CN103154035B - 针对her2的单克隆抗体 - Google Patents

针对her2的单克隆抗体 Download PDF

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Publication number
CN103154035B
CN103154035B CN201180036934.5A CN201180036934A CN103154035B CN 103154035 B CN103154035 B CN 103154035B CN 201180036934 A CN201180036934 A CN 201180036934A CN 103154035 B CN103154035 B CN 103154035B
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antibody
region
her2
cancer
seq
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Chinese (zh)
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CN103154035A (zh
Inventor
B.d.戈艾杰
S.d.海杰
T.里德尔
R.霍埃特
O.巴德斯加尔德
J.v.d.温克尔
D.萨蒂恩
P.帕伦
A.F.拉布里恩
J.梅斯特斯
J.舒尔曼
E.N.v.d.布林克
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Genmab AS
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Genmab AS
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Priority claimed from PCT/EP2011/056388 external-priority patent/WO2011131746A2/en
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Priority to CN201710259581.4A priority Critical patent/CN107253992B/zh
Priority to CN202210148377.6A priority patent/CN114805583A/zh
Publication of CN103154035A publication Critical patent/CN103154035A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/528—CH4 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180036934.5A 2010-05-27 2011-05-27 针对her2的单克隆抗体 Active CN103154035B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201710259581.4A CN107253992B (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体
CN202210148377.6A CN114805583A (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US34918010P 2010-05-27 2010-05-27
US61/349180 2010-05-27
DKPA201000467 2010-05-27
DKPA201000467 2010-05-27
DKPA201100312 2011-04-20
EPPCT/EP2011/056388 2011-04-20
DKPA201100312 2011-04-20
PCT/EP2011/056388 WO2011131746A2 (en) 2010-04-20 2011-04-20 Heterodimeric antibody fc-containing proteins and methods for production thereof
PCT/EP2011/058779 WO2011147986A1 (en) 2010-05-27 2011-05-27 Monoclonal antibodies against her2

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201710259581.4A Division CN107253992B (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体
CN202210148377.6A Division CN114805583A (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体

Publications (2)

Publication Number Publication Date
CN103154035A CN103154035A (zh) 2013-06-12
CN103154035B true CN103154035B (zh) 2017-05-10

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CN201180036934.5A Active CN103154035B (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体
CN201710259581.4A Active CN107253992B (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体
CN202210148377.6A Pending CN114805583A (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体

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CN201710259581.4A Active CN107253992B (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体
CN202210148377.6A Pending CN114805583A (zh) 2010-05-27 2011-05-27 针对her2的单克隆抗体

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US (5) US9862769B2 (enExample)
EP (2) EP2576621B1 (enExample)
JP (2) JP6320753B2 (enExample)
CN (3) CN103154035B (enExample)
AU (5) AU2011257121A1 (enExample)
CA (2) CA3051311A1 (enExample)
IL (3) IL299365A (enExample)
NZ (1) NZ604003A (enExample)
WO (1) WO2011147986A1 (enExample)

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* Cited by examiner, † Cited by third party
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Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancer;Rita Nahta et al.;《NATURE CLINICAL PRACTICE ONCOLOGY》;20060531;第3卷(第5期);第269页左栏第1段至第270页右栏第1段，第274页右栏第3段至第275页右栏第2段，表1-2，图1 *

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