CN103880965B - 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 - Google Patents
被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 Download PDFInfo
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| RU2012127383A (ru) * | 2009-12-02 | 2014-01-10 | Акселерон Фарма Инк. | Композиции и способы для увеличения времени полужизни fc-слитых белков в сыворотке |
| ES2611479T3 (es) * | 2010-06-16 | 2017-05-09 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Anticuerpos contra endoplasmina y su uso |
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| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
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| EP2718328A4 (en) * | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF SERUM |
| CN104203982B (zh) | 2011-10-28 | 2018-08-31 | 特瓦制药澳大利亚私人有限公司 | 多肽构建体及其用途 |
| WO2013096346A1 (en) * | 2011-12-22 | 2013-06-27 | Development Center For Biotechnology | Bispecific t-cell activator antibody |
| US9492562B2 (en) | 2012-01-20 | 2016-11-15 | Vib Vzw | Targeted human-interferon fusion proteins |
| PL2822575T3 (pl) * | 2012-03-03 | 2020-08-10 | Immungene, Inc. | Zmodyfikowane sposobami inżynierii cząsteczki fuzyjne przeciwciało-mutant interferonu |
| EP4219536A3 (en) * | 2012-04-30 | 2023-08-23 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
| US20150166654A1 (en) | 2012-05-30 | 2015-06-18 | Chugai Seiyaku Kabushiki Kaisha | Target tissue-specific antigen-binding molecule |
| CN103505722B (zh) * | 2012-06-19 | 2016-04-13 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗/预防对常规抗肿瘤疗法有抗性的肿瘤中的用途及相关的产品和方法 |
| WO2014028502A1 (en) * | 2012-08-13 | 2014-02-20 | ImmunGene Inc. | Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases |
| WO2014031646A2 (en) * | 2012-08-20 | 2014-02-27 | Gliknik Inc. | Molecules with antigen binding and polyvalent fc gamma receptor binding activity |
| WO2014089354A1 (en) * | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| PT2970512T (pt) | 2013-03-12 | 2019-01-17 | Biocon Ltd | Proteínas de fusão imunomoduladoras e métodos para produção das mesmas |
| ES2774976T3 (es) | 2013-04-29 | 2020-07-23 | Teva Pharmaceuticals Australia Pty Ltd | Anticuerpos anti-CD38 y fusiones con interferón alfa-2b atenuado |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| WO2014194100A1 (en) | 2013-05-29 | 2014-12-04 | The Regents Of The University Of California | Anti-cspg4 fusions with interferon for the treatment of malignancy |
| US20160237156A1 (en) | 2013-07-11 | 2016-08-18 | The California Institute For Biomedical Research | Immunoglobulin fusion proteins and compositions thereof |
| CN105705641B (zh) | 2013-07-18 | 2021-07-13 | 弗拉芒区生物技术研究所 | 涉及具有强烈降低的受体结合亲和力的细胞因子的融合因子 |
| JP6475712B2 (ja) | 2013-07-19 | 2019-02-27 | ヴィブ ブイゼットダブリュー | サイトカインアンタゴニストの標的化 |
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- 2016-11-02 JP JP2016215048A patent/JP2017031215A/ja active Pending
- 2016-11-22 US US15/359,456 patent/US10182984B2/en active Active
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| WO2001097844A1 (en) * | 2000-06-22 | 2001-12-27 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
| CN1751122A (zh) * | 2003-02-18 | 2006-03-22 | 默克专利有限公司 | 具有改进特性的干扰素α突变蛋白的融合蛋白 |
Non-Patent Citations (1)
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| 抗HBsAg Fab片段和α-干扰素融合蛋白的克隆及表达;郑伟等;《中华肝脏病杂志》;19981231;第6卷(第4期);摘要,第231页右栏第1段 * |
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