CN102391358B - 抗体纯化 - Google Patents

抗体纯化 Download PDF

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Publication number
CN102391358B
CN102391358B CN201110327798.7A CN201110327798A CN102391358B CN 102391358 B CN102391358 B CN 102391358B CN 201110327798 A CN201110327798 A CN 201110327798A CN 102391358 B CN102391358 B CN 102391358B
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China
Prior art keywords
antibody
disease
hcp
tnf
eluate
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Ceased
Application number
CN201110327798.7A
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English (en)
Chinese (zh)
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CN102391358A (zh
Inventor
M·W·万
G·阿夫格尼诺斯
G·扎比斯-帕帕斯托伊特西斯
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AbbVie Biotechnology Ltd
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Abbott Biotech Ltd Bermuda
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Application filed by Abbott Biotech Ltd Bermuda filed Critical Abbott Biotech Ltd Bermuda
Publication of CN102391358A publication Critical patent/CN102391358A/zh
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
CN201110327798.7A 2006-04-05 2007-04-04 抗体纯化 Ceased CN102391358B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78972506P 2006-04-05 2006-04-05
US60/789725 2006-04-05
US79041406P 2006-04-06 2006-04-06
US60/790414 2006-04-06
CN200780019220.7A CN101454025B (zh) 2006-04-05 2007-04-04 抗体纯化

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200780019220.7A Division CN101454025B (zh) 2006-04-05 2007-04-04 抗体纯化

Publications (2)

Publication Number Publication Date
CN102391358A CN102391358A (zh) 2012-03-28
CN102391358B true CN102391358B (zh) 2016-08-10

Family

ID=38581592

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201110327798.7A Ceased CN102391358B (zh) 2006-04-05 2007-04-04 抗体纯化
CN2012103014312A Pending CN102887955A (zh) 2006-04-05 2007-04-04 抗体纯化
CN200780019220.7A Active CN101454025B (zh) 2006-04-05 2007-04-04 抗体纯化
CN201310142761.6A Pending CN103509116A (zh) 2006-04-05 2007-04-04 抗体纯化

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN2012103014312A Pending CN102887955A (zh) 2006-04-05 2007-04-04 抗体纯化
CN200780019220.7A Active CN101454025B (zh) 2006-04-05 2007-04-04 抗体纯化
CN201310142761.6A Pending CN103509116A (zh) 2006-04-05 2007-04-04 抗体纯化

Country Status (16)

Country Link
US (17) US7863426B2 (enExample)
EP (4) EP2738179A1 (enExample)
JP (7) JP2009532474A (enExample)
KR (4) KR20150006085A (enExample)
CN (4) CN102391358B (enExample)
AU (1) AU2007235484B2 (enExample)
BR (1) BRPI0709726A2 (enExample)
CA (2) CA2647029A1 (enExample)
IL (1) IL194236A (enExample)
MX (1) MX2008012896A (enExample)
NZ (4) NZ610566A (enExample)
RU (2) RU2466740C2 (enExample)
SG (2) SG10201406358SA (enExample)
TW (2) TWI392684B (enExample)
WO (1) WO2007117490A2 (enExample)
ZA (1) ZA200808372B (enExample)

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CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
US20040009172A1 (en) * 2002-04-26 2004-01-15 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
NZ555692A (en) * 2002-07-19 2009-02-28 Abbott Biotech Ltd Treatment of TNF alpha related disorders
US20090280065A1 (en) * 2006-04-10 2009-11-12 Willian Mary K Uses and Compositions for Treatment of Psoriasis
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
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TWI439284B (zh) 2004-04-09 2014-06-01 Abbvie Biotechnology Ltd 用於治療ＴＮＦα相關失調症之多重可變劑量療法
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
US20060083741A1 (en) * 2004-10-08 2006-04-20 Hoffman Rebecca S Treatment of respiratory syncytial virus (RSV) infection
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
JP5757495B2 (ja) 2005-05-16 2015-07-29 アッヴィ バイオテクノロジー リミテッド びらん性多発性関節炎の治療のためのｔｎｆ阻害剤の使用
TWI424161B (zh) 2005-11-01 2014-01-21 Abbvie Biotechnology Ltd 利用生物標記診斷關節黏連脊椎炎之方法及組合物
KR20080111487A (ko) * 2006-03-20 2008-12-23 메다렉스, 인코포레이티드 단백질 정제 방법
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US20080118496A1 (en) * 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
WO2007120626A2 (en) 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of ankylosing spondylitis
US20090317399A1 (en) * 2006-04-10 2009-12-24 Pollack Paul F Uses and compositions for treatment of CROHN'S disease
EP2007426A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS
US9399061B2 (en) 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
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