CN103052711B - 具有含氮脂环式骨架的单链核酸分子 - Google Patents
具有含氮脂环式骨架的单链核酸分子 Download PDFInfo
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- CN103052711B CN103052711B CN201180037592.9A CN201180037592A CN103052711B CN 103052711 B CN103052711 B CN 103052711B CN 201180037592 A CN201180037592 A CN 201180037592A CN 103052711 B CN103052711 B CN 103052711B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410217512.3A CN104059911B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
CN201410217071.7A CN104004018B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010174915 | 2010-08-03 | ||
JP2010-174915 | 2010-08-03 | ||
JP2010230806 | 2010-10-13 | ||
JP2010-230806 | 2010-10-13 | ||
JP2010269823 | 2010-12-02 | ||
JP2010-269823 | 2010-12-02 | ||
JP2011-152381 | 2011-07-08 | ||
JP2011152381 | 2011-07-08 | ||
PCT/JP2011/067292 WO2012017919A1 (ja) | 2010-08-03 | 2011-07-28 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410217071.7A Division CN104004018B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
CN201410217512.3A Division CN104059911B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103052711A CN103052711A (zh) | 2013-04-17 |
CN103052711B true CN103052711B (zh) | 2016-08-03 |
Family
ID=45559420
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410217512.3A Active CN104059911B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
CN201180037592.9A Active CN103052711B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
CN201410217071.7A Active CN104004018B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410217512.3A Active CN104059911B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410217071.7A Active CN104004018B (zh) | 2010-08-03 | 2011-07-28 | 具有含氮脂环式骨架的单链核酸分子 |
Country Status (10)
Country | Link |
---|---|
EP (4) | EP2674494B1 (ja) |
JP (3) | JP4965745B2 (ja) |
KR (3) | KR101894701B1 (ja) |
CN (3) | CN104059911B (ja) |
DK (1) | DK2674494T3 (ja) |
ES (4) | ES2528285T3 (ja) |
HK (2) | HK1189910A1 (ja) |
PT (1) | PT2674494E (ja) |
TW (2) | TWI572716B (ja) |
WO (1) | WO2012017919A1 (ja) |
Families Citing this family (43)
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US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
EP2824184B1 (en) | 2012-03-04 | 2017-09-27 | Bonac Corporation | micro-RNA INHIBITOR |
WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Vegf遺伝子の発現抑制用一本鎖核酸分子 |
JP6283859B2 (ja) * | 2012-03-29 | 2018-02-28 | 国立大学法人九州大学 | ペリオスチン遺伝子の発現抑制核酸分子、ペリオスチン遺伝子の発現抑制方法、およびその用途 |
WO2013180038A1 (ja) | 2012-05-26 | 2013-12-05 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
JPWO2015046451A1 (ja) * | 2013-09-27 | 2017-03-09 | 株式会社アクアセラピューティクス | 眼科疾患を除くペリオスチン発現に起因する疾患用医薬、およびその用途 |
WO2015093495A1 (ja) * | 2013-12-16 | 2015-06-25 | 株式会社ボナック | TGF-β1遺伝子発現制御のための一本鎖核酸分子 |
CN105899663B (zh) | 2013-12-26 | 2019-07-26 | 学校法人东京医科大学 | 用于基因表达控制的人工模拟miRNA及其用途 |
CN106068324B (zh) * | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
JP6492014B2 (ja) * | 2013-12-27 | 2019-03-27 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型miRNAおよびその用途 |
US10337009B2 (en) * | 2014-12-15 | 2019-07-02 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting TGF-β1 expression |
MX2017008587A (es) * | 2014-12-27 | 2017-10-20 | Bonac Corp | Mirna natural para controlar la expresion de gen y uso del mismo. |
JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
US20180099004A1 (en) * | 2015-04-17 | 2018-04-12 | The University Of Tokyo | Therapeutic agent for eye disease |
RU2714257C2 (ru) | 2015-10-30 | 2020-02-13 | Бонак Корпорейшн | КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ В СТАБИЛЬНОМ СОСТОЯНИИ ОДНОЦЕПОЧЕЧНУЮ МОЛЕКУЛУ НУКЛЕИНОВОЙ КИСЛОТЫ, КОТОРАЯ ПОДАВЛЯЕТ ЭКСПРЕССИЮ ГЕНА TGF-β1 |
WO2017115872A1 (ja) * | 2015-12-29 | 2017-07-06 | 国立大学法人北海道大学 | プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途 |
CN116064544A (zh) | 2016-01-26 | 2023-05-05 | 日产化学株式会社 | 单链寡核苷酸 |
AU2017213405B2 (en) * | 2016-01-30 | 2021-02-04 | Bonac Corporation | Artificial single guide RNA and use thereof |
WO2017188042A1 (ja) * | 2016-04-26 | 2017-11-02 | 住友化学株式会社 | 一本鎖核酸分子用モノマーの製造方法 |
CA3052801A1 (en) * | 2017-02-06 | 2018-08-09 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
JPWO2018182008A1 (ja) | 2017-03-31 | 2020-02-06 | 株式会社ボナック | 遺伝子発現制御機能を有する環状型核酸分子 |
WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | B型肝炎治療用核酸分子 |
TW201910514A (zh) * | 2017-07-28 | 2019-03-16 | 日商杏林製藥股份有限公司 | 纖維化治療劑 |
EP3696269A4 (en) * | 2017-10-13 | 2021-09-01 | Bonac Corporation | SINGLE STRAND NUCLEIC ACID MOLECULE AND ITS PRODUCTION PROCESS |
TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
AU2019237599A1 (en) | 2018-03-20 | 2020-11-12 | Nissan Chemical Corporation | Antisense oligonucleotide having reduced toxicity |
KR20200136363A (ko) | 2018-03-30 | 2020-12-07 | 도레이 카부시키가이샤 | 헤어핀형 1개쇄 rna 분자의 제조 방법 |
EP3778914A4 (en) * | 2018-03-30 | 2022-01-19 | Sumitomo Chemical Company, Ltd. | PROCEDURE FOR DELIVERING SINGLE STRAND RNA |
KR20210069628A (ko) | 2018-10-02 | 2021-06-11 | 도레이 카부시키가이샤 | 헤어핀형 단일쇄 rna 분자의 제조 방법 |
WO2020152869A1 (ja) | 2019-01-25 | 2020-07-30 | 杏林製薬株式会社 | 線維症治療剤 |
EP3950127A4 (en) | 2019-03-29 | 2023-01-04 | Sumitomo Chemical Company Limited | INORGANIC POROUS SUPPORT AND METHOD FOR PRODUCTION OF NUCLEIC ACID USING THE SAME |
WO2020202949A1 (ja) | 2019-03-29 | 2020-10-08 | 住友化学株式会社 | Rnaの製造方法 |
JP7368456B2 (ja) | 2019-03-29 | 2023-10-24 | 住友化学株式会社 | 無機多孔質担体、及びこれを用いた核酸の製造方法 |
CN113631264A (zh) | 2019-03-29 | 2021-11-09 | 住友化学株式会社 | 无机多孔质担载体及使用其的核酸的制造方法 |
CN113631265A (zh) | 2019-03-29 | 2021-11-09 | 住友化学株式会社 | 无机多孔质担载体、及使用其的核酸的制造方法 |
JPWO2021070494A1 (ja) | 2019-10-11 | 2021-04-15 | ||
WO2021153770A1 (en) | 2020-01-29 | 2021-08-05 | Sumitomo Chemical Company, Limited | Process of preparing nucleic acid oligomer |
KR20220133878A (ko) | 2020-01-29 | 2022-10-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
JPWO2021193954A1 (ja) * | 2020-03-27 | 2021-09-30 | ||
CN115551805B (zh) | 2020-05-13 | 2023-10-20 | 住友化学株式会社 | 无机多孔质基材、无机多孔质担载体、及核酸的制造方法 |
JPWO2022009959A1 (ja) | 2020-07-09 | 2022-01-13 | ||
EP4219520A1 (en) | 2020-09-24 | 2023-08-02 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
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WO2004090108A2 (en) * | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | Irna conjugates |
WO2006088490A2 (en) * | 2004-06-30 | 2006-08-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
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2011
- 2011-07-28 KR KR1020187010010A patent/KR101894701B1/ko active IP Right Grant
- 2011-07-28 ES ES13167536.5T patent/ES2528285T3/es active Active
- 2011-07-28 EP EP13184178.5A patent/EP2674494B1/en active Active
- 2011-07-28 KR KR1020137004646A patent/KR101849801B1/ko active IP Right Grant
- 2011-07-28 ES ES11748250.5T patent/ES2443346T3/es active Active
- 2011-07-28 DK DK13184178.5T patent/DK2674494T3/en active
- 2011-07-28 CN CN201410217512.3A patent/CN104059911B/zh active Active
- 2011-07-28 EP EP13167536.5A patent/EP2628801B1/en active Active
- 2011-07-28 CN CN201180037592.9A patent/CN103052711B/zh active Active
- 2011-07-28 KR KR1020187010011A patent/KR101894702B1/ko active IP Right Grant
- 2011-07-28 PT PT131841785T patent/PT2674494E/pt unknown
- 2011-07-28 ES ES13184178.5T patent/ES2527660T3/es active Active
- 2011-07-28 ES ES13167541.5T patent/ES2533129T3/es active Active
- 2011-07-28 CN CN201410217071.7A patent/CN104004018B/zh active Active
- 2011-07-28 EP EP13167541.5A patent/EP2639307B1/en active Active
- 2011-07-28 EP EP11748250.5A patent/EP2436767B1/en active Active
- 2011-07-28 JP JP2011537085A patent/JP4965745B2/ja active Active
- 2011-07-28 WO PCT/JP2011/067292 patent/WO2012017919A1/ja active Application Filing
- 2011-08-02 TW TW104132132A patent/TWI572716B/zh active
- 2011-08-02 TW TW100127384A patent/TWI515294B/zh active
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2012
- 2012-02-10 JP JP2012026878A patent/JP5261677B2/ja active Active
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2013
- 2013-03-12 JP JP2013048777A patent/JP5555346B2/ja active Active
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2014
- 2014-03-26 HK HK14102959.9A patent/HK1189910A1/xx not_active IP Right Cessation
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2015
- 2015-01-28 HK HK15100974.3A patent/HK1200460A1/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004090108A2 (en) * | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | Irna conjugates |
WO2006088490A2 (en) * | 2004-06-30 | 2006-08-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
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