CN102532133A - 适用作詹纳斯激酶抑制剂的吖吲哚类 - Google Patents

适用作詹纳斯激酶抑制剂的吖吲哚类 Download PDF

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Publication number
CN102532133A
CN102532133A CN2011103519191A CN201110351919A CN102532133A CN 102532133 A CN102532133 A CN 102532133A CN 2011103519191 A CN2011103519191 A CN 2011103519191A CN 201110351919 A CN201110351919 A CN 201110351919A CN 102532133 A CN102532133 A CN 102532133A
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compound
disease
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treat
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Chinese (zh)
Inventor
L·法莫
G·马蒂内兹-伯塔拉
A·皮尔斯
F·萨利特罗
王健
M·沃纳姆科
王天生
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38197739&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102532133(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN102532133A publication Critical patent/CN102532133A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
CN2011103519191A 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类 Pending CN102532133A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US60/759,367 2006-01-17
US84247106P 2006-09-06 2006-09-06
US60/842,471 2006-09-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800032602A Division CN101374839A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类

Publications (1)

Publication Number Publication Date
CN102532133A true CN102532133A (zh) 2012-07-04

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ID=38197739

Family Applications (3)

Application Number Title Priority Date Filing Date
CN2011103519191A Pending CN102532133A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类
CN2011104033161A Pending CN102532134A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类
CN201510004860.7A Pending CN104650077A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2011104033161A Pending CN102532134A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类
CN201510004860.7A Pending CN104650077A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类

Country Status (19)

Country Link
US (6) US7767816B2 (https=)
EP (3) EP1973911B1 (https=)
JP (4) JP5591471B2 (https=)
KR (3) KR101409727B1 (https=)
CN (3) CN102532133A (https=)
AR (1) AR060316A1 (https=)
AU (1) AU2007207533B8 (https=)
BR (2) BRPI0706537A2 (https=)
CA (1) CA2636189A1 (https=)
CL (1) CL2008002140A1 (https=)
HK (1) HK1210780A1 (https=)
IL (1) IL191902A0 (https=)
NO (1) NO20083501L (https=)
NZ (3) NZ569899A (https=)
RU (2) RU2453548C2 (https=)
TW (4) TW201412738A (https=)
UA (1) UA95940C2 (https=)
WO (1) WO2007084557A2 (https=)
ZA (2) ZA200805053B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105732617A (zh) * 2011-02-01 2016-07-06 默克专利股份公司 7-氮杂吲哚衍生物

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI372624B (en) 2004-03-30 2012-09-21 Vertex Pharma Azaindoles useful as inhibitors of jak and other protein kinases
WO2006127587A1 (en) * 2005-05-20 2006-11-30 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
EP2270014A1 (en) 2005-09-22 2011-01-05 Incyte Corporation Azepine inhibitors of janus kinases
EP2455382B1 (en) 2005-12-13 2016-10-26 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
CN102532133A (zh) * 2006-01-17 2012-07-04 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
JP2009532475A (ja) * 2006-04-05 2009-09-10 バーテックス ファーマシューティカルズ インコーポレイテッド ヤヌスキナーゼの阻害剤として有用なデアザプリン
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
AU2007338754A1 (en) * 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
EP2121692B1 (en) 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
CN101778825A (zh) * 2007-03-22 2010-07-14 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的n-杂环类化合物
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
EP3070090B1 (en) 2007-06-13 2018-12-12 Incyte Holdings Corporation Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
US8158616B2 (en) 2008-03-11 2012-04-17 Incyte Corporation Azetidine and cyclobutane derivatives as JAK inhibitors
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US8450489B2 (en) 2013-05-28
RU2453548C2 (ru) 2012-06-20
US8822681B2 (en) 2014-09-02
TWI405761B (zh) 2013-08-21
JP2013010793A (ja) 2013-01-17
JP5728454B2 (ja) 2015-06-03
CN104650077A (zh) 2015-05-27
JP2013010792A (ja) 2013-01-17
KR20080085174A (ko) 2008-09-23
NZ601687A (en) 2014-03-28
TW201412738A (zh) 2014-04-01
BRPI0722364A2 (pt) 2011-08-16
ZA200805053B (en) 2010-11-24
EP2559694A3 (en) 2013-04-03
TW201302747A (zh) 2013-01-16
US9120790B2 (en) 2015-09-01
US20140336171A1 (en) 2014-11-13
CN102532134A (zh) 2012-07-04
RU2011151085A (ru) 2013-06-20
HK1210780A1 (en) 2016-05-06
NZ569899A (en) 2011-06-30
AU2007207533B2 (en) 2012-05-31
NO20083501L (no) 2008-10-14
EP2537849A3 (en) 2013-04-03
US20130237516A1 (en) 2013-09-12
WO2007084557A3 (en) 2007-09-27
KR20120091305A (ko) 2012-08-17
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EP1973911A2 (en) 2008-10-01

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