FI900577A0 - 1-bentzyl-3-hydroximetyl-indazoletrar med alifatiska 2-hydroxisyror. - Google Patents

1-bentzyl-3-hydroximetyl-indazoletrar med alifatiska 2-hydroxisyror.

Info

Publication number
FI900577A0
FI900577A0 FI900577A FI900577A FI900577A0 FI 900577 A0 FI900577 A0 FI 900577A0 FI 900577 A FI900577 A FI 900577A FI 900577 A FI900577 A FI 900577A FI 900577 A0 FI900577 A0 FI 900577A0
Authority
FI
Finland
Prior art keywords
indazoletrar
hydroxisyror
bentzyl
alifatiska
hydroximethyl
Prior art date
Application number
FI900577A
Other languages
English (en)
Other versions
FI102678B (fi
FI102678B1 (fi
Inventor
Bruno Silvestrini
Leandro Baiocchi
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of FI900577A0 publication Critical patent/FI900577A0/fi
Application granted granted Critical
Publication of FI102678B publication Critical patent/FI102678B/fi
Publication of FI102678B1 publication Critical patent/FI102678B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
FI900577A 1989-02-07 1990-02-06 Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste FI102678B1 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8947620A IT1230441B (it) 1989-02-07 1989-02-07 Eteri della serie dell'indazolo

Publications (3)

Publication Number Publication Date
FI900577A0 true FI900577A0 (fi) 1990-02-06
FI102678B FI102678B (fi) 1999-01-29
FI102678B1 FI102678B1 (fi) 1999-01-29

Family

ID=11261479

Family Applications (1)

Application Number Title Priority Date Filing Date
FI900577A FI102678B1 (fi) 1989-02-07 1990-02-06 Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste

Country Status (36)

Country Link
US (2) US4999367A (fi)
EP (1) EP0382276B1 (fi)
JP (1) JP2870925B2 (fi)
KR (1) KR0145525B1 (fi)
CN (2) CN1046505C (fi)
AR (1) AR247386A1 (fi)
AT (1) ATE127115T1 (fi)
AU (1) AU624895B2 (fi)
BG (1) BG50273A3 (fi)
CA (1) CA2009503C (fi)
CZ (1) CZ280121B6 (fi)
DD (2) DD295363A5 (fi)
DE (2) DE69021902T2 (fi)
DK (1) DK0382276T3 (fi)
EG (1) EG19170A (fi)
ES (1) ES2020171T3 (fi)
FI (1) FI102678B1 (fi)
GE (1) GEP19971030B (fi)
GR (2) GR910300073T1 (fi)
HU (1) HU204793B (fi)
IL (1) IL93132A (fi)
IN (1) IN170957B (fi)
IT (1) IT1230441B (fi)
LT (1) LT3604B (fi)
LV (1) LV10612B (fi)
NZ (1) NZ232258A (fi)
PE (1) PE25091A1 (fi)
PH (1) PH26552A (fi)
PL (2) PL163730B1 (fi)
PT (1) PT93067B (fi)
RO (1) RO106252B1 (fi)
RU (3) RU2066318C1 (fi)
SK (1) SK56390A3 (fi)
UA (1) UA26852C2 (fi)
YU (1) YU47943B (fi)
ZA (1) ZA90644B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253703B (it) * 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) * 1997-11-26 1999-08-24 Intel Corporation Two-transistor DRAM cell for logic process technology
US7514463B2 (en) 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
AU2009221063B2 (en) 2008-03-07 2013-03-21 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
KR101640844B1 (ko) 2008-03-07 2016-07-19 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1, ｃｘ3ｃｒ1 및 ｐ40의 발현을 기초로 한 질환들의 치료에서 이의 용도
EP2254869B1 (en) 2008-03-07 2017-05-31 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. Neue 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of cx3cr1 und p40
PT2462119E (pt) 2009-08-03 2014-07-25 Acraf Processo para a preparação de 1-benzil-3-hidroximetil-1 hindazole e derivados do mesmo e intermédios de magnésio requeridos
UA108742C2 (uk) * 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
CA3095012C (en) 2012-05-01 2023-02-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
EP2850062B1 (en) 2012-05-18 2017-07-19 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
CA2871542A1 (en) 2012-05-18 2013-11-21 Sanofi Pyrazole derivatives and their use as lpar5 antagonists
CN108047136B (zh) * 2017-12-20 2021-07-09 长春普华制药股份有限公司 一种苄达酸的精制方法
EP3990433A4 (en) * 2019-06-25 2023-07-26 Translatum Medicus Inc. METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28032A (en) * 1966-08-29 1971-08-25 Acraf Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it) 1980-07-29 1986-06-25 Acraf Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it) 1981-11-27 1988-01-28 Acraf Trattamento della cataratta
IT1194564B (it) 1983-04-18 1988-09-22 Acraf Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it) 1986-08-01 1988-12-06 Acraf Metodo per il tratamento di lenti a contatto

Also Published As

Publication number Publication date
PT93067A (pt) 1990-08-31
IT8947620A0 (it) 1989-02-07
PH26552A (en) 1992-08-19
LV10612A (lv) 1995-04-20
SK278441B6 (en) 1997-05-07
HU204793B (en) 1992-02-28
DE69021902D1 (de) 1995-10-05
EG19170A (en) 1994-11-30
AR247386A1 (es) 1994-12-29
RU2066318C1 (ru) 1996-09-10
US4999367A (en) 1991-03-12
DD291995A5 (de) 1991-07-18
CN1034016C (zh) 1997-02-12
FI102678B (fi) 1999-01-29
UA26852C2 (uk) 1999-12-29
ES2020171T3 (es) 1995-12-01
EP0382276A2 (en) 1990-08-16
AU4906690A (en) 1990-08-16
ATE127115T1 (de) 1995-09-15
PL163720B1 (pl) 1994-04-29
PL163730B1 (pl) 1994-04-29
BG50273A3 (en) 1992-06-15
EP0382276B1 (en) 1995-08-30
DK0382276T3 (da) 1996-01-15
CZ280121B6 (cs) 1995-11-15
KR0145525B1 (ko) 1998-08-17
JPH02240065A (ja) 1990-09-25
CN1044810A (zh) 1990-08-22
CA2009503C (en) 2000-04-11
IL93132A0 (en) 1990-11-05
DE382276T1 (de) 1991-11-28
YU20690A (sh) 1992-07-20
YU47943B (sh) 1996-07-24
DD295363A5 (de) 1991-10-31
JP2870925B2 (ja) 1999-03-17
IL93132A (en) 1994-05-30
ES2020171A4 (es) 1991-08-01
PT93067B (pt) 1995-12-29
EP0382276A3 (en) 1990-12-12
KR900012913A (ko) 1990-09-03
LV10612B (en) 1995-08-20
CN1046505C (zh) 1999-11-17
IT1230441B (it) 1991-10-23
LTIP872A (en) 1995-03-27
DE69021902T2 (de) 1996-05-23
CZ56390A3 (en) 1995-06-14
RU2055071C1 (ru) 1996-02-27
IN170957B (fi) 1992-06-20
US5112986A (en) 1992-05-12
CA2009503A1 (en) 1990-08-07
RO106252B1 (ro) 1993-03-31
ZA90644B (en) 1991-01-30
HU900689D0 (en) 1990-04-28
RU2044729C1 (ru) 1995-09-27
NZ232258A (en) 1991-06-25
PE25091A1 (es) 1991-08-17
FI102678B1 (fi) 1999-01-29
GEP19971030B (en) 1997-06-13
AU624895B2 (en) 1992-06-25
SK56390A3 (en) 1997-05-07
LT3604B (en) 1995-12-27
CN1088201A (zh) 1994-06-22
GR3018165T3 (en) 1996-02-29
GR910300073T1 (en) 1991-11-15
HUT53088A (en) 1990-09-28

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI

FG Patent granted

Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI