ES2167869T3 - Procedimiento para preparar acidos nicotinicos. - Google Patents

Procedimiento para preparar acidos nicotinicos.

Info

Publication number
ES2167869T3
ES2167869T3 ES98906497T ES98906497T ES2167869T3 ES 2167869 T3 ES2167869 T3 ES 2167869T3 ES 98906497 T ES98906497 T ES 98906497T ES 98906497 T ES98906497 T ES 98906497T ES 2167869 T3 ES2167869 T3 ES 2167869T3
Authority
ES
Spain
Prior art keywords
procedure
nicotinic
nicotinic acids
hydrogen
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98906497T
Other languages
English (en)
Inventor
Padam N Sharma
Marazban H Vandrevala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2167869T3 publication Critical patent/ES2167869T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/08—Formation or introduction of functional groups containing oxygen of carboxyl groups or salts, halides or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento mejorado para la preparación de ácidos nicotínicos representados por la fórmula estructural (I) que se preparan haciendo reaccionar un compuesto de amida nicotínica de fórmula (a) con un nitrito, en condiciones ácidas. En el procedimiento de la invención los grupos R{sup,1}, R{sup,2} y R{sup,3} en los compuestos se seleccionan independientemente del grupo constituido por hidrógeno y átomos de halógeno, y R{sup,4} se selecciona del grupo constituido por hidrógeno, alquilo inferior y arilo. El procedimiento proporciona compuestos de ácido nicotínico con un mejor rendimiento.
ES98906497T 1997-03-03 1998-02-18 Procedimiento para preparar acidos nicotinicos. Expired - Lifetime ES2167869T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/811,087 US5739342A (en) 1997-03-03 1997-03-03 Process for the preparation of nicotinic acids

Publications (1)

Publication Number Publication Date
ES2167869T3 true ES2167869T3 (es) 2002-05-16

Family

ID=25205520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98906497T Expired - Lifetime ES2167869T3 (es) 1997-03-03 1998-02-18 Procedimiento para preparar acidos nicotinicos.

Country Status (13)

Country Link
US (1) US5739342A (es)
EP (1) EP0968189B1 (es)
JP (1) JP2001513108A (es)
KR (1) KR100517007B1 (es)
AT (1) ATE208378T1 (es)
AU (1) AU737619B2 (es)
CA (1) CA2282381C (es)
DE (1) DE69802388T2 (es)
DK (1) DK0968189T3 (es)
ES (1) ES2167869T3 (es)
IL (1) IL131177A (es)
PT (1) PT968189E (es)
WO (1) WO1998039298A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6441182B1 (en) 1999-06-10 2002-08-27 Bayer Aktiengesellschaft Method for the production of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid
US7691582B2 (en) 2002-09-27 2010-04-06 The Regents Of The University Of Michigan Methods of secretory vimentin detection and modulation
US7093640B2 (en) * 2003-02-10 2006-08-22 Kitaru Innovations, Inc. Tape dispenser having a retaining and application area
WO2007064077A1 (en) * 2005-09-16 2007-06-07 Lg Life Sciences Ltd. A process for preparing beta-ketoester compounds
KR102359436B1 (ko) 2015-06-05 2022-02-09 (주)아모레퍼시픽 메틸 2-프로필-6-(트리플루오로메틸) 니코티네이트의 제조방법
US11236070B2 (en) 2019-05-16 2022-02-01 Novartis Ag Chemical process
US11465872B2 (en) 2020-06-25 2022-10-11 Snj Patents, Llc Tape dispenser
CN113666867A (zh) * 2021-09-16 2021-11-19 宁夏常晟药业有限公司 一种2,6-二氯-5-氟烟酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
US4616019A (en) * 1984-01-26 1986-10-07 Abbott Laboratories Naphthyridine antibacterial compounds
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
IE62600B1 (en) * 1987-08-04 1995-02-22 Abbott Lab Naphtyridine antianaerobic compounds
EP0333020A3 (en) * 1988-03-18 1991-03-20 Abbott Laboratories Process for the preparation of substituted pyridines
US5204478A (en) * 1992-08-20 1993-04-20 Warner-Lambert Company Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride

Also Published As

Publication number Publication date
CA2282381C (en) 2007-06-12
ATE208378T1 (de) 2001-11-15
PT968189E (pt) 2002-04-29
AU737619B2 (en) 2001-08-23
EP0968189A1 (en) 2000-01-05
EP0968189B1 (en) 2001-11-07
KR100517007B1 (ko) 2005-09-27
DK0968189T3 (da) 2002-02-18
JP2001513108A (ja) 2001-08-28
DE69802388T2 (de) 2002-08-08
DE69802388D1 (de) 2001-12-13
IL131177A (en) 2005-08-31
US5739342A (en) 1998-04-14
KR20000075874A (ko) 2000-12-26
WO1998039298A1 (en) 1998-09-11
CA2282381A1 (en) 1998-09-11
AU6170798A (en) 1998-09-22
IL131177A0 (en) 2001-01-28

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