CN103874702B - 作为γ分泌酶调节剂的经取代的吲哚衍生物 - Google Patents

作为γ分泌酶调节剂的经取代的吲哚衍生物 Download PDF

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Publication number
CN103874702B
CN103874702B CN201280034912.XA CN201280034912A CN103874702B CN 103874702 B CN103874702 B CN 103874702B CN 201280034912 A CN201280034912 A CN 201280034912A CN 103874702 B CN103874702 B CN 103874702B
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China
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group
alkyl
mmol
yield
fluoro
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Expired - Fee Related
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CN201280034912.XA
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English (en)
Chinese (zh)
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CN103874702A (zh
Inventor
G.B.明内
F.P.比斯乔夫
H.J.M.吉森
A.I.维特
S.M.A.皮伊特斯
D.J-C.伯特洛特
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Cellzome Ltd
Janssen Pharmaceuticals Inc
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Cellzome Ltd
Ortho McNeil Janssen Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
CN201280034912.XA 2011-07-15 2012-07-12 作为γ分泌酶调节剂的经取代的吲哚衍生物 Expired - Fee Related CN103874702B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11174120.3 2011-07-15
EP11174120 2011-07-15
PCT/EP2012/063667 WO2013010904A1 (en) 2011-07-15 2012-07-12 Novel substituted indole derivatives as gamma secretase modulators

Publications (2)

Publication Number Publication Date
CN103874702A CN103874702A (zh) 2014-06-18
CN103874702B true CN103874702B (zh) 2015-12-09

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Country Link
US (1) US9115143B2 (https=)
EP (1) EP2731948B1 (https=)
JP (1) JP6068464B2 (https=)
KR (1) KR101913135B1 (https=)
CN (1) CN103874702B (https=)
AR (1) AR087182A1 (https=)
AU (1) AU2012285931B2 (https=)
BR (1) BR112014000713A2 (https=)
CA (1) CA2841102C (https=)
EA (1) EA023045B1 (https=)
ES (1) ES2555167T3 (https=)
IL (1) IL230422B (https=)
IN (1) IN2014MN00258A (https=)
MX (1) MX2014000626A (https=)
TW (1) TWI567079B (https=)
WO (1) WO2013010904A1 (https=)

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KR102781141B1 (ko) 2017-12-15 2025-03-13 브리스톨-마이어스 스큅 컴퍼니 치환된 인돌 에테르 화합물
EA202091484A1 (ru) 2017-12-18 2021-03-25 Бристол-Маерс Сквибб Компани 4-азаиндольные соединения
JP7304352B2 (ja) 2017-12-19 2023-07-06 ブリストル－マイヤーズ スクイブ カンパニー ６－アザインドール化合物
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KR102730859B1 (ko) 2017-12-20 2024-11-15 브리스톨-마이어스 스큅 컴퍼니 아릴 및 헤테로아릴 치환된 인돌 화합물
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EP3628669A1 (en) * 2018-09-28 2020-04-01 GenKyoTex Suisse SA Novel compounds as nadph oxidase inhibitors
CN112955450A (zh) 2018-10-24 2021-06-11 百时美施贵宝公司 经取代的吲哚和吲唑化合物
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CN117946116A (zh) 2018-12-13 2024-04-30 豪夫迈·罗氏有限公司 6,7-二氢-5h-吡咯并[1,2-b][1,2,4]三唑-2-胺衍生物
KR102904576B1 (ko) 2019-05-09 2025-12-24 브리스톨-마이어스 스큅 컴퍼니 치환된 벤즈이미다졸론 화합물
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CN114829350B (zh) 2019-10-04 2024-05-28 百时美施贵宝公司 经取代的咔唑化合物

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EA201490287A1 (ru) 2014-05-30
JP6068464B2 (ja) 2017-01-25
US9115143B2 (en) 2015-08-25
KR20140063595A (ko) 2014-05-27
WO2013010904A1 (en) 2013-01-24
BR112014000713A2 (pt) 2017-01-10
TW201315736A (zh) 2013-04-16
ES2555167T3 (es) 2015-12-29
AU2012285931B2 (en) 2017-01-12
CN103874702A (zh) 2014-06-18
IL230422B (en) 2018-03-29
JP2014518286A (ja) 2014-07-28
CA2841102C (en) 2019-08-13
MX2014000626A (es) 2014-04-30
EP2731948A1 (en) 2014-05-21
NZ619683A (en) 2015-01-30
EA023045B1 (ru) 2016-04-29
KR101913135B1 (ko) 2018-10-30
US20140148450A1 (en) 2014-05-29
CA2841102A1 (en) 2013-01-24
AR087182A1 (es) 2014-02-26
TWI567079B (zh) 2017-01-21
EP2731948B1 (en) 2015-09-09
IN2014MN00258A (https=) 2015-09-25

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