CN1054123C - 氨基甲酸衍生物的制备方法 - Google Patents
氨基甲酸衍生物的制备方法 Download PDFInfo
- Publication number
- CN1054123C CN1054123C CN92100713A CN92100713A CN1054123C CN 1054123 C CN1054123 C CN 1054123C CN 92100713 A CN92100713 A CN 92100713A CN 92100713 A CN92100713 A CN 92100713A CN 1054123 C CN1054123 C CN 1054123C
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- CN
- China
- Prior art keywords
- compound
- general formula
- group
- same
- definition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Abstract
Description
化合物 | 剂量(mg/kg) | 动物数 | 反应潜力(秒)平均±S.E. | 改善率(%) |
未处理小鼠CO2-处理小鼠实施例2未处理小鼠CO2处理小鼠实施例2 | --10--30 | 202020303030 | 278.5±12.054.8±15.2150.7±27.1**269.7±12.1103.6±18.5231.2±19.0** | 42.976.8 |
未处理小鼠CO2-处理小鼠实施例49 | --1030 | 20202020 | 300.0±087.3±18.9154.0±27.2183.7±26.3** | 45.3 |
未处理小鼠CO2处理小鼠硝吡胺甲酯 | --5 | 101010 | 300.0±0170.4±32.192.9±28.1 | -59.8 |
未处理小鼠CO2-处理小鼠比复美兰(Bifemelane) | --10 | 192019 | 282.5±12.1131.1±23.9188.5±27.1 | 37.9 |
未处理小鼠CO2-处理小鼠引朵杂嗪(Indeloxaxine) | --40 | 303030 | 300.0±0184.5±18.3219.3±17.8 | 30.1 |
未处理小鼠CO2-处理小鼠化合物A | --100 | 101010 | 300.0±0152.9±37.8175.3±36.7 | 15.2 |
Claims (1)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31922/1991 | 1991-01-31 | ||
JP31922/91 | 1991-01-31 | ||
JP3192291 | 1991-01-31 | ||
JP030071/92 | 1992-01-21 | ||
JP030071/1992 | 1992-01-21 | ||
JP03007192A JP3169188B2 (ja) | 1991-01-31 | 1992-01-21 | カルバミン酸誘導体及びその製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1064075A CN1064075A (zh) | 1992-09-02 |
CN1054123C true CN1054123C (zh) | 2000-07-05 |
Family
ID=26368350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN92100713A Expired - Fee Related CN1054123C (zh) | 1991-01-31 | 1992-01-31 | 氨基甲酸衍生物的制备方法 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0497303B1 (zh) |
JP (1) | JP3169188B2 (zh) |
KR (1) | KR960009429B1 (zh) |
CN (1) | CN1054123C (zh) |
AU (1) | AU643590B2 (zh) |
CA (1) | CA2060393C (zh) |
DE (1) | DE69225625T2 (zh) |
ES (1) | ES2118094T3 (zh) |
HU (2) | HUT60260A (zh) |
TW (1) | TW199889B (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0522914A1 (fr) * | 1991-06-27 | 1993-01-13 | Synthelabo | Dérivés de 2-pipéridinylpyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique |
SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
DE19750401A1 (de) * | 1997-11-14 | 1999-05-20 | Bayer Ag | Kondensierte Pyridin-Derivate |
GB9822440D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
GB0218326D0 (en) * | 2002-08-07 | 2002-09-11 | Glaxo Group Ltd | Compounds |
KR100477987B1 (ko) | 2002-09-11 | 2005-03-23 | 삼성에스디아이 주식회사 | 리튬-황 전지용 양극 및 이를 포함하는 리튬-황 전지 |
US20070004763A1 (en) * | 2005-06-10 | 2007-01-04 | Nand Baindur | Aminoquinoline and aminoquinazoline kinase modulators |
FR2948368B1 (fr) * | 2009-07-21 | 2011-07-22 | Servier Lab | Nouveaux composes piperidiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2000136A (en) * | 1977-06-03 | 1979-01-04 | Pfizer Ltd | Therapeutic agents |
GB2021108A (en) * | 1978-05-18 | 1979-11-28 | Pfizer Ltd | 6,7-Di(lower alkoxy)-4-amino- 2-(substituted piperidino) quinazolines |
US4613603A (en) * | 1984-07-11 | 1986-09-23 | Sanofi | Compounds with a nitrogen-containing heterocyclic nucleus, and drugs in which they are present |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63170356A (ja) * | 1986-12-30 | 1988-07-14 | Yamanouchi Pharmaceut Co Ltd | アニリン誘導体及びその製造法 |
-
1992
- 1992-01-21 JP JP03007192A patent/JP3169188B2/ja not_active Expired - Fee Related
- 1992-01-27 TW TW081100559A patent/TW199889B/zh active
- 1992-01-27 HU HU929200251D patent/HUT60260A/hu unknown
- 1992-01-27 HU HU9200251A patent/HU222246B1/hu not_active IP Right Cessation
- 1992-01-29 ES ES92101449T patent/ES2118094T3/es not_active Expired - Lifetime
- 1992-01-29 DE DE69225625T patent/DE69225625T2/de not_active Expired - Fee Related
- 1992-01-29 EP EP92101449A patent/EP0497303B1/en not_active Expired - Lifetime
- 1992-01-30 AU AU10649/92A patent/AU643590B2/en not_active Ceased
- 1992-01-30 KR KR92001383A patent/KR960009429B1/ko not_active IP Right Cessation
- 1992-01-30 CA CA002060393A patent/CA2060393C/en not_active Expired - Fee Related
- 1992-01-31 CN CN92100713A patent/CN1054123C/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2000136A (en) * | 1977-06-03 | 1979-01-04 | Pfizer Ltd | Therapeutic agents |
GB2021108A (en) * | 1978-05-18 | 1979-11-28 | Pfizer Ltd | 6,7-Di(lower alkoxy)-4-amino- 2-(substituted piperidino) quinazolines |
US4613603A (en) * | 1984-07-11 | 1986-09-23 | Sanofi | Compounds with a nitrogen-containing heterocyclic nucleus, and drugs in which they are present |
Also Published As
Publication number | Publication date |
---|---|
DE69225625T2 (de) | 1999-01-28 |
EP0497303A2 (en) | 1992-08-05 |
HUT60260A (en) | 1992-08-28 |
AU643590B2 (en) | 1993-11-18 |
TW199889B (zh) | 1993-02-11 |
DE69225625D1 (de) | 1998-07-02 |
KR920014798A (ko) | 1992-08-25 |
CA2060393A1 (en) | 1992-08-01 |
JP3169188B2 (ja) | 2001-05-21 |
EP0497303B1 (en) | 1998-05-27 |
CN1064075A (zh) | 1992-09-02 |
HU9200251D0 (en) | 1992-04-28 |
EP0497303A3 (en) | 1992-09-23 |
KR960009429B1 (en) | 1996-07-19 |
CA2060393C (en) | 2002-03-12 |
AU1064992A (en) | 1992-08-06 |
ES2118094T3 (es) | 1998-09-16 |
HU222246B1 (hu) | 2003-05-28 |
JPH0558999A (ja) | 1993-03-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Ping Shan Longshi Inventor before: Pingshan soil |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: TAKASHI HIRAYAMA TO: HIRAYAMA TAKASHI |
|
CI01 | Correction of invention patent gazette |
Correction item: Abstract of the description Correct: Summary submitted in January 31, 1992 False: Abstract is not a summary of this patent Number: 27 Page: 1 Volume: 16 |
|
CI03 | Correction of invention patent |
Correction item: Abstract of the description Correct: Summary submitted in January 31, 1992 False: Abstract is not a summary of this patent Number: 27 Page: The title page Volume: 16 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ABSTRACT OF DESCRIPTION; FROM: ABSTRACT IS NOT THIS PATENT ABSTRACT TO: JANUARY 31, 1992 SUBMITTED BY THE ABSTRACT |
|
ERR | Gazette correction |
Free format text: CORRECT: ABSTRACT OF DESCRIPTION; FROM: ABSTRACT IS NOT THIS PATENT ABSTRACT TO: JANUARY 31, 1992 SUBMITTED BY THE ABSTRACT |
|
C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
OR01 | Other related matters | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |