CN103224497A - 蛋白激酶抑制剂 - Google Patents

蛋白激酶抑制剂 Download PDF

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Publication number
CN103224497A
CN103224497A CN2013100825419A CN201310082541A CN103224497A CN 103224497 A CN103224497 A CN 103224497A CN 2013100825419 A CN2013100825419 A CN 2013100825419A CN 201310082541 A CN201310082541 A CN 201310082541A CN 103224497 A CN103224497 A CN 103224497A
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amino
group
alkyl
pyrimidine
pyrrolo
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Chinese (zh)
Inventor
宋永红
徐亲
S·M·鲍尔
Z·J·贾
M·梅赫罗特拉
A·潘迪
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Portola Pharmaceuticals LLC
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Portola Pharmaceuticals LLC
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
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  • Urology & Nephrology (AREA)
  • Neurology (AREA)
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  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2013100825419A 2008-04-22 2009-04-22 蛋白激酶抑制剂 Pending CN103224497A (zh)

Applications Claiming Priority (2)

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US4707708P 2008-04-22 2008-04-22
US61/047,077 2008-04-22

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US (2) US8258144B2 (enExample)
EP (1) EP2271631B1 (enExample)
JP (1) JP2011518219A (enExample)
CN (2) CN102066338A (enExample)
AU (1) AU2009238590A1 (enExample)
BR (1) BRPI0910668A2 (enExample)
CA (1) CA2723185A1 (enExample)
IL (1) IL208719A0 (enExample)
NZ (1) NZ588830A (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104086551A (zh) * 2014-06-06 2014-10-08 人福医药集团股份公司 化合物及其制备方法和用途
CN116813550A (zh) * 2022-03-28 2023-09-29 上海医药工业研究院有限公司 吲唑类衍生物、其制备方法、药物组合物及应用

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