CN103179981B - 安全和功能性的人源化抗β‑淀粉样蛋白抗体 - Google Patents
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| CN101820911B (zh) * | 2007-06-12 | 2015-05-06 | Ac免疫有限公司 | β淀粉样蛋白的人源化抗体 |
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| WO2009048537A2 (en) * | 2007-10-05 | 2009-04-16 | Genentech, Inc. | Humanized antibody |
| RU2604181C2 (ru) | 2007-10-05 | 2016-12-10 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
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| US20130190606A1 (en) * | 2012-01-25 | 2013-07-25 | Huntington Medical Research Institutes | Combined quantitative mri and quantitative mrs for diagnosis of alzheimers disease and hippocampal sclerosis |
| WO2013177062A2 (en) | 2012-05-21 | 2013-11-28 | Genentech, Inc. | Methods for improving safety of blood-brain barrier transport |
| WO2015038888A1 (en) | 2013-09-13 | 2015-03-19 | Genentech, Inc. | Methods and compositions comprising purified recombinant polypeptides |
| MX2016002799A (es) | 2013-09-13 | 2016-05-26 | Genentech Inc | Composiciones y metodos para detectar y cuantificar la proteina en la celula hospedera en las lineas de celulas y productos de polipeptidos recombinantes. |
| BR112016018170A2 (pt) * | 2014-02-08 | 2018-02-20 | Genentech, Inc. | métodos para tratar doença de alzheimer |
| CN107208062B (zh) | 2015-01-16 | 2021-03-09 | 新加坡科技研究局 | 从多能干细胞分化巨噬细胞 |
| CN108350052A (zh) | 2015-11-09 | 2018-07-31 | 英属哥伦比亚大学 | 淀粉样蛋白β中间区域中的表位及其构象选择性抗体 |
| JP7452829B2 (ja) | 2015-11-09 | 2024-03-19 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータのエピトープおよびそれに対する抗体 |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| CN109602895A (zh) * | 2018-12-27 | 2019-04-12 | 中山大学附属第医院 | Mfg-e8在制备用于选择性调控淀粉样蛋白诱导的小胶质细胞极化的药物中的应用 |
| CN111518206B (zh) | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| US12352719B2 (en) | 2019-09-20 | 2025-07-08 | KYCERA AVX Components Corporation | Somatic cell-based electrical biosensor |
| WO2021081101A1 (en) * | 2019-10-22 | 2021-04-29 | Biogen Ma Inc. | Anti-beta-amyloid antibody for treating alzheimer's disease |
| CN111518793A (zh) * | 2020-05-20 | 2020-08-11 | 谭骏 | 年轻人血源APPα-分泌酶在阿尔茨海默病中的应用 |
| BR112023001061A2 (pt) | 2020-07-23 | 2023-04-04 | Othair Prothena Ltd | Anticorpos antiabeta |
| JP2024500357A (ja) * | 2020-12-11 | 2024-01-09 | 元 篠崎 | 神経炎症を定量化するためのデバイス、システム、及び方法 |
| EP4373576A1 (en) * | 2021-07-22 | 2024-05-29 | Genentech, Inc. | Brain targeting compositions and methods of use thereof |
| CN117586388A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 改进的β淀粉样蛋白寡聚体特异性结合抗体 |
| WO2025134068A1 (en) | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Antibody drug conjugates targeting proteinopathies, and uses thereof |
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| GB1590524A (en) | 1976-11-24 | 1981-06-03 | Nat Res Dev | Assay of immune complexes |
| US4210622A (en) | 1977-09-07 | 1980-07-01 | National Research Development Corporation | Kit for assay of immune complexes |
| US4331649A (en) | 1978-10-10 | 1982-05-25 | Burroughs Wellcome Co. | Immune complex assay |
| EP0091760B1 (en) | 1982-04-09 | 1986-07-02 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Anti immune complex antibody and preparation thereof |
| US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| US4753893A (en) | 1985-05-31 | 1988-06-28 | Biostar Medical Products, Inc. | Method and article for detection of immune complexes |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5525339A (en) | 1986-08-27 | 1996-06-11 | Dms Pharmaceutical Inc. | Isolated components of dense microspheres derived from mammalian brain tissue and antibodies thereto |
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| ZA201300569B (en) | 2016-03-30 |
| MX2013000971A (es) | 2013-06-28 |
| US20120064065A1 (en) | 2012-03-15 |
| CN103179981A (zh) | 2013-06-26 |
| NZ606357A (en) | 2015-05-29 |
| CA2806909C (en) | 2019-12-17 |
| MY164579A (en) | 2018-01-15 |
| RU2607368C2 (ru) | 2017-01-10 |
| JP2017051188A (ja) | 2017-03-16 |
| EP2598882A2 (en) | 2013-06-05 |
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