ES2002427A6 - Procedimient para la preparacion de nuevos analogos de gonadoliberina - Google Patents
Procedimient para la preparacion de nuevos analogos de gonadoliberinaInfo
- Publication number
- ES2002427A6 ES2002427A6 ES8602700A ES8602700A ES2002427A6 ES 2002427 A6 ES2002427 A6 ES 2002427A6 ES 8602700 A ES8602700 A ES 8602700A ES 8602700 A ES8602700 A ES 8602700A ES 2002427 A6 ES2002427 A6 ES 2002427A6
- Authority
- ES
- Spain
- Prior art keywords
- gonadoliberine
- analogues
- preparing
- carbon atoms
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ANALOGOS DE GONADOLIBERINA DE FORMULA I GLP-HIS-TRP-SER-X-W-LEU-ARG-PRO-Y(I) DONDE: X SIGNIFICA PHE-, TIR O 3,5-DIBROMO-TIROSIL; X REPRESENTA ASU O ASP(OR), DONDE R SIGNIFICA ALQUILO QUE TIENE DE 1 A 6 ATOMOS DE CARBONO O FENIL O FENIL (ALQUILO QUE TIENE DE 1 A 4 ATOMOS DE CARBONO), PUDIENDO ESTAR SUSTITUIDOS OPCIONALMENTE LOS DOS ULTIMOS GRUPOS POR NITRO O UNO O MAS ATOMOS HALOGENOS; E Y SIGNIFICA GLICINAMIDA, AZA-GLICINAMIDA O ALQUILAMINO QUE TIENE DE 1 A 4 ATOMOS DE CARBONO; Y SUS SALES DE ADICION DE ACIDO. EL PROCEDIMIENTO IMPLICA LA REACCION DE UN PEPTIDO OPCIONALMENTE PROTEGIDO. LOS COMPUESTOS OBTENIDOS TIENEN APLICACIONES FARMACEUTICAS PARA INFLUENCIAR LOS PROCESOS SEXUALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU854070A HU194280B (en) | 1985-10-22 | 1985-10-22 | Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2002427A6 true ES2002427A6 (es) | 1988-08-01 |
Family
ID=10966780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8602700A Expired ES2002427A6 (es) | 1985-10-22 | 1986-10-21 | Procedimient para la preparacion de nuevos analogos de gonadoliberina |
Country Status (11)
Country | Link |
---|---|
US (1) | US4948873A (es) |
EP (1) | EP0220654A3 (es) |
JP (1) | JPS6299397A (es) |
AU (1) | AU588058B2 (es) |
DK (1) | DK504386A (es) |
ES (1) | ES2002427A6 (es) |
FI (1) | FI864261A (es) |
GR (1) | GR862589B (es) |
HU (1) | HU194280B (es) |
IL (1) | IL80379A0 (es) |
ZA (1) | ZA867985B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
DD295857A5 (de) * | 1990-06-26 | 1991-11-14 | Akad Wissenschaften Ddr | Verfahren zur herstellung von gnrh-dekapeptiden |
CN114805542A (zh) * | 2022-04-29 | 2022-07-29 | 江苏尤里卡生物科技有限公司 | 一种基于尿液中促性腺激素的纯化方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1309689A (en) * | 1969-11-17 | 1973-03-14 | Yoshitomi Pharmaceutical | Cyclic polypeptide |
US3888836A (en) * | 1972-05-30 | 1975-06-10 | Merck & Co Inc | Pentapeptide intermediate of lhrh and derivatives thereof |
US3888838A (en) * | 1972-07-10 | 1975-06-10 | Ayerst Mckenna & Harrison | Decapeptide having luteinizing hormone (lh)-and follicle stimulating hormone (fsh)-releasing activity, salts and compositions thereof, a process for preparing same, and intermediates therefor |
CA1030526A (en) * | 1973-11-01 | 1978-05-02 | Samuel Wilkinson | Biologically active amides |
DE2438350C3 (de) * | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
US4234571A (en) * | 1979-06-11 | 1980-11-18 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
FR2465486A1 (fr) * | 1979-09-21 | 1981-03-27 | Roussel Uclaf | Nouvelle application utilisant la lh-rh ou des agonistes |
US4377515A (en) * | 1979-10-01 | 1983-03-22 | Merck & Co., Inc. | Long lasting agonists and antagonists of LH-RH |
US4382922A (en) * | 1980-08-29 | 1983-05-10 | The Salk Institute For Biological Studies | Peptides affecting gonadal function |
HU185535B (en) * | 1982-05-25 | 1985-02-28 | Mta Koezponti Hivatala | Process for preparing new gonadoliberin derivatives |
FI832053L (fi) * | 1982-06-10 | 1983-12-11 | Syntex Inc | Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande |
CS230614B1 (en) * | 1982-08-06 | 1984-08-13 | Martin Cs Flegel | Analogues of realising factor for luteining and folliculstimulated hormon |
US4410514A (en) * | 1982-12-06 | 1983-10-18 | The Salk Institute For Biological Studies | GnRH Agonists |
HU187503B (en) * | 1983-03-29 | 1986-01-28 | Magyar Tudomanyos Akademia,Hu | Process for preparing gonadoliberine derivatives containing beta-aspartyl group |
EP0145032B1 (en) * | 1983-08-16 | 1987-11-04 | Akzo N.V. | Lh- rh antagonists |
US4569927A (en) * | 1984-02-23 | 1986-02-11 | The Salk Institute For Biological Studies | GnRH Antagonists IV |
US4677193A (en) * | 1985-02-22 | 1987-06-30 | The Salk Institute For Biological Studies | Peptides containing an aliphatic-aromatic ketone side chain |
HU193093B (en) * | 1985-04-16 | 1987-08-28 | Innofinance | Process for stimulating sexual activity of birds and domestic mammalians and process for producing spermatocytes for their propagation |
-
1985
- 1985-10-22 HU HU854070A patent/HU194280B/hu not_active IP Right Cessation
-
1986
- 1986-10-21 AU AU64231/86A patent/AU588058B2/en not_active Ceased
- 1986-10-21 ES ES8602700A patent/ES2002427A6/es not_active Expired
- 1986-10-21 FI FI864261A patent/FI864261A/fi not_active IP Right Cessation
- 1986-10-21 DK DK504386A patent/DK504386A/da not_active Application Discontinuation
- 1986-10-21 ZA ZA867985A patent/ZA867985B/xx unknown
- 1986-10-21 IL IL80379A patent/IL80379A0/xx unknown
- 1986-10-21 EP EP86114532A patent/EP0220654A3/en not_active Withdrawn
- 1986-10-21 JP JP61248528A patent/JPS6299397A/ja active Pending
- 1986-10-21 GR GR862589A patent/GR862589B/el unknown
- 1986-10-21 US US07/921,770 patent/US4948873A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0220654A2 (en) | 1987-05-06 |
FI864261A (fi) | 1987-04-23 |
HU194280B (en) | 1988-01-28 |
IL80379A0 (en) | 1987-01-30 |
JPS6299397A (ja) | 1987-05-08 |
DK504386A (da) | 1987-04-23 |
DK504386D0 (da) | 1986-10-21 |
AU6423186A (en) | 1987-04-30 |
ZA867985B (en) | 1987-08-26 |
HUT42508A (en) | 1987-07-28 |
GR862589B (en) | 1987-02-23 |
FI864261A0 (fi) | 1986-10-21 |
EP0220654A3 (en) | 1989-09-06 |
US4948873A (en) | 1990-08-14 |
AU588058B2 (en) | 1989-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19981103 |