CN103271906A - 螺-吲哚酮化合物作为治疗剂的用途 - Google Patents
螺-吲哚酮化合物作为治疗剂的用途 Download PDFInfo
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- CN103271906A CN103271906A CN2013101646702A CN201310164670A CN103271906A CN 103271906 A CN103271906 A CN 103271906A CN 2013101646702 A CN2013101646702 A CN 2013101646702A CN 201310164670 A CN201310164670 A CN 201310164670A CN 103271906 A CN103271906 A CN 103271906A
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- alkyl
- heteroaryl
- cyclic hydrocarbon
- heterocyclic radical
- aryl
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P3/06—Antihyperlipidemics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Neurology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| CN119798270A (zh) * | 2025-01-06 | 2025-04-11 | 中国海洋大学 | 靶向egfr的小分子化合物及其应用 |
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| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| MX2009003875A (es) * | 2006-10-12 | 2009-04-22 | Xenon Pharmaceuticals Inc | Derivados y compuestos relacionados de espiro(furo[3,2-c]piridina- 3,3'-indol)-2' (1'h)ona para el tratamiento de enfermedades mediadas por los canales de sodio, tal como dolor. |
| MX2009003876A (es) | 2006-10-12 | 2009-05-11 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos. |
| PT2350090E (pt) * | 2008-10-17 | 2015-11-13 | Xenon Pharmaceuticals Inc | Composto espiro-oxindol e suas utilizações como agentes terapêuticos |
| WO2010045197A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| US8217051B2 (en) * | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| AR077252A1 (es) * | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| PE20121350A1 (es) | 2009-10-14 | 2012-10-20 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol |
| PE20121699A1 (es) * | 2010-02-26 | 2012-12-22 | Xenon Pharmaceuticals Inc | Composiciones farmaceuticas del compuesto espiro-oxindol para administracion topica |
| US8598156B2 (en) | 2010-03-25 | 2013-12-03 | Glaxosmithkline Llc | Chemical compounds |
| EP2407469A1 (en) * | 2010-07-13 | 2012-01-18 | Chemo Ibérica, S.A. | Salt of sitagliptin |
| WO2012049555A1 (en) | 2010-10-13 | 2012-04-19 | Lupin Limited | Spirocyclic compounds as voltage-gated sodium channel modulators |
| PH12013501825A1 (en) * | 2011-03-03 | 2018-04-11 | Cadila Healthcare Ltd | Novel salts of dpp-iv inhibitor |
| CN102321095B (zh) * | 2011-05-26 | 2014-09-10 | 兰州大学 | 手性螺环吲哚-吡喃嘧啶碱类化合物及其制备和应用 |
| GB2499666A (en) * | 2012-02-27 | 2013-08-28 | Nanyang Polytechnic | Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders |
| WO2013154712A1 (en) | 2012-04-12 | 2013-10-17 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
| JO3383B1 (ar) * | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
| CN103554121B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物及其应用 |
| CN103554120B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物的制备方法 |
| SI3080134T1 (sl) | 2013-12-13 | 2018-11-30 | Vertex Pharmaceuticals Incorporated | Predzdravila piridon amidov uporabna kot modulatorji natrijevih kanalov |
| KR20160118345A (ko) * | 2014-02-06 | 2016-10-11 | 애브비 인코포레이티드 | 6-헤테로아릴옥시- 및 6-아릴옥시-퀴놀린-2-카복사미드 및 이의 용도 |
| US20170137415A1 (en) | 2014-03-29 | 2017-05-18 | Lupin Limited | Sulfonamide compounds as voltage gated sodium channel modulators |
| BR112016028888A2 (pt) | 2014-06-12 | 2017-08-22 | Adamed Sp Zoo | compostos que compreendem o sistema 1,1',2,5'-tetra hidro espiro [indol-3,2'-pirrol]-2,5'-diona como inibidores de interação proteína-proteína p53-mdm2 |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| TW201722938A (zh) | 2015-09-04 | 2017-07-01 | 魯賓有限公司 | 作為電位閘控鈉通道調節子之磺醯胺化合物 |
| EA201891313A1 (ru) | 2015-12-18 | 2018-11-30 | Мерк Шарп И Доум Корп. | Замещенные гидроксиалкиламинами и гидроксициклоалкиламинами соединения диаминарилсульфонамидов с избирательной активностью в потенциалзависимых натриевых каналах |
| NZ744468A (en) | 2016-01-20 | 2022-07-01 | Chemocentryx Inc | 2-oxindole compounds |
| WO2017218920A1 (en) | 2016-06-16 | 2017-12-21 | Teva Pharmaceuticals International Gmbh | Asymmetric synthesis of funapide |
| WO2018163077A1 (en) | 2017-03-08 | 2018-09-13 | Lupin Limited | Indanyl compounds as voltage gated sodium channel modulators |
| US11358977B2 (en) | 2017-05-16 | 2022-06-14 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
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2007
- 2007-10-12 MX MX2009003876A patent/MX2009003876A/es active IP Right Grant
- 2007-10-12 TW TW096138356A patent/TW200833695A/zh unknown
- 2007-10-12 EP EP07868434A patent/EP2073806B1/en not_active Not-in-force
- 2007-10-12 JP JP2009532606A patent/JP5460324B2/ja not_active Expired - Fee Related
- 2007-10-12 RU RU2009117642/15A patent/RU2009117642A/ru not_active Application Discontinuation
- 2007-10-12 CA CA002665698A patent/CA2665698A1/en not_active Abandoned
- 2007-10-12 US US12/445,264 patent/US8466188B2/en not_active Expired - Fee Related
- 2007-10-12 CN CN2013101646702A patent/CN103271906A/zh active Pending
- 2007-10-12 BR BRPI0719210 patent/BRPI0719210A2/pt not_active IP Right Cessation
- 2007-10-12 CL CL200702950A patent/CL2007002950A1/es unknown
- 2007-10-12 WO PCT/US2007/081247 patent/WO2008060789A2/en not_active Ceased
- 2007-10-12 AU AU2007319580A patent/AU2007319580B2/en not_active Ceased
- 2007-10-12 CN CN200780038111A patent/CN101631546A/zh active Pending
- 2007-10-12 AT AT07868434T patent/ATE545416T1/de active
- 2007-10-12 AR ARP070104540A patent/AR063280A1/es unknown
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2013
- 2013-09-30 JP JP2013204440A patent/JP2013256539A/ja not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119798270A (zh) * | 2025-01-06 | 2025-04-11 | 中国海洋大学 | 靶向egfr的小分子化合物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009003876A (es) | 2009-05-11 |
| JP5460324B2 (ja) | 2014-04-02 |
| BRPI0719210A2 (pt) | 2015-05-05 |
| TW200833695A (en) | 2008-08-16 |
| AU2007319580A1 (en) | 2008-05-22 |
| EP2073806B1 (en) | 2012-02-15 |
| AR063280A1 (es) | 2009-01-21 |
| JP2010506854A (ja) | 2010-03-04 |
| AU2007319580B2 (en) | 2012-11-29 |
| US8466188B2 (en) | 2013-06-18 |
| EP2073806A2 (en) | 2009-07-01 |
| WO2008060789A3 (en) | 2008-07-24 |
| CA2665698A1 (en) | 2008-05-22 |
| CN101631546A (zh) | 2010-01-20 |
| US20110172282A9 (en) | 2011-07-14 |
| JP2013256539A (ja) | 2013-12-26 |
| RU2009117642A (ru) | 2010-11-20 |
| ATE545416T1 (de) | 2012-03-15 |
| WO2008060789A2 (en) | 2008-05-22 |
| CL2007002950A1 (es) | 2008-02-01 |
| US20100173967A1 (en) | 2010-07-08 |
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