CN103140474A - 治疗aids的萘-2-基乙酸衍生物 - Google Patents
治疗aids的萘-2-基乙酸衍生物 Download PDFInfo
- Publication number
- CN103140474A CN103140474A CN201180038442XA CN201180038442A CN103140474A CN 103140474 A CN103140474 A CN 103140474A CN 201180038442X A CN201180038442X A CN 201180038442XA CN 201180038442 A CN201180038442 A CN 201180038442A CN 103140474 A CN103140474 A CN 103140474A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- aryl
- heterocycle
- heteroaryl
- carbocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(*)(C(O)=O)c1c(*)c(c(*)c(*)c(*)c2*)c2c(*)c1* Chemical compound *C(*)(C(O)=O)c1c(*)c(c(*)c(*)c(*)c2*)c2c(*)c1* 0.000 description 19
- AREYBIZUKSMRQI-UHFFFAOYSA-N Cc(cc1)c2nccc3c2c1OCC3 Chemical compound Cc(cc1)c2nccc3c2c1OCC3 AREYBIZUKSMRQI-UHFFFAOYSA-N 0.000 description 3
- YTTBIVJAIVYRAR-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c1c(C)cc(cc(C)cc2)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)OC(C(O)=O)c1c(C)cc(cc(C)cc2)c2c1-c(cc1)ccc1Cl YTTBIVJAIVYRAR-UHFFFAOYSA-N 0.000 description 2
- QMDMUBHRSVOJIS-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c1c(C)cc(cc(cc2)F)c2c1-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)OC(C(O)=O)c1c(C)cc(cc(cc2)F)c2c1-c(cc1)c2nccc3c2c1OCC3 QMDMUBHRSVOJIS-UHFFFAOYSA-N 0.000 description 2
- MHMJNBHDCKQLKY-UHFFFAOYSA-N Cc1c2ncccc2c(C(F)(F)F)cc1 Chemical compound Cc1c2ncccc2c(C(F)(F)F)cc1 MHMJNBHDCKQLKY-UHFFFAOYSA-N 0.000 description 2
- RSRNSJHVAOPEKF-UHFFFAOYSA-N CC(C)(C)OC(C(C1(C)c(cc2)ccc2Cl)C(C)=C(c2cnc(N)nc2)c2c1cccc2)C(O)=O Chemical compound CC(C)(C)OC(C(C1(C)c(cc2)ccc2Cl)C(C)=C(c2cnc(N)nc2)c2c1cccc2)C(O)=O RSRNSJHVAOPEKF-UHFFFAOYSA-N 0.000 description 1
- MXFKDWIXPUETMB-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)C(C(C)=C(C1(C)C2=CC=CC1)C#CCN(C)C)=C2c(cc1)ccc1Cl Chemical compound CC(C)(C)OC(C(O)=O)C(C(C)=C(C1(C)C2=CC=CC1)C#CCN(C)C)=C2c(cc1)ccc1Cl MXFKDWIXPUETMB-UHFFFAOYSA-N 0.000 description 1
- VZQZRMRBXPDMJD-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c(cc2)c1c(Cc(cc1)ccc1OC)c2OC Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c(cc2)c1c(Cc(cc1)ccc1OC)c2OC VZQZRMRBXPDMJD-UHFFFAOYSA-N 0.000 description 1
- BBIGUXDQNOJTJB-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c(cc2)c1cc2F Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c(cc2)c1cc2F BBIGUXDQNOJTJB-UHFFFAOYSA-N 0.000 description 1
- GRNZZDVTAFJMPA-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(-c(cc1)ccc1Cl)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(-c(cc1)ccc1Cl)ccc2 GRNZZDVTAFJMPA-UHFFFAOYSA-N 0.000 description 1
- VHTVTCMJCRYFKO-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(-c1cncnc1)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(-c1cncnc1)ccc2 VHTVTCMJCRYFKO-UHFFFAOYSA-N 0.000 description 1
- OPAHFPZNSWBUPS-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(Br)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(Br)ccc2 OPAHFPZNSWBUPS-UHFFFAOYSA-N 0.000 description 1
- TUZVUYQCNOZPML-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(C#CCN(C)C)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(C#CCN(C)C)ccc2 TUZVUYQCNOZPML-UHFFFAOYSA-N 0.000 description 1
- UQUFFKFOHPBEBD-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(C)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(C)ccc2 UQUFFKFOHPBEBD-UHFFFAOYSA-N 0.000 description 1
- BMBAUVHQGDPCRF-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(Cl)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(Cl)ccc2 BMBAUVHQGDPCRF-UHFFFAOYSA-N 0.000 description 1
- DACJPLYHLZWVFG-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(F)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(F)ccc2 DACJPLYHLZWVFG-UHFFFAOYSA-N 0.000 description 1
- NKGBNLAUPMFDBB-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(OC)ccc2 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c2c1c(OC)ccc2 NKGBNLAUPMFDBB-UHFFFAOYSA-N 0.000 description 1
- SYIASABOLYYIMU-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)cc1c2cccc1Cl)c2-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)cc1c2cccc1Cl)c2-c(cc1)c2nccc3c2c1OCC3 SYIASABOLYYIMU-UHFFFAOYSA-N 0.000 description 1
- LKLCKMKMRMEONQ-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)cc1c2cccc1F)c2-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)cc1c2cccc1F)c2-c(cc1)c2nccc3c2c1OCC3 LKLCKMKMRMEONQ-UHFFFAOYSA-N 0.000 description 1
- OWVNSSBLSGXWMK-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c1c(-c(cc2)ccc2Cl)c(cc(cc2)Cl)c2cc1C Chemical compound CC(C)(C)OC(C(O)=O)c1c(-c(cc2)ccc2Cl)c(cc(cc2)Cl)c2cc1C OWVNSSBLSGXWMK-UHFFFAOYSA-N 0.000 description 1
- CRYBOXNDHGJLDR-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c1c(C)c(C#N)c(cccc2)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)OC(C(O)=O)c1c(C)c(C#N)c(cccc2)c2c1-c(cc1)ccc1Cl CRYBOXNDHGJLDR-UHFFFAOYSA-N 0.000 description 1
- MEXXXCUZABWMKW-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c1c(C)c(C(C=C2)=CNC2=O)c(cccc2)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)OC(C(O)=O)c1c(C)c(C(C=C2)=CNC2=O)c(cccc2)c2c1-c(cc1)ccc1Cl MEXXXCUZABWMKW-UHFFFAOYSA-N 0.000 description 1
- BPIXTRIGPYFLIN-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c1c(C)c(C(C=N2)=CNC2=O)c(cccc2)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)OC(C(O)=O)c1c(C)c(C(C=N2)=CNC2=O)c(cccc2)c2c1-c(cc1)ccc1Cl BPIXTRIGPYFLIN-UHFFFAOYSA-N 0.000 description 1
- MCHYQICAMWBAGU-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c1c(C)cc(cc(cc2)OC)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)OC(C(O)=O)c1c(C)cc(cc(cc2)OC)c2c1-c(cc1)ccc1Cl MCHYQICAMWBAGU-UHFFFAOYSA-N 0.000 description 1
- RQZHXBZOMFWRQE-VWLOTQADSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C(F)F)cc1c2cccc1)c2-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C(F)F)cc1c2cccc1)c2-c(cc1)c2nccc3c2c1OCC3 RQZHXBZOMFWRQE-VWLOTQADSA-N 0.000 description 1
- RLLGRSXHHJWZPH-QFIPXVFZSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)cc1c2cccc1)c2C1=CCCCCC1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)cc1c2cccc1)c2C1=CCCCCC1 RLLGRSXHHJWZPH-QFIPXVFZSA-N 0.000 description 1
- WUDAUSAGZIVOOP-DEOSSOPVSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)cc1ccccc11)c1-c(cc1)c2ncccc2c1F Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)cc1ccccc11)c1-c(cc1)c2ncccc2c1F WUDAUSAGZIVOOP-DEOSSOPVSA-N 0.000 description 1
- IBLSWEMAXRKDGA-VWLOTQADSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)cc1ccccc11)c1-c1c2nc(C)ccc2ccc1F Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)cc1ccccc11)c1-c1c2nc(C)ccc2ccc1F IBLSWEMAXRKDGA-VWLOTQADSA-N 0.000 description 1
- IHHLCDCPUVNYGW-SANMLTNESA-N CC(C)(C)O[C@H](C(O)=O)c(c(CF)cc1c2cccc1)c2-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(CF)cc1c2cccc1)c2-c(cc1)c2nccc3c2c1OCC3 IHHLCDCPUVNYGW-SANMLTNESA-N 0.000 description 1
- NSUAZFSFTQGZDR-QFIPXVFZSA-N CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)c(C)cc2Cl)c(cccc2)c2cc1C Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)c(C)cc2Cl)c(cccc2)c2cc1C NSUAZFSFTQGZDR-QFIPXVFZSA-N 0.000 description 1
- QQZKNYRJSUEEGK-QFIPXVFZSA-N CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c(cccc2)c2cc1C=C Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c(cccc2)c2cc1C=C QQZKNYRJSUEEGK-QFIPXVFZSA-N 0.000 description 1
- BEIVMRADRUKUNI-NRFANRHFSA-N CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c(cccc2)c2cc1CO Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c(cccc2)c2cc1CO BEIVMRADRUKUNI-NRFANRHFSA-N 0.000 description 1
- RYJVPOOCKCVIMG-QFIPXVFZSA-N CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c(cccc2)c2cc1COC Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c(cccc2)c2cc1COC RYJVPOOCKCVIMG-QFIPXVFZSA-N 0.000 description 1
- AUORPJDNNGIBQA-VWLOTQADSA-N CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c2cc(C#CC(C)(C)N)ccc2cc1C Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c2cc(C#CC(C)(C)N)ccc2cc1C AUORPJDNNGIBQA-VWLOTQADSA-N 0.000 description 1
- XTNPJFWVKKEFPR-NDEPHWFRSA-N CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c2cc(C#CC3(CCCCC3)N)ccc2cc1C Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c2cc(C#CC3(CCCCC3)N)ccc2cc1C XTNPJFWVKKEFPR-NDEPHWFRSA-N 0.000 description 1
- BIYLFIDFHHNZPU-NRFANRHFSA-N CC(C)(C)O[C@H](C(O)=O)c1c(C)c(Br)c(cccc2)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C)c(Br)c(cccc2)c2c1-c(cc1)ccc1Cl BIYLFIDFHHNZPU-NRFANRHFSA-N 0.000 description 1
- FAHMXPZDUWHOQA-SANMLTNESA-N CC(C)(C)O[C@H](C(O)=O)c1c(C)c(F)c(cccc2)c2c1-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C)c(F)c(cccc2)c2c1-c(cc1)c2nccc3c2c1OCC3 FAHMXPZDUWHOQA-SANMLTNESA-N 0.000 description 1
- ZLJNYQIBRVDLHU-MHZLTWQESA-N CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(C)c(F)c2)c2c1-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(C)c(F)c2)c2c1-c(cc1)c2nccc3c2c1OCC3 ZLJNYQIBRVDLHU-MHZLTWQESA-N 0.000 description 1
- NKBQZMKVJXRGPE-DEOSSOPVSA-N CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3c[nH]nc3)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3c[nH]nc3)c2c1-c(cc1)ccc1Cl NKBQZMKVJXRGPE-DEOSSOPVSA-N 0.000 description 1
- YXLXCWFMQMZLRJ-SANMLTNESA-N CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3cccnc3)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3cccnc3)c2c1-c(cc1)ccc1Cl YXLXCWFMQMZLRJ-SANMLTNESA-N 0.000 description 1
- VIMBTHJPXDNFBQ-SANMLTNESA-N CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3ccncc3)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3ccncc3)c2c1-c(cc1)ccc1Cl VIMBTHJPXDNFBQ-SANMLTNESA-N 0.000 description 1
- MEIIFCAGTBURKT-VWLOTQADSA-N CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3cncnc3)c2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C)cc(cc(cc2)-c3cncnc3)c2c1-c(cc1)ccc1Cl MEIIFCAGTBURKT-VWLOTQADSA-N 0.000 description 1
- IIHPEJVAYQOIOW-BPARTEKVSA-N CC(C)(C)O[C@H](C(O)=O)c1c(C2=CC(C)(C)CCC2O)c2ccccc2cc1C Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C2=CC(C)(C)CCC2O)c2ccccc2cc1C IIHPEJVAYQOIOW-BPARTEKVSA-N 0.000 description 1
- WVVKXACVKZEUJU-NRFANRHFSA-N CC(C)(C)O[C@H](C(O)=O)c1c(C2=CCCCC2)c2ccccc2cc1C Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(C2=CCCCC2)c2ccccc2cc1C WVVKXACVKZEUJU-NRFANRHFSA-N 0.000 description 1
- ZTZZKMMCVONOIC-UHFFFAOYSA-N CC(C)(C)[O-2]C(C(O)=O)C(C(C)=CC(C1)C2=CC(F)=C1F)=C2c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)[O-2]C(C(O)=O)C(C(C)=CC(C1)C2=CC(F)=C1F)=C2c(cc1)c2nccc3c2c1OCC3 ZTZZKMMCVONOIC-UHFFFAOYSA-N 0.000 description 1
- XSFTYWUDCFJDCQ-UHFFFAOYSA-N CC(C)(C)[O-2]c1cc(OCCc2ccn3)c2c3c1-c1c(CC(O)=O)c(CF)cc2c1cccc2 Chemical compound CC(C)(C)[O-2]c1cc(OCCc2ccn3)c2c3c1-c1c(CC(O)=O)c(CF)cc2c1cccc2 XSFTYWUDCFJDCQ-UHFFFAOYSA-N 0.000 description 1
- LUPPVKCNEZKQDF-UHFFFAOYSA-N CC(C=C1c2c(cc3)OCC1)Nc2c3-c1c(cccc2)c2cc(CF)c1CCO Chemical compound CC(C=C1c2c(cc3)OCC1)Nc2c3-c1c(cccc2)c2cc(CF)c1CCO LUPPVKCNEZKQDF-UHFFFAOYSA-N 0.000 description 1
- JMFLOZPMTACVPX-CEISFSOZSA-N CC(CC1)CC=C1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)cc2c1cccc2 Chemical compound CC(CC1)CC=C1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)cc2c1cccc2 JMFLOZPMTACVPX-CEISFSOZSA-N 0.000 description 1
- MDFGSFVBTWBHLO-UHFFFAOYSA-N CC(Cc(cc1)cc(F)c1F)=O Chemical compound CC(Cc(cc1)cc(F)c1F)=O MDFGSFVBTWBHLO-UHFFFAOYSA-N 0.000 description 1
- PNKKQHSYBPLLNA-UHFFFAOYSA-N CCOC(C(C(C(C)=C(C1(C)C2=CC=CC1)Br)=C2c(cc1)ccc1Cl)OC(C)(C)C)=O Chemical compound CCOC(C(C(C(C)=C(C1(C)C2=CC=CC1)Br)=C2c(cc1)ccc1Cl)OC(C)(C)C)=O PNKKQHSYBPLLNA-UHFFFAOYSA-N 0.000 description 1
- AOLLIFZRXDPQMO-UHFFFAOYSA-N CCOC(C(c1c(-c(cc2)ccc2Cl)c(cc(cc2)Br)c2cc1C)O)=O Chemical compound CCOC(C(c1c(-c(cc2)ccc2Cl)c(cc(cc2)Br)c2cc1C)O)=O AOLLIFZRXDPQMO-UHFFFAOYSA-N 0.000 description 1
- XULVQOOVDWCFEZ-UHFFFAOYSA-N CCOC(C(c1c(-c2ccc(C)cc2)c(cc(cc2)Br)c2cc1C)=O)=O Chemical compound CCOC(C(c1c(-c2ccc(C)cc2)c(cc(cc2)Br)c2cc1C)=O)=O XULVQOOVDWCFEZ-UHFFFAOYSA-N 0.000 description 1
- JJFIWBPXECTJCT-UHFFFAOYSA-N CCOC(C(c1c(C2C=CC(Cl)=CC2C)c(cc(cc2)C#CC(C)(C)O)c2cc1C)OC(C)(C)C)=O Chemical compound CCOC(C(c1c(C2C=CC(Cl)=CC2C)c(cc(cc2)C#CC(C)(C)O)c2cc1C)OC(C)(C)C)=O JJFIWBPXECTJCT-UHFFFAOYSA-N 0.000 description 1
- VCXVVAZLQJZTTA-UHFFFAOYSA-N CCOC(CC(C(CO)CC1C2CCCC1)=C2C1(C)C=CC(C)=CC1)O Chemical compound CCOC(CC(C(CO)CC1C2CCCC1)=C2C1(C)C=CC(C)=CC1)O VCXVVAZLQJZTTA-UHFFFAOYSA-N 0.000 description 1
- WSUQYOXMPCIKOL-NDEPHWFRSA-N CCOC([C@H](c1c(C)c(F)c(cccc2)c2c1-c(cc1)c2nccc3c2c1OCC3)OC(C)(C)C)=O Chemical compound CCOC([C@H](c1c(C)c(F)c(cccc2)c2c1-c(cc1)c2nccc3c2c1OCC3)OC(C)(C)C)=O WSUQYOXMPCIKOL-NDEPHWFRSA-N 0.000 description 1
- LMECNNLFMYBZCB-NDEPHWFRSA-N CCc(cc(CC(C)(C)C([C@@H](C(O)=O)OC(C)(C)C)=C1c(cc2)c3nccc4c3c2OCC4)c1c1)c1F Chemical compound CCc(cc(CC(C)(C)C([C@@H](C(O)=O)OC(C)(C)C)=C1c(cc2)c3nccc4c3c2OCC4)c1c1)c1F LMECNNLFMYBZCB-NDEPHWFRSA-N 0.000 description 1
- BUUXBDOETSKRSE-QFIPXVFZSA-N CCc1cc(cccc2)c2c(-c(cc2)ccc2Cl)c1[C@@H](C(O)=O)OC(C)(C)C Chemical compound CCc1cc(cccc2)c2c(-c(cc2)ccc2Cl)c1[C@@H](C(O)=O)OC(C)(C)C BUUXBDOETSKRSE-QFIPXVFZSA-N 0.000 description 1
- BSBDPNPJDOXXIT-XTVWLNAFSA-N CCc1cc2cc(C)c([C@@H](C(OCC)=O)OC(C)(C)C)c(-c(cc3)c4N=CC(C)C5c4c3OCC5)c2cc1F Chemical compound CCc1cc2cc(C)c([C@@H](C(OCC)=O)OC(C)(C)C)c(-c(cc3)c4N=CC(C)C5c4c3OCC5)c2cc1F BSBDPNPJDOXXIT-XTVWLNAFSA-N 0.000 description 1
- JIQXCKBYSXWKON-DQXUUOSFSA-N CCc1cc2cc(C)c([C@@H](C(OCC)=O)OC(C)(C)C)c(C(C=C3)=C4N=CC=C5C4(C)C3OCC5)c2cc1F Chemical compound CCc1cc2cc(C)c([C@@H](C(OCC)=O)OC(C)(C)C)c(C(C=C3)=C4N=CC=C5C4(C)C3OCC5)c2cc1F JIQXCKBYSXWKON-DQXUUOSFSA-N 0.000 description 1
- ZDTRTQQGQWYIHG-UHFFFAOYSA-N Cc(cc1)c2NCCC3c2c1OCC3 Chemical compound Cc(cc1)c2NCCC3c2c1OCC3 ZDTRTQQGQWYIHG-UHFFFAOYSA-N 0.000 description 1
- XEJHEHMTWJYXGE-UHFFFAOYSA-N Cc(cc1)c2ncccc2c1F Chemical compound Cc(cc1)c2ncccc2c1F XEJHEHMTWJYXGE-UHFFFAOYSA-N 0.000 description 1
- MKRNDEDVTKRERI-UHFFFAOYSA-N Cc1c2ncccc2cc(F)c1 Chemical compound Cc1c2ncccc2cc(F)c1 MKRNDEDVTKRERI-UHFFFAOYSA-N 0.000 description 1
- VZDGZGNZGMJNPR-UHFFFAOYSA-N Cc1cc(CC(O)=O)ccc1F Chemical compound Cc1cc(CC(O)=O)ccc1F VZDGZGNZGMJNPR-UHFFFAOYSA-N 0.000 description 1
- FQTVQUQRFSHYCF-UHFFFAOYSA-N Cc1ccc(ccc(F)c2C)c2n1 Chemical compound Cc1ccc(ccc(F)c2C)c2n1 FQTVQUQRFSHYCF-UHFFFAOYSA-N 0.000 description 1
- LZJIFUXABIJCKY-UHFFFAOYSA-N Cc1ccc2OCCC3c2c1N(C)CC3 Chemical compound Cc1ccc2OCCC3c2c1N(C)CC3 LZJIFUXABIJCKY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Image Processing (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36131410P | 2010-07-02 | 2010-07-02 | |
| US61/361,314 | 2010-07-02 | ||
| PCT/US2011/042880 WO2012003497A1 (en) | 2010-07-02 | 2011-07-01 | Napht- 2 -ylacetic acid derivatives to treat aids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103140474A true CN103140474A (zh) | 2013-06-05 |
Family
ID=44454746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180038442XA Pending CN103140474A (zh) | 2010-07-02 | 2011-07-01 | 治疗aids的萘-2-基乙酸衍生物 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9102614B2 (https=) |
| EP (1) | EP2588450B1 (https=) |
| JP (2) | JP5984218B2 (https=) |
| KR (1) | KR20130135826A (https=) |
| CN (1) | CN103140474A (https=) |
| AP (1) | AP2013006706A0 (https=) |
| AR (1) | AR082079A1 (https=) |
| AU (1) | AU2011274322B2 (https=) |
| BR (1) | BR112013000043A2 (https=) |
| CA (1) | CA2802308C (https=) |
| CL (1) | CL2012003722A1 (https=) |
| CO (1) | CO6660497A2 (https=) |
| CR (1) | CR20130045A (https=) |
| EA (1) | EA201291300A1 (https=) |
| EC (1) | ECSP13012417A (https=) |
| ES (1) | ES2634490T3 (https=) |
| IL (1) | IL223558A0 (https=) |
| MA (1) | MA34397B1 (https=) |
| MX (1) | MX2012015097A (https=) |
| NZ (1) | NZ604598A (https=) |
| PE (1) | PE20130385A1 (https=) |
| PH (1) | PH12013500011A1 (https=) |
| PT (1) | PT2588450T (https=) |
| SG (1) | SG186820A1 (https=) |
| TW (1) | TWI453208B (https=) |
| UY (1) | UY33480A (https=) |
| WO (1) | WO2012003497A1 (https=) |
| ZA (1) | ZA201209596B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804211A (zh) * | 2014-03-12 | 2014-05-21 | 天津市炜杰科技有限公司 | 4-(乙酰基氨基)-2-羟基-3-(2-羰基乙基)苯甲酸甲酯的合成方法 |
| WO2021104470A1 (zh) * | 2019-11-29 | 2021-06-03 | 南京明德新药研发有限公司 | 抗hbv的1,7-萘啶类化合物 |
| CN117326921A (zh) * | 2023-09-27 | 2024-01-02 | 山东京博农化科技股份有限公司 | 一种1-(2,4,6-三氯苯基)-丙基-2-酮的制备方法 |
Families Citing this family (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS53347B (sr) | 2008-12-09 | 2014-10-31 | Gilead Sciences, Inc. | Modulatori toll-sličnih receptora |
| EP2588455B1 (en) | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| MX2012015097A (es) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Derivados de acido naft-2-ilacetico para tratar sida. |
| EP2511273B8 (en) * | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| AU2012278976B2 (en) | 2011-07-06 | 2017-05-11 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
| US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2013062028A1 (ja) | 2011-10-25 | 2013-05-02 | 塩野義製薬株式会社 | Hiv複製阻害剤 |
| US9731001B2 (en) | 2011-12-22 | 2017-08-15 | Universite Laval | Three-dimensional cavities of dendritic cell immunoreceptor (DCIR), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (HIV-1) |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| UY34750A (es) | 2012-04-20 | 2013-11-29 | Gilead Sciences Inc | ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?. |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2719685A1 (en) | 2012-10-11 | 2014-04-16 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EA030003B1 (ru) | 2012-12-21 | 2018-06-29 | Джилид Сайэнс, Инк. | Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции |
| TW201443037A (zh) | 2013-01-09 | 2014-11-16 | Gilead Sciences Inc | 治療用化合物 |
| ES2642265T3 (es) | 2013-01-09 | 2017-11-16 | Gilead Sciences, Inc. | Compuestos terapéuticos para el tratamiento de infecciones virales |
| US9220710B2 (en) | 2013-01-09 | 2015-12-29 | Gilead Sciences, Inc. | Therapeutic compounds |
| TW201441197A (zh) | 2013-01-31 | 2014-11-01 | Shionogi & Co | Hiv複製抑制劑 |
| TWI694071B (zh) | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物 |
| WO2014164409A1 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2014164467A1 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| ES2619708T3 (es) | 2013-03-13 | 2017-06-26 | VIIV Healthcare UK (No.5) Limited | Inhibidores de la replicación del virus de inmunodeficiencia humana |
| CN105008369B (zh) | 2013-03-14 | 2017-07-11 | 百时美施贵宝公司 | 人类免疫缺陷病毒复制抑制剂 |
| JP2016512558A (ja) | 2013-03-14 | 2016-04-28 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ヒト免疫不全ウイルス複製の阻害剤 |
| EP2821082A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use |
| EP2821104A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| NO2865735T3 (https=) | 2013-07-12 | 2018-07-21 | ||
| ES2859102T3 (es) | 2013-07-12 | 2021-10-01 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH |
| EP3105236B1 (en) | 2014-02-12 | 2017-10-18 | ViiV Healthcare UK (No.5) Limited | Benzothiazole macrocycles as inhibitors of human immunodeficiency virus replication |
| WO2015126758A1 (en) | 2014-02-18 | 2015-08-27 | Bristol-Myers Squibb Company | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9834566B2 (en) | 2014-02-18 | 2017-12-05 | VIIV Healthcare UK (No.5) Limited | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9409922B2 (en) | 2014-02-18 | 2016-08-09 | Bristol-Myers Squibb Company | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
| PT3107913T (pt) | 2014-02-19 | 2018-09-28 | Viiv Healthcare Uk No 5 Ltd | Inibidores da replicação do vírus da imunodeficiência humana |
| US9273067B2 (en) | 2014-02-19 | 2016-03-01 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US10202353B2 (en) | 2014-02-28 | 2019-02-12 | Gilead Sciences, Inc. | Therapeutic compounds |
| US9975906B2 (en) | 2014-05-16 | 2018-05-22 | Shionogi & Co., Ltd. | Tricyclic heterocycle derivatives having HIV replication inhibitory effect |
| NO2717902T3 (https=) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| JP6522732B2 (ja) | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ, インコーポレイテッド | Hivを治療するためのトール様受容体の調節因子 |
| WO2016036759A1 (en) | 2014-09-04 | 2016-03-10 | Gilead Sciences, Inc. | Methods of treating or preventing hiv in patients using a combination of tenofovir alafenamide and dolutegravir |
| SG11201701520TA (en) | 2014-09-16 | 2017-04-27 | Gilead Sciences Inc | Solid forms of a toll-like receptor modulator |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| SG11201705192PA (en) | 2014-12-24 | 2017-07-28 | Gilead Sciences Inc | Fused pyrimidine compounds for the treatment of hiv |
| TWI699355B (zh) | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| BR112017013440A2 (pt) | 2014-12-24 | 2018-01-09 | Gilead Sciences, Inc. | compostos de isoquinolina para o tratamento de hiv |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | N4-ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| US9670205B2 (en) | 2015-03-04 | 2017-06-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| KR20190057158A (ko) | 2015-04-02 | 2019-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도 |
| TWI700284B (zh) * | 2015-05-29 | 2020-08-01 | 日商塩野義製藥股份有限公司 | 具有hiv複製抑制作用之含氮3環性衍生物 |
| US20210292327A1 (en) | 2015-08-26 | 2021-09-23 | Gilead Sciences, Inc. | Deuterated toll-like receptor modulators |
| CA2997955A1 (en) | 2015-09-15 | 2017-03-23 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
| AU2016330895A1 (en) | 2015-09-30 | 2018-05-10 | Gilead Sciences, Inc. | Compounds and combinations for the treatment of HIV |
| JP6732915B2 (ja) | 2015-12-15 | 2020-07-29 | ギリアード サイエンシーズ, インコーポレイテッド | ヒト免疫不全ウイルス中和抗体 |
| CN119462611A (zh) | 2016-08-19 | 2025-02-18 | 吉利德科学公司 | 用于预防性或治疗性治疗hiv病毒感染的治疗性化合物 |
| WO2018042331A1 (en) | 2016-08-31 | 2018-03-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Combinations and uses and treatments thereof |
| WO2018042332A1 (en) | 2016-08-31 | 2018-03-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Combinations and uses and treatments thereof |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| AU2017318601B2 (en) | 2016-09-02 | 2020-09-03 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| WO2018051250A1 (en) | 2016-09-14 | 2018-03-22 | Viiv Healthcare Company | Combination comprising tenofovir alafenamide, bictegravir and 3tc |
| EP3519409B1 (en) | 2016-09-28 | 2024-09-18 | Gilead Sciences, Inc. | Benzothiazol-6-yl acetic acid derivatives and their use for treating hiv infection |
| ES2881949T3 (es) | 2016-10-27 | 2021-11-30 | Gilead Sciences Inc | Forma cristalina de base libre de darunavir |
| TW201835068A (zh) | 2017-01-03 | 2018-10-01 | 英商Viiv醫療保健英國(No.5)有限公司 | 作為人類免疫缺乏病毒複製之抑制劑之吡啶-3-基乙酸衍生物 |
| EP3565810A1 (en) | 2017-01-03 | 2019-11-13 | ViiV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| TW202510891A (zh) | 2017-01-31 | 2025-03-16 | 美商基利科學股份有限公司 | 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型 |
| AR110922A1 (es) | 2017-02-06 | 2019-05-15 | Gilead Sciences Inc | Compuestos inhibidores del vih |
| AR112257A1 (es) | 2017-06-21 | 2019-10-09 | Gilead Sciences Inc | Anticuerpos multiespecíficos dirigidos al vih-1 gp120 y cd3 humana, composiciones que los comprende, ácido nucleico, vector y célula huésped relacionados, método para producirlos, método para detectar células que expresan gp120 y cd3, kit de anticuerpos, fragmentos de anticuerpo que se une a gp120 y método para producirlos |
| CN110958883A (zh) | 2017-06-30 | 2020-04-03 | Viiv保健公司 | 组合及其用途和疗法 |
| SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
| AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
| TWI687415B (zh) | 2017-08-17 | 2020-03-11 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
| CN111051305A (zh) | 2017-08-22 | 2020-04-21 | 吉利德科学公司 | 治疗性杂环化合物 |
| JOP20180092A1 (ar) | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
| EP3700573A1 (en) | 2017-10-24 | 2020-09-02 | Gilead Sciences, Inc. | Methods of treating patients co-infected with a virus and tuberculosis |
| PT3706762T (pt) | 2017-12-07 | 2024-12-05 | Univ Emory | N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3740209A1 (en) | 2018-01-19 | 2020-11-25 | Gilead Sciences, Inc. | Metabolites of bictegravir |
| JP7083398B2 (ja) | 2018-02-15 | 2022-06-10 | ギリアード サイエンシーズ, インコーポレイテッド | ピリジン誘導体およびhiv感染を処置するためのその使用 |
| EP3752496B1 (en) | 2018-02-16 | 2023-07-05 | Gilead Sciences, Inc. | Methods and intermediates for preparing a therapeutic compound useful in the treatment of retroviridae viral infection |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| DK4257600T3 (da) | 2018-07-03 | 2025-05-26 | Gilead Sciences Inc | Antistoffer rettet mod hiv gp120 og fremgangsmåder til at bruge dem |
| US11186579B2 (en) | 2018-07-06 | 2021-11-30 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| AU2019297362B2 (en) | 2018-07-06 | 2022-05-26 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| KR20210033492A (ko) | 2018-07-16 | 2021-03-26 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 캡시드 억제제 |
| TWI829205B (zh) | 2018-07-30 | 2024-01-11 | 美商基利科學股份有限公司 | 抗hiv化合物 |
| JP7313438B2 (ja) | 2018-09-19 | 2023-07-24 | ギリアード サイエンシーズ, インコーポレイテッド | Hivの予防のためのインテグラーゼ阻害剤 |
| EP3860717A1 (en) | 2018-10-03 | 2021-08-11 | Gilead Sciences, Inc. | Imidozopyrimidine derivatives |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| WO2020176510A1 (en) | 2019-02-25 | 2020-09-03 | Gilead Sciences, Inc. | Protein kinase c agonists |
| WO2020176505A1 (en) | 2019-02-25 | 2020-09-03 | Gilead Sciences, Inc. | Protein kinase c agonists |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| WO2020178770A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| MY201239A (en) | 2019-03-22 | 2024-02-13 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
| US20200347036A1 (en) | 2019-04-17 | 2020-11-05 | Gilead Sciences, Inc. | Solid forms of an hiv protease inhibitor |
| TW202231277A (zh) | 2019-05-21 | 2022-08-16 | 美商基利科學股份有限公司 | 鑑別對使用gp120 v3聚醣導向之抗體的治療敏感之hiv病患的方法 |
| TWI810456B (zh) | 2019-05-22 | 2023-08-01 | 美商基利科學股份有限公司 | Tlr7調節化合物及hiv疫苗之組合 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| RU2717101C1 (ru) | 2019-06-03 | 2020-03-18 | Андрей Александрович Иващенко | Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения |
| CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| WO2020263830A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| KR20240137107A (ko) | 2019-07-16 | 2024-09-19 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신, 및 이의 제조 및 사용 방법 |
| US20220257619A1 (en) | 2019-07-18 | 2022-08-18 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| CA3157275C (en) | 2019-11-26 | 2026-02-10 | Gilead Sciences, Inc. | Capsid inhibitors for the prevention of hiv |
| IL294032A (en) | 2019-12-24 | 2022-08-01 | Carna Biosciences Inc | Compounds that regulate diacylglycerol kinase |
| PE20221569A1 (es) | 2020-02-24 | 2022-10-06 | Gilead Sciences Inc | Compuestos tetraciclicos para el tratamiento de infecciones por vih |
| WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| EP4153181A1 (en) | 2020-05-21 | 2023-03-29 | Gilead Sciences, Inc. | Pharmaceutical compositions comprising bictegravir |
| TWI858267B (zh) | 2020-06-25 | 2024-10-11 | 美商基利科學股份有限公司 | 用於治療hiv之蛋白殼抑制劑 |
| EP4192474B1 (en) | 2020-08-07 | 2025-09-10 | Gilead Sciences, Inc. | Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use |
| ES3064867T3 (en) | 2020-09-30 | 2026-04-29 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| PL4244396T3 (pl) | 2020-11-11 | 2025-12-22 | Gilead Sciences, Inc. | Sposoby identyfikacji pacjentów z hiv wrażliwych na terapię przeciwciałami skierowanymi na miejsce wiązania cd4 gp120 |
| US11613546B2 (en) | 2021-01-19 | 2023-03-28 | Gilead Sciences, Inc. | Substituted pyridotriazine compounds and uses thereof |
| WO2022245671A1 (en) | 2021-05-18 | 2022-11-24 | Gilead Sciences, Inc. | Methods of using flt3l-fc fusion proteins |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ, インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ, インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| US12084467B2 (en) | 2021-12-03 | 2024-09-10 | Gilead Sciences, Inc. | Therapeutic compounds for HIV virus infection |
| US12404262B2 (en) | 2021-12-03 | 2025-09-02 | Gilead Sciences, Inc. | Therapeutic compounds for HIV virus infection |
| CR20240223A (es) | 2021-12-03 | 2024-07-08 | Gilead Sciences Inc | Compuestos terapéuticos para la infección por el virus del vih |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| TWI867601B (zh) | 2022-07-01 | 2024-12-21 | 美商基利科學股份有限公司 | 可用於hiv病毒感染之疾病預防性或治療性治療的治療性化合物 |
| CA3259040A1 (en) | 2022-07-12 | 2024-01-18 | Gilead Sciences, Inc. | HIV Immunogenic Polypeptides and Vaccines and Their Uses |
| AU2023330037A1 (en) | 2022-08-26 | 2025-03-06 | Gilead Sciences, Inc. | Dosing and scheduling regimen for broadly neutralizing antibodies |
| US20240226130A1 (en) | 2022-10-04 | 2024-07-11 | Gilead Sciences, Inc. | 4'-thionucleoside analogues and their pharmaceutical use |
| US20240390349A1 (en) | 2023-04-19 | 2024-11-28 | Gilead Sciences, Inc. | Dosing regimen of capsid inhibitor |
| US20250042926A1 (en) | 2023-05-31 | 2025-02-06 | Gilead Sciences, Inc. | Therapeutic compounds for hiv |
| CN121219281A (zh) | 2023-05-31 | 2025-12-26 | 吉利德科学公司 | 用于治疗hiv的化合物的固体形式 |
| US20250051375A1 (en) | 2023-05-31 | 2025-02-13 | Gilead Sciences, Inc. | Anti-hiv compounds |
| WO2025029247A1 (en) | 2023-07-28 | 2025-02-06 | Gilead Sciences, Inc. | Weekly regimen of lenacapavir for the treatment and prevention of hiv |
| WO2025042394A1 (en) | 2023-08-23 | 2025-02-27 | Gilead Sciences, Inc. | Dosing regimen of hiv capsid inhibitor |
| WO2025076542A1 (en) | 2023-10-05 | 2025-04-10 | Jones R Brad | Atovaquone as an ros inducer for use in the elimination of hiv-infected t-cells |
| US20250127801A1 (en) | 2023-10-11 | 2025-04-24 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| US20250122219A1 (en) | 2023-10-11 | 2025-04-17 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| TW202515549A (zh) | 2023-10-11 | 2025-04-16 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| US20250230163A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Solid forms of hiv integrase inhibitors |
| WO2025184452A1 (en) | 2024-03-01 | 2025-09-04 | Gilead Sciences, Inc. | Solid forms of hiv integrase inhibitors |
| US20250333424A1 (en) | 2024-03-01 | 2025-10-30 | Gilead Sciences, Inc. | Antiviral compounds |
| US20250296932A1 (en) | 2024-03-01 | 2025-09-25 | Gilead Sciences, Inc. | Pharmaceutical compositions comprising hiv integrase inhibitors |
| WO2025212814A1 (en) | 2024-04-03 | 2025-10-09 | Gilead Sciences, Inc. | Anti-hiv compounds |
| US20260007683A1 (en) | 2024-06-14 | 2026-01-08 | Gilead Sciences, Inc. | Pharmaceutical compositions comprising hiv integrase inhibitors |
| WO2026076265A1 (en) | 2024-10-03 | 2026-04-09 | Gilead Sciences, Inc. | Combination therapy comprising bridged tricyclic carbamoylpyridone compounds and p-glycoprotein inhibitors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044117C (zh) * | 1992-12-22 | 1999-07-14 | 伊莱利利公司 | 用于抑制人免疫缺陷病毒蛋白酶的化合物及其制备方法和药物用途 |
| WO2008071587A2 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors |
| WO2009062285A1 (en) * | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3895028A (en) | 1972-09-12 | 1975-07-15 | Tokyo Tanabe Co | Alpha-(2-phenylbenzothiazol-5-yl)propionic acid |
| JPS4994667A (https=) | 1973-01-23 | 1974-09-09 | ||
| FR2453163A1 (fr) | 1979-04-03 | 1980-10-31 | Rolland Sa A | Derives de benzothiazole, leur procede de preparation et leurs applications en therapeutique |
| US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| GB8403739D0 (en) | 1984-02-13 | 1984-03-14 | Roussel Lab Ltd | Chemical compounds |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| JPH03287558A (ja) * | 1990-04-05 | 1991-12-18 | Teijin Ltd | 酵素阻害剤 |
| EP0533833B1 (en) | 1990-06-13 | 1995-12-20 | GLAZIER, Arnold | Phosphorous produgs |
| EP0481214B1 (en) | 1990-09-14 | 1998-06-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Prodrugs of phosphonates |
| US5733906A (en) | 1993-10-12 | 1998-03-31 | Eli Lilly And Company | Inhibitors of HIV Protease useful for the treatment of Aids |
| DE69434931T2 (de) | 1993-04-02 | 2007-11-22 | Rigel Pharmaceuticals, Inc., South San Francisco | Methode zur selektiven inaktivierung der viralen replication |
| US5434188A (en) | 1994-03-07 | 1995-07-18 | Warner-Lambert Company | 1-ether and 1-thioether-naphthalene-2-carboxamides as inhibitors of cell adhesion and as inhibitors of the activation of HIV |
| DE4428932A1 (de) | 1994-08-16 | 1996-02-22 | Hoechst Ag | Substituierte-Chinolinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| UA56992C2 (uk) * | 1995-05-08 | 2003-06-16 | Фармація Енд Апджон Компані | <font face="Symbol">a</font>-ПІРИМІДИНТІОАЛКІЛЗАМІЩЕНІ ТА <font face="Symbol">a</font>-ПІРИМІДИНОКСОАЛКІЛЗАМІЩЕНІ СПОЛУКИ |
| CA2327929A1 (en) | 1998-04-09 | 1999-10-21 | Merck & Co., Inc. | Oxidation process using periodic acid |
| WO2000063152A1 (en) | 1999-02-22 | 2000-10-26 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Acetylated and related analogues of chicoric acid as hiv integrase inhibitors |
| US20020052323A1 (en) | 2000-08-30 | 2002-05-02 | Jinhai Wang | Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents |
| CA2430234C (en) | 2000-11-21 | 2008-02-12 | Sunesis Pharmaceuticals, Inc. | An extended tethering approach for rapid identification of ligands |
| FR2819507B1 (fr) | 2001-01-17 | 2007-09-28 | Inst Rech Developpement Ird | Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus |
| JP2004043416A (ja) * | 2001-08-16 | 2004-02-12 | Japan Tobacco Inc | β−ケトアミド化合物及びその医薬用途 |
| FR2839646B1 (fr) | 2002-05-17 | 2008-04-11 | Bioalliance Pharma | Utilisation de derives de quinoleine a effet anti-integrase et ses applications |
| CN1671380B (zh) | 2002-08-02 | 2010-05-26 | 泰博特克药品有限公司 | 广谱2-氨基-苯并噻唑磺酰胺类hiv蛋白酶抑制剂 |
| ATE404537T1 (de) | 2002-08-13 | 2008-08-15 | Shionogi & Co | Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung |
| WO2004030611A2 (en) * | 2002-08-23 | 2004-04-15 | Ribapharm Inc. | Non-nucleoside reverse transcriptase inhibitors |
| AU2003273633A1 (en) | 2002-09-26 | 2004-04-19 | K.U.Leuven Research And Development | Integrase cofactor |
| SK2662004A3 (sk) | 2002-11-20 | 2005-06-02 | Japan Tobacco, Inc. | Zlúčenina s obsahom 4-oxochinolínu a jej použitie ako inhibítora integráz |
| UA80571C2 (en) | 2002-11-22 | 2007-10-10 | Lilly Co Eli | Quinolinyl-pyrrolopyrazoles |
| WO2004087153A2 (en) | 2003-03-28 | 2004-10-14 | Chiron Corporation | Use of organic compounds for immunopotentiation |
| EP1730135B1 (en) * | 2004-03-10 | 2010-09-22 | The United States of America, represented by the Secretary, Department of Health and Human Services | Qiunolin-4-ones as inhibitors of retroviral integrase for the treatment of hiv, aids and aids related complex (arc) |
| WO2006001958A2 (en) | 2004-05-21 | 2006-01-05 | Merck & Co., Inc. | Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity |
| US7087610B2 (en) | 2004-06-03 | 2006-08-08 | Bristol-Myers Squibb Company | Benzothiazole antiviral agents |
| CA2571309A1 (en) | 2004-06-22 | 2006-01-05 | Smithkline Beecham Corporation | Chemical compounds |
| TWI306401B (en) | 2004-08-13 | 2009-02-21 | Nat Health Research Institutes | Benzothiazolium compounds |
| US20060094755A1 (en) | 2004-10-28 | 2006-05-04 | Bioflexis, Llc | Novel quinoline-based metal chelators as antiviral agents |
| TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| WO2006124780A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase |
| US7473784B2 (en) | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| TW200803863A (en) | 2005-11-10 | 2008-01-16 | Schering Corp | Method for inhibiting protein kinases |
| US7939545B2 (en) | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| CA2651979A1 (en) | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Triazolopyridazine derivatives |
| JO2841B1 (en) | 2006-06-23 | 2014-09-15 | تيبوتيك فارماسيوتيكالز ليمتد | 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV) |
| US8435774B2 (en) | 2006-06-28 | 2013-05-07 | Qiagen Gmbh | Enhancing reactivation of thermostable reversibly inactivated enzymes |
| WO2008053478A2 (en) | 2006-10-30 | 2008-05-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions and methods for inhibiting hiv-1 replication and integrase activity |
| ES2402322T3 (es) | 2007-11-15 | 2013-04-30 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
| ATE541841T1 (de) * | 2007-11-15 | 2012-02-15 | Boehringer Ingelheim Int | Inhibitoren der replikation des human immunodeficiency virus |
| ES2463720T3 (es) | 2007-11-16 | 2014-05-29 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de inmunodeficiencia humana |
| GB0801940D0 (en) | 2008-02-01 | 2008-03-12 | Univ Leuven Kath | Inhibitors of lentiviral replication |
| EP2265270A1 (en) | 2008-02-04 | 2010-12-29 | OSI Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
| AR074199A1 (es) | 2008-11-20 | 2010-12-29 | Glaxosmithkline Llc | Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer. |
| EP2196453A1 (en) * | 2008-12-10 | 2010-06-16 | Cellvir | Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| WO2011002635A1 (en) | 2009-06-30 | 2011-01-06 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| US9095596B2 (en) | 2009-10-15 | 2015-08-04 | Southern Research Institute | Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such |
| SG181423A1 (en) | 2009-12-23 | 2012-07-30 | Univ Leuven Kath | Novel antiviral compounds |
| US20110223131A1 (en) | 2010-02-24 | 2011-09-15 | Gilead Sciences, Inc. | Antiviral compounds |
| JP6086326B2 (ja) | 2010-05-24 | 2017-03-01 | ユニヴァーシティー オブ ロチェスター | 二環式ヘテロアリールキナーゼ阻害剤および使用方法 |
| MX2012015097A (es) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Derivados de acido naft-2-ilacetico para tratar sida. |
| EP2588455B1 (en) | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| US8633200B2 (en) | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2640729B1 (en) | 2010-11-15 | 2016-12-21 | VIIV Healthcare UK Limited | Inhibitors of hiv replication |
| KR20140003438A (ko) | 2010-11-15 | 2014-01-09 | 카톨리에케 유니버시테이트 루벤 | 항바이러스성 축합 헤테로사이클릭 화합물 |
| AR084457A1 (es) | 2010-12-22 | 2013-05-15 | Lundbeck & Co As H | Derivados de biciclo[3,2,1]octilamida |
| WO2012102985A1 (en) | 2011-01-24 | 2012-08-02 | Glaxosmithkline Llc | Isoquinoline compounds and methods for treating hiv |
| CA2830845A1 (en) | 2011-04-04 | 2012-10-11 | Gilead Sciences, Inc. | Solid state forms of hiv inhibitor |
| CA2830838A1 (en) | 2011-04-04 | 2012-11-10 | Gilead Sciences, Inc. | Process for the preparation of an hiv integrase inhibitor |
| EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2511273B8 (en) * | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| WO2013002357A1 (ja) | 2011-06-30 | 2013-01-03 | 塩野義製薬株式会社 | Hiv複製阻害剤 |
| US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2757887B1 (en) | 2011-09-22 | 2017-04-26 | VIIV Healthcare UK Limited | Pyrrolopyridinone compounds and methods for treating hiv |
| WO2013058448A1 (ko) | 2011-10-20 | 2013-04-25 | 한국해양연구원 | 내분비계 장애물질 노출에 대응하는 바다송사리 유전자 및 이를 이용한 수생태계 환경오염 진단 방법 |
| WO2013062028A1 (ja) | 2011-10-25 | 2013-05-02 | 塩野義製薬株式会社 | Hiv複製阻害剤 |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| KR102668696B1 (ko) | 2012-01-12 | 2024-05-29 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2013157622A1 (ja) | 2012-04-19 | 2013-10-24 | 塩野義製薬株式会社 | Hiv複製阻害剤 |
| UY34750A (es) | 2012-04-20 | 2013-11-29 | Gilead Sciences Inc | ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?. |
| CA2876370A1 (en) | 2012-07-12 | 2014-01-16 | Viiv Healthcare Uk Limited | Compounds and methods for treating hiv |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2014055603A1 (en) | 2012-10-03 | 2014-04-10 | Gilead Sciences, Inc. | Process for the preparation of an hiv integrase inhibitor |
| WO2014055618A1 (en) | 2012-10-03 | 2014-04-10 | Gilead Sciences, Inc. | Solid state forms of hiv inhibitor: hemi-succinate of (2s)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid) |
-
2011
- 2011-07-01 MX MX2012015097A patent/MX2012015097A/es not_active Application Discontinuation
- 2011-07-01 AP AP2013006706A patent/AP2013006706A0/xx unknown
- 2011-07-01 US US13/806,067 patent/US9102614B2/en active Active
- 2011-07-01 SG SG2012095410A patent/SG186820A1/en unknown
- 2011-07-01 WO PCT/US2011/042880 patent/WO2012003497A1/en not_active Ceased
- 2011-07-01 PE PE2012002654A patent/PE20130385A1/es not_active Application Discontinuation
- 2011-07-01 MA MA35607A patent/MA34397B1/fr unknown
- 2011-07-01 KR KR1020137002778A patent/KR20130135826A/ko not_active Withdrawn
- 2011-07-01 EP EP11738878.5A patent/EP2588450B1/en active Active
- 2011-07-01 JP JP2013518778A patent/JP5984218B2/ja active Active
- 2011-07-01 NZ NZ604598A patent/NZ604598A/en unknown
- 2011-07-01 AU AU2011274322A patent/AU2011274322B2/en active Active
- 2011-07-01 EA EA201291300A patent/EA201291300A1/ru unknown
- 2011-07-01 TW TW100123357A patent/TWI453208B/zh not_active IP Right Cessation
- 2011-07-01 UY UY0001033480A patent/UY33480A/es not_active Application Discontinuation
- 2011-07-01 ES ES11738878.5T patent/ES2634490T3/es active Active
- 2011-07-01 BR BR112013000043A patent/BR112013000043A2/pt not_active IP Right Cessation
- 2011-07-01 PH PH1/2013/500011A patent/PH12013500011A1/en unknown
- 2011-07-01 PT PT117388785T patent/PT2588450T/pt unknown
- 2011-07-01 CN CN201180038442XA patent/CN103140474A/zh active Pending
- 2011-07-01 CA CA2802308A patent/CA2802308C/en active Active
- 2011-07-01 AR ARP110102376A patent/AR082079A1/es not_active Application Discontinuation
-
2012
- 2012-12-11 IL IL223558A patent/IL223558A0/en unknown
- 2012-12-18 ZA ZA2012/09596A patent/ZA201209596B/en unknown
- 2012-12-28 CL CL2012003722A patent/CL2012003722A1/es unknown
- 2012-12-28 CO CO12236161A patent/CO6660497A2/es active IP Right Grant
-
2013
- 2013-01-30 CR CR20130045A patent/CR20130045A/es unknown
- 2013-02-04 EC ECSP13012417 patent/ECSP13012417A/es unknown
-
2015
- 2015-08-10 JP JP2015158510A patent/JP2015193671A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044117C (zh) * | 1992-12-22 | 1999-07-14 | 伊莱利利公司 | 用于抑制人免疫缺陷病毒蛋白酶的化合物及其制备方法和药物用途 |
| WO2008071587A2 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors |
| WO2009062285A1 (en) * | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
Non-Patent Citations (1)
| Title |
|---|
| KADALI S. SAGAR,等: "Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans", 《BIOORGANIC & MEDICINAL CHEMISTRY》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804211A (zh) * | 2014-03-12 | 2014-05-21 | 天津市炜杰科技有限公司 | 4-(乙酰基氨基)-2-羟基-3-(2-羰基乙基)苯甲酸甲酯的合成方法 |
| CN103804211B (zh) * | 2014-03-12 | 2016-04-06 | 天津市炜杰科技有限公司 | 4-(乙酰基氨基)-2-羟基-3-(2-羰基乙基)苯甲酸甲酯的合成方法 |
| WO2021104470A1 (zh) * | 2019-11-29 | 2021-06-03 | 南京明德新药研发有限公司 | 抗hbv的1,7-萘啶类化合物 |
| CN114761405A (zh) * | 2019-11-29 | 2022-07-15 | 南京明德新药研发有限公司 | 抗hbv的1,7-萘啶类化合物 |
| CN117326921A (zh) * | 2023-09-27 | 2024-01-02 | 山东京博农化科技股份有限公司 | 一种1-(2,4,6-三氯苯基)-丙基-2-酮的制备方法 |
| CN117326921B (zh) * | 2023-09-27 | 2026-03-06 | 山东京博农化科技股份有限公司 | 一种1-(2,4,6-三氯苯基)-丙基-2-酮的制备方法 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103140474A (zh) | 治疗aids的萘-2-基乙酸衍生物 | |
| CN103209963A (zh) | 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物 | |
| EP2614064B1 (en) | Inhibitors of human immunodeficiency virus replication | |
| CN104583214B (zh) | 人类免疫缺陷病毒复制的抑制剂 | |
| TWI635085B (zh) | 經雙環取代之尿嘧啶類及其用途 | |
| CN104066732B (zh) | 新型抗病毒吡咯并吡啶衍生物及其制备方法 | |
| CN108368084B (zh) | 联芳基激酶抑制剂 | |
| TW201936572A (zh) | 芳基醚及其用途 | |
| TW201643153A (zh) | 溴結構域抑制劑 | |
| US20130281434A1 (en) | Therapeutic compounds | |
| WO2015124063A1 (zh) | 丙肝病毒抑制剂及其制药用途 | |
| CN113272302A (zh) | 抗生素化合物、其制造方法、包含其的药物组合物及其用途 | |
| CN109651208B (zh) | N-芳基磺酰胺类化合物,其药物组合物及其用途 | |
| WO2019063015A1 (zh) | 作为RORγ抑制剂的磺酰基取代的双环化合物 | |
| WO2016177690A1 (en) | Tricyclic piperidine compounds | |
| CN119569728B (zh) | 吡啶并吡咯类衍生物及其在制备富亮氨酸重复激酶2抑制剂中的应用 | |
| HK1184789A (en) | Napht- 2 -ylacetic acid derivatives to treat aids | |
| HK1184789B (en) | Napht- 2 -ylacetic acid derivatives to treat aids | |
| WO2018151240A1 (ja) | 3,6,7,8-テトラヒドロシクロペンタ[e]インドール化合物 | |
| HK40116585A (zh) | Sarm1调节剂、其制备和用途 | |
| CN104177320B (zh) | 一种脲取代联苯类化合物及其组合物及用途 | |
| HK40078921A (en) | Tricyclic compounds as egfr inhibitors | |
| OA16293A (en) | Napht-2-Y lacetic acid derivatives to treat AIDS. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130605 |