CN102770402B - 制造二苯甲酮衍生物的新方法 - Google Patents

制造二苯甲酮衍生物的新方法 Download PDF

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Publication number
CN102770402B
CN102770402B CN201180006347.1A CN201180006347A CN102770402B CN 102770402 B CN102770402 B CN 102770402B CN 201180006347 A CN201180006347 A CN 201180006347A CN 102770402 B CN102770402 B CN 102770402B
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China
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compound
formula
reaction
solvent
represent
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CN201180006347.1A
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English (en)
Chinese (zh)
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CN102770402A (zh
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拉斯·埃克隆德
乔纳斯·尼尔松
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Nobel Chemicals AB
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Cambrex Karlskoga AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201180006347.1A 2010-01-19 2011-01-19 制造二苯甲酮衍生物的新方法 Expired - Fee Related CN102770402B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29609610P 2010-01-19 2010-01-19
US61/296,096 2010-01-19
PCT/GB2011/000058 WO2011089385A1 (en) 2010-01-19 2011-01-19 New processes for producing benzophenone derivatives

Publications (2)

Publication Number Publication Date
CN102770402A CN102770402A (zh) 2012-11-07
CN102770402B true CN102770402B (zh) 2016-01-20

Family

ID=43827282

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180006347.1A Expired - Fee Related CN102770402B (zh) 2010-01-19 2011-01-19 制造二苯甲酮衍生物的新方法

Country Status (13)

Country Link
US (1) US9085519B2 (enExample)
EP (1) EP2526080B1 (enExample)
JP (1) JP5850857B2 (enExample)
CN (1) CN102770402B (enExample)
BR (1) BR112012017845A2 (enExample)
DK (1) DK2526080T3 (enExample)
ES (1) ES2460022T3 (enExample)
HR (1) HRP20140558T1 (enExample)
PL (1) PL2526080T3 (enExample)
PT (1) PT2526080E (enExample)
RS (1) RS53353B (enExample)
SI (1) SI2526080T1 (enExample)
WO (1) WO2011089385A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2909163A1 (en) * 2012-10-19 2015-08-26 Fermion Oy A process for the preparation of ospemifene
US9321712B2 (en) 2012-10-19 2016-04-26 Fermion Oy Process for the preparation of ospemifene
CN104030896A (zh) * 2013-03-07 2014-09-10 天津药物研究院 一种简易去除欧司哌米芬特异杂质的方法
US20170297999A1 (en) * 2014-09-16 2017-10-19 Shionogo & Co., Ltd Method for producing triphenylbutene derivative
ES2717546T3 (es) 2014-12-29 2019-06-21 Olon Spa Proceso para la preparación de ospemifeno y fispemifeno
WO2016110805A1 (en) * 2015-01-09 2016-07-14 Glenmark Pharmaceuticals Limited Process for preparation of ospemifene
WO2017102675A1 (de) 2015-12-15 2017-06-22 Basf Se Verfahren zur herstellung von hydroxybenzophenonpolyglykolether-(meth)acrylat
KR102377433B1 (ko) 2016-03-15 2022-03-23 시오노기 앤드 컴파니, 리미티드 페녹시에탄올 유도체의 제조 방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625048A (en) * 1982-08-13 1986-11-25 Hoffmann-La Roche Inc. Carbamic acid esters
US5750576A (en) * 1994-09-07 1998-05-12 Orion-Yhtyma Oy Triphenylethylenes for the prevention and treatment of osteoporosis
US6576645B1 (en) * 1999-11-16 2003-06-10 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US20080207956A1 (en) * 2007-02-14 2008-08-28 Marja Sodervall Method for the preparation of therapeutically valuable triphenylbutene derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2182786A (en) 1938-09-14 1939-12-12 Dow Chemical Co Hydroxy-alkyl ethers of benzophenone
US2831768A (en) 1956-01-19 1958-04-22 Eastman Kodak Co Polymeric light-sensitive photographic elements
CS196471B1 (cs) 1977-11-28 1980-03-31 Ivan Lukac Nové p-acylované fenoxyetanoly
EP0072475B1 (de) 1981-08-17 1986-08-20 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Carbaminsäureester, Verfahren zu deren Herstellung, Schädlingsbekämpfungsmittel, die diese Verbindungen als Wirkstoffe enthalten, sowie Verwendung solcher Verbindungen und Mittel zur Bekämpfung von Schädlingen
GB2126576B (en) 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
DE3814781A1 (de) * 1988-04-30 1989-11-09 Basf Ag Verfahren zur herstellung von 2-hydroxy-4-(2'-hydroxyethoxy)-benzophenonen
DE3936592A1 (de) 1989-11-03 1991-05-08 Basf Ag Verfahren zur herstellung und reinigung von 2-hydroxy-4-(2'-hydroxy-ethoxy)phenylarylketonen
GB9803521D0 (en) 1998-02-19 1998-04-15 Orion Yhtymo Oy New compounds and pharmaceutical compositions thereof
WO2001060775A1 (en) 2000-02-17 2001-08-23 Appleton Papers Inc. Process for preparing alkoxy or arylmethoxy aroxyethanes
US7504530B2 (en) 2007-02-14 2009-03-17 Hormos Medical Ltd. Methods for the preparation of fispemifene from ospemifene

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625048A (en) * 1982-08-13 1986-11-25 Hoffmann-La Roche Inc. Carbamic acid esters
US5750576A (en) * 1994-09-07 1998-05-12 Orion-Yhtyma Oy Triphenylethylenes for the prevention and treatment of osteoporosis
US6576645B1 (en) * 1999-11-16 2003-06-10 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US20080207956A1 (en) * 2007-02-14 2008-08-28 Marja Sodervall Method for the preparation of therapeutically valuable triphenylbutene derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Insights into the General and Efficient Cross McMurry Reactions between Ketones;Xin-Fang Duan等;《J. Org. Chem.》;20060123;第71卷;第9873-9876页 *

Also Published As

Publication number Publication date
US20130035514A1 (en) 2013-02-07
HRP20140558T1 (hr) 2014-08-01
BR112012017845A2 (pt) 2016-03-29
US9085519B2 (en) 2015-07-21
JP5850857B2 (ja) 2016-02-03
EP2526080B1 (en) 2014-03-26
CN102770402A (zh) 2012-11-07
RS53353B (sr) 2014-10-31
PT2526080E (pt) 2014-05-06
WO2011089385A1 (en) 2011-07-28
PL2526080T3 (pl) 2014-08-29
DK2526080T3 (da) 2014-04-28
SI2526080T1 (sl) 2014-07-31
EP2526080A1 (en) 2012-11-28
ES2460022T3 (es) 2014-05-13
JP2013517320A (ja) 2013-05-16
HK1179244A1 (en) 2013-09-27

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