CN103052711B - 具有含氮脂环式骨架的单链核酸分子 - Google Patents

具有含氮脂环式骨架的单链核酸分子 Download PDF

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CN103052711B
CN103052711B CN201180037592.9A CN201180037592A CN103052711B CN 103052711 B CN103052711 B CN 103052711B CN 201180037592 A CN201180037592 A CN 201180037592A CN 103052711 B CN103052711 B CN 103052711B
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nucleic acid
formula
single stranded
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CN103052711A (zh
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大木忠明
林宏刚
白水久男
滨崎智洋
伊藤彰浩
铃木宽
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Bo Nake Of Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Biochemistry (AREA)
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  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
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  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201180037592.9A 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子 Active CN103052711B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201410217071.7A CN104004018B (zh) 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子
CN201410217512.3A CN104059911B (zh) 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2010-174915 2010-08-03
JP2010174915 2010-08-03
JP2010230806 2010-10-13
JP2010-230806 2010-10-13
JP2010-269823 2010-12-02
JP2010269823 2010-12-02
JP2011-152381 2011-07-08
JP2011152381 2011-07-08
PCT/JP2011/067292 WO2012017919A1 (ja) 2010-08-03 2011-07-28 含窒素脂環式骨格を有する一本鎖核酸分子

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CN201410217071.7A Division CN104004018B (zh) 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子
CN201410217512.3A Division CN104059911B (zh) 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子

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CN103052711A CN103052711A (zh) 2013-04-17
CN103052711B true CN103052711B (zh) 2016-08-03

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CN201410217512.3A Active CN104059911B (zh) 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子
CN201180037592.9A Active CN103052711B (zh) 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子

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CN201410217512.3A Active CN104059911B (zh) 2010-08-03 2011-07-28 具有含氮脂环式骨架的单链核酸分子

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EP (4) EP2639307B1 (ja)
JP (3) JP4965745B2 (ja)
KR (3) KR101849801B1 (ja)
CN (3) CN104004018B (ja)
DK (1) DK2674494T3 (ja)
ES (4) ES2533129T3 (ja)
HK (2) HK1189910A1 (ja)
PT (1) PT2674494E (ja)
TW (2) TWI572716B (ja)
WO (1) WO2012017919A1 (ja)

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CN103052711A (zh) 2013-04-17
CN104059911B (zh) 2017-01-04
EP2628801A1 (en) 2013-08-21
DK2674494T3 (en) 2015-02-23
TW201219570A (en) 2012-05-16
PT2674494E (pt) 2015-02-27
ES2443346T3 (es) 2014-02-19
EP2436767B1 (en) 2013-11-20
HK1189910A1 (en) 2014-06-20
WO2012017919A1 (ja) 2012-02-09
TW201615835A (zh) 2016-05-01
EP2639307A2 (en) 2013-09-18
HK1200460A1 (en) 2015-08-07
EP2436767A1 (en) 2012-04-04
CN104059911A (zh) 2014-09-24
KR20180040727A (ko) 2018-04-20
JPWO2012017919A1 (ja) 2013-10-03
KR20130095738A (ko) 2013-08-28
EP2639307A3 (en) 2014-02-05
ES2527660T3 (es) 2015-01-28
EP2639307A8 (en) 2014-04-30
ES2533129T3 (es) 2015-04-07
EP2674494B1 (en) 2014-12-17
KR101894701B1 (ko) 2018-09-04
CN104004018A (zh) 2014-08-27
JP2013138681A (ja) 2013-07-18
EP2436767A4 (en) 2012-05-09
TWI515294B (zh) 2016-01-01
TWI572716B (zh) 2017-03-01
EP2639307B1 (en) 2015-03-04
EP2628801B1 (en) 2015-01-07
KR101849801B1 (ko) 2018-04-17
JP2013034470A (ja) 2013-02-21
EP2674494A1 (en) 2013-12-18
JP4965745B2 (ja) 2012-07-04
KR101894702B1 (ko) 2018-09-04
CN104004018B (zh) 2017-01-04
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