PL2773748T3 - Neurony dopaminergiczne (da) do wszczepiania - Google Patents
Neurony dopaminergiczne (da) do wszczepianiaInfo
- Publication number
- PL2773748T3 PL2773748T3 PL12846715T PL12846715T PL2773748T3 PL 2773748 T3 PL2773748 T3 PL 2773748T3 PL 12846715 T PL12846715 T PL 12846715T PL 12846715 T PL12846715 T PL 12846715T PL 2773748 T3 PL2773748 T3 PL 2773748T3
- Authority
- PL
- Poland
- Prior art keywords
- engraftment
- neurons
- midbrain dopamine
- midbrain
- dopamine
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161555828P | 2011-11-04 | 2011-11-04 | |
EP12846715.6A EP2773748B1 (en) | 2011-11-04 | 2012-11-02 | Midbrain dopamine (da) neurons for engraftment |
PCT/US2012/063339 WO2013067362A1 (en) | 2011-11-04 | 2012-11-02 | Midbrain dopamine (da) neurons for engraftment |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2773748T3 true PL2773748T3 (pl) | 2020-06-15 |
Family
ID=48192829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12846715T PL2773748T3 (pl) | 2011-11-04 | 2012-11-02 | Neurony dopaminergiczne (da) do wszczepiania |
Country Status (16)
Country | Link |
---|---|
US (3) | US10280398B2 (pl) |
EP (2) | EP3693455A1 (pl) |
JP (6) | JP6461602B2 (pl) |
KR (4) | KR102581669B1 (pl) |
CN (5) | CN110684734A (pl) |
AU (3) | AU2012332269B2 (pl) |
BR (2) | BR122020000182B8 (pl) |
CA (2) | CA3177246A1 (pl) |
DK (1) | DK2773748T3 (pl) |
EA (1) | EA201490796A1 (pl) |
ES (1) | ES2779453T3 (pl) |
HK (1) | HK1201879A1 (pl) |
IL (4) | IL286793B (pl) |
PL (1) | PL2773748T3 (pl) |
PT (1) | PT2773748T (pl) |
WO (1) | WO2013067362A1 (pl) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010096496A2 (en) | 2009-02-17 | 2010-08-26 | Memorial Sloan-Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
CA2831609C (en) | 2011-03-30 | 2019-06-11 | Cellular Dynamics International, Inc. | Priming of pluripotent stem cells for neural differentiation |
WO2013067362A1 (en) | 2011-11-04 | 2013-05-10 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (da) neurons for engraftment |
EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
EP3031908B1 (en) | 2013-08-06 | 2018-12-05 | Takeda Pharmaceutical Company Limited | Method for producing dopaminergic neurons |
WO2015069736A1 (en) * | 2013-11-08 | 2015-05-14 | The Mclean Hospital Corporation | METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS |
ES2939807T3 (es) * | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
WO2015143622A1 (zh) * | 2014-03-25 | 2015-10-01 | 云南中科灵长类生物医学重点实验室 | 一种建立神经上皮干细胞的培养基、方法及其应用 |
WO2016028880A1 (en) | 2014-08-19 | 2016-02-25 | Cellular Dynamics International, Inc. | Neural networks formed from cells derived from pluripotent stem cells |
US9730975B2 (en) * | 2014-11-25 | 2017-08-15 | The Penn State Research Foundation | Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair |
EP3061809B1 (en) | 2015-02-27 | 2019-01-30 | Miltenyi Biotec GmbH | Method for generation of a cell composition of mesencephalic dopaminergic progenitor cells |
EP3281151B1 (en) * | 2015-04-10 | 2023-03-29 | President and Fellows of Harvard College | Methods and devices for live cell imaging analysis |
US10081791B2 (en) | 2015-05-07 | 2018-09-25 | William J. Freed | Modeling connections between dopaminergic neurons and the cerebral cortex |
EP4070803A1 (en) | 2015-06-01 | 2022-10-12 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (mda) neurons |
CN108368486B (zh) | 2015-10-07 | 2023-06-27 | 纪念斯隆-凯特琳癌症中心 | 鉴定神经肌肉接头活动的调节剂的体外方法 |
CN105567642B (zh) * | 2016-02-01 | 2019-07-12 | 中国科学院生物物理研究所 | 一种着色性干皮病人多能干细胞的制备方法 |
