GB2021108A - 6,7-Di(lower alkoxy)-4-amino- 2-(substituted piperidino) quinazolines - Google Patents

6,7-Di(lower alkoxy)-4-amino- 2-(substituted piperidino) quinazolines

Info

Publication number
GB2021108A
GB2021108A GB7917000A GB7917000A GB2021108A GB 2021108 A GB2021108 A GB 2021108A GB 7917000 A GB7917000 A GB 7917000A GB 7917000 A GB7917000 A GB 7917000A GB 2021108 A GB2021108 A GB 2021108A
Authority
GB
United Kingdom
Prior art keywords
phenyl
lower alkyl
substituted
lower alkoxy
piperidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7917000A
Other versions
GB2021108B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB7917000A priority Critical patent/GB2021108B/en
Publication of GB2021108A publication Critical patent/GB2021108A/en
Application granted granted Critical
Publication of GB2021108B publication Critical patent/GB2021108B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4

Abstract

The title compounds wherein the substituent on the piperidino group is in, the 3- or 4-position and has the formula -(CH2)nCONR<1>R<2>,- O(CH2)nCONR<1>R<2> or - OCH(phenyl)CONR<1>R<2> wherein n is 0, 1 or 2; R<1> is hydrogen or lower alkyl; and R<2> is lower alkyl, phenyl, cycloalkyl, or lower alkyl substituted by certain stated substituents, with the proviso that any O, N or halogen atom in R<2> is separated by at least 2 carbon atoms from the nitrogen atom to which R<2> is attached; or R<1> and R<2> taken together with the nitrogen atom to which they are attached from a morpholino group optionally substituted by 1 or 2 lower alkyl groups, or a 1,2,3,4-tetrahydroiso -quinolyl group optionally substituted on the benzene ring portion by 1 or 2 lower alkoxy groups wherein phenyl groups are optional substituted are antihypertensives. Also claimed are the compounds' pharmaceutically acceptable bioprecursors and acid addition salts, processes for the preparation of the compounds, and pharmaceutical compositions containing them. In addition the invention covers certain intermediate acids per se, these being 6,7-di(lower alkoxy)-4-amino-2-(substituted piperidino) quinazolines wherein the substituent on the piperidino group is again in the 3- or 4-position and has the formula -(CH2)nCOOH, -O(CH2)nCOOH or -OCH(phenyl)COOH wherein n is 0, 1 or 2. Also covered are the acids functional equivalents as acylating agents.
GB7917000A 1978-05-18 1979-05-16 6,7 - di - 4 - amino - 2 - quinazolines Expired GB2021108B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7917000A GB2021108B (en) 1978-05-18 1979-05-16 6,7 - di - 4 - amino - 2 - quinazolines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2035178 1978-05-18
GB7917000A GB2021108B (en) 1978-05-18 1979-05-16 6,7 - di - 4 - amino - 2 - quinazolines

Publications (2)

Publication Number Publication Date
GB2021108A true GB2021108A (en) 1979-11-28
GB2021108B GB2021108B (en) 1982-07-21

Family

ID=26254615

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7917000A Expired GB2021108B (en) 1978-05-18 1979-05-16 6,7 - di - 4 - amino - 2 - quinazolines

Country Status (1)

Country Link
GB (1) GB2021108B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447919A1 (en) * 1979-01-31 1980-08-29 Pfizer 2-Piperidino-4-amino-quinazoline derivs. - useful as cardiovascular agents, esp. for treating hypertension (PT 16.6.80)
EP0497303A2 (en) * 1991-01-31 1992-08-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
US5300515A (en) * 1991-01-31 1994-04-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
US5675006A (en) * 1992-08-31 1997-10-07 Brantford Chemicals Inc. Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
US8569282B2 (en) 2007-12-11 2013-10-29 Cytopathfinder, Inc. Carboxamide compounds and their use

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447919A1 (en) * 1979-01-31 1980-08-29 Pfizer 2-Piperidino-4-amino-quinazoline derivs. - useful as cardiovascular agents, esp. for treating hypertension (PT 16.6.80)
EP0497303A2 (en) * 1991-01-31 1992-08-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
EP0497303A3 (en) * 1991-01-31 1992-09-23 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
AU643590B2 (en) * 1991-01-31 1993-11-18 Kyorin Pharmaceutical Co. Ltd. Carbamic acid derivatives and method for preparing the same
US5300515A (en) * 1991-01-31 1994-04-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
CN1054123C (en) * 1991-01-31 2000-07-05 杏林制药株式会社 Carbamic acid derivatives and method for preparing same
US5675006A (en) * 1992-08-31 1997-10-07 Brantford Chemicals Inc. Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
US5686612A (en) * 1992-08-31 1997-11-11 Brantford Chemicals Inc. Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof
US6080860A (en) * 1992-08-31 2000-06-27 Brantford Chemicalss Inc. Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
US8569282B2 (en) 2007-12-11 2013-10-29 Cytopathfinder, Inc. Carboxamide compounds and their use

Also Published As

Publication number Publication date
GB2021108B (en) 1982-07-21

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Legal Events

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PCNP Patent ceased through non-payment of renewal fee