KR101409727B1 - 야누스 키나제의 억제제로서 유용한 아자인돌 - Google Patents

야누스 키나제의 억제제로서 유용한 아자인돌 Download PDF

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KR101409727B1
KR101409727B1 KR1020087017472A KR20087017472A KR101409727B1 KR 101409727 B1 KR101409727 B1 KR 101409727B1 KR 1020087017472 A KR1020087017472 A KR 1020087017472A KR 20087017472 A KR20087017472 A KR 20087017472A KR 101409727 B1 KR101409727 B1 KR 101409727B1
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ring
compounds
disease
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KR20080085174A (ko
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룩 파머
가브리엘 마르티네-보텔라
알버트 피어스
프란세스코 살리투로
지안 왕
마리온 위너메이커
톈성 왕
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버텍스 파마슈티칼스 인코포레이티드
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D495/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
KR1020087017472A 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌 Expired - Fee Related KR101409727B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US60/759,367 2006-01-17
US84247106P 2006-09-06 2006-09-06
US60/842,471 2006-09-06
PCT/US2007/001225 WO2007084557A2 (en) 2006-01-17 2007-01-17 Azaindoles useful as inhibitors of janus kinases

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020127014597A Division KR101235103B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌
KR1020137005929A Division KR20130041313A (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌

Publications (2)

Publication Number Publication Date
KR20080085174A KR20080085174A (ko) 2008-09-23
KR101409727B1 true KR101409727B1 (ko) 2014-06-20

Family

ID=38197739

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020087017472A Expired - Fee Related KR101409727B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌
KR1020127014597A Expired - Fee Related KR101235103B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌
KR1020137005929A Withdrawn KR20130041313A (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020127014597A Expired - Fee Related KR101235103B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌
KR1020137005929A Withdrawn KR20130041313A (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌

Country Status (19)

Country Link
US (6) US7767816B2 (https=)
EP (3) EP1973911B1 (https=)
JP (4) JP5591471B2 (https=)
KR (3) KR101409727B1 (https=)
CN (3) CN102532133A (https=)
AR (1) AR060316A1 (https=)
AU (1) AU2007207533B8 (https=)
BR (2) BRPI0706537A2 (https=)
CA (1) CA2636189A1 (https=)
CL (1) CL2008002140A1 (https=)
HK (1) HK1210780A1 (https=)
IL (1) IL191902A0 (https=)
NO (1) NO20083501L (https=)
NZ (3) NZ569899A (https=)
RU (2) RU2453548C2 (https=)
TW (4) TW201412738A (https=)
UA (1) UA95940C2 (https=)
WO (1) WO2007084557A2 (https=)
ZA (2) ZA200805053B (https=)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI372624B (en) 2004-03-30 2012-09-21 Vertex Pharma Azaindoles useful as inhibitors of jak and other protein kinases
WO2006127587A1 (en) * 2005-05-20 2006-11-30 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
EP2270014A1 (en) 2005-09-22 2011-01-05 Incyte Corporation Azepine inhibitors of janus kinases
EP2455382B1 (en) 2005-12-13 2016-10-26 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
CN102532133A (zh) * 2006-01-17 2012-07-04 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
JP2009532475A (ja) * 2006-04-05 2009-09-10 バーテックス ファーマシューティカルズ インコーポレイテッド ヤヌスキナーゼの阻害剤として有用なデアザプリン
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
AU2007338754A1 (en) * 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
EP2121692B1 (en) 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
CN101778825A (zh) * 2007-03-22 2010-07-14 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的n-杂环类化合物
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JP5591471B2 (ja) 2014-09-17
JP2014210823A (ja) 2014-11-13
ZA200904147B (en) 2011-04-28
CN102532133A (zh) 2012-07-04
KR20130041313A (ko) 2013-04-24
AU2007207533B8 (en) 2012-06-28
IL191902A0 (en) 2008-12-29
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US8450489B2 (en) 2013-05-28
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US8822681B2 (en) 2014-09-02
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JP5728454B2 (ja) 2015-06-03
CN104650077A (zh) 2015-05-27
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KR20080085174A (ko) 2008-09-23
NZ601687A (en) 2014-03-28
TW201412738A (zh) 2014-04-01
BRPI0722364A2 (pt) 2011-08-16
ZA200805053B (en) 2010-11-24
EP2559694A3 (en) 2013-04-03
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US9120790B2 (en) 2015-09-01
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CN102532134A (zh) 2012-07-04
RU2011151085A (ru) 2013-06-20
HK1210780A1 (en) 2016-05-06
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AU2007207533B2 (en) 2012-05-31
NO20083501L (no) 2008-10-14
EP2537849A3 (en) 2013-04-03
US20130237516A1 (en) 2013-09-12
WO2007084557A3 (en) 2007-09-27
KR20120091305A (ko) 2012-08-17
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EP1973911A2 (en) 2008-10-01

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