FR2447919A1 - 2-Piperidino-4-amino-quinazoline derivs. - useful as cardiovascular agents, esp. for treating hypertension (PT 16.6.80) - Google Patents
2-Piperidino-4-amino-quinazoline derivs. - useful as cardiovascular agents, esp. for treating hypertension (PT 16.6.80)Info
- Publication number
- FR2447919A1 FR2447919A1 FR8002012A FR8002012A FR2447919A1 FR 2447919 A1 FR2447919 A1 FR 2447919A1 FR 8002012 A FR8002012 A FR 8002012A FR 8002012 A FR8002012 A FR 8002012A FR 2447919 A1 FR2447919 A1 FR 2447919A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- esp
- useful
- quinazoline
- treating hypertension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Quinazoline derivs. of formula (I) and their pharmaceutically acceptable acid addition salts are new. In (I) R = 1-4 C alkyl, benzyl or (3-6C cycloalkyl)-methyl; R1=1-4C alkyl; X is CH2CH2 substd. by one phenyl and opt. by 1 or 2 methyl; R2 = H, 1-4C alkyl or is phenyl opt. substd. by 1 or 2, 1-4C alkyl or alkoxy, halo, CR3, CONR3R4 or SO2N-R3R4. R3 and R4 = H or 1-4C alkyl. (I) are prepd. e.g. from the corresp. 2-halo-quinazoline and appropriate 4-substd. piperidine. (I) are regulators of the cardiovascular system and are esp. useful for treating hypertension in animals and humans. The usual oral dose is 1-50 mg/day for a 70 kg adult and the intravenous dose is 10-20% of the oral dose.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7903398 | 1979-01-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2447919A1 true FR2447919A1 (en) | 1980-08-29 |
FR2447919B1 FR2447919B1 (en) | 1983-02-11 |
Family
ID=10502852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8002012A Granted FR2447919A1 (en) | 1979-01-31 | 1980-01-30 | 2-Piperidino-4-amino-quinazoline derivs. - useful as cardiovascular agents, esp. for treating hypertension (PT 16.6.80) |
Country Status (28)
Country | Link |
---|---|
JP (1) | JPS55104278A (en) |
AR (1) | AR222208A1 (en) |
AT (1) | AT373595B (en) |
BE (1) | BE881448A (en) |
CA (1) | CA1131636A (en) |
CS (1) | CS231970B2 (en) |
DD (1) | DD148720A5 (en) |
DE (1) | DE3003323A1 (en) |
DK (1) | DK540879A (en) |
ES (1) | ES8101583A1 (en) |
FI (1) | FI63936C (en) |
FR (1) | FR2447919A1 (en) |
GR (1) | GR73626B (en) |
HU (1) | HU184233B (en) |
IE (1) | IE800178L (en) |
IL (1) | IL59252A (en) |
IT (1) | IT1149902B (en) |
LU (1) | LU82115A1 (en) |
NL (1) | NL8000571A (en) |
NO (1) | NO800230L (en) |
NZ (1) | NZ192744A (en) |
PH (1) | PH15436A (en) |
PL (1) | PL121890B1 (en) |
PT (1) | PT70749A (en) |
SE (1) | SE8000699L (en) |
SU (1) | SU895291A3 (en) |
YU (1) | YU22980A (en) |
ZA (1) | ZA80557B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2483920A1 (en) * | 1980-06-09 | 1981-12-11 | Synthelabo | Antihypertensive piperidino quinazoline(s) - prepd. from benzyloxy piperidine and a 2:halo-4:amino 6,7-di:methoxy quinazoline |
ES515338A0 (en) * | 1981-09-09 | 1983-11-01 | Orion Yhtymae Oy | "METHOD FOR THE PREPARATION OF SUBSTITUTED PIPERIDINYLQUINAZOLIDINES". |
US5280032A (en) * | 1989-02-14 | 1994-01-18 | Toyama Chemical Co., Ltd. | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same |
US9458131B2 (en) * | 2011-11-08 | 2016-10-04 | Emory University | Compounds and compositions used to epigenetically transform cells and methods related thereto |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2409267A1 (en) * | 1977-11-16 | 1979-06-15 | Pfizer | 4-AMINO-2-PIPERIDINOQUINAZOLINE DERIVATIVES, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
GB2021108A (en) * | 1978-05-18 | 1979-11-28 | Pfizer Ltd | 6,7-Di(lower alkoxy)-4-amino- 2-(substituted piperidino) quinazolines |
-
1979
- 1979-01-30 IE IE800178A patent/IE800178L/en unknown
- 1979-12-18 DK DK540879A patent/DK540879A/en not_active Application Discontinuation
-
1980
- 1980-01-28 PH PH23559A patent/PH15436A/en unknown
- 1980-01-29 NZ NZ192744A patent/NZ192744A/en unknown
- 1980-01-29 CS CS80607A patent/CS231970B2/en unknown
- 1980-01-29 IT IT19537/80A patent/IT1149902B/en active
- 1980-01-29 AT AT0046980A patent/AT373595B/en not_active IP Right Cessation
- 1980-01-29 YU YU00229/80A patent/YU22980A/en unknown
- 1980-01-29 SE SE8000699A patent/SE8000699L/en not_active Application Discontinuation
- 1980-01-29 FI FI800252A patent/FI63936C/en not_active IP Right Cessation
- 1980-01-29 IL IL59252A patent/IL59252A/en unknown
- 1980-01-30 JP JP990580A patent/JPS55104278A/en active Granted
- 1980-01-30 FR FR8002012A patent/FR2447919A1/en active Granted
- 1980-01-30 CA CA344,714A patent/CA1131636A/en not_active Expired
- 1980-01-30 BE BE0/199187A patent/BE881448A/en not_active IP Right Cessation
- 1980-01-30 PL PL1980221683A patent/PL121890B1/en unknown
- 1980-01-30 ZA ZA00800557A patent/ZA80557B/en unknown
- 1980-01-30 DE DE19803003323 patent/DE3003323A1/en not_active Ceased
- 1980-01-30 PT PT70749A patent/PT70749A/en unknown
- 1980-01-30 NO NO800230A patent/NO800230L/en unknown
- 1980-01-30 AR AR279793A patent/AR222208A1/en active
- 1980-01-30 NL NL8000571A patent/NL8000571A/en not_active Application Discontinuation
- 1980-01-30 SU SU802877159A patent/SU895291A3/en active
- 1980-01-30 HU HU80202A patent/HU184233B/en unknown
- 1980-01-31 DD DD80218769A patent/DD148720A5/en unknown
- 1980-01-31 ES ES488129A patent/ES8101583A1/en not_active Expired
- 1980-01-31 LU LU82115A patent/LU82115A1/en unknown
- 1980-02-11 GR GR61081A patent/GR73626B/el unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2409267A1 (en) * | 1977-11-16 | 1979-06-15 | Pfizer | 4-AMINO-2-PIPERIDINOQUINAZOLINE DERIVATIVES, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
GB2021108A (en) * | 1978-05-18 | 1979-11-28 | Pfizer Ltd | 6,7-Di(lower alkoxy)-4-amino- 2-(substituted piperidino) quinazolines |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |