CN102361857B - 可用作抗糖尿病剂的环状苯并咪唑衍生物 - Google Patents
可用作抗糖尿病剂的环状苯并咪唑衍生物 Download PDFInfo
- Publication number
- CN102361857B CN102361857B CN200980147275.5A CN200980147275A CN102361857B CN 102361857 B CN102361857 B CN 102361857B CN 200980147275 A CN200980147275 A CN 200980147275A CN 102361857 B CN102361857 B CN 102361857B
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- alkyl
- phenyl
- unsubstituted
- substituted
- halogen
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- LGOJYYSQOTWUSU-YPCHIDBBSA-N C/C(/c(cc1)ccc1-c1cc(F)ccc1)=C\C=C1\NC(Oc2ccc(C)c(C(O)=O)c2)=NC1=C Chemical compound C/C(/c(cc1)ccc1-c1cc(F)ccc1)=C\C=C1\NC(Oc2ccc(C)c(C(O)=O)c2)=NC1=C LGOJYYSQOTWUSU-YPCHIDBBSA-N 0.000 description 1
- KHMILAPQGZSSST-UHFFFAOYSA-N CC1(C)OB(c(cc2)ccc2-c2ccccc2O)OC1(C)C Chemical compound CC1(C)OB(c(cc2)ccc2-c2ccccc2O)OC1(C)C KHMILAPQGZSSST-UHFFFAOYSA-N 0.000 description 1
- ANCNERBUZFQLBL-UHFFFAOYSA-N CC1=CC=CCc2c1ccc(C(F)(F)F)c2 Chemical compound CC1=CC=CCc2c1ccc(C(F)(F)F)c2 ANCNERBUZFQLBL-UHFFFAOYSA-N 0.000 description 1
- DDRYSANPJIXAQG-UHFFFAOYSA-N CCc(ccc(O)c1)c1C(OC)=O Chemical compound CCc(ccc(O)c1)c1C(OC)=O DDRYSANPJIXAQG-UHFFFAOYSA-N 0.000 description 1
- CGWNBAFDWOFOMB-UHFFFAOYSA-N CS(c([nH]c1c2)nc1cc(I)c2F)(=O)=O Chemical compound CS(c([nH]c1c2)nc1cc(I)c2F)(=O)=O CGWNBAFDWOFOMB-UHFFFAOYSA-N 0.000 description 1
- ZYPUMJMGMIHXIW-UHFFFAOYSA-N Cc(c(C(O)=O)c1)ccc1Oc([nH]c1c2)nc1cc(-c(c(F)c1)ccc1OC)c2Cl Chemical compound Cc(c(C(O)=O)c1)ccc1Oc([nH]c1c2)nc1cc(-c(c(F)c1)ccc1OC)c2Cl ZYPUMJMGMIHXIW-UHFFFAOYSA-N 0.000 description 1
- YFHCTVCJFUZFTO-UHFFFAOYSA-N Cc(c(C(O)=O)c1)ccc1Oc([nH]c1c2)nc1cc(-c1ccc(C3(CO)CC3)cc1)c2Cl Chemical compound Cc(c(C(O)=O)c1)ccc1Oc([nH]c1c2)nc1cc(-c1ccc(C3(CO)CC3)cc1)c2Cl YFHCTVCJFUZFTO-UHFFFAOYSA-N 0.000 description 1
- YZFVUQSAJMLFOZ-UHFFFAOYSA-N Cc(c(F)c1)ccc1Br Chemical compound Cc(c(F)c1)ccc1Br YZFVUQSAJMLFOZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19433708P | 2008-09-26 | 2008-09-26 | |
| US61/194337 | 2008-09-26 | ||
| PCT/US2009/057686 WO2010036613A1 (en) | 2008-09-26 | 2009-09-21 | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102361857A CN102361857A (zh) | 2012-02-22 |
| CN102361857B true CN102361857B (zh) | 2015-09-16 |
Family
ID=41395799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980147275.5A Active CN102361857B (zh) | 2008-09-26 | 2009-09-21 | 可用作抗糖尿病剂的环状苯并咪唑衍生物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8394969B2 (enExample) |
| EP (1) | EP3924343A1 (enExample) |
| JP (1) | JP5764064B2 (enExample) |
| CN (1) | CN102361857B (enExample) |
| AR (1) | AR073677A1 (enExample) |
| AU (1) | AU2009296820B2 (enExample) |
| CA (1) | CA2737694C (enExample) |
| MX (1) | MX2011003239A (enExample) |
| TW (1) | TWI393709B (enExample) |
| WO (1) | WO2010036613A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011004258A (es) * | 2008-10-22 | 2011-06-01 | Merck Sharp & Dohme | Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos. |
| MX2011004505A (es) | 2008-10-29 | 2011-05-31 | Merck Sharp & Dohme | Derivados novedosos de bencimidazol ciclico, utiles como agentes antidiabeticos. |
| CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| ES2679918T3 (es) | 2010-02-18 | 2018-08-31 | Vtv Therapeutics Llc | Derivados de imidazol condensados sustituidos, composiciones farmacéuticas y métodos de uso de los mismos |
| CA2786314A1 (en) * | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8344137B2 (en) * | 2010-04-14 | 2013-01-01 | Hoffman-La Roche Inc. | 3,3-dimethyl tetrahydroquinoline derivatives |
| RU2635662C2 (ru) | 2010-09-10 | 2017-11-15 | Сионоги Энд Ко., Лтд. | Конденсированное с гетерокольцом имидазольное производное, обладающее активирующим амрк действием |
| WO2012047772A2 (en) * | 2010-10-07 | 2012-04-12 | Schering Corporation | Imidazole derivatives |
| WO2012064569A1 (en) * | 2010-11-08 | 2012-05-18 | Merck Sharp & Dohme Corp. | Imidazole derivatives |
| FR2968213B1 (fr) | 2010-12-03 | 2014-03-21 | Oreal | Utilisation d'une association amincissante |
| AR084174A1 (es) | 2010-12-21 | 2013-04-24 | Lilly Co Eli | Compuestos de imidazol-2-benzamida utiles para el tratamiento de osteoartritis y una composicion farmaceutica |
| SG192941A1 (en) * | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| CA2837312A1 (en) | 2011-05-26 | 2012-11-29 | Sunovion Pharmaceuticals Inc. | Metabotropic glutamate receptor 5 allosteric modulators and methods of use thereof |
| CN103781786A (zh) | 2011-07-15 | 2014-05-07 | 盐野义制药株式会社 | 具有ampk活化作用的氮杂苯并咪唑衍生物 |
| TWI449702B (zh) * | 2012-07-11 | 2014-08-21 | Merck Sharp & Dohme | 作為抗糖尿病劑之新穎環氮雜苯并咪唑衍生物 |
| KR20150036245A (ko) | 2012-08-02 | 2015-04-07 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 트리시클릭 화합물 |
| JP2015526468A (ja) * | 2012-08-22 | 2015-09-10 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 新規なアザベンズイミダゾールヘキサヒドロフロ［３，２−ｂ］フラン誘導体 |
| US9382243B2 (en) | 2012-08-22 | 2016-07-05 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydropyran derivatives |
| US9527839B2 (en) | 2012-08-22 | 2016-12-27 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydropyran derivatives |
| US9540364B2 (en) | 2012-08-22 | 2017-01-10 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydrofuran derivatives |
| US9868733B2 (en) | 2012-08-22 | 2018-01-16 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydrofuran derivatives |
| EP2887807B1 (en) * | 2012-08-22 | 2019-09-18 | Merck Sharp & Dohme Corp. | Benzimidazole hexahydrofuro[3,2-b]furan derivatives useful as amp-activated protein kinase activators |
| CA2903657A1 (en) | 2013-02-27 | 2014-09-04 | Shionogi & Co., Ltd. | Indole and azaindole derivatives each having ampk-activating activity |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| ES2747973T3 (es) | 2013-11-15 | 2020-03-12 | Merck Sharp & Dohme | Compuestos tricíclicos antidiabéticos |
| WO2015089809A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Antidiabetic substituted heteroaryl compounds |
| EP3089748A4 (en) | 2014-01-02 | 2017-09-27 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
| EP3091970B1 (en) | 2014-01-10 | 2020-10-28 | Rgenix, Inc. | Lxr agonists and uses thereof |
| WO2016031842A1 (ja) | 2014-08-27 | 2016-03-03 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するアザインドール誘導体 |
| CA2965781A1 (en) * | 2014-10-28 | 2016-05-06 | Shionogi & Co., Ltd. | Heterocyclic derivative having ampk activating effect |
| WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
| CN104961703A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 一类苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
| CN104961702A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
| CN105596333A (zh) * | 2016-02-02 | 2016-05-25 | 白强 | 一种防治糖尿病及其并发症的药物组合物及其应用 |
| EP3421467A4 (en) | 2016-02-26 | 2019-08-07 | Shionogi & Co., Ltd | 5-PHENYLAZAINDOLE DERIVATIVE HAVING AMPK ACTIVATION EFFECT |
| EP3459949A4 (en) | 2016-05-20 | 2020-04-08 | Shionogi & Co., Ltd | 5-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE AND 5-SUBSTITUTED AZABENZIMIDAZOLE DERIVATIVE WITH AMPK ACTIVATION EFFECT |
| US11174246B2 (en) * | 2016-08-19 | 2021-11-16 | Rigel Pharmaceuticals, Inc. | Direct AMPK activators |
| CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| CN108503632B (zh) * | 2018-06-26 | 2020-07-28 | 北京圣永制药有限公司 | 一种吲哚类衍生物及其在糖尿病中的应用 |
| AU2020259143A1 (en) | 2019-04-19 | 2021-11-11 | Assistance Publique Hopitaux De Paris | pl6INK4a inhibitor for preventing or treating Huntington's disease |
| HUE067466T2 (hu) | 2019-12-13 | 2024-10-28 | Inspirna Inc | Fémsók és alkalmazásuk |
| MX2022009898A (es) * | 2020-02-13 | 2022-08-25 | Genfleet Therapeutics Shanghai Inc | Compuesto de dihidronaftiridinona y metodo de preparacion del mismo y uso medico del mismo. |
| JP7745559B2 (ja) | 2020-02-28 | 2025-09-29 | キャリーオペ，インク． | Ｇｐｒ４０アゴニスト |
| AR121842A1 (es) * | 2020-04-15 | 2022-07-13 | Ache Laboratorios Farmaceuticos Sa | Compuesto de benzimidazol para el tratamiento de trastornos metabólicos |
| BR112022023359A2 (pt) | 2020-05-19 | 2023-04-18 | Kallyope Inc | Ativadores de ampk |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| WO2023092094A2 (en) | 2021-11-19 | 2023-05-25 | The Broad Institute, Inc. | Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof |
| TW202329944A (zh) * | 2021-11-23 | 2023-08-01 | 美商克力歐普股份有限公司 | Ampk活化劑 |
| CN117050043A (zh) * | 2022-05-13 | 2023-11-14 | 中国海洋大学 | 一种3-苯基二苯并呋喃类化合物及其制备方法和用途 |
| CN117243950A (zh) * | 2023-10-31 | 2023-12-19 | 首都医科大学附属北京朝阳医院 | Mk-3903在制备预防和/或治疗缺血性心脏病的药物中的应用 |
| WO2025101276A1 (en) * | 2023-11-06 | 2025-05-15 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Compositions and methods for making and using immune cells |
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| US20040044056A1 (en) * | 2000-11-15 | 2004-03-04 | Osamu Okamoto | Benzimidazole derivatives |
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| Publication number | Publication date |
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| WO2010036613A8 (en) | 2010-11-18 |
| JP2012503661A (ja) | 2012-02-09 |
| CA2737694C (en) | 2013-07-02 |
| WO2010036613A1 (en) | 2010-04-01 |
| TWI393709B (zh) | 2013-04-21 |
| US8394969B2 (en) | 2013-03-12 |
| AU2009296820B2 (en) | 2014-03-20 |
| US20100081643A1 (en) | 2010-04-01 |
| CA2737694A1 (en) | 2010-04-01 |
| TW201016672A (en) | 2010-05-01 |
| JP5764064B2 (ja) | 2015-08-12 |
| AU2009296820A1 (en) | 2010-04-01 |
| AR073677A1 (es) | 2010-11-24 |
| CN102361857A (zh) | 2012-02-22 |
| EP3924343A1 (en) | 2021-12-22 |
| MX2011003239A (es) | 2011-04-28 |
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