CN104379731A - 用于植入的中脑多巴胺(da)神经元 - Google Patents

用于植入的中脑多巴胺(da)神经元 Download PDF

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Publication number
CN104379731A
CN104379731A CN201280066145.0A CN201280066145A CN104379731A CN 104379731 A CN104379731 A CN 104379731A CN 201280066145 A CN201280066145 A CN 201280066145A CN 104379731 A CN104379731 A CN 104379731A
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cell
base plate
neurone
inhibitor
midbrain
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L·施图德
J-W·沈
S·克里克斯
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Sloan Kettering Institute for Cancer Research
Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Priority to CN201910438392.2A priority Critical patent/CN110684734A/zh
Priority to CN201910438394.1A priority patent/CN113481159A/zh
Priority to CN201910438266.7A priority patent/CN110684733A/zh
Priority to CN201910438393.7A priority patent/CN113528442A/zh
Publication of CN104379731A publication Critical patent/CN104379731A/zh
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CN201280066145.0A 2011-11-04 2012-11-02 用于植入的中脑多巴胺(da)神经元 Pending CN104379731A (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201910438392.2A CN110684734A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438394.1A CN113481159A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438266.7A CN110684733A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438393.7A CN113528442A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元

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US201161555828P 2011-11-04 2011-11-04
US61/555,828 2011-11-04
PCT/US2012/063339 WO2013067362A1 (en) 2011-11-04 2012-11-02 Midbrain dopamine (da) neurons for engraftment

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CN201910438392.2A Division CN110684734A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438393.7A Division CN113528442A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438266.7A Division CN110684733A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438394.1A Division CN113481159A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元

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CN201280066145.0A Pending CN104379731A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺(da)神经元
CN201910438393.7A Pending CN113528442A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438266.7A Pending CN110684733A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438394.1A Pending CN113481159A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438392.2A Pending CN110684734A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元

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CN201910438393.7A Pending CN113528442A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438266.7A Pending CN110684733A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438394.1A Pending CN113481159A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元
CN201910438392.2A Pending CN110684734A (zh) 2011-11-04 2012-11-02 用于植入的中脑多巴胺（da）神经元

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US (3) US10280398B2 (es)
EP (2) EP2773748B1 (es)
JP (6) JP6461602B2 (es)
KR (4) KR102581669B1 (es)
CN (5) CN104379731A (es)
AU (3) AU2012332269B2 (es)
BR (2) BR112014010776B1 (es)
CA (2) CA2854578C (es)
DK (1) DK2773748T3 (es)
EA (1) EA201490796A1 (es)
ES (1) ES2779453T3 (es)
HK (1) HK1201879A1 (es)
IL (4) IL286793B (es)
PL (1) PL2773748T3 (es)
PT (1) PT2773748T (es)
WO (1) WO2013067362A1 (es)

Cited By (10)

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CN105567642A (zh) * 2016-02-01 2016-05-11 中国科学院生物物理研究所 一种着色性干皮病人多能干细胞的制备方法
CN109844102A (zh) * 2016-08-16 2019-06-04 富士胶片细胞动力股份有限公司 分化多能细胞的方法
CN110730667A (zh) * 2016-11-23 2020-01-24 波尔多大学 神经组织单元和这种单元用于植入哺乳动物的神经系统的用途
CN112011510A (zh) * 2019-05-30 2020-12-01 中国科学院上海有机化学研究所 一种由人多能干细胞制备多巴胺神经元的方法
CN113388580A (zh) * 2021-06-16 2021-09-14 中国医学科学院医学实验动物研究所 一种诱导脂肪干细胞分化为功能性多巴胺能神经元的方法及用途
CN113728103A (zh) * 2018-12-11 2021-11-30 罗切斯特大学 治疗精神分裂症和其他神经精神病症的方法
CN114729323A (zh) * 2019-11-22 2022-07-08 诺和诺德股份有限公司 旋转聚集的神经微球及其应用
WO2022222974A1 (zh) * 2021-04-21 2022-10-27 上海跃赛生物科技有限公司 一种质控和富集人多巴胺能神经前体细胞的方法
CN115354028A (zh) * 2021-10-28 2022-11-18 中国科学院动物研究所 一种中脑多巴胺细胞群、其制造方法以及用途
CN115521903A (zh) * 2022-09-30 2022-12-27 中国科学院生态环境研究中心 体外诱导人多能干细胞分化为多巴胺能神经元的方法

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US8642334B2 (en) 2009-02-17 2014-02-04 Memorial Sloan Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
US9487752B2 (en) 2011-03-30 2016-11-08 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
AU2012332269B2 (en) 2011-11-04 2018-05-31 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (DA) neurons for engraftment
WO2014176606A1 (en) 2013-04-26 2014-10-30 Memorial Sloan-Kettering Center Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
CN105658788B (zh) 2013-08-06 2020-07-10 武田药品工业株式会社 多巴胺能神经元的制备方法
WO2015069736A1 (en) * 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
EP3119881B1 (en) 2014-03-21 2023-03-01 FUJIFILM Cellular Dynamics, Inc. Production of midbrain dopaminergic neurons and methods for the use thereof
CN105121633B (zh) * 2014-03-25 2018-05-01 云南中科灵长类生物医学重点实验室 一种建立神经上皮干细胞的培养基、方法及其应用
US10444227B2 (en) 2014-08-19 2019-10-15 FUJIFILM Cellular Dynamics, Inc. Neural networks formed from cells derived from pluripotent stem cells
CN109251894B (zh) 2014-11-25 2022-10-04 宾州研究基金会 人神经胶质细胞转化成用于大脑和脊髓修复的神经细胞的化学重编程
EP3061809B1 (en) 2015-02-27 2019-01-30 Miltenyi Biotec GmbH Method for generation of a cell composition of mesencephalic dopaminergic progenitor cells
WO2016164857A1 (en) * 2015-04-10 2016-10-13 President And Fellows Of Harvard College Methods and devices for live cell imaging analysis
US10081791B2 (en) 2015-05-07 2018-09-25 William J. Freed Modeling connections between dopaminergic neurons and the cerebral cortex
HRP20220482T1 (hr) * 2015-06-01 2022-07-08 Memorial Sloan Kettering Cancer Center Postupci in vitro diferencijacije neurona dopamina srednjeg mozga (mda)
WO2017062854A1 (en) 2015-10-07 2017-04-13 Memorial Sloan-Kettering Cancer Center In vitro methods of identifying modulators of neuromuscular junction activity
KR20180105236A (ko) 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법
WO2017176779A1 (en) * 2016-04-05 2017-10-12 The Regents Of The University Of California Cellularized hydrogels and methods of using the same
CN105861532A (zh) * 2016-04-08 2016-08-17 北京大学深圳医院 一种基于miRNA491调节DAT基因表达的方法
KR101870240B1 (ko) * 2016-04-12 2018-06-22 서울대학교산학협력단 지방줄기세포에서 신경줄기세포, 신경세포 및 가바성 신경세포로의 분화 유도 방법
SG11201809279YA (en) * 2016-04-22 2018-11-29 Univ Kyoto Method for producing dopamine-producing neural precursor cells
CA3057104A1 (en) * 2017-03-21 2018-09-27 Memorial Sloan-Kettering Cancer Center Stem cell-derived astrocytes, methods of making and methods of use
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