁诺·斯尔维斯特利尼
林德罗·拜奥施
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
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Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco ACRAF SpA filed Critical Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Publication of CN1044810A publication Critical patent/CN1044810A/zh
Application granted granted Critical
Publication of CN1046505C publication Critical patent/CN1046505C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN90100599A 1989-02-07 1990-02-07 1－苄基－3－羟甲基－吲唑与脂族2－羟基酸的醚的制法 Expired - Fee Related CN1046505C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT47620A/89 1989-02-07
IT8947620A IT1230441B (it) 1989-02-07 1989-02-07 Eteri della serie dell'indazolo

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN93117740A Division CN1034016C (zh) 1989-02-07 1993-09-15 1-苄基-3-羟甲基-吲唑的制法

Publications (2)

Publication Number Publication Date
CN1044810A CN1044810A (zh) 1990-08-22
CN1046505C true CN1046505C (zh) 1999-11-17

Family

ID=11261479

Family Applications (2)

Application Number Title Priority Date Filing Date
CN90100599A Expired - Fee Related CN1046505C (zh) 1989-02-07 1990-02-07 1－苄基－3－羟甲基－吲唑与脂族2－羟基酸的醚的制法
CN93117740A Expired - Fee Related CN1034016C (zh) 1989-02-07 1993-09-15 1-苄基-3-羟甲基-吲唑的制法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN93117740A Expired - Fee Related CN1034016C (zh) 1989-02-07 1993-09-15 1-苄基-3-羟甲基-吲唑的制法

Country Status (36)

Country Link
US (2) US4999367A (https=)
EP (1) EP0382276B1 (https=)
JP (1) JP2870925B2 (https=)
KR (1) KR0145525B1 (https=)
CN (2) CN1046505C (https=)
AR (1) AR247386A1 (https=)
AT (1) ATE127115T1 (https=)
AU (1) AU624895B2 (https=)
BG (1) BG50273A3 (https=)
CA (1) CA2009503C (https=)
CZ (1) CZ280121B6 (https=)
DD (2) DD295363A5 (https=)
DE (2) DE382276T1 (https=)
DK (1) DK0382276T3 (https=)
EG (1) EG19170A (https=)
ES (1) ES2020171T3 (https=)
FI (1) FI102678B1 (https=)
GE (1) GEP19971030B (https=)
GR (2) GR910300073T1 (https=)
HU (1) HU204793B (https=)
IL (1) IL93132A (https=)
IN (1) IN170957B (https=)
IT (1) IT1230441B (https=)
LT (1) LT3604B (https=)
LV (1) LV10612B (https=)
NZ (1) NZ232258A (https=)
PE (1) PE25091A1 (https=)
PH (1) PH26552A (https=)
PL (2) PL163730B1 (https=)
PT (1) PT93067B (https=)
RO (1) RO106252B1 (https=)
RU (3) RU2066318C1 (https=)
SK (1) SK56390A3 (https=)
UA (1) UA26852C2 (https=)
YU (1) YU47943B (https=)
ZA (1) ZA90644B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253703B (it) * 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) * 1997-11-26 1999-08-24 Intel Corporation Two-transistor DRAM cell for logic process technology
US7514463B2 (en) 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
EA019711B1 (ru) 2008-03-07 2014-05-30 Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А. ПРОИЗВОДНЫЕ 1-БЕНЗИЛ-3-ГИДРОКСИМЕТИЛИНДАЗОЛА, СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, ОБУСЛОВЛЕННЫХ ЭКСПРЕССИЕЙ МСР-1, СХ3CR1 ИЛИ р40
AU2009221063B2 (en) 2008-03-07 2013-03-21 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
JP5509100B2 (ja) 2008-03-07 2014-06-04 アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ 新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体及びそのＭＣＰ−１，ＣＸ３ＣＲ１及びｐ４０の発現に基づく疾病の治療への使用
GEP20135879B (en) * 2009-08-03 2013-07-10 Aziende Chimiche Riunite Angelini Francesco A C R A F S P A It Method of 1-benzyl-3-hydroxymethyl-1h-indazole preparation, derivatives thereof, and required magnesium intermediates
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
ES2656292T3 (es) 2012-05-01 2018-02-26 Translatum Medicus Inc. Métodos de tratamiento y diagnóstico de enfermedades oculares que causan ceguera
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
US9346762B2 (en) 2012-05-18 2016-05-24 Sanofi Pyrazole derivatives and their use as LPAR5 antagonists
EP2850062B1 (en) 2012-05-18 2017-07-19 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
CN108047136B (zh) * 2017-12-20 2021-07-09 长春普华制药股份有限公司 一种苄达酸的精制方法
EP3990433A4 (en) * 2019-06-25 2023-07-26 Translatum Medicus Inc. METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28032A (en) * 1966-08-29 1971-08-25 Acraf Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it) 1980-07-29 1986-06-25 Acraf Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it) 1981-11-27 1988-01-28 Acraf Trattamento della cataratta
IT1194564B (it) 1983-04-18 1988-09-22 Acraf Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it) 1986-08-01 1988-12-06 Acraf Metodo per il tratamento di lenti a contatto

