YU20690A - Estri1-benzil-3-hidroksimetil-indazola sa alifatičnim 2-hidroksi kiselinama - Google Patents

Estri1-benzil-3-hidroksimetil-indazola sa alifatičnim 2-hidroksi kiselinama

Info

Publication number
YU20690A
YU20690A YU20690A YU20690A YU20690A YU 20690 A YU20690 A YU 20690A YU 20690 A YU20690 A YU 20690A YU 20690 A YU20690 A YU 20690A YU 20690 A YU20690 A YU 20690A
Authority
YU
Yugoslavia
Prior art keywords
benzyl
formula
estri1
alyphatic
indazole
Prior art date
Application number
YU20690A
Other languages
English (en)
Other versions
YU47943B (sh
Inventor
B. Silvestrini
L. Baiocchi
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority to SI9010206A priority Critical patent/SI9010206A/sl
Publication of YU20690A publication Critical patent/YU20690A/sh
Priority to HRP-206/90A priority patent/HRP940878B1/xx
Publication of YU47943B publication Critical patent/YU47943B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

ESTRI1-BENZIL-3-HIDROKSIMETIL-INDAZOLA SA ALIFATIČNIM 2-HIDROKSI KISELINAMA. Pronalaskom su obezbedjena jedinjenja formule: A---CH2---O---CRR'---COOR"' u kojoj A predstavlja 1-benzil-indazol-3-il jezgro; R i R', koji mogu da budu isti ili različiti, predstavljaju vodonik ili C1-5 alkil; R"' je vodonik ili ostatak alifatičnog zasićenog alkohola sa 1-4 ugljenikova atoma; i, kada je R"' vodonik, njihove soli sa farmaceutski prihvatljivim bazama. Pronalazak obezbedjuje i intermedijere i postupke za dobijanje jedinjenja formule (I), prema sledećim reakcionim šemama: predstavlja alkalni metal, X je odlazeća grupa kao što je halogen ili ostatak sulfonske kiseline i R" je C1-5 alkil. Jedinjenja formule (I) i njihove soli sa farmaceutski prihvatljivim bazama korisni su, na primer, kao antiinflamatorna sredstva ili kao analgetici.
YU20690A 1989-02-07 1990-02-05 Etri 1-benzil-3-hidroksimetil-indazola sa alifatičnim 2-hidroksi kiselinama i postupak dobijanja YU47943B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9010206A SI9010206A (sl) 1989-02-07 1990-02-05 Etri 1-benzil-3-hidroksimetil-indazola z alifatskimi 2-hidroksi kislinami
HRP-206/90A HRP940878B1 (en) 1989-02-07 1994-10-28 Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8947620A IT1230441B (it) 1989-02-07 1989-02-07 Eteri della serie dell'indazolo

Publications (2)

Publication Number Publication Date
YU20690A true YU20690A (sh) 1992-07-20
YU47943B YU47943B (sh) 1996-07-24

Family

ID=11261479

Family Applications (1)

Application Number Title Priority Date Filing Date
YU20690A YU47943B (sh) 1989-02-07 1990-02-05 Etri 1-benzil-3-hidroksimetil-indazola sa alifatičnim 2-hidroksi kiselinama i postupak dobijanja

Country Status (36)

Country Link
US (2) US4999367A (sh)
EP (1) EP0382276B1 (sh)
JP (1) JP2870925B2 (sh)
KR (1) KR0145525B1 (sh)
CN (2) CN1046505C (sh)
AR (1) AR247386A1 (sh)
AT (1) ATE127115T1 (sh)
AU (1) AU624895B2 (sh)
BG (1) BG50273A3 (sh)
CA (1) CA2009503C (sh)
CZ (1) CZ280121B6 (sh)
DD (2) DD291995A5 (sh)
DE (2) DE69021902T2 (sh)
DK (1) DK0382276T3 (sh)
EG (1) EG19170A (sh)
ES (1) ES2020171T3 (sh)
FI (1) FI102678B (sh)
GE (1) GEP19971030B (sh)
GR (2) GR910300073T1 (sh)
HU (1) HU204793B (sh)
IL (1) IL93132A (sh)
IN (1) IN170957B (sh)
IT (1) IT1230441B (sh)
LT (1) LT3604B (sh)
LV (1) LV10612B (sh)
NZ (1) NZ232258A (sh)
PE (1) PE25091A1 (sh)
PH (1) PH26552A (sh)
PL (2) PL163730B1 (sh)
PT (1) PT93067B (sh)
RO (1) RO106252B1 (sh)
RU (3) RU2066318C1 (sh)
SK (1) SK278441B6 (sh)
UA (1) UA26852C2 (sh)
YU (1) YU47943B (sh)
ZA (1) ZA90644B (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253703B (it) * 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) * 1997-11-26 1999-08-24 Intel Corporation Two-transistor DRAM cell for logic process technology
US7514463B2 (en) * 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
GEP20135913B (en) 2008-03-07 2013-08-26 Acraf 1-benzyl-3-hydroxymethylindazole derivatives and use thereat treatment of diseases based on mcp-1 and cx3cr1 expression
WO2009109616A2 (en) 2008-03-07 2009-09-11 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
KR101599867B1 (ko) * 2008-03-07 2016-03-04 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 신규한 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1, ｃｘ3ｃｒ1 및 ｐ40의 발현을 기초로 한 질환들의 치료에서 이의 용도
KR101736301B1 (ko) * 2009-08-03 2017-05-29 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 1-벤질-3-하이드록시메틸-1ｈ-인다졸 및 이의 유도체 및 필요한 마그네슘 중간체들의 제조 방법
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
ES2656292T3 (es) 2012-05-01 2018-02-26 Translatum Medicus Inc. Métodos de tratamiento y diagnóstico de enfermedades oculares que causan ceguera
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
RU2645344C2 (ru) 2012-05-18 2018-02-21 Санофи Производные пиразола и их применение в качестве lpar5 антагонистов
EP2850062B1 (en) 2012-05-18 2017-07-19 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
CN108047136B (zh) * 2017-12-20 2021-07-09 长春普华制药股份有限公司 一种苄达酸的精制方法
US11753382B2 (en) 2019-06-25 2023-09-12 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28032A (en) * 1966-08-29 1971-08-25 Acraf Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it) 1980-07-29 1986-06-25 Acraf Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it) 1981-11-27 1988-01-28 Acraf Trattamento della cataratta
IT1194564B (it) 1983-04-18 1988-09-22 Acraf Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it) 1986-08-01 1988-12-06 Acraf Metodo per il tratamento di lenti a contatto

Also Published As

Publication number Publication date
SK56390A3 (en) 1997-05-07
GR910300073T1 (en) 1991-11-15
CA2009503C (en) 2000-04-11
GEP19971030B (en) 1997-06-13
DE69021902T2 (de) 1996-05-23
ZA90644B (en) 1991-01-30
AU624895B2 (en) 1992-06-25
RU2055071C1 (ru) 1996-02-27
KR900012913A (ko) 1990-09-03
HUT53088A (en) 1990-09-28
ES2020171T3 (es) 1995-12-01
AR247386A1 (es) 1994-12-29
PT93067B (pt) 1995-12-29
LV10612A (lv) 1995-04-20
JPH02240065A (ja) 1990-09-25
IL93132A0 (en) 1990-11-05
CN1046505C (zh) 1999-11-17
DE382276T1 (de) 1991-11-28
IT8947620A0 (it) 1989-02-07
IL93132A (en) 1994-05-30
LTIP872A (en) 1995-03-27
EP0382276A3 (en) 1990-12-12
DK0382276T3 (da) 1996-01-15
DE69021902D1 (de) 1995-10-05
CZ56390A3 (en) 1995-06-14
ES2020171A4 (es) 1991-08-01
SK278441B6 (en) 1997-05-07
ATE127115T1 (de) 1995-09-15
LV10612B (en) 1995-08-20
RO106252B1 (ro) 1993-03-31
IN170957B (sh) 1992-06-20
KR0145525B1 (ko) 1998-08-17
FI102678B1 (fi) 1999-01-29
US4999367A (en) 1991-03-12
PH26552A (en) 1992-08-19
HU204793B (en) 1992-02-28
CA2009503A1 (en) 1990-08-07
EP0382276B1 (en) 1995-08-30
RU2066318C1 (ru) 1996-09-10
EP0382276A2 (en) 1990-08-16
FI102678B (fi) 1999-01-29
CN1034016C (zh) 1997-02-12
CZ280121B6 (cs) 1995-11-15
US5112986A (en) 1992-05-12
CN1044810A (zh) 1990-08-22
NZ232258A (en) 1991-06-25
JP2870925B2 (ja) 1999-03-17
HU900689D0 (en) 1990-04-28
CN1088201A (zh) 1994-06-22
UA26852C2 (uk) 1999-12-29
AU4906690A (en) 1990-08-16
DD295363A5 (de) 1991-10-31
RU2044729C1 (ru) 1995-09-27
IT1230441B (it) 1991-10-23
YU47943B (sh) 1996-07-24
PL163720B1 (pl) 1994-04-29
BG50273A3 (en) 1992-06-15
PE25091A1 (es) 1991-08-17
LT3604B (en) 1995-12-27
PT93067A (pt) 1990-08-31
EG19170A (en) 1994-11-30
PL163730B1 (pl) 1994-04-29
GR3018165T3 (en) 1996-02-29
FI900577A0 (fi) 1990-02-06
DD291995A5 (de) 1991-07-18

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