ES2002427A6 - Procedimient para la preparacion de nuevos analogos de gonadoliberina - Google Patents

Procedimient para la preparacion de nuevos analogos de gonadoliberina

Info

Publication number
ES2002427A6
ES2002427A6 ES8602700A ES8602700A ES2002427A6 ES 2002427 A6 ES2002427 A6 ES 2002427A6 ES 8602700 A ES8602700 A ES 8602700A ES 8602700 A ES8602700 A ES 8602700A ES 2002427 A6 ES2002427 A6 ES 2002427A6
Authority
ES
Spain
Prior art keywords
gonadoliberine
analogues
preparing
carbon atoms
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602700A
Other languages
English (en)
Inventor
Janos Seprodi
Istvan Teplan
Istvan Schon
Judit Erchegyi
Zsolt Vadasz
Nyeki Olga Kuprinanee
Tamas Szirtes
Andras Selmeczi
Bela Kanyicska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES2002427A6 publication Critical patent/ES2002427A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ANALOGOS DE GONADOLIBERINA DE FORMULA I GLP-HIS-TRP-SER-X-W-LEU-ARG-PRO-Y(I) DONDE: X SIGNIFICA PHE-, TIR O 3,5-DIBROMO-TIROSIL; X REPRESENTA ASU O ASP(OR), DONDE R SIGNIFICA ALQUILO QUE TIENE DE 1 A 6 ATOMOS DE CARBONO O FENIL O FENIL (ALQUILO QUE TIENE DE 1 A 4 ATOMOS DE CARBONO), PUDIENDO ESTAR SUSTITUIDOS OPCIONALMENTE LOS DOS ULTIMOS GRUPOS POR NITRO O UNO O MAS ATOMOS HALOGENOS; E Y SIGNIFICA GLICINAMIDA, AZA-GLICINAMIDA O ALQUILAMINO QUE TIENE DE 1 A 4 ATOMOS DE CARBONO; Y SUS SALES DE ADICION DE ACIDO. EL PROCEDIMIENTO IMPLICA LA REACCION DE UN PEPTIDO OPCIONALMENTE PROTEGIDO. LOS COMPUESTOS OBTENIDOS TIENEN APLICACIONES FARMACEUTICAS PARA INFLUENCIAR LOS PROCESOS SEXUALES.
ES8602700A 1985-10-22 1986-10-21 Procedimient para la preparacion de nuevos analogos de gonadoliberina Expired ES2002427A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU854070A HU194280B (en) 1985-10-22 1985-10-22 Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES2002427A6 true ES2002427A6 (es) 1988-08-01

Family

ID=10966780

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602700A Expired ES2002427A6 (es) 1985-10-22 1986-10-21 Procedimient para la preparacion de nuevos analogos de gonadoliberina

Country Status (11)

Country Link
US (1) US4948873A (es)
EP (1) EP0220654A3 (es)
JP (1) JPS6299397A (es)
AU (1) AU588058B2 (es)
DK (1) DK504386A (es)
ES (1) ES2002427A6 (es)
FI (1) FI864261A (es)
GR (1) GR862589B (es)
HU (1) HU194280B (es)
IL (1) IL80379A0 (es)
ZA (1) ZA867985B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
DD295857A5 (de) * 1990-06-26 1991-11-14 Akad Wissenschaften Ddr Verfahren zur herstellung von gnrh-dekapeptiden
CN114805542A (zh) * 2022-04-29 2022-07-29 江苏尤里卡生物科技有限公司 一种基于尿液中促性腺激素的纯化方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309689A (en) * 1969-11-17 1973-03-14 Yoshitomi Pharmaceutical Cyclic polypeptide
US3888836A (en) * 1972-05-30 1975-06-10 Merck & Co Inc Pentapeptide intermediate of lhrh and derivatives thereof
US3888838A (en) * 1972-07-10 1975-06-10 Ayerst Mckenna & Harrison Decapeptide having luteinizing hormone (lh)-and follicle stimulating hormone (fsh)-releasing activity, salts and compositions thereof, a process for preparing same, and intermediates therefor
FR2249677B1 (es) * 1973-11-01 1978-07-28 Wellcome Found
DE2438350C3 (de) * 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
FR2465486A1 (fr) * 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH
US4382922A (en) * 1980-08-29 1983-05-10 The Salk Institute For Biological Studies Peptides affecting gonadal function
HU185535B (en) * 1982-05-25 1985-02-28 Mta Koezponti Hivatala Process for preparing new gonadoliberin derivatives
FI832053L (fi) * 1982-06-10 1983-12-11 Syntex Inc Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
CS230614B1 (en) * 1982-08-06 1984-08-13 Martin Cs Flegel Analogues of realising factor for luteining and folliculstimulated hormon
US4410514A (en) * 1982-12-06 1983-10-18 The Salk Institute For Biological Studies GnRH Agonists
HU187503B (en) * 1983-03-29 1986-01-28 Magyar Tudomanyos Akademia,Hu Process for preparing gonadoliberine derivatives containing beta-aspartyl group
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
US4569927A (en) * 1984-02-23 1986-02-11 The Salk Institute For Biological Studies GnRH Antagonists IV
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
HU193093B (en) * 1985-04-16 1987-08-28 Innofinance Process for stimulating sexual activity of birds and domestic mammalians and process for producing spermatocytes for their propagation

Also Published As

Publication number Publication date
ZA867985B (en) 1987-08-26
EP0220654A3 (en) 1989-09-06
US4948873A (en) 1990-08-14
HUT42508A (en) 1987-07-28
GR862589B (en) 1987-02-23
AU588058B2 (en) 1989-09-07
IL80379A0 (en) 1987-01-30
EP0220654A2 (en) 1987-05-06
HU194280B (en) 1988-01-28
FI864261A0 (fi) 1986-10-21
DK504386A (da) 1987-04-23
AU6423186A (en) 1987-04-30
DK504386D0 (da) 1986-10-21
FI864261A (fi) 1987-04-23
JPS6299397A (ja) 1987-05-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103