Also Published As

Publication number Publication date
DD295363A5 (de) 1991-10-31
DE382276T1 (de) 1991-11-28
CN1034016C (zh) 1997-02-12
YU20690A (sh) 1992-07-20
CZ56390A3 (en) 1995-06-14
KR900012913A (ko) 1990-09-03
AR247386A1 (es) 1994-12-29
FI102678B (fi) 1999-01-29
IT1230441B (it) 1991-10-23
EP0382276A2 (en) 1990-08-16
LT3604B (en) 1995-12-27
CA2009503A1 (en) 1990-08-07
GR3018165T3 (en) 1996-02-29
PT93067B (pt) 1995-12-29
PL163720B1 (pl) 1994-04-29
SK278441B6 (en) 1997-05-07
ES2020171A4 (es) 1991-08-01
IN170957B (https=) 1992-06-20
FI102678B1 (fi) 1999-01-29
EG19170A (en) 1994-11-30
DE69021902T2 (de) 1996-05-23
DE69021902D1 (de) 1995-10-05
HU900689D0 (en) 1990-04-28
IL93132A (en) 1994-05-30
ES2020171T3 (es) 1995-12-01
GR910300073T1 (en) 1991-11-15
US5112986A (en) 1992-05-12
AU624895B2 (en) 1992-06-25
RU2055071C1 (ru) 1996-02-27
ZA90644B (en) 1991-01-30
PT93067A (pt) 1990-08-31
HU204793B (en) 1992-02-28
FI900577A0 (fi) 1990-02-06
CN1088201A (zh) 1994-06-22
JPH02240065A (ja) 1990-09-25
AU4906690A (en) 1990-08-16
BG50273A3 (en) 1992-06-15
PH26552A (en) 1992-08-19
DD291995A5 (de) 1991-07-18
RU2044729C1 (ru) 1995-09-27
EP0382276B1 (en) 1995-08-30
EP0382276A3 (en) 1990-12-12
HUT53088A (en) 1990-09-28
LV10612A (lv) 1995-04-20
SK56390A3 (en) 1997-05-07
KR0145525B1 (ko) 1998-08-17
RO106252B1 (ro) 1993-03-31
IL93132A0 (en) 1990-11-05
NZ232258A (en) 1991-06-25
PL163730B1 (pl) 1994-04-29
PE25091A1 (es) 1991-08-17
US4999367A (en) 1991-03-12
CN1044810A (zh) 1990-08-22
IT8947620A0 (it) 1989-02-07
JP2870925B2 (ja) 1999-03-17
GEP19971030B (en) 1997-06-13
CZ280121B6 (cs) 1995-11-15
DK0382276T3 (da) 1996-01-15
CA2009503C (en) 2000-04-11
LTIP872A (en) 1995-03-27
ATE127115T1 (de) 1995-09-15
UA26852C2 (uk) 1999-12-29
RU2066318C1 (ru) 1996-09-10
YU47943B (sh) 1996-07-24
LV10612B (en) 1995-08-20

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SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee