CN103748078B - 可裂解脂质 - Google Patents
可裂解脂质 Download PDFInfo
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- CN103748078B CN103748078B CN201280036307.6A CN201280036307A CN103748078B CN 103748078 B CN103748078 B CN 103748078B CN 201280036307 A CN201280036307 A CN 201280036307A CN 103748078 B CN103748078 B CN 103748078B
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- lipid
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- 0 CCCCCC=CCC=CCCCCCCCCC(CC1)C1C(COCCCCCCCCC=CCC=CCCCCC)CSSCC1=C**C=N1 Chemical compound CCCCCC=CCC=CCCCCCCCCC(CC1)C1C(COCCCCCCCCC=CCC=CCCCCC)CSSCC1=C**C=N1 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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- C07C323/44—X or Y being nitrogen atoms
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- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- C12Y—ENZYMES
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- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
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- C12Y302/01022—Alpha-galactosidase (3.2.1.22)
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Abstract
Description
批次5926-48 | Zave(nm) | PDI | Dv50(nm) | Dv90(nm) |
冻干前 | 103.8 | 0.236 | 60.2 | 156 |
冻干后 | 117.0 | 0.247 | 49.0 | 176 |
Claims (64)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610884286.3A CN107095849A (zh) | 2011-06-08 | 2012-06-08 | 可裂解脂质 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161494882P | 2011-06-08 | 2011-06-08 | |
US201161494745P | 2011-06-08 | 2011-06-08 | |
US61/494,882 | 2011-06-08 | ||
US61/494,745 | 2011-06-08 | ||
PCT/US2012/041663 WO2012170889A1 (en) | 2011-06-08 | 2012-06-08 | Cleavable lipids |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610884286.3A Division CN107095849A (zh) | 2011-06-08 | 2012-06-08 | 可裂解脂质 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103748078A CN103748078A (zh) | 2014-04-23 |
CN103748078B true CN103748078B (zh) | 2016-11-09 |
Family
ID=46317534
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610884286.3A Pending CN107095849A (zh) | 2011-06-08 | 2012-06-08 | 可裂解脂质 |
CN201280036307.6A Active CN103748078B (zh) | 2011-06-08 | 2012-06-08 | 可裂解脂质 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610884286.3A Pending CN107095849A (zh) | 2011-06-08 | 2012-06-08 | 可裂解脂质 |
Country Status (9)
Country | Link |
---|---|
US (6) | US9717690B2 (zh) |
EP (7) | EP4074693A1 (zh) |
JP (5) | JP6022557B2 (zh) |
CN (2) | CN107095849A (zh) |
AU (1) | AU2012267578B2 (zh) |
CA (2) | CA3198966A1 (zh) |
DK (2) | DK2718269T3 (zh) |
ES (2) | ES2795110T3 (zh) |
WO (1) | WO2012170889A1 (zh) |
Families Citing this family (258)
Publication number | Priority date | Publication date | Assignee | Title |
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