KR20180105236A (ko) | 2016-02-05 | 2018-09-27 | 메모리얼 슬로안-케터링 캔서 센터 | 줄기 세포-유래 외배엽 계통 전구체의 분화 방법 |
WO2017176779A1 (en) * | 2016-04-05 | 2017-10-12 | The Regents Of The University Of California | Cellularized hydrogels and methods of using the same |
CN105861532A (zh) * | 2016-04-08 | 2016-08-17 | 北京大学深圳医院 | 一种基于miRNA491调节DAT基因表达的方法 |
KR101870240B1 (ko) * | 2016-04-12 | 2018-06-22 | 서울대학교산학협력단 | 지방줄기세포에서 신경줄기세포, 신경세포 및 가바성 신경세포로의 분화 유도 방법 |
CN109072198B (zh) * | 2016-04-22 | 2022-08-26 | 国立大学法人京都大学 | 产多巴胺神经祖细胞的制备方法 |
AU2017313065B2 (en) * | 2016-08-16 | 2021-06-24 | Fujifilm Cellular Dynamics Inc. | Methods for differentiating pluripotent cells |
FR3058892B1 (fr) * | 2016-11-23 | 2021-04-09 | Univ Bordeaux | Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere |
EP3600360A4 (en) * | 2017-03-21 | 2021-04-21 | Memorial Sloan-Kettering Cancer Center | ASTROCYTES FROM STEM CELLS, MANUFACTURING METHODS AND METHODS OF USE |
AU2018272068A1 (en) * | 2017-05-25 | 2020-01-16 | Icahn School Of Medicine At Mount Sinai | Method and composition for generating basal forebrain cholinergic neurons (BFCNs) |
CN107828728A (zh) * | 2017-10-26 | 2018-03-23 | 中山大学 | 一种制备中脑多巴胺神经元的方法 |
KR102201417B1 (ko) * | 2018-05-02 | 2021-01-11 | (주) 에스바이오메딕스 | 도파민 신경세포의 분리방법 및 이를 이용하여 분리된 도파민 신경세포를 포함하는 파킨슨병 치료용 약제학적 조성물 |
KR102111030B1 (ko) * | 2018-05-10 | 2020-05-14 | 한국과학기술원 | Jab1을 포함하는 신경세포 분화 탐지용 바이오마커 또는 신경세포 분화 촉진용 조성물 |
JP2022511568A (ja) * | 2018-12-11 | 2022-01-31 | ユニバーシティー オブ ロチェスター | 統合失調症及び他の神経精神障害の治療方法 |
CN112011510B (zh) * | 2019-05-30 | 2023-01-03 | 中国科学院上海有机化学研究所 | 一种由人多能干细胞制备多巴胺神经元的方法 |
US20220254448A1 (en) | 2019-07-25 | 2022-08-11 | The Scripps Research Institute | Methods of identifying dopaminergic neurons and progenitor cells |
KR102183208B1 (ko) * | 2019-07-25 | 2020-11-25 | 한국과학기술연구원 | Ngn2(neurogenin-2)를 이용하여 척수 손상 모델에서 반응성 성상세포를 신경세포로 리프로그래밍하는 방법 |
US20220389378A1 (en) * | 2019-11-22 | 2022-12-08 | Novo Nordisk A/S | Spin-aggregated neural microspheres and the application thereof |
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CN115768875A (zh) * | 2020-04-02 | 2023-03-07 | 纪念斯隆-凯特琳癌症中心 | 产生中脑多巴胺神经元的方法、中脑神经元及其用途 |
WO2021216623A1 (en) | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
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CN114292814A (zh) * | 2020-09-22 | 2022-04-08 | 上海跃赛生物科技有限公司 | 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法 |
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CN117500916A (zh) | 2021-04-16 | 2024-02-02 | 博恩赛尔公司 | 制备、扩增和纯化中脑多巴胺能祖细胞的方法 |
CN117202914A (zh) * | 2021-04-21 | 2023-12-08 | 上海跃赛生物科技有限公司 | 一种质控和富集人多巴胺能神经前体细胞的方法 |
CN113388580B (zh) * | 2021-06-16 | 2022-02-18 | 中国医学科学院医学实验动物研究所 | 一种诱导脂肪干细胞分化为功能性多巴胺能神经元的方法及用途 |
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WO2023004371A1 (en) * | 2021-07-21 | 2023-01-26 | Aspen Neuroscience, Inc. | Methods of differentiating neural cells and predicting engraftment thereof and related compositions |
US20230081881A1 (en) | 2021-07-21 | 2023-03-16 | Aspen Neuroscience, Inc. | Transposon-based modulation of gba1 and related compositions and uses thereof |
CN113481160B (zh) * | 2021-08-20 | 2022-04-29 | 北京太东生物科技有限公司 | 视网膜色素上皮细胞诱导培养基及其应用 |
KR20240055838A (ko) | 2021-09-10 | 2024-04-29 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 유도된 만능 줄기 세포 유래된 세포의 조성물 및 이의 사용 방법 |
CN117089520A (zh) * | 2021-10-28 | 2023-11-21 | 中国科学院动物研究所 | 一种中脑多巴胺细胞群、其制造方法以及用途 |
CA3235390A1 (en) | 2021-10-29 | 2023-05-04 | Deepika Rajesh | Dopaminergic neurons comprising mutations and methods of use thereof |
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