CN102695416B - 激酶抑制剂 - Google Patents

激酶抑制剂 Download PDF

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Publication number
CN102695416B
CN102695416B CN201080049613.4A CN201080049613A CN102695416B CN 102695416 B CN102695416 B CN 102695416B CN 201080049613 A CN201080049613 A CN 201080049613A CN 102695416 B CN102695416 B CN 102695416B
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pyrido
phenylamino
pyrimidin
trifluoromethyl
pyrimidine
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Chinese (zh)
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CN102695416A (zh
Inventor
金洪宇
高钟声
李宰圭
宋浩俊
金泳三
李熙圭
崔章植
林顺熙
张纯花
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Oscotec Inc
Genosco
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Oscotec Inc
Genosco
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Pulmonology (AREA)
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  • Immunology (AREA)
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CN201080049613.4A 2009-10-29 2010-10-29 激酶抑制剂 Active CN102695416B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25622209P 2009-10-29 2009-10-29
US61/256,222 2009-10-29
PCT/US2010/054853 WO2011053861A1 (en) 2009-10-29 2010-10-29 Kinase inhibitors

Publications (2)

Publication Number Publication Date
CN102695416A CN102695416A (zh) 2012-09-26
CN102695416B true CN102695416B (zh) 2017-03-08

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ID=43922599

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Country Status (18)

Country Link
US (1) US8404677B2 (https=)
EP (1) EP2493313B1 (https=)
JP (1) JP5993742B2 (https=)
KR (1) KR101690358B1 (https=)
CN (1) CN102695416B (https=)
BR (1) BR112012010085B1 (https=)
CA (1) CA2779105C (https=)
CL (1) CL2012001073A1 (https=)
EA (1) EA029273B1 (https=)
ES (1) ES2658290T3 (https=)
IL (1) IL219447A (https=)
MX (1) MX2012004846A (https=)
MY (1) MY173494A (https=)
NZ (2) NZ630860A (https=)
SG (1) SG10201407012XA (https=)
TR (1) TR201802464T4 (https=)
WO (1) WO2011053861A1 (https=)
ZA (1) ZA201203842B (https=)

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WO2013125543A1 (ja) * 2012-02-20 2013-08-29 武田薬品工業株式会社 複素環化合物
CN104271576A (zh) * 2012-02-23 2015-01-07 艾伯维公司 激酶的吡啶并嘧啶酮抑制剂
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WO2014001973A1 (en) 2012-06-29 2014-01-03 Pfizer Inc. NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS
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KR20150042256A (ko) * 2012-08-13 2015-04-20 노파르티스 아게 비장 티로신 키나제 (syk)의 억제제로서의 비시클릭 헤테로아릴 시클로알킬디아민 유도체
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JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
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JP6487921B2 (ja) 2013-12-17 2019-03-20 ファイザー・インク ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン
WO2015146928A1 (ja) * 2014-03-24 2015-10-01 武田薬品工業株式会社 複素環化合物
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WO2016204429A1 (ko) * 2015-06-18 2016-12-22 한국화학연구원 헤테로아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물.
BR112018000808A2 (pt) 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
KR102161364B1 (ko) 2015-09-14 2020-09-29 화이자 인코포레이티드 LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
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