JPS5632442A - Polyprenylcarboxylic acid amide - Google Patents

Polyprenylcarboxylic acid amide

Info

Publication number
JPS5632442A
JPS5632442A JP10866879A JP10866879A JPS5632442A JP S5632442 A JPS5632442 A JP S5632442A JP 10866879 A JP10866879 A JP 10866879A JP 10866879 A JP10866879 A JP 10866879A JP S5632442 A JPS5632442 A JP S5632442A
Authority
JP
Japan
Prior art keywords
compound
formula
reagent
wittig
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10866879A
Other languages
Japanese (ja)
Other versions
JPS6251263B2 (en
Inventor
Isao Yamatsu
Yuichi Inai
Shinya Abe
Hideaki Watanabe
Shunji Igarashi
Hiroyuki Shiojiri
Yoshio Tanabe
Kuniko Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP10866879A priority Critical patent/JPS5632442A/en
Priority to PH24388A priority patent/PH16234A/en
Priority to US06/175,213 priority patent/US4456603A/en
Priority to CH598880A priority patent/CH644582A5/en
Priority to AU61342/80A priority patent/AU531466B2/en
Priority to FR8017742A priority patent/FR2463122A1/en
Priority to DE19803030462 priority patent/DE3030462A1/en
Priority to GB8026161A priority patent/GB2058782B/en
Priority to SE8005712A priority patent/SE446977B/en
Priority to ES494230A priority patent/ES494230A0/en
Priority to IT24157/80A priority patent/IT1132406B/en
Priority to NL8004609A priority patent/NL8004609A/en
Priority to CA000358233A priority patent/CA1148153A/en
Publication of JPS5632442A publication Critical patent/JPS5632442A/en
Priority to FR8122993A priority patent/FR2497802A1/en
Priority to SE8404308A priority patent/SE8404308L/en
Priority to US06/677,893 priority patent/US4639450A/en
Publication of JPS6251263B2 publication Critical patent/JPS6251263B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:Title compounds of formula I (n is integer of 1W4; a, b are H or a bond between a and b is formed; R1, R2 are H, lower alkyl, phenyl, or they may form 5- or 6-membered heterocyclic ring together with the adjacent nitrogen atom).
EXAMPLE: 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraene amide.
USE: Treatment for hepatic disorders: they are of low toxicity and show ameliorative and pyrophylactic effects on hepatic disorders.
PREPARATION: The Wittig's reagent that is derived from a compound of formula III (X is halogen) is made to act on a compound of formula II to give the compound of formula I. The Wittig's reagent is, e.g., a compound of formula IV (R is alkyl), which is derived from a compound of formula III and trialkyl phosphite. In the reaction, a basic reagent such as butyllithium is added in general.
COPYRIGHT: (C)1981,JPO&Japio
JP10866879A 1979-08-14 1979-08-28 Polyprenylcarboxylic acid amide Granted JPS5632442A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
JP10866879A JPS5632442A (en) 1979-08-28 1979-08-28 Polyprenylcarboxylic acid amide
PH24388A PH16234A (en) 1979-08-14 1980-08-04 Polyphenylcarboxylic acid amides
US06/175,213 US4456603A (en) 1979-08-14 1980-08-04 Polyprenylcarboxylic acid amides useful for treating liver dysfunction
CH598880A CH644582A5 (en) 1979-08-14 1980-08-07 POLYPRENYLCARBOXYLIC ACID AMIDES.
AU61342/80A AU531466B2 (en) 1979-08-14 1980-08-11 Acid amides
FR8017742A FR2463122A1 (en) 1979-08-14 1980-08-12 POLYPRENYLCARBOXYLIC AMIDES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED ON SAID AMIDE
DE19803030462 DE3030462A1 (en) 1979-08-14 1980-08-12 POLYPRENYL CARBONIC ACID AMIDES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND
GB8026161A GB2058782B (en) 1979-08-14 1980-08-12 Polyprenylcarboxylic acid amides
ES494230A ES494230A0 (en) 1979-08-14 1980-08-13 A PROCEDURE FOR THE PREPARATION OF AMIDES OF PO-LIPRENILCARBOXILICO ACID
SE8005712A SE446977B (en) 1979-08-14 1980-08-13 POLYPRENYL CARBOXYLIC ACAMAMIDS, THE PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
IT24157/80A IT1132406B (en) 1979-08-14 1980-08-14 POLYPRENYLCARBOXYLIC ACID AMID
NL8004609A NL8004609A (en) 1979-08-14 1980-08-14 CARBONIC ACID AMIDS AND PHARMACEUTICAL PREPARATION AND METHOD FOR PREPARING THEREOF.
CA000358233A CA1148153A (en) 1979-08-14 1980-08-14 Polyprenylcarboxylic acid amides
FR8122993A FR2497802A1 (en) 1979-08-14 1981-12-09 NOVEL POLYPRENYLCARBOXYL AMIDES, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION BASED ON SAID AMIDE
SE8404308A SE8404308L (en) 1979-08-14 1984-08-29 POLYPRENYL CARBOXYLIC ACAMAMIDS, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US06/677,893 US4639450A (en) 1979-08-14 1984-12-04 Polyprenylcarboxylic acid morpholides and pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10866879A JPS5632442A (en) 1979-08-28 1979-08-28 Polyprenylcarboxylic acid amide

Publications (2)

Publication Number Publication Date
JPS5632442A true JPS5632442A (en) 1981-04-01
JPS6251263B2 JPS6251263B2 (en) 1987-10-29

Family

ID=14490643

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10866879A Granted JPS5632442A (en) 1979-08-14 1979-08-28 Polyprenylcarboxylic acid amide

Country Status (1)

Country Link
JP (1) JPS5632442A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020171210A1 (en) * 2019-02-21 2020-08-27 株式会社萩原農場生産研究所 Cancer cell growth inhibiting composition and processed food

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020171210A1 (en) * 2019-02-21 2020-08-27 株式会社萩原農場生産研究所 Cancer cell growth inhibiting composition and processed food

Also Published As

Publication number Publication date
JPS6251263B2 (en) 1987-10-29

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