CN1025032C - 制备2-甲氧基甲基-青霉烯衍生物的方法 - Google Patents

制备2-甲氧基甲基-青霉烯衍生物的方法 Download PDF

Info

Publication number
CN1025032C
CN1025032C CN88103425A CN88103425A CN1025032C CN 1025032 C CN1025032 C CN 1025032C CN 88103425 A CN88103425 A CN 88103425A CN 88103425 A CN88103425 A CN 88103425A CN 1025032 C CN1025032 C CN 1025032C
Authority
CN
China
Prior art keywords
formula
compound
salt
methyl
penem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN88103425A
Other languages
English (en)
Chinese (zh)
Other versions
CN1030079A (zh
Inventor
马科·奥佩简妮
吉奥凡妮·弗兰塞斯奇
埃托尔·皮罗恩
弗兰科·茨里妮
科斯坦弟诺·达拉布卢纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmitalia Carlo Erba SL
Original Assignee
Farmitalia Carlo Erba SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SL filed Critical Farmitalia Carlo Erba SL
Priority to CN91103934A priority Critical patent/CN1056420A/zh
Publication of CN1030079A publication Critical patent/CN1030079A/zh
Application granted granted Critical
Publication of CN1025032C publication Critical patent/CN1025032C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN88103425A 1987-06-10 1988-06-08 制备2-甲氧基甲基-青霉烯衍生物的方法 Expired - Fee Related CN1025032C (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN91103934A CN1056420A (zh) 1987-06-10 1988-06-08 制备含2-甲氧基甲基-青霉烯衍生物的药用组合物方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878713515A GB8713515D0 (en) 1987-06-10 1987-06-10 Methoxymethyl compounds
GB8713515 1987-06-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN91103934A Division CN1056420A (zh) 1987-06-10 1988-06-08 制备含2-甲氧基甲基-青霉烯衍生物的药用组合物方法

Publications (2)

Publication Number Publication Date
CN1030079A CN1030079A (zh) 1989-01-04
CN1025032C true CN1025032C (zh) 1994-06-15

Family

ID=10618657

Family Applications (2)

Application Number Title Priority Date Filing Date
CN88103425A Expired - Fee Related CN1025032C (zh) 1987-06-10 1988-06-08 制备2-甲氧基甲基-青霉烯衍生物的方法
CN91103934A Pending CN1056420A (zh) 1987-06-10 1988-06-08 制备含2-甲氧基甲基-青霉烯衍生物的药用组合物方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN91103934A Pending CN1056420A (zh) 1987-06-10 1988-06-08 制备含2-甲氧基甲基-青霉烯衍生物的药用组合物方法

Country Status (30)

Country Link
US (1) US4952577A (enExample)
EP (1) EP0295100B1 (enExample)
JP (1) JP2547341B2 (enExample)
KR (1) KR890000495A (enExample)
CN (2) CN1025032C (enExample)
AT (1) AT395590B (enExample)
AU (2) AU609488B2 (enExample)
CA (1) CA1300604C (enExample)
CH (2) CH682324A5 (enExample)
CS (2) CS268197B2 (enExample)
DE (1) DE3851470T2 (enExample)
DK (1) DK313788A (enExample)
ES (1) ES2009935A6 (enExample)
FI (1) FI89490C (enExample)
FR (1) FR2616434B1 (enExample)
GB (2) GB8713515D0 (enExample)
HK (1) HK65291A (enExample)
HU (1) HU198943B (enExample)
IE (1) IE61905B1 (enExample)
IL (1) IL86640A (enExample)
IT (1) IT1221792B (enExample)
MY (1) MY103733A (enExample)
NO (1) NO171501C (enExample)
NZ (1) NZ224923A (enExample)
PH (1) PH26311A (enExample)
PT (1) PT87679B (enExample)
SG (1) SG60791G (enExample)
SU (1) SU1586517A3 (enExample)
YU (1) YU46914B (enExample)
ZA (1) ZA884081B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416208A (en) * 1989-07-05 1995-05-16 Farmitalia Carlo Erba S R L Process for penems
GB8915392D0 (en) * 1989-07-05 1989-08-23 Erba Carlo Spa Process for penems
RU2051919C1 (ru) * 1990-08-20 1996-01-10 Сантори Лимитед Соединения пенема и фармацевтическая композиция на их основе
JP3148235B2 (ja) * 1990-08-20 2001-03-19 サントリー株式会社 抗菌性ペネム化合物
WO1992003444A1 (en) * 1990-08-20 1992-03-05 Suntory Limited Penem compounds
GB9210371D0 (en) * 1992-05-14 1992-07-01 Erba Carlo Spa Hydroxy protecting group removal in penems
US5399679A (en) * 1992-06-16 1995-03-21 Farmitalia Carlo Erba S.R.L. (1'R,3S,4R)4-acylthio azetidinones
GB9216102D0 (en) * 1992-07-29 1992-09-09 Smithkline Beecham Plc Pharmaceutical substances
PE20080940A1 (es) * 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
US4558042A (en) * 1981-05-06 1985-12-10 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0201459A1 (de) * 1985-05-06 1986-11-12 Ciba-Geigy Ag Acylaminomethylpenemverbindungen, ihre Herstellung und sie enthaltende pharmazeutische Präparate
GB2166435B (en) * 1985-05-09 1988-08-24 Erba Carlo Spa Penams, their preparation and their use
EP0233155A1 (de) * 1986-02-14 1987-08-19 Ciba-Geigy Ag Aminoacyloxymethyl-Verbindungen
GB8624686D0 (en) * 1986-10-15 1986-11-19 Erba Farmitalia Preparing penems
JPH01207387A (ja) * 1988-02-15 1989-08-21 Res Assoc Util Of Light Oil 炭化水素の製造方法

Also Published As

Publication number Publication date
SG60791G (en) 1991-08-23
YU46914B (sh) 1994-06-24
GB2205831B (en) 1991-03-27
AU609488B2 (en) 1991-05-02
IE881687L (en) 1988-12-10
JPS63316784A (ja) 1988-12-26
CH682324A5 (enExample) 1993-08-31
HU198943B (en) 1989-12-28
FI882696L (fi) 1988-12-11
HK65291A (en) 1991-08-23
AU8146191A (en) 1991-10-24
CN1056420A (zh) 1991-11-27
GB8713515D0 (en) 1987-07-15
AT395590B (de) 1993-01-25
CA1300604C (en) 1992-05-12
HUT47295A (en) 1989-02-28
DE3851470T2 (de) 1995-02-09
EP0295100B1 (en) 1994-09-14
FR2616434A1 (fr) 1988-12-16
FI89490C (fi) 1993-10-11
CS414991A3 (en) 1992-06-17
NO171501C (no) 1993-03-24
CS268197B2 (en) 1990-03-14
YU112188A (en) 1989-06-30
DK313788A (da) 1988-12-11
EP0295100A1 (en) 1988-12-14
IL86640A0 (en) 1988-11-30
ATA146488A (de) 1992-06-15
CH678058A5 (enExample) 1991-07-31
IE61905B1 (en) 1994-11-30
IT8820868A0 (it) 1988-06-06
PT87679B (pt) 1992-10-30
FR2616434B1 (fr) 1994-04-08
GB2205831A (en) 1988-12-21
CS397588A2 (en) 1989-04-14
CN1030079A (zh) 1989-01-04
NO882528L (no) 1988-12-12
NZ224923A (en) 1989-08-29
NO882528D0 (no) 1988-06-08
FI89490B (fi) 1993-06-30
IT1221792B (it) 1990-07-12
DE3851470D1 (de) 1994-10-20
GB8813622D0 (en) 1988-07-13
PH26311A (en) 1992-04-29
KR890000495A (ko) 1989-03-15
ZA884081B (en) 1989-02-22
JP2547341B2 (ja) 1996-10-23
MY103733A (en) 1993-09-30
AU1746188A (en) 1988-12-15
SU1586517A3 (ru) 1990-08-15
FI882696A0 (fi) 1988-06-08
PT87679A (pt) 1988-07-01
IL86640A (en) 1993-01-31
ES2009935A6 (es) 1989-10-16
NO171501B (no) 1992-12-14
DK313788D0 (da) 1988-06-09
US4952577A (en) 1990-08-28

Similar Documents

Publication Publication Date Title
CN100335054C (zh) 喹诺酮羧酸和萘啶酮羧酸衍生物在治疗幽门螺杆菌感染和其相关的胃十二指肠疾病中的应用
CN1481381A (zh) 二苯基氮杂环丁酮衍生物、它们的制备方法、含有这些化合物的药物和它们的用途
CN1160051A (zh) 新的取代噁唑烷酮
CN1067078C (zh) 2β－链烯基青霉烷砜类及其制备方法和用途
CN1025032C (zh) 制备2-甲氧基甲基-青霉烯衍生物的方法
CN1036713C (zh) 碳代青霉烯衍生物、其中间体、制备方法和含它的药物组合物
CN1163494C (zh) 碳青霉烯衍生物、其用途及其中间体化合物
CN1113064C (zh) 顺式取代氨基环丙烷衍生物
CN1046286C (zh) 新的头孢烯衍生物
CN1286686A (zh) 紫杉烷衍生物
CN1031533A (zh) 稳定的1-氧青霉烯-3-羧酸
CN1078720A (zh) 丁二烯衍生物及其制备方法
CN1093861C (zh) 1－甲基碳青霉烯衍生物
CN1511156A (zh) 碳青霉烯化合物
CN1244582C (zh) 喹诺酮羧酸类化合物及其制备方法和医药用途
CN1112364C (zh) 1,3,4－噻二唑碳青霉烯化合物及其制备方法和用途
CN1317008A (zh) 新的抗菌化合物
CN1024012C (zh) 新型头孢菌素衍生物制备方法
CN1041596A (zh) 稳定的氧青霉烯-3-羟酸的制备及其作为β-内酰胺酶抑制剂的应用
CN1688589A (zh) β－内酰胺酶抑制剂前体药物
CN1094941C (zh) 吡啶并苯并噁嗪衍生物
CN100347179C (zh) 经口给药用碳青霉素烯化合物的新的合成中间体及其制造方法
CN86107742A (zh) 季胺化的2-位具有杂硫烷硫取代基的碳代氰霉烯
CN1154649C (zh) 碳青霉烯-3-甲酸衍生物
CN1219512C (zh) 含奥沙培南－3－羧酸的药物组合物

